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Epigenetic Regulation in the Nervous System: Basic Mechanisms and Clinical Impact by J. David Sweatt
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genetics
neuroscience
My Mad Dad: The Diary of an Unravelling Mind
Robyn Hollingworth - 2018
His brilliant mind, which saw him building power stations and literally bringing light into the lives of others, has succumbed to darkness.As Robyn settles back in the rhythms of life in the rain-soaked vast Welsh valleys, she keeps a diary charting her journey as the dad she knew disappears before her eyes. Lyrical, poignant and with flashes of brilliant humour, My Mad Dad explores how in helping others we can heal ourselves. 'At some point the cared for become the carers...this isn't a shame and it isn't a tragedy and it isn't a chore. It is an honour. To be able to return the gift of love that someone bestows upon you is a gift in itself. This is a story of caring...'
The Bell Curve: Intelligence and Class Structure in American Life
Richard J. Herrnstein - 1994
The controversial book linking intelligence to class and race in modern society, and what public policy can do to mitigate socioeconomic differences in IQ, birth rate, crime, fertility, welfare, and poverty.
Last Ape Standing: The Seven-Million-Year Story of How and Why We Survived
Chip Walter - 2013
These weren't simply variations on apes, but upright-walking humans who lived side by side, competing, cooperating, sometimes even mating with our direct ancestors. Why did the line of ancient humans who eventually evolved into us survive when the others were shown the evolutionary door? Chip Walter draws on new scientific discoveries to tell the fascinating tale of how our survival was linked to our ancestors being born more prematurely than others, having uniquely long and rich childhoods, evolving a new kind of mind that made us resourceful and emotionally complex; how our highly social nature increased our odds of survival; and why we became self aware in ways that no other animal seems to be. Last Ape Standing also profiles the mysterious "others" who evolved with us-the Neanderthals of Europe, the "Hobbits" of Indonesia, the Denisovans of Siberia and the just-discovered Red Deer Cave people of China who died off a mere eleven thousand years ago. Last Ape Standing is evocative science writing at its best-a witty, engaging and accessible story that explores the evolutionary events that molded us into the remarkably unique creatures we are; an investigation of why we do, feel, and think the things we do as a species, and as people-good and bad, ingenious and cunning, heroic and conflicted.
Innate: How the Wiring of Our Brains Shapes Who We Are
Kevin J. Mitchell - 2018
Guiding us through important new research, including his own groundbreaking work, he explains how variations in the way our brains develop before birth strongly influence our psychology and behavior throughout our lives, shaping our personality, intelligence, sexuality, and even the way we perceive the world.We all share a genetic program for making a human brain, and the program for making a brain like yours is specifically encoded in your DNA. But, as Mitchell explains, the way that program plays out is affected by random processes of development that manifest uniquely in each person, even identical twins. The key insight of Innate is that the combination of these developmental and genetic variations creates innate differences in how our brains are wired--differences that impact all aspects of our psychology--and this insight promises to transform the way we see the interplay of nature and nurture.Innate also explores the genetic and neural underpinnings of disorders such as autism, schizophrenia, and epilepsy, and how our understanding of these conditions is being revolutionized. In addition, the book examines the social and ethical implications of these ideas and of new technologies that may soon offer the means to predict or manipulate human traits.
The Other Side of Normal: How Biology Is Providing the Clues to Unlock the Secrets of Normal and Abnormal Behavior
Jordan Smoller - 2012
Other bestselling works of neurobiology and the mind have focused on mental illness and abnormal behaviors—like the Oliver Sacks classic, The Man Who Mistook His Wife for a Hat—but The Other Side of Normal is an eye-opening, thought-provoking, utterly fascinating and totally accessible exploration of the universals of human experience. It will change forever our understanding of who we are and what makes us that way.
