Just ask biotechnologist Matti Leisola. It all started when a student loaned the Finnish scientist a book criticizing evolutionary theory. Leisola reacted angrily, and set out to defend evolution, but found his efforts raised more questions than they answered. He soon morphed into a full-on Darwin skeptic, even as he was on his way to becoming a leading bio-engineer.Heretic is the story of Leisola's adventures making waves-and many friends and enemies-at major research labs and universities across Europe. Tracing his investigative path, the book draws on Leisola's expertise in molecular biology to show how the evidence points more strongly than ever to the original biotechnologist-a designing intelligence whose skill and reach dwarf those of even our finest bioengineers, and leave blind evolution in the dust.Endorsements "Award-winning Finnish biotechnologist Matti Leisola has written a fascinating account of what happens when a scientist follows the evidence wherever it leads. Leisola's account of how he succeeded should inspire up-and-coming scientists who face the same challenge." Biologist Jonathan Wells, PhD, author of Icons of Evolution and Zombie Science "Scientists, like all other intellectuals, have ideas about what constitutes and what does not constitute reality. However, they are often not aware-and sometimes not ready to admit-that such ideas represent the principles of their philosophy. Leisola and Witt's Heretic is a unique first-hand account of the life-long adventures of a scientist who dared to challenge philosophical principles of colleague scientists. In my opinion, the outcome shows that to many scientists their philosophy is dearer than their science." Biochemist and inventor Branko Kozulic, PhD "This book is an exciting story about how a scientist's relentless search for truth makes him a heretic in the eyes of a cultural community more concerned about prestige than principle." Tapio Puolimatka, PhD and EdD, University of Jyvaskyla, Finland "This book is a personal, strong, and motivated plea for intelligent design (ID) and 'swims against the current' of Darwinian evolution, now generally accepted in scientific circles and society. I personally do not endorse ID, but I am a good friend of the author, whom I also highly respect as a scientist active in academia and in the biotech industry over so many years. Heretic inspires readers to think critically and to open up a civilized discussion on neo-Darwinism versus ID. It covers the science and philosophical parts adequately; it is accessible to a large readership; and statements are underpinned by relevant research and literature data. Its value lies in the author's lifelong engagement and personal crusade to stimulate the public debate among scientists as well as laymen over Darwinism (chance/random mutation and natural selection) versus ID, a vision that Leisola strongly advocates." Dr. Erick J. Vandamme, Emeritus Professor of Bioscience Engineering, Ghent University, Belgium "Matti Leisola has written the exciting story of almost the entire spectrum of aberrant motives, absurd fears, and unreasonable reactions to intelligent design (ID) by evolutionary scientists, clergymen, and church institutions alike, notably during his career as a scientist over the last some forty years. I would add a word on the fears of so many critics that accepting ID also means accepting the dogmata of some 1700 years of church history. ID is thoroughly neutral concerning such topics. So, the reader is invited to carefully check the historical and, what is more, the enormous wealth of scientific data Matti Leisola has presented in the present book: Test them carefully with an open mind and form your own independent opinion!" Dr. Wolf-Ekkehard Lonnig, geneticist, Cologne,

    

    Just a half century ago, this idea was revolutionary. In April 1953, James Watson and Francis Crick published in Nature their groundbreaking work revealing the double helix structure of DNA. While this discovery received wide attention from both mainstream media and the academic community, it was just one part of the bigger story in this history of molecular biology. By the mid-1950s, the scientific community confirmed that genes were indeed comprised of DNA; they just needed to crack the genetic code—and the race was on. Life’s Greatest Secret is the full and rich history of this challenge and the characters—many of whom were not biologists—whose work contributed to this grand scientific endeavor: mathematician and father of cybernetics Norbert Wiener, physicist Erwin Schrödinger, information theorist Claude Shannon, and biologists Jacques Monod and Marshall Nirenberg.In Life’s Greatest Secret, science historian and zoologist Matthew Cobb shows that the race to crack the genetic code was mostly a matter of craft—individuals or small groups struggling with ideas and concepts as much as they were with facts, trying to find the right experiment to answer the right questions, even if they didn’t know what the questions were, and finding that, even when the most definitive answer served mostly to reveal more ignorance, whether in 1953, with Watson and Crick, or in 1961, when Nirenberg and Matthaei showed how DNA codes for specific amino acids, and again and again thereafter, or in 2000, with the first publication of a human genome. Each discovery was a leap forward in our understanding of the natural world and our place within in, akin to the discoveries of Galileo and Einstein in the realm of physics, or the publication of Darwin’s On the Origin of Species. And each served to show how much bigger the problem was that anyone had previously imagined, a trend that continues, as Cobb shows, even today, whether we are discussing gene regulation, epigenetics, or GMOs.Life’s Greatest Secret is a story of ideas and of experimentation, of ingenuity, insight, and dead-ends, in the hunt to make the greatest discovery of twentieth century biology. Ultimately, though, this is a story of humans exploring what it is that makes us human.

