We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Two veterans of decades of adventuring in Grand Canyon chronicle the first complete and comprehensive history of Canyon misadventures. These episodes span the entire era of visitation from the time of the first river exploration by John Wesley Powell and his crew of 1869 to that of tourists falling off its rims in Y2K. These accounts of the 550 people who have met untimely deaths in the Canyon set a new high water mark for offering the most astounding array of adventures, misadventures, and life saving lessons published between any two covers. Over the Edge promises to be the most intense yet informative book on Grand Canyon ever written.

    Sacred ruins, grand hotels, wildlife preserves, hilltop villages, snack shacks, castles, festivals, reefs, restaurants, cathedrals, hidden islands, opera houses, museums, and more. Each entry tells exactly why it's essential to visit. Then come the nuts and bolts: addresses, websites, phone and fax numbers, best times to visit. Stop dreaming and get going.This hefty volume reminds vacationers that hot tourist spots are small percentage of what's worth seeing out there. A quick sampling: Venice's Cipriani Hotel; California's Monterey Peninsula; the Lewis and Clark Trail in Oregon; the Great Wall of China; Robert Louis Stevenson's home in Western Samoa; and the Alhambra in Andalusia, Spain. Veteran travel guide writer Schultz divides the book geographically, presenting a little less than a page on each location. Each entry lists exactly where to find the spot (e.g. Moorea is located "12 miles/19 km northwest of Tahiti; 10 minutes by air, 1 hour by boat") and when to go (e.g., if you want to check out The Complete Fly Fisher hotel in Montana, "May and Sept.-Oct. offer productive angling in a solitary setting"). This is an excellent resource for the intrepid traveler.Copyright 2003 Reed Business Information, Inc.

    Yet today there is only one—homo sapiens. What happened to the others? And what may happen to us?In this first volume of the full-color illustrated adaptation of his groundbreaking book, renowned historian Yuval Harari tells the story of humankind’s creation and evolution, exploring the ways in which biology and history have defined us and enhanced our understanding of what it means to be “human.” From examining the role evolving humans have played in the global ecosystem to charting the rise of empires, Sapiens challenges us to reconsider accepted beliefs, connect past developments with contemporary concerns, and view specific events within the context of larger ideas. Featuring 256 pages of full-color illustrations and easy-to-understand text covering the first part of the full-length original edition, this adaptation of the mind-expanding book furthers the ongoing conversation as it introduces Harari’s ideas to a wide new readership.

    Told through an examination of animal and plant life today - with occasional juxtapositions of extinct fossil forms to reveal the origin of living creatures - "Life on Earth" is an astonishing pageant of life, with a cast of characters drawn from the whole range of living animals the world over. Attenborough's perceptive, dynamic approach to the evolution of some four million species of living organisms that populate the planet is to trace the most significant thread in the history of each major group. He then proceeds to explain from the evidence of living representatives and fossil remains why certain animals adapted and survived, evolved to more complex and "higher" forms of life, while others, by some inherent limitation imposed by their physiology or structure, failed and became extinct. "Life on Earth" is a book of wonders. A model of clarity and ease as a guide, Attenborough takes the reader around the world with him into jungles where orchids have petals that "impersonate" wasps to attract pollinating insects; to Australia, where honeypot ants force feed nectar to workers of a special caste, then hang them up by their forelegs like living storage jars; to remote mountains in Japan where little monkeys called macaques have learned to combat the winter snows by bathing in hot volcanic springs.

    No book has ever told the story of beer in a graphic format as a liberating or emancipating force that improved the life of everyday people. Visually riffing on abstract subjects like pasteurization, "original gravity," and "lagering," artist Aaron McConnell has a flair for cinematic action and demonstrates versatility in depicting characters and episodes from beer's rich history. Hand-drawn in a classic, accessible style, The Comic Book Story of Beer makes a great gift, and will appeal to the most avid comic book geek and those who live for beer.

    . . a Victorian baby! In Ungovernable, Oneill conducts an unforgettable tour through the backwards, pseudoscientific, downright bizarre parenting fashions of the Victorians, advising us on: - How to be sure you're not too ugly, sickly, or stupid to breed- What positions and room decor will help you conceive a son- How much beer, wine, cyanide and heroin to consume while pregnant- How to select the best peasant teat for your child- Which foods won't turn your children into sexual deviants- And so much moreEndlessly surprising, wickedly funny, and filled with juicy historical tidbits and images, Ungovernable provides much-needed perspective on -- and comic relief from -- the age-old struggle to bring up baby.