Identically Different: Why You Can Change Your Genes
Tim Spector - 2012
What makes you so different to your siblings? Why do you vote a certain way, remain faithful for twenty years, believe in God, love salads, be heterosexual, get cancer or depression, dislike sport or never put on weight? Using fascinating case studies of identical twins, Tim Spector draws gems from his exhaustive research project that has spanned twenty years to show how even real-life 'clones' with the same upbringing turn out in reality to be very different. Based on cutting-edge discoveries that are pushing the frontiers of our knowledge of genetics, he show us that - contrary to recent scientific teaching - nothing is completely hard-wired or pre-ordained. Challenging, enlightening and entertaining, Tim Spector explains theories such as why the Dutch have become the tallest nation in the world, why autism is more heritable than breast cancer and what could cause a fit and healthy man to have a heart attack within weeks of his overweight, heavy drinking, heavy smoking identical twin. Conceptually, he argues, we are not just skin and bones controlled by our genes but minds and bodies made of plastic. This plastic is dynamic - slowly changing shape and evolving, driven by many processes we still cannot comprehend. Many of the subtle differences between us appear now to be due to chance or fate, but as science rapidly evolves and explains current mysteries we will be able to become more active participants in this human moulding process. Then we can really begin to understand why we are who we are and what makes each of us so unique and quintessentially human.
Consilience: The Unity of Knowledge
Edward O. Wilson - 1998
In Consilience (a word that originally meant "jumping together"), Edward O. Wilson renews the Enlightenment's search for a unified theory of knowledge in disciplines that range from physics to biology, the social sciences and the humanities.Using the natural sciences as his model, Wilson forges dramatic links between fields. He explores the chemistry of the mind and the genetic bases of culture. He postulates the biological principles underlying works of art from cave-drawings to Lolita. Presenting the latest findings in prose of wonderful clarity and oratorical eloquence, and synthesizing it into a dazzling whole, Consilience is science in the path-clearing traditions of Newton, Einstein, and Richard Feynman.
Nature Via Nurture: Genes, Experience and What Makes Us Human
Matt Ridley - 2003
Armed with the extraordinary new discoveries about our genes, Ridley turns his attention to the nature versus nurture debate to bring the first popular account of the roots of human behaviour. What makes us who we are?In February 2001 it was announced that the genome contains not 100,000 genes as originally expected but only 30,000. This startling revision led some scientists to conclude that there are simply not enough human genes to account for all the different ways people behave: we must be made by nurture, not nature.Matt Ridley argues that the emerging truth is far more interesting than this myth. Nurture depends on genes, too, and genes need nurture. Genes not only predetermine the broad structure of the brain; they also absorb formative experiences, react to social cues and even run memory. They are consequences as well as causes of the will.Published fifty years after the discovery of the double helix of DNA, Nature via Nurture chronicles a new revolution in our understanding of genes. Ridley recounts the hundred years' war between the partisans of nature and nurture to explain how this paradoxical creature, the human being, can be simultaneously free-willed and motivated by instinct and culture. Nature via Nurture is an enthralling, up-to-the-minute account of how genes build brains to absorb experience.
The Birth of the Mind: How a Tiny Number of Genes Creates The Complexities of Human Thought
Gary F. Marcus - 1963
nurture debate by linking the findings of the Human Genome Project to the development of the brain. Scientists have long struggled to understand how a tiny number of genes could contain the instructions for building the human brain, arguably the most complex device in the known universe. Synthesizing up-to-the-minute research with his own original findings on child development, Marcus is the first to resolve this apparent contradiction. Vibrantly written and completely accessible to the lay reader, The Birth of the Mind will forever change the way we think about our origins and ourselves.
How to Grow a Human: Adventures in Who We Are and How We Are Made
Philip Ball - 2019
This was life—but whose? In his most mind-bending book yet, Ball makes that disconcerting question the focus of a tour through what scientists can now do in cell biology and tissue culture. He shows how these technologies could lead to tailor-made replacement organs for when ours fail, to new medical advances for repairing damage and assisting conception, and to new ways of “growing a human.” For example, it might prove possible to turn skin cells not into neurons but into eggs and sperm, or even to turn oneself into the constituent cells of embryos. Such methods would also create new options for gene editing, with all the attendant moral dilemmas. Ball argues that such advances can therefore never be about “just the science,” because they come already surrounded by a host of social narratives, preconceptions, and prejudices. But beyond even that, these developments raise questions about identity and self, birth and death, and force us to ask how mutable the human body really is—and what forms it might take in years to come.
No Two Alike: Human Nature and Human Individuality
Judith Rich Harris - 2006
Why do people—even identical twins reared in the same home—differ so much in personality? Armed with an inquiring mind and insights from evolutionary psychology, Judith Rich Harris sets out to solve the mystery of human individuality.
