They always keep a bag packed. They seldom have more than twenty-four hours' notice before they are dispatched. The phone calls that tell them to head to the airport, sometimes in the middle of the night, may give them no more information than the country they are traveling to and the epidemic they will tackle when they get there.The universal human instinct is to run from an outbreak of disease. These doctors run toward it.They are the disease detective corps of the U.S. Centers for Disease Control and Prevention (CDC), the federal agency that tracks and tries to prevent disease outbreaks and bioterrorist attacks around the world. They are formally called the Epidemic Intelligence Service (EIS) -- a group founded more than fifty years ago out of fear that the Korean War might bring the use of biological weapons -- and, like intelligence operatives in the traditional sense, they perform their work largely in anonymity. They are not household names, but over the years they were first to confront the outbreaks that became known as hantavirus, Ebola virus, and AIDS. Now they hunt down the deadly threats that dominate our headlines: West Nile virus, anthrax, and SARS.In this riveting narrative, Maryn McKenna -- the only journalist ever given full access to the EIS in its fifty-three-year history -- follows the first class of disease detectives to come to the CDC after September 11, the first to confront not just naturally occurring outbreaks but the man-made threat of bioterrorism. They are talented researchers -- many with young families -- who trade two years of low pay and extremely long hours for the chance to be part of the group that has helped eradicate smallpox, push back polio, and solve the first major outbreaks of Legionnaires' disease, toxic shock syndrome, and "E. coli" O157.Urgent, exhilarating, and compelling, "Beating Back the Devil" goes with the EIS as they try to stop epidemics -- before the epidemics stop us.

    It hold the remains of an ancient sea where dozens of strange creatures lived—a forgotten corner of evolution preserved in awesome detail. In this book Stephen Jay Gould explores what the Burgess Shale tells us about evolution and the nature of history.

