The latest edition offers greatly expanded coverage of directed mutagenesis and protein engineering, therapeutic agents, and genetic engineering of plants. Updated chapters reflect recent developments in biotechnology and the societal issues related to it, such as cloning, gene therapy, and patenting and releasing genetically engineered organisms. Over 480 figures, including 200 that are new in this edition, illustrate all key concepts. "Milestones" summarize important research papers in the history of biotechnology and their effects on the field. As in previous editions, the authors clearly explain all concepts and techniques to provide maximum understanding of the subject, avoiding confusing scientific jargon and excessive detail wherever possible. Each chapter concludes with a summary, references, and review questions. Ideally suited as a text for third- and fourth-year undergraduates as well as graduate students, this book is also an excellent reference for health professionals, scientists, engineers, or attorneys interested in biotechnology.

    It aims to give readers a fundamental overview of the technologies that make up the telecommunications infrastructure.

    Scholars and students need to be able to analyze, design and curate information into useful tools of communication, insight and understanding. This book is the starting point in learning the process and skills of data visualization, teaching the concepts and skills of how to present data and inspiring effective visual design. Benefits of this book: A flexible step-by-step journey that equips you to achieve great data visualization.A curated collection of classic and contemporary examples, giving illustrations of good and bad practice Examples on every page to give creative inspiration Illustrations of good and bad practice show you how to critically evaluate and improve your own work Advice and experience from the best designers in the field Loads of online practical help, checklists, case studies and exercises make this the most comprehensive text available

    However, despite all of the recent advances in computer vision research, the dream of having a computer interpret an image at the same level as a two-year old remains elusive. Why is computer vision such a challenging problem and what is the current state of the art?Computer Vision: Algorithms and Applications explores the variety of techniques commonly used to analyze and interpret images. It also describes challenging real-world applications where vision is being successfully used, both for specialized applications such as medical imaging, and for fun, consumer-level tasks such as image editing and stitching, which students can apply to their own personal photos and videos.More than just a source of "recipes," this exceptionally authoritative and comprehensive textbook/reference also takes a scientific approach to basic vision problems, formulating physical models of the imaging process before inverting them to produce descriptions of a scene. These problems are also analyzed using statistical models and solved using rigorous engineering techniquesTopics and features: Structured to support active curricula and project-oriented courses, with tips in the Introduction for using the book in a variety of customized courses Presents exercises at the end of each chapter with a heavy emphasis on testing algorithms and containing numerous suggestions for small mid-term projects Provides additional material and more detailed mathematical topics in the Appendices, which cover linear algebra, numerical techniques, and Bayesian estimation theory Suggests additional reading at the end of each chapter, including the latest research in each sub-field, in addition to a full Bibliography at the end of the book Supplies supplementary course material for students at the associated website, http: //szeliski.org/Book/ Suitable for an upper-level undergraduate or graduate-level course in computer science or engineering, this textbook focuses on basic techniques that work under real-world conditions and encourages students to push their creative boundaries. Its design and exposition also make it eminently suitable as a unique reference to the fundamental techniques and current research literature in computer vision.

    In this book, you’ll learn how many of the most fundamental data science tools and algorithms work by implementing them from scratch. If you have an aptitude for mathematics and some programming skills, author Joel Grus will help you get comfortable with the math and statistics at the core of data science, and with hacking skills you need to get started as a data scientist. Today’s messy glut of data holds answers to questions no one’s even thought to ask. This book provides you with the know-how to dig those answers out. Get a crash course in Python Learn the basics of linear algebra, statistics, and probability—and understand how and when they're used in data science Collect, explore, clean, munge, and manipulate data Dive into the fundamentals of machine learning Implement models such as k-nearest Neighbors, Naive Bayes, linear and logistic regression, decision trees, neural networks, and clustering Explore recommender systems, natural language processing, network analysis, MapReduce, and databases

    … The book the National Security Agency wanted never to be published." –Wired Magazine "…monumental… fascinating… comprehensive… the definitive work on cryptography for computer programmers…" –Dr. Dobb's Journal"…easily ranks as one of the most authoritative in its field." —PC Magazine"…the bible of code hackers." –The Millennium Whole Earth CatalogThis new edition of the cryptography classic provides you with a comprehensive survey of modern cryptography. The book details how programmers and electronic communications professionals can use cryptography—the technique of enciphering and deciphering messages-to maintain the privacy of computer data. It describes dozens of cryptography algorithms, gives practical advice on how to implement them into cryptographic software, and shows how they can be used to solve security problems. Covering the latest developments in practical cryptographic techniques, this new edition shows programmers who design computer applications, networks, and storage systems how they can build security into their software and systems. What's new in the Second Edition? * New information on the Clipper Chip, including ways to defeat the key escrow mechanism * New encryption algorithms, including algorithms from the former Soviet Union and South Africa, and the RC4 stream cipher * The latest protocols for digital signatures, authentication, secure elections, digital cash, and more * More detailed information on key management and cryptographic implementations

    This book offers a full range of exercises, a precise and conceptual presentation, and a new media package designed specifically to meet the needs of today's readers. The exercises gradually increase in difficulty, helping readers learn to generalize and apply the concepts. The refined table of contents introduces the exponential, logarithmic, and trigonometric functions in Chapter 7 of the text.KEY TOPICS Functions, Limits and Continuity, Differentiation, Applications of Derivatives, Integration, Applications of Definite Integrals, Integrals and Transcendental Functions, Techniques of Integration, Further Applications of Integration, Conic Sections and Polar Coordinates, Infinite Sequences and Series, Vectors and the Geometry of Space, Vector-Valued Functions and Motion in Space, Partial Derivatives, Multiple Integrals, Integration in Vector Fields.MARKET For all readers interested in Calculus.

