The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

    There were always 2 areas in my life that I was never really happy about - money and career. I decided to put what I had learned over the last 6 years to the test. I compiled a selection of practical exercises for my own personal use and have regularly used a variety of them since January 2013. What has happened in my life in that short time is nothing short of a miracle. I am now financially free and have quit my full time job. My income continues to rise and I have never been happier. Consistently focusing on these practical exercises kept my attention on the end result and that is the real to key to success. This book provides you with the practical know how to manifest whatever it is you choose in your life, whether that is financial freedom, better relationships, your dream home, better health, loving friendships, a successful business or a healthy, happy family. The power is in your hands. In this book, you now have the fuel to fire up that power.

    This book is a clarion call to action, and action now. After reading this, we know for sure that nothing, not even a pandemic, must divert us from the most serious problem facing every living creature on the planet. In plain language, Jonathon Porritt is spelling it out. This is our last chance. Read, mark, learn, and inwardly digest. Then act.' Michael Morpurgo Climate change is the defining issue of our time - we know, beyond reasonable doubt, what that science now tells us. Just as climate change is accelerating, so too must we – summoning up a greater sense of urgency, courage and shared endeavour than humankind has ever seen before.    The Age of Climate Change is an age of superlatives: most extreme this, biggest that, most costly ever. The impacts worsen every year, played out in people’s backyards and communities, and more and more people around the world now realise this is going to be a massive challenge for the rest of their lives. In Hope in Hell, Porritt confronts that dilemma head on. He believes we have time to do what needs to be done, but only if we move now – and move together. In this ultimately optimistic book, he explores all these reasons to be hopeful: new technology; the power of innovation; the mobilisation of young people – and a sense of intergenerational solidarity as older generations come to understand their own obligation to secure a safer world for their children and grandchildren.

    We need a brand new way to take it all in. 'Information is Beautiful' transforms the ideas surrounding and swamping us into graphs and maps that anyone can follow at a single glance.

    With extensive treatment of the heart of epidemiology-from study designs to descriptive epidemiology to quantitative measures-this reader-friendly text is accessible and interesting to a wide range of beginning students in all health-related disciplines. A unique focus is given to real-world applications of epidemiology and the development of skills that students can apply in subsequent course work and in the field. The text is also accompanied by a complete package of instructor and student resources available through a companion Web site.

    Drink? is the first book of its kind, written by a scientist and rooted in 40 years of medical research and hands-on experience treating patients. Professor David Nutt cuts through the noise to explain its long- and short-term effects, making complex science digestible and taking readers through the journey of alcohol inside the bodyand brain from the very first sip.Drink? holds the key to all the questions you want (and need) to know the answers to, covering mental health, sleep, hormones, fertility and addiction.He will illuminate our minds on what 'responsible drinking' truly means and equip us with the knowledge we need to make rational, informed decisions about our consumption now and in the future.This book attempts to do this in a language every drinker can understand and sheds light on how such a simple molecule can induce so much pleasure and pain at the same time.

    In Coming Apocalypse he explains how and why the 'crisis' developed and explains the sort of future we can expect now that lockdowns have destroyed the global economy and changed our way of life. Our world will never be as it was in January 2020. Dr Coleman explains what he believes we can expect.

    coli as the culprit, and the legal teams on both sides of the historic lawsuits that ensued. This is the story of the permanent transformation of our food supply chain, and the young maverick lawyer, Bill Marler, who staked his career on bringing the victims justice without compromise. Fast Food Nation meets A Civil Action in this riveting account of how we learned the hard way to truly watch what we eat.

    As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"-- an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes--which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones--each custom-designed for maximum health benefits.

    The doctor-patient relationship--the heart of medicine--is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality. By freeing physicians from the tasks that interfere with human connection, AI will create space for the real healing that takes place between a doctor who can listen and a patient who needs to be heard.Innovative, provocative, and hopeful, Deep Medicine shows us how the awesome power of AI can make medicine better, for all the humans involved.

     Few people know much about stem cell research beyond the ethical questions raised by using embryos. But in the last decade, stem cell research has made huge advances toward eliminating some of our most intractable diseases. Now this sweeping and accessible book introduces us to this cutting-edge science that will revolutionize medicine and change the way we think about and treat disease. Alice Park takes us from stem cell's controversial beginnings to the recent electrifying promise of being able to create the versatile cells without using embryos at all. She shows us how stem cells give researchers an unprecedented ability to study disease while giving patients the promise of replacing diseased cells with healthy new ones. And she profiles the scientists and leaders-many with their own compelling stories-who have fueled the quest and will continue to shape the field in years to come.

    At a summer tea party in Cambridge, England, a guest states that tea poured into milk tastes different from milk poured into tea. Her notion is shouted down by the scientific minds of the group. But one man, Ronald Fisher, proposes to scientifically test the hypothesis. There is no better person to conduct such an experiment, for Fisher is a pioneer in the field of statistics.The Lady Tasting Tea spotlights not only Fisher's theories but also the revolutionary ideas of dozens of men and women which affect our modern everyday lives. Writing with verve and wit, David Salsburg traces breakthroughs ranging from the rise and fall of Karl Pearson's theories to the methods of quality control that rebuilt postwar Japan's economy, including a pivotal early study on the capacity of a small beer cask at the Guinness brewing factory. Brimming with intriguing tidbits and colorful characters, The Lady Tasting Tea salutes the spirit of those who dared to look at the world in a new way.

    The Atlas of Disease is the first book to tell these stories in a new an innovative way, interweaving new maps with contemporary illustrations to chart some of the world's most deadly pandemics and epidemics.   In The Atlas of Disease, Sandra Hempel reveals how maps have uncovered insightful information about the history of disease, from the seventeenth century plague maps that revealed the radical idea that diseases might be carried and spread by humans, to cholera maps in the 1800s showing the disease was carried by water, right up to the AIDs epidemic in the 1980s, and the recent devastating ebola outbreak.    Crucially, The Atlas of Disease will also explore how cartographic techniques have been used to combat epidemics by revealing previously hidden patterns. These discoveries have changed the course of history, affected human evolution, stimulated advances in medicine and saved countless lives.