    Who knew that he also was a pivotal figure in the development of the airplane, the hydrofoil, genetic engineering, and more? Charlotte Gray does, and she tells us how and why she brought to life the passionate mind and heart of the man behind so many amazing ideas and innovations. --Lauren Nemroff Some Questions for Charlotte Gray [image] 1. Most people picture Alexander Graham Bell as that grandfatherly looking man with a long white beard who invented the telephone. What's wrong with that image? The image of Alexander Graham Bell as a kindly Santa Claus figure is the one we all know: It is as familiar as the one of Einstein with his hair in a frizzy grey mass. But when Alexander Graham Bell was struggling to invent the telephone, he was a skinny, clean-shaven, neurotically intense young man and a hypochondriac, with obsessive work habits and a very volatile nature. Reading his letters and journals, I was shocked to discover how often he would ricochet between euphoria and depression. Invention was Alexander Graham Bell's passion, but I frequently wondered whether, if he had not had an early success and the right wife, his difficult personality would have prevented him achieving anything. I think it is important to revise the grandfatherly stereotype of Bell in order to show that invention is difficult, and inventors are not easy, placid people to live with. 2. In what way does Bell's genius different from other inventors of his age, such as Thomas Edison or the Wright brothers? The wonderful thing about the inventions of such nineteenth century giants as Bell, Edison and the Wright brothers is that, with a little bit of effort, even those of us who never did Grade 12 physics can actually understand how their inventions worked. One could never say that about today's microelectronic technology. Intuition and imagination were all crucial for the breakthroughs made by Edison, the Wright brothers and Bell. However, what sets Bell apart from Edison and the Wright brothers was that he didn't have an entrepreneurial bone in his body. He was more like a holdover from the eighteenth century Enlightenment, while the others were go-getting twentieth-century hustlers. Edison was always looking for financial backers; he announced his breakthroughs before he had even built working prototypes; he was one of the first inventors to put together a real R and D team at a purpose-built laboratory, at Menlo Park. He understood that invention is, in his own words, "One percent inspiration, ninety percent perspiration." Similarly the Wright Brothers were eager to make money out of their flying machines. They refused to share their technological breakthroughs, guarded their patents fiercely, and wouldn't give any demonstrations to the public of their biplanes. Bell was the opposite--totally absorbed in extending the frontiers of knowledge, and completely careless about commercial exploitation of his ideas. 3. Is it true that "necessity is the mother of invention" or is it something else? Invention has many mothers - the right materials, a widespread understanding that this will improve the world in some way, the right individual to pursue the elusive dream. In the case of the telephone, one can argue that there was no overwhelming necessity for a new form of communication: the telegraph had been working well for 30 years, and only a few people realized that a device that could carry the human voice, rather than the Morse code, would pull people together in a revolutionary way. As soon as telephones appeared in the market, their advantages were obvious. But there was still incredible resistance. In Britain, the upper classes were slow to acquire telephones because they posed a class issue: who should answer them? Everybody knew that, in a house with servants, the servant answered the door when the telegraph boy rang the bell. But should master or servant speak on the phone? The democratic nature of the telephone--anybody could use it, not just qualified operators--also shackled its spread. In Russia after the revolution, Stalin is said to have vetoed the idea of a modern telephone system. "It will unmake our work," the dictator decreed. "No greater instrument for counter-revolution and conspiracy can be imagined." So did necessity drive the invention of the telephone? No--when Bell first started speculating on its impact, people thought he was mad. But it quickly became a total necessity…imagine life without electronic communication today! 4. It was amazing to learn that Bell's mother and his wife were both deaf, and that from an early age he was immersed in research on the nature of sound and oral communication. How important were these personal relationships in shaping his outlook and inventions? One of my greatest surprises when I started research for Reluctant Genius was the discovery that Bell's first ambition was to be a teacher of the deaf, and that he remained committed to the cause of improved education for the hearing impaired throughout his life. I had no idea of this side of him, or of his long relationship with Helen Keller. The fact that the two most important women in his life, his mother and his wife, were deaf was of crucial importance both to his own work, and to his attitude to others. His respect for their