Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine.In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. Theimmune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immuneresponses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading toserious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immunesystem v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable.

    Their attitude towards Einstein is like that of Mark Twain towards the writer of a work on mathematics: here was a man who had written an entire book of which Mark could not understand a single sentence. Einstein, therefore, is great in the public eye partly because he has made revolutionary discoveries which cannot be translated into the common tongue. We stand in proper awe of a man whose thoughts move on heights far beyond our range, whose achievements can be measured only by the few who are able to follow his reasoning and challenge his conclusions. There is, however, another side to his personality. It is revealed in the addresses, letters, and occasional writings brought together in this book. These fragments form a mosaic portrait of Einstein the man. Each one is, in a sense, complete in itself; it presents his views on some aspect of progress, education, peace, war, liberty, or other problems of universal...

    E.P. Sanders, an influential Pauline scholar, analyzes the fundamental beliefs and vigorous contradictions in Paul's thought, discovering a philosophy that is less of a monolithic system than the apostle's convictions would seem to suggest. This volume offers an incisive summation of Paul's career, as well as his role in the development of early Christianity. Both lucid and judicious, it is the most compelling short introduction to Paul now available.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    The Essential Chomsky brings together selections from his most important writings since 1959-from his groundbreaking critique of B.F. Skinner to his bestselling works Hegermony or Survival and Failed States-concerning subjects ranging from critiques of corporate media and U.S. interventionism to intellectual freedom and the political economy of human rights. With a foreword by Anthony Arnove, The Essential Chomsky is an unprecedented, comprehensive overview of Chomsky's thought.

    In this Very Short Introduction, Peter Marshall illuminates the causes and consequences of this pivotal movement in western Christianity. The Reformation began as an argument aboutwhat Christians needed to do to be saved, but rapidly engulfed society in a series of fundamental changes. This book provides a lively and up-to-date guide that explains doctrinal debates in a clear and non-technical way, but also explores the effects the Reformation had on politics, society, art, and minorities. Marshall argues that the Reformation was not a solely European phenomenon, but that varieties of faith exported from Europe transformed Christianity into a truly world religion. The complex legacy of the Reformation is also assessed. Its religious fervor produced remarkable storiesof sanctity and heroism, and some extraordinary artistic achievements. But violence, holy war, and martyrdom were equally its products. A paradox of the Reformation--that it intensified intolerance while establishing pluralism--is one we still wrestle with today.

    Now, in this Very Short Introduction, Lee provides a magnificent look at the genre in which she is an undisputed master--the art of biography. Here Lee considers the cultural and historical background of different types of biographies, looks at the factors that affect biographers, and asks whether there are different strategies, ethics, and principles required for writing about one person compared to another. She also discusses contemporary biographical publications and considers what kind of lives are the most popular and in demand. And along the way, she answers such questions as why do certain people and historical events arouse so much interest? How can biographies be compared with history and works of fiction? Does a biography need to be true? Is it acceptable to omit or conceal things? Does the biographer need to personally know the subject? Must a biographer be subjective?About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    The author has now revised the original edition to clear up a number of difficulties he and others have found in the original book.Rawls aims to express an essential part of the common core of the democratic tradition - justice as fairness - and to provide an alternative to utilitarianism, which had dominated the Anglo-Saxon tradition of political thought since the nineteenth century. Rawls substitutes the ideal of the social contract as a more satisfactory account of the basic rights and liberties of citizens as free and equal persons. "Each person," writes Rawls, "possesses an inviolability founded on justice that even the welfare of society as a whole cannot override." Advancing the ideas of Rousseau, Kant, Emerson, and Lincoln, Rawls's theory is as powerful today as it was when first published.

    It begins with a Preface, created after the rest of the manuscript was completed, that explains the core of his method and what sets it apart from any preceding philosophy. The Introduction, written before the rest of the work, summarizes and completes Kant's ideas on skepticism by rendering it moot and encouraging idealism and self-realization. The body of the work is divided into six sections of varying length, entitled "Consciousness," "Self-Consciousness," "Reason," "Spirit," "Religion," and "Absolute Knowledge." A myriad of topics are discussed, and explained in such a harmoniously complex way that the method has been termed Hegelian dialectic. Ultimately, the work as a whole is a remarkable study of the mind's growth from its direct awareness to scientific philosophy, proving to be a difficult yet highly influential and enduring work.

    He charts life in Roman Britain from the first Roman invasion under Julius Caesar to the final collapse of the Roman Empire in the West around AD 500.

    Cress's translation from the French of the Adam and Tannery critical edition is prized for its accuracy, elegance, and economy. The translation featured in the Third Edition has been thoroughly revised from the 1979 First Edition and includes page references to the critical edition for ease of comparison.

    Drawing inspiration from six of the finest minds in history - Socrates, Epicurus, Seneca, Montaigne, Schopenhauer and Nietzsche - he addresses lack of money, the pain of love, inadequacy, anxiety and conformity. De Botton's book led one critic to call philosophy 'the new rock and roll'.

    From humble beginnings on the seven hills beside the Tiber, the city of Rome grew to dominate the ancient Mediterranean. Led by her senatorial aristocracy, Republican armies defeated Carthage and the successor kingdoms of Alexander the Great, and brought the surrounding peoples to east and west into the Roman sphere. In this Very Short Introduction, David M. Gwynn provides a fascinating introduction to the history of the Roman Republic, ranging from the origins of Rome and the vivid Roman legends that surround the foundations of the city, to the overthrow of the monarchy in 509 BC, the five hundred years of republican rule, the rise of Julius Caesar and Caesar Augustus, and the establishment of the Principate. Gwynn considers the political structure of the Republic, including its unique constitution, and he highlights literary and material sources, bringing to life the culture and society of Republican Rome. He also reflects on the Roman values and beliefs of the time, in order to shed light on the Republic's dramatic rise and fall. Finally, Gwynn reflects on the remarkable legacy of the Roman Republic, including its modern-day resonance and legacy in literature and in film, where it is often presented as a model, a source of inspiration, but also a warning.

    This is the only introduction to Romanticism that incorporates not only the English but the Continental movements, and notonly literature but music, art, religion, and philosophy. Balancing lively details with intriguing topics, it sheds light on such subjects as the Sensibility movement, which preceded Romanticism; the rising prestige of the poet as inspired prophet; the suffering and neglect of the poet; therather different figure of the poetess; Romanticism as a religious trend; Romantic philosophy and science; and Romantic responses to the French Revolution, the Orient, gypsies, and the condition of women. Ferber offers a definition and several general propositions about this very diverse movement, as well as a discussion of the word Romantic and where it came from. Finally, some two hundred authors or artists are cited or quoted, many at length, including Blake, Wordsworth, Coleridge, Byron, Shelley, Keats, Emerson, Hugo, Goethe, Pushkin, Beethoven, Berlioz, Chopin, and Delacroix.