    Now in its new Sixth Edition, the book continues to help readers develop their problem-solving skills with an extensive variety of highly interesting problems related to engineering design. In the new edition, more than 50% of the homework problems are new. There are also many new sample problems. To help readers build necessary visualization and problem-solving skills, the book strongly emphasizes drawing free-body diagrams--the most important skill needed to solve mechanics problems.

    This edition retains the scope and emphasis that have made the book very successful while adding over twenty new numerical examples and over 550 new end-of-chapter problems.

    In this unconventional introduction, physicist Leonard Susskind and hacker-scientist George Hrabovsky offer a first course in physics and associated math for the ardent amateur. Unlike most popular physics books—which give readers a taste of what physicists know but shy away from equations or math—Susskind and Hrabovsky actually teach the skills you need to do physics, beginning with classical mechanics, yourself. Based on Susskind's enormously popular Stanford University-based (and YouTube-featured) continuing-education course, the authors cover the minimum—the theoretical minimum of the title—that readers need to master to study more advanced topics.An alternative to the conventional go-to-college method, The Theoretical Minimum provides a tool kit for amateur scientists to learn physics at their own pace.

    It encompasses lucid descriptions of behaviour, evolutionary history, development, proximate mechanisms and applications.

    Wolfram lets the world see his work in A New Kind of Science, a gorgeous, 1,280-page tome more than a decade in the making. With patience, insight, and self-confidence to spare, Wolfram outlines a fundamental new way of modeling complex systems. On the frontier of complexity science since he was a boy, Wolfram is a champion of cellular automata--256 "programs" governed by simple nonmathematical rules. He points out that even the most complex equations fail to accurately model biological systems, but the simplest cellular automata can produce results straight out of nature--tree branches, stream eddies, and leopard spots, for instance. The graphics in A New Kind of Science show striking resemblance to the patterns we see in nature every day. Wolfram wrote the book in a distinct style meant to make it easy to read, even for nontechies; a basic familiarity with logic is helpful but not essential. Readers will find themselves swept away by the elegant simplicity of Wolfram's ideas and the accidental artistry of the cellular automaton models. Whether or not Wolfram's revolution ultimately gives us the keys to the universe, his new science is absolutely awe-inspiring. --Therese Littleton

    In those twelve months, Einstein shattered many cherished scientific beliefs with five extraordinary papers that would establish him as the world's leading physicist. This book brings those papers together in an accessible format. The best-known papers are the two that founded special relativity: On the Electrodynamics of Moving Bodies and Does the Inertia of a Body Depend on Its Energy Content? In the former, Einstein showed that absolute time had to be replaced by a new absolute: the speed of light. In the second, he asserted the equivalence of mass and energy, which would lead to the famous formula E = mc2.The book also includes On a Heuristic Point of View Concerning the Production and Transformation of Light, in which Einstein challenged the wave theory of light, suggesting that light could also be regarded as a collection of particles. This helped to open the door to a whole new world--that of quantum physics. For ideas in this paper, he won the Nobel Prize in 1921.The fourth paper also led to a Nobel Prize, although for another scientist, Jean Perrin. On the Movement of Small Particles Suspended in Stationary Liquids Required by the Molecular-Kinetic Theory of Heat concerns the Brownian motion of such particles. With profound insight, Einstein blended ideas from kinetic theory and classical hydrodynamics to derive an equation for the mean free path of such particles as a function of the time, which Perrin confirmed experimentally. The fifth paper, A New Determination of Molecular Dimensions, was Einstein's doctoral dissertation, and remains among his most cited articles. It shows how to calculate Avogadro's number and the size of molecules.These papers, presented in a modern English translation, are essential reading for any physicist, mathematician, or astrophysicist. Far more than just a collection of scientific articles, this book presents work that is among the high points of human achievement and marks a watershed in the history of science. Coinciding with the 100th anniversary of the miraculous year, this new paperback edition includes an introduction by John Stachel, which focuses on the personal aspects of Einstein's youth that facilitated and led up to the miraculous year.

    

    Intuition and computational abilities are stressed. Original material on DE and multiple integrals has been expanded.

    This clear, concise look at the basic principles and concepts of genetics uses a human genetics perspective to discuss the methods and experiments upon which genetic principles are based, such as DNA replication.

    This text covers the basics of emerging areas in power electronics and a broad range of topics such as power switching devices, conversion methods, analysis and techniques, and applications. Its unique approach covers the characteristics of semiconductor devices first, then discusses the applications of these devices for power conversions. Four main applications are included: flexible ac transmissions (FACTs), static switches, power supplies, dc drives, and ac drives. - New chapters - Including Ch. 9, Multilevel Inverters, Ch. 13, Flexible AC Transmission Systems, and Ch. 17, Gate Drive Circuits.', gives students the latest information available on these topics. - New sections throughout - Including Semiconductor Basics, State-Space Analysis of Regulators, Vector Controls, Stepper Motor Control and more, gives students the latest information available on these topics. - Well-written and easy-to-follow, helps students maintain interest in the text. - Numerous worked-out examples, demonstrates for students the applications of conversion techniques in design and analysis of converter cir