intelligences and personalities meant that, unlike many of his contemporaries, he never assumed that deafness was linked to intellectual disability. Moreover, his scientific interest in their condition informed his telephone research. Because he knew why their ears didn't work, he understood how sound should reach the brain in a hearing person's ear, through the ear drum. None of his competitors made that intuitive leap. Their early attempts to build working telephones were foiled because they didn't include the diaphragm that mimicked the action of the ear drum, and which was the key feature of Bell's first phone. Lastly, Bell was also fascinated by the intergenerational transmission of deafness. This led to his research on genetics in general - and the program he initiated at his summer home, in Cape Breton, to breed a flock of "super sheep" that would always have twin births. 5. Bell's wife, Mabel Hubbard Bell, was a remarkable person in her own right. Why was it so important to tell her story? Too often, biographies of "Great Men" suggest they achieved everything by their own efforts. A few did, of course, but most depended on the support and encouragement of others--parents, partners, associates--to provide the right environment in which they could achieve their goals. Behind every great man….This was the case with Alexander Graham Bell. He would always have had his "Eureka Moment", in the summer of 1874, when he realized how a "talking telegraph" might work. But without Mabel, we probably would never have heard of him. He would not have patented the invention or found the business partners who helped him moved his invention from the laboratory to the market place. Mabel's father, Gardiner Hubbard, was his patent lawyer: Mabel herself ensured that he went to the Philadelphia Exposition, in 1876, to demonstrate his new apparatus. In later years, Mabel provided all kinds of other practical help, in ensuring that her exasperating husband could focus on his inventions. She handled the financial side of their marriage: she found qualified young men who could help him work on his flying machines: she was always cheering him up and stroking his ego when he got depressed. And she created, along with their two daughters, a warm family environment which gave balance to Bell's life - and which so many of his contemporaries, including Thomas Edison, never enjoyed. I was determined to give Mabel her due in the story of Bell. I found her such an attractive and intriguing figure. She was stone deaf, ten years younger than her husband, and their relationship began as a teacher-student one. It would be easy to assume that this brilliant, world famous man would be the dominant figure in the relationship. In fact, the reverse is true. 6. What do you think Bell would think of cell phones, the internet and other wireless means of communication? Bell himself anticipated "electric communication": he was very frustrated by how long it took for a letter from Nova Scotia to reach Europe. I'm sure he would be delighted by the internet. However, he would be appalled by the constant buzz of other technological advances, and the way we've allowed them to trump all other forms of human intercourse. This is a man who wouldn't have a telephone in his own study, because its ring would disturb his train of thought. He was a gracious, well-mannered man who would have been horrified by the way many of us let our cell phones to interrupt our face-to-face conversations. And if somebody pulled out a Blackberry and started punching into it while Bell was speaking of him--well, Alec would have muttered, "Shee-e-esh" (the nearest he ever got to swearing) and stomped out of the room. 7. What was the most exciting research discovery that you made? As a biographer, I have to say that my most exciting discovery was the wealth of material I had to work with. Because Alexander Graham Bell could never speak to his wife on the telephone, he and Mabel exchanged long, intimate, colourful letters whenever they were apart--and that was often. I was thrilled to discover, at the Alexander Graham Bell Historic Site in Baddeck, Nova Scotia, 180 three-ring binders of family correspondence (another set is housed at the Library of Congress, Washington.) These letters let me explore the inner-workings of the mind of a genius, and of a remarkable marriage, in a way that I had hardly dared hope for. I was also amazed at the range of Bell's activities. The telephone, the photophone (which sent sounds down beams of light), an early iron lung, a desalination process for salt water, flying machines, hydrofoils, genetic experiments…his scientific interests were enormously varied. And at the same time, he was doing so much else, for example with the Smithsonian Institute, and the National Geographic Society. And throughout his career, there was his long-running commitment to deaf education. It was hard not to be overwhelmed! 8. What are you working on right now? Yes, I'm already launched on my next biography. (In fact, I find it very hard not to start my next book before the previous one is even in the stores--I have a psychological need to live both my own life and someone else's!) My next project is a short biography of Nellie McClung, the Canadian author and political activist.