Understanding the Mysteries of Human Behavior
Mark R. Leary - 2013
What makes you happy? Where did your personality come from? Why do you have trouble controlling certain behaviors? Why do you behave differently as an adult than you did as an adolescent? Since the start of recorded history, and probably even before, people have been interested in answering questions about why we behave the way we do. And many fields - including philosophy, psychology, and even theology - are focused on finding explanations. But it's only in recent decades that researchers can finally approach, understand, and solve the mysteries of emotion, thought, and behavior - solutions that help each of us to better know ourselves and the people around us. The result is not only a more solid understanding of what it means to be human, but a stronger foundation from which to live more effectively with others and to grasp their intricate behaviors and quirks. Now you can gain those benefits through a series of 24 intriguing lectures from an award-winning teacher. Professor Leary takes you on a fascinating journey into the complex heart of who you are, using the latest theories, case studies, experiments, and stories to cast light on a wide variety of human behaviors, both ordinary and puzzling. Throughout these lectures, you'll learn about the various interacting forces that influence your behavior. These include your genetic blueprint, your personal experiences, your upbringing, and the people and social groups that surround you.
Brain Storms: The Race to Unlock the Mysteries of Parkinson's Disease
Jon Palfreman - 2015
In Brain Storms, the award-winning journalist Jon Palfreman tells their story, a story that became his own when he was diagnosed with the debilitating illness. Palfreman chronicles how scientists have worked to crack the mystery of what was once called the shaking palsy, from the earliest clinical descriptions of tremors, gait freezing, and micrographia to the cutting edge of neuroscience, and charts the victories and setbacks of a massive international effort to best the disease. He takes us back to the late 1950s and the discovery of L-dopa. He delves into a number of other therapeutic approaches to this perplexing condition, from partial lobotomies and deep brain stimulation to neural grafting. And he shares inspiring stories of brave individuals living with Parkinson's, from a former professional ballet dancer who tricks her body to move freely again to a patient who cannot walk but astounds doctors when he is able to ride a bicycle with no trouble at all. With the baby boom generation beginning to retire and the population steadily aging, the race is on to discover a means to stop or reverse neurodegenerative conditions like Parkinson's and Alzheimer's. Brain Storms is the long-overdue, riveting, and deeply personal story of that race, and a passionate, insightful, and urgent look into the lives of those affected.
Biopunk: Kitchen-Counter Scientists Hack the Software of Life
Marcus Wohlsen - 2011
"If you want to change the world in some big way," he says, "that's where you should start-biological molecules." The most disruptive force on the planet resides in DNA. Biotech companies and academic researchers are just beginning to unlock the potential of piecing together life from scratch. Champions of synthetic biology believe that turning genetic code into Lego-like blocks to build never-before-seen organisms could solve the thorniest challenges in medicine, energy, and environmental protection. But as the hackers who cracked open the potential of the personal computer and the Internet proved, the most revolutionary discoveries often emerge from out-of-the-way places, forged by brilliant outsiders with few resources besides boundless energy and great ideas. In "Biopunk," Marcus Wohlsen chronicles a growing community of DIY scientists working outside the walls of corporations and universities who are committed to democratizing DNA the way the Internet did information. The "biohacking" movement, now in its early, heady days, aims to unleash an outbreak of genetically modified innovation by making the tools and techniques of biotechnology accessible to everyone. Borrowing their idealism from the worlds of open-source software, artisinal food, Internet startups, and the Peace Corps, biopunks are devoted advocates for open-sourcing the basic code of life. They believe in the power of individuals with access to DNA to solve the world's biggest problems. You'll meet a new breed of hackers who aren't afraid to get their hands wet, from entrepreneurs who aim to bring DNA-based medical tools to the poorest of the poor to a curious tinkerer who believes a tub of yogurt and a jellyfish gene could protect the world's food supply. These biohackers include: -A duo who started a cancer drug company in their kitchen -A team who built an open-source DNA copy machine -A woman who developed a genetic test in her apartment for a deadly disease that had stricken her family Along with the potential of citizen science to bring about disruptive change, Wohlsen explores the risks of DIY bioterrorism, the possibility of genetic engineering experiments gone awry, and whether the ability to design life from scratch on a laptop might come sooner than we think.