With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    But work takes a strange turn when she is promoted onto the Pfizer account and suddenly finds herself on the other side of the curtain, developing ads for an anti-depressant drug. Overwhelmed by her professional life and the self-scrutiny it inspires, her mania takes hold. She quits her job to become an artist, only to be hospitalized by her parents against her will. Over the course of her two weeks in the ward, she tries to find a path out of the hospital and this cycle of treatment. One where she can live the life she wants, finding freedom and autonomy, without sacrificing her dreams in order to stay well.

    Some of those words include: the, a, for, above, and even even. Put them together and you have the funniest, most heartfelt, and most inspirational memoir on survival, success, and the importance of believing in yourself since Old Yeller.The question you’re probably asking yourself right now is: What does Kevin Hart have that a book also has?According to the three people who have seen Kevin Hart and a book in the same room, the answer is clear:A book is compact. Kevin Hart is compact.A book has a spine that holds it together. Kevin Hart has a spine that holds him together.A book has a beginning. Kevin Hart’s life uniquely qualifies him to write this book by also having a beginning.It begins in North Philadelphia. He was born an accident, unwanted by his parents. His father was a drug addict who was in and out of jail. His brother was a crack dealer and petty thief. And his mother was overwhelmingly strict, beating him with belts, frying pans, and his own toys.The odds, in short, were stacked against our young hero, just like the odds that are stacked against the release of a new book in this era of social media (where Hart has a following of over 100 million, by the way).But Kevin Hart, like Ernest Hemingway, JK Rowling, and Chocolate Droppa before him, was able to defy the odds and turn it around. In his literary debut, he takes the reader on a journey through what his life was, what it is today, and how he’s overcome each challenge to become the man he is today.And that man happens to be the biggest comedian in the world, with tours that sell out football stadiums and films that have collectively grossed over $3.5 billion.He achieved this not just through hard work, determination, and talent: It was through his unique way of looking at the world. Because just like a book has chapters, Hart sees life as a collection of chapters that each person gets to write for himself or herself.“Not only do you get to choose how you interpret each chapter, but your interpretation writes the next chapter,” he says. “So why not choose the interpretation that serves your life the best?”

    The case would become one of the most famous in modern medicine—and a total failure. As Nature Made Him tells the extraordinary story of David Reimer, who, when finally informed of his medical history, made the decision to live as a male. A macabre tale of medical arrogance, it is first and foremost a human drama of one man's—and one family's—amazing survival in the face of terrible odds.

    It is 4 a.m. I have run arrest calls, treated life-threatening bleeding, held the hand of a young woman dying of cancer, scuttled down miles of dim corridors wanting to sob with sheer exhaustion, forgotten to eat, forgotten to drink, drawn on every fibre of strength that I possess to keep my patients safe from harm.'How does it feel to be spat out of medical school into a world of pain, loss and trauma that you feel wholly ill-equipped to handle? To be a medical novice who makes decisions which - if you get them wrong - might forever alter, or end, a person's life?In 'Your Life in My Hands', television journalist turned junior doctor Rachel Clarke captures the extraordinary realities of life on the NHS frontline. During last year's historic junior doctor strikes, Rachel was at the forefront of the campaign against the government's imposed contract upon young doctors. Her heartfelt, deeply personal account of life as a junior doctor in today's NHS is both a powerful polemic on the degradation of Britain's most vital public institution and a love letter of optimism and hope to that same health service.

    Now Alan Alda has written a memoir as elegant, funny, and affecting as his greatest performances."My mother didn't try to stab my father until I was six," begins Alda's irresistible story. The son of a popular actor and a loving but mentally ill mother, he spent his early childhood backstage in the erotic and comic world of burlesque and went on, after early struggles, to achieve extraordinary success in his profession.Yet Never Have Your Dog Stuffed is not a memoir of show-business ups and downs. It is a moving and funny story of a boy growing into a man who then realizes he has only just begun to grow.It is the story of turning points in Alda's life, events that would make him what he is-if only he could survive them.From the moment as a boy when his dead dog is returned from the taxidermist's shop with a hideous expression on his face, and he learns that death can't be undone, to the decades-long effort to find compassion for the mother he lived with but never knew, to his acceptance of his father, both personally and professionally, Alda learns the hard way that change, uncertainty, and transformation are what life is made of, and true happiness is found in embracing them.Never Have Your Dog Stuffed, filled with curiosity about nature, good humor, and honesty, is the crowning achievement of an actor, author, and director, but surprisingly, it is the story of a life more filled with turbulence and laughter than any Alda has ever played on the stage or screen.

    This "rueful, riveting, piercingly funny" (Julia Cameron) book is written by a Harvard graduate--but it tells a story in which hearts trump brains every time. It's a tale about mothering a Down syndrome child that opts for sass over sap, and it's a book of heavenly visions and inexplicable phenomena that's as down-to-earth as anyone could ask for. This small masterpiece is Martha Beck's own story--of leaving behind the life of a stressed-out superachiever, opening herself to things she'd never dared consider, meeting her son for (maybe) the first time...and "unlearn[ing] virtually everything Harvard taught [her] about what is precious and what is garbage.""Beck [is] very funny, particularly about the most serious possible subjects--childbirth, angels and surviving at Harvard." --New York Times Book Review"Immensely appealing...hooked me on the first page and propelled me right through visions and out-of-body experiences I would normally scoff at." --Detroit Free Press"I challenge any reader not to be moved by it." --Newsday"Brilliant." --Minneapolis Star-Tribune

    The bestselling author of 'Damaged' tells the story of Dawn, a sweet and seemingly well-balanced girl whose outward appearance masks a traumatic childhood of suffering at the hands of the very people who should have cared for her.