    He had mentored many tech leaders in his illustrious career as an investor, but few things had made him prouder, or been better for his fund's bottom line, than his early service to Mark Zuckerberg. Still a large shareholder in Facebook, he had every good reason to stay on the bright side. Until he simply couldn't. ZUCKED is McNamee's intimate reckoning with the catastrophic failure of the head of one of the world's most powerful companies to face up to the damage he is doing. It's a story that begins with a series of rude awakenings. First there is the author's dawning realization that the platform is being manipulated by some very bad actors. Then there is the even more unsettling realization that Zuckerberg and Sheryl Sandberg are unable or unwilling to share his concerns, polite as they may be to his face."

    The term “complexity” can be misleading, however, because what makes West’s discoveries so beautiful is that he has found an underlying simplicity that unites the seemingly complex and diverse phenomena of living systems, including our bodies, our cities and our businesses. Fascinated by issues of aging and mortality, West applied the rigor of a physicist to the biological question of why we live as long as we do and no longer. The result was astonishing, and changed science, creating a new understanding of energy use and metabolism: West found that despite the riotous diversity in the sizes of mammals, they are all, to a large degree, scaled versions of each other. If you know the size of a mammal, you can use scaling laws to learn everything from how much food it eats per day, what its heart-rate is, how long it will take to mature, its lifespan, and so on. Furthermore, the efficiency of the mammal’s circulatory systems scales up precisely based on weight: if you compare a mouse, a human and an elephant on a logarithmic graph, you find with every doubling of average weight, a species gets 25% more efficient—and lives 25% longer. This speaks to everything from how long we can expect to live to how many hours of sleep we need. Fundamentally, he has proven, the issue has to do with the fractal geometry of the networks that supply energy and remove waste from the organism's body. West's work has been game-changing for biologists, but then he made the even bolder move of exploring his work's applicability to cities. Cities, too, are constellations of networks and laws of scalability relate with eerie precision to them. For every doubling in a city's size, the city needs 15% less road, electrical wire, and gas stations to support the same population. More amazingly, for every doubling in size, cities produce 15% more patents and more wealth, as well as 15% more crime and disease. This broad pattern lays the groundwork for a new science of cities. Recently, West has applied his revolutionary work on cities and biological life to the business world. This investigation has led to powerful insights into why some companies thrive while others fail. The implications of these discoveries are far-reaching, and are just beginning to be explored. Scale is a thrilling scientific adventure story about the elemental natural laws that bind us together in simple but profound ways. Through the brilliant mind of Geoffrey West, we can envision how cities, companies and biological life alike are dancing to the same simple, powerful tune, however diverse and unrelated they are to each other.From the Hardcover edition.

    Randall never gave sleep much thought. That is, until he began sleepwalking. One midnight crash into a hallway wall sent him on an investigation into the strange science of sleep.In Dreamland, Randall explores the research that is investigating those dark hours that make up nearly a third of our lives. Taking readers from military battlefields to children’s bedrooms, Dreamland shows that sleep isn't as simple as it seems. Why did the results of one sleep study change the bookmakers’ odds for certain Monday Night Football games? Do women sleep differently than men? And if you happen to kill someone while you are sleepwalking, does that count as murder?This book is a tour of the often odd, sometimes disturbing, and always fascinating things that go on in the peculiar world of sleep. You’ll never look at your pillow the same way again.

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.

    For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony.Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.In this riveting, shocking, and beautifully written book, biologist Alanna Collen draws on the latest scientific research to show how our personal colony of microbes influences our weight, our immune system, our mental health, and even our choice of partner. She argues that so many of our modern diseases—obesity, autism, mental illness, digestive disorders, allergies, autoimmunity afflictions, and even cancer—have their root in our failure to cherish our most fundamental and enduring relationship: that with our personal colony of microbes.Many of the questions about modern diseases left unanswered by the Human Genome Project are illuminated by this new science. And the good news is that unlike our human cells, we can change our microbes for the better. Collen's book is a revelatory and indispensable guide. It is science writing at its most relevant: life—and your body—will never seem the same again.

    When attorney Chris Hansen learned that the U.S. government was issuing patents for human genes to biotech companies, his first thought was, How can a corporation own what makes us who we are? Then he discovered that women were being charged exorbitant fees to test for hereditary breast and ovarian cancers, tests they desperately needed—all because Myriad Genetics had patented the famous BRCA genes. So he sued them. Jorge L. Contreras, one of the nation’s foremost authorities on human genetics law, has devoted years to investigating the groundbreaking civil rights case known as AMP v. Myriad. In The Genome Defense Contreras gives us the view from inside as Hansen and his team of ACLU lawyers, along with a committed group of activists, scientists, and physicians, take their one-in-a-million case all the way to the U.S. Supreme Court. Contreras interviewed more than a hundred key players involved in all aspects of the case—from judges and policy makers to ethicists and genetic counselors, as well as cancer survivors and those whose lives would be impacted by the decision—expertly weaving together their stories into a fascinating narrative of this pivotal moment in history.  The Genome Defense is a powerful and compelling story about how society must balance scientific discovery with corporate profits and the rights of all people.