    The sixth edition explores core concepts in considerable depth and presents experimental detail when it helps to explain and reinforce the concepts. The majority of discussions have been modified to reflect the latest changes in the field. The book also builds on its strong illustration program by opening each chapter with “VIP” art that serves as a visual summary for the chapter. Over 60 new micrographs and computer-derived images have been added to enhance the material. Biologists benefit from these changes as they build their skills in making the connection. Doody Review Services Reviewer: Bruce A. Fenderson, PhD(Thomas Jefferson University) Description: The author expertly organizes, explains, and illustrates the chemical and cellular basis of life on Earth in this comprehensive and exciting introduction to cell and molecular biology. The 18 fascinating chapters cover topics ranging from control of gene expression to mechanisms of immune response. There is even a chapter on laboratory techniques. The focus of the book is on biological chemistry, with an emphasis on core concepts and experimental approaches. Purpose: The purpose is to provide a textbook for an introductory course in cell and molecular biology. The author hopes that students will visualize a world filled with "giant molecules and minuscule structures" that constitute the chemistry of life. He encourages students to consider the evidence that is presented to support a biological model, think of alternate explanations, and plan experiments that may lead to new hypotheses. One of the author's goals is to help students develop their independent, critical-thinking skills. Audience: This is an excellent companion textbook for undergraduate and graduate-level courses in cell and molecular biology. It is written for students across a wide range of life science disciplines

    Boundless works with subject matter experts to select the best open educational resources available on the web, review the content for quality, and create introductory, college-level textbooks designed to meet the study needs of university students.<br><br>This textbook covers:<br><br><b>Human Anatomy and Physiology Introduction</b> -- Anatomy and Physiology Overview, Life, Homeostasis, Anatomical Terms, Clinical Cases<br><br><b>General Chemistry</b> -- Matter and Energy, Element Properties: Atomic structure, Chemical Bonds, Chemical Reactions, Inorganic Compounds, Organic Compounds<br><br><b>Cellular Structure and Function</b> -- the study of cells, Cell membranes and the fluid mosaic model, Transport across membranes, How reception works in cell signaling, Nucleus and Ribosomes, Organelles, The Cytoskeleton, External cellular components, Cell division: process and importance, The cell cycle, Transcription and translation, RNA processing, Translation to a polypeptide, Transcription, Apoptosis signals an orderly cell death<br><br><b>Tissues</b> -- Epithelial Tissue, Cell Junctions, Clinical Cases, Tissue Repair, Tissue Development, Cancer, Connective Tissue, Membranes, Nervous Tissue<br><br><b>The Integumentary System</b> -- The Skin, Accessory Structures of the Skin, Functions of the Integumentary System, Wound Healing, Integumentary System Development, Skin Disorders, Imbalances, Diseases, and Clinical Cases<br><br><b>Skeletal Tissue</b> -- Cartilage, Bone Classification, Bone Formation, Bone and Calcium, Bone Development, Bone Diseases, Disorders, Imbalances, and Clinical Cases<br><br><b>The Skeletal System</b> -- Overview of the Musculoskeletal system, Divisions of the Skeletal System, The Axial Skeleton, Skull, Hyoid Bone, Vertebral Column, Thorax, Clinical Cases of the Axial Skeleton, The Appendicular Skeleton, The Pectoral (Shoulder) Girdle, Upper Limb, The Pelvic (Hip) Girdle, Lower Limb, Skeletal System Development, Clinical Cases of the Appendicular Skeleton<br><br><b>Joints</b> -- Classification of Joints, Synovial Joints, Joint Development, Clinical Cases<br><br><b>Muscle Tissue</b> -- Overview of Muscle Tissue, Skeletal Muscle, Control of Muscle Tension, Muscle Metabolism, Exercise and Skeletal Muscle Tissue, Smooth Muscle, Clinical Cases: Muscle Disorders, Development of Muscle<br><br><b>The Muscular System</b> -- Overview of the Muscular System, Head And Neck Muscles, Trunk Muscles, Muscles of the Upper Limb, Muscles of the Lower Limb, Clinical Cases and Muscular System Disorders<br><br><b>Nervous Tissue</b> -- Overview of the Nervous System, Neuroglia, Neurons, Collections of Nervous Tissue, Neurophysiology<br><br><b>Central Nervous System (CNS)</b> -- The Brain, Consciousness, Sleep, Language, and Memory, Protection of the Brain, Parts of The Brain Stem, The Cerebellum, The Diencephalon, Cerebral Cortex (or Cerebral Hemispheres), Functional Systems of the Cerebral Cortex, Development of the CNS, Brain Disorders and Clinical Cases, The Spinal Cord, Spinal Cord Anatomy, Disorders and Clinical Cases of the Spinal Cord<br><br><b>Peripheral Nervous System (PNS)</b> -- Sensation, Sensory Receptors, Somatosensory System, Nerves, Cranial Nerves, Spinal Nerves, Distribution of Spinal Nerves, Motor Activity, Motor Pathways, Reflexes, Pain, Development of the Nervous System, Disorders of Spinal Nerves and Clinical Cases<br><br><b>Autonomic Nervous System (ANS)</b> -- Autonomic Nervous System, ANS Anatomy, Physiology of ANS,