    A failed salesman turned local reporter, he wanted to test himself, see how he might respond to pressure and danger. He signed up for emergency medical training and became, at age twenty-six, a newly minted EMT running calls in the worst sections of Atlanta. His life entered a different realm—one of blood, violence, and amazing grace.Thoroughly intimidated at first and frequently terrified, he experienced on a nightly basis the adrenaline rush of walking into chaos. But in his downtime, Kevin reflected on how people’s facades drop away when catastrophe strikes. As his hours on the job piled up, he realized he was beginning to see into the truth of things. There is no pretense five beats into a chest compression, or in an alley next to a crack den, or on a dimly lit highway where cars have collided. Eventually, what had at first seemed impossible happened: Kevin acquired mastery. And in the process he was able to discern the professional differences between his freewheeling peers, what marked each—as he termed them—as “a tourist,” “true believer,” or “killer.”Combining indelible scenes that remind us of life’s fragile beauty with laugh-out-loud moments that keep us smiling through the worst, A Thousand Naked Strangers is an absorbing read about one man’s journey of self-discovery—a trip that also teaches us about ourselves.

    Laurie finds grown-up life just as harrowing as her reckless youth, as she meets Mr. Right, moves in, settles down, and crosses the toe-stubbing threshold of matrimony. From her mother's grade-school warning to avoid kids in tie-dyed shirts because their hippie parents spent their food money on drugs and art supplies; to her night-before-the-wedding panic over whether her religion is the one where you step on the glass; to her unfortunate overpreparation for the mandatory drug-screening urine test at work; to her audition as a Playboy centerfold as research for a newspaper story, Autobiography of a Fat Bride has the same zits-and-all candor and outrageous humor that made Idiot Girls an instant cult phenomenon. In Autobiography of a Fat Bride, Laurie contemplates family, home improvement, and the horrible tyrannies of cosmetic saleswomen. She finds that life doesn't necessarily get any easier as you get older. But it does get funnier.

    There would be uncontrolled, impulsive rages followed with denial, disavowed responsibility, and then extreme outpourings of affection. How does a child learn to feel safe in this topsy-turvy world of conditional love?Leve captures the chaos and lasting impact of a child’s life under siege and explores how the coping mechanisms she developed to survive later incapacitated her as an adult. There were material comforts, but no emotional safety, except for summer visits to her father’s home in South East Asia—an escape that was terminated after he attempted to gain custody. Following the death of a loving caretaker, a succession of replacements raised Leve—relationships which resulted in intense attachment and loss. It was not until decades later, when Leve moved to other side of the world, that she could begin to emancipate herself from the past. In a relationship with a man who has children, caring for them yields clarity of what was missing.In telling her haunting story, Leve seeks to understand the effects of chronic psychological maltreatment on a child’s developing brain, and to discover how to build a life for herself that she never dreamed possible: An unabbreviated life.

    Following his father’s death, Issa, grief-stricken and vulnerable, travels down a road that leads to psychosis—and to one of the most nightmarish scenarios conceivable.Issa receives the insanity plea and is committed to an insane asylum with no release date. But that is only the beginning of his odyssey. Institutional and sexual sins cause further punishments, culminating in a heated legal battle for freedom. Written with great verve and immediacy, The Hospital Always Wins paints a detailed picture of a broken mental health system but also reveals the power of art, when nurtured in a benign environment, to provide a resource for recovery. Ultimately this is a story about survival and atonement through creativity and courage against almost insurmountable odds.

     Join Dana Schwartz on a journey revisiting all of the awful choices she made in her early twenties through the internet's favorite method of self-knowledge: the quiz. Part-memoir, part-VERY long personality test, Choose Your Own Disaster is a manifesto about the millennial experience and modern feminism and how the easy advice of "you can be anything you want!" is actually pretty fucking difficult when there are so many possible versions of yourself it seems like you could be. Dana has no idea who she is, but at least she knows she's a Carrie, a Ravenclaw, a Raphael, a Belle, a former emo kid, a Twitter addict, and a millennial just trying her best. This long-form personality quiz manages to combine humor with unflinching honesty as one young woman tries to find herself amid the many, many choices that your twenties have to offer.

    Today, their daily YouTube talk show, Good Mythical Morning, is the most-watched daily talk show on the Internet, and nearly 12 million subscribers tune in to see the guys broadcast brainy trivia, wild experiments, and hilarious banter (not to mention the occasional cereal bath). Now the award-winning comedians are finally bringing their “Mythical” world to the printed page in their first book.A hilarious blend of autobiography, trivia, and advice, Rhett & Link's Book of Mythicality: A Field Guide to Curiosity, Creativity, and Tomfoolery will offer twenty ways to add “Mythicality” to your life, including:Eat Something That Scares YouMake a Bold Hair ChoiceInvent Something RidiculousSay “I Love You” Like It's Never Been SaidSpeak at Your Own FuneralThe goal of these offbeat prompts? To learn new things, laugh more often, and earn a few grown-up merit badges along the way. Heartfelt and completely original, this book will be the perfect gift for anyone looking for a fresh dose of humor and fun.

    In between, the beloved actress, writer, and Hollywood power-bruncher gets Kanye West'd at her best friend's birthday, thwarts an "only in LA" crime, and learns what it means to have it all.