     -Byte, September 1995 I can't begin to tell you how many pleasurable hours of study and recreation they have afforded me! I have pored over them in cars, restaurants, at work, at home... and even at a Little League game when my son wasn't in the line-up. -Charles Long If you think you're a really good programmer... read [Knuth's] Art of Computer Programming... You should definitely send me a resume if you can read the whole thing. -Bill Gates It's always a pleasure when a problem is hard enough that you have to get the Knuths off the shelf. I find that merely opening one has a very useful terrorizing effect on computers. -Jonathan Laventhol This first volume in the series begins with basic programming concepts and techniques, then focuses more particularly on information structures-the representation of information inside a computer, the structural relationships between data elements and how to deal with them efficiently. Elementary applications are given to simulation, numerical methods, symbolic computing, software and system design. Dozens of simple and important algorithms and techniques have been added to those of the previous edition. The section on mathematical preliminaries has been extensively revised to match present trends in research. Ebook (PDF version) produced by Mathematical Sciences Publishers (MSP), http: //msp.org

    Essentially, you make an initial guess, and then get more data to improve it. Bayes Theorem, or Bayes Rule, has a ton of real world applications, from estimating your risk of a heart attack to making recommendations on Netflix But It Isn't That Complicated This book is a short introduction to Bayes Theorem. It is only 15 pages long, and is intended to show you how Bayes Theorem works as quickly as possible. The examples are intentionally kept simple to focus solely on Bayes Theorem without requiring that the reader know complicated probability distributions. If you want to learn the basics of Bayes Theorem as quickly as possible, with some easy to duplicate examples, this is a good book for you.

    However, according to Hofstadter, the formal system that underlies all mental activity transcends the system that supports it. If life can grow out of the formal chemical substrate of the cell, if consciousness can emerge out of a formal system of firing neurons, then so too will computers attain human intelligence. Gödel, Escher, Bach is a wonderful exploration of fascinating ideas at the heart of cognitive science: meaning, reduction, recursion, and much more.

    By using objects early to solve interesting problems and defining objects later in the course, Building Java Programs develops programming knowledge for a broad audience. Introduction to Java Programming, Primitive Data and Definite Loops, Introduction to Parameters and Objects, Conditional Execution, Program Logic and Indefinite Loops, File Processing, Arrays, Defining Classes, Inheritance and Interfaces, ArrayLists, Java Collections Framework, Recursion, Searching and Sorting, Graphical User Interfaces. For all readers interested in introductory programming.

    In the modern experimentalist paradigm, these techniques address clear causal questions such as: Do smaller classes increase learning? Should wife batterers be arrested? How much does education raise wages? Mostly Harmless Econometrics shows how the basic tools of applied econometrics allow the data to speak.In addition to econometric essentials, Mostly Harmless Econometrics covers important new extensions--regression-discontinuity designs and quantile regression--as well as how to get standard errors right. Joshua Angrist and Jorn-Steffen Pischke explain why fancier econometric techniques are typically unnecessary and even dangerous. The applied econometric methods emphasized in this book are easy to use and relevant for many areas of contemporary social science.An irreverent review of econometric essentials A focus on tools that applied researchers use most Chapters on regression-discontinuity designs, quantile regression, and standard errors Many empirical examples A clear and concise resource with wide applications

    It can be freely downloaded and it works on multiple computer platforms. This book provides an elementary introduction to R. In each chapter, brief introductory sections are followed by code examples and comments from the computational and statistical viewpoint. A supplementary R package containing the datasets can be downloaded from the web.

    With this book, you'll learn how to load data, assemble and disassemble data objects, navigate R's environment system, write your own functions, and use all of R's programming tools.RStudio Master Instructor Garrett Grolemund not only teaches you how to program, but also shows you how to get more from R than just visualizing and modeling data. You'll gain valuable programming skills and support your work as a data scientist at the same time.Work hands-on with three practical data analysis projects based on casino gamesStore, retrieve, and change data values in your computer's memoryWrite programs and simulations that outperform those written by typical R usersUse R programming tools such as if else statements, for loops, and S3 classesLearn how to write lightning-fast vectorized R codeTake advantage of R's package system and debugging toolsPractice and apply R programming concepts as you learn them

    Edited by the Sustainability Institute’s Diana Wright, this essential primer brings systems thinking out of the realm of computers and equations and into the tangible world, showing readers how to develop the systems-thinking skills that thought leaders across the globe consider critical for 21st-century life.Some of the biggest problems facing the world—war, hunger, poverty, and environmental degradation—are essentially system failures. They cannot be solved by fixing one piece in isolation from the others, because even seemingly minor details have enormous power to undermine the best efforts of too-narrow thinking.While readers will learn the conceptual tools and methods of systems thinking, the heart of the book is grander than methodology. Donella Meadows was known as much for nurturing positive outcomes as she was for delving into the science behind global dilemmas. She reminds readers to pay attention to what is important, not just what is quantifiable, to stay humble, and to stay a learner.In a world growing ever more complicated, crowded, and interdependent, Thinking in Systems helps readers avoid confusion and helplessness, the first step toward finding proactive and effective solutions.