    He is one of the foremost figures of contemporary neuroscience, and his decades-long quest to understand the inner workings of the brain’s memory machine has begun to pay off. Award-winning journalist Terry McDermott spent nearly two years observing Lynch at work and now gives us a fascinating and dramatic account of daily life in his lab—the highs and lows, the drudgery and eureka moments, the agonizing failures. He provides detailed, lucid explanations of the cutting-edge science that enabled Lynch to reveal the inner workings of the molecular machine that manufactures memory. After establishing the building blocks, Lynch then set his sights on uncovering the complicated structure of memory as it is stored across many neurons. Adding practical significance to his groundbreaking work, Lynch discovered a class of drugs that could fix the memory machine when it breaks, drugs that would enhance brain function during the memory process and that hold out the possibility of cures for a wide range of neurological conditions, including Alzheimer’s disease, Parkinson’s disease, and attention deficit hyperactivity disorder. Here is an essential story of science, scientists, and scientific achievement—galvanizing in the telling and thrilling in its far-reaching implications.

    America faced a troubling question: What happened? How was this epidemic allowed to spread so far before it was taken seriously? In answering these questions, Shilts weaves the disparate threads into a coherent story, pinning down every evasion and contradiction at the highest levels of the medical, political, and media establishments. Shilts shows that the epidemic spread wildly because the federal government put budget ahead of the nation's welfare; health authorities placed political expediency before the public health; and scientists were often more concerned with international prestige than saving lives. Against this backdrop, Shilts tells the heroic stories of individuals in science and politics, public health and the gay community, who struggled to alert the nation to the enormity of the danger it faced. And the Band Played On is both a tribute to these heroic people and a stinging indictment of the institutions that failed the nation so badly.

    She draws from her own experiences of illness and bodily injury to engage in an exploration that extends far beyond her life, spanning wide-ranging territory—from poverty tourism to phantom diseases, street violence to reality television, illness to incarceration—in its search for a kind of sight shaped by humility and grace.

    In recent years, scientists like Kathryn Paige Harden have shown that DNA makes us different, in our personalities and in our health--and in ways that matter for educational and economic success in our current society.In The Genetic Lottery, Harden introduces readers to the latest genetic science, dismantling dangerous ideas about racial superiority and challenging us to grapple with what equality really means in a world where people are born different. Weaving together personal stories with scientific evidence, Harden shows why our refusal to recognize the power of DNA perpetuates the myth of meritocracy, and argues that we must acknowledge the role of genetic luck if we are ever to create a fair society.Reclaiming genetic science from the legacy of eugenics, this groundbreaking book offers a bold new vision of a society where everyone thrives, regardless of how one fares in the genetic lottery.

    In Will My Cat Eat My Eyeballs?, best-selling author and mortician Caitlin Doughty answers the most intriguing questions she’s ever received about what happens to our bodies when we die. In a brisk, informative, and morbidly funny style, Doughty explores everything from ancient Egyptian death rituals and the science of skeletons to flesh-eating insects and the proper depth at which to bury your pet if you want Fluffy to become a mummy. Now featuring an interview with a clinical expert on discussing these issues with young people—the source of some of our most revealing questions about death—Will My Cat Eat My Eyeballs? confronts our common fear of dying with candid, honest, and hilarious facts about what awaits the body we leave behind.

    Who are these people, what motivates them, and why should you care?Consider these facts: Everything around us is turning into computers. Your typewriter is gone, replaced by a computer. Your phone has turned into a computer. So has your camera. Soon your TV will. Your car was not only designed on computers, but has more processing power in it than a room-sized mainframe did in 1970. Letters, encyclopedias, newspapers, and even your local store are being replaced by the Internet.Hackers & Painters: Big Ideas from the Computer Age, by Paul Graham, explains this world and the motivations of the people who occupy it. In clear, thoughtful prose that draws on illuminating historical examples, Graham takes readers on an unflinching exploration into what he calls “an intellectual Wild West.”The ideas discussed in this book will have a powerful and lasting impact on how we think, how we work, how we develop technology, and how we live. Topics include the importance of beauty in software design, how to make wealth, heresy and free speech, the programming language renaissance, the open-source movement, digital design, internet startups, and more.