    Tirelessly trekking across miles of the Thames’ muddy shores, where others only see the detritus of city life, Maiklem unearths evidence of England’s captivating, if sometimes murky, history—with some objects dating back to 43 AD, when London was but an outpost of the Roman Empire. From medieval mail worn by warriors on English battlefields to nineteenth-century glass marbles mass-produced for the nation’s first soda bottles, Maiklem deduces the historical significance of these artifacts with the quirky enthusiasm and sharp-sightedness of a twenty-first century Sherlock Holmes.Seamlessly interweaving reflections from her own life with meditations on the art of wandering, Maiklem ultimately delivers—for Anglophiles and history lovers alike—a memorable treatise on the objects we leave in our wake, and the stories they can reveal if only we take a moment to look.

    Well-behaved women seldom make history. Good thing these women are far from well behaved . . .Illustrated in a contemporary animation style, Rejected Princesses turns the ubiquitous "pretty pink princess" stereotype portrayed in movies, and on endless toys, books, and tutus on its head, paying homage instead to an awesome collection of strong, fierce, and yes, sometimes weird, women: warrior queens, soldiers, villains, spies, revolutionaries, and more who refused to behave and meekly accept their place.An entertaining mix of biography, imagery, and humor written in a fresh, young, and riotous voice, this thoroughly researched exploration salutes these awesome women drawn from both historical and fantastical realms, including real life, literature, mythology, and folklore. Each profile features an eye-catching image of both heroic and villainous women in command from across history and around the world, from a princess-cum-pirate in fifth century Denmark, to a rebel preacher in 1630s Boston, to a bloodthirsty Hungarian countess, and a former prostitute who commanded a fleet of more than 70,000 men on China’s seas.

    How did they come to be the villains of the natural world? And why can the same plant be considered beautiful in some places but be deemed a menace in others?In Weeds, renowned nature writer Richard Mabey embarks on an engaging journey with the verve and historical breadth of Michael Pollan. Weaving together the insights of botanists, gardeners, artists, and writers with his own travels and lifelong fascination, Mabey shows how these "botanical thugs" can destroy ecosystems but also can restore war zones and derelict cities; he reveals how weeds have been portrayed, from the "thorns and thistles" of Genesis to Shakespeare, Walden, and Invasion of the Body Snatchers; and he explains how kudzu overtook the American South, how poppies sprang up in First World War battlefields, and how "American weed" replaced the forests of Vietnam ravaged by Agent Orange.Hailed as "a profound and sympathetic meditation on weeds in relation to human beings" (Sunday Times), Weeds shows how useful these unloved plants can be, from serving as the first crops and medicines, to bur-dock inspiring the invention of Velcro, to cow parsley becoming the latest fashionable wedding adornment. Mabey argues that we have caused plants to become weeds through our reckless treatment of the earth, and he delivers a provocative defense of the plants we love to hate.

    Increasingly fascinated by this most shameful of experiences, she began to explore the lonely city by way of art. Moving fluidly between works and lives -- from Edward Hopper's Nighthawks to Andy Warhol's Time Capsules, from Henry Darger's hoarding to the depredations of the AIDS crisis -- Laing conducts an electric, dazzling investigation into what it means to be alone, illuminating not only the causes of loneliness but also how it might be resisted and redeemed.

    But to those who collect them, the map trade can be a cutthroat business, inhabited by quirky and sometimes disreputable characters in search of a finite number of extremely rare objects. Once considered a respectable antiquarian map dealer, E. Forbes Smiley spent years doubling as a map thief —until he was finally arrested slipping maps out of books in the Yale University library. The Map Thief delves into the untold history of this fascinating high-stakes criminal and the inside story of the industry that consumed him. Acclaimed reporter Michael Blanding has interviewed all the key players in this stranger-than-fiction story, and shares the fascinating histories of maps that charted the New World, and how they went from being practical instruments to quirky heirlooms to highly coveted objects. Though pieces of the map theft story have been written before, Blanding is the first reporter to explore the story in full—and had the rare privilege of having access to Smiley himself after he’d gone silent in the wake of his crimes. Moreover, although Smiley swears he has admitted to all of the maps he stole, libraries claim he stole hundreds more—and offer intriguing clues to prove it. Now, through a series of exclusive interviews with Smiley and other key individuals, Blanding teases out an astonishing tale of destruction and redemption. The Map Thief interweaves Smiley’s escapades with the stories of the explorers and mapmakers he knew better than anyone. Tracking a series of thefts as brazen as the art heists in Provenance and a subculture as obsessive as the oenophiles in The Billionaire’s Vinegar, Blanding has pieced together an unforgettable story of high-stakes crime.

    Here, a young graduate student from Rome, Francesca Cappelletti, makes a discovery that inspires a search for a work of art of incalculable value, a painting lost for almost two centuries.The artist was Caravaggio, a master of the Italian Baroque. He was a genius, a revolutionary painter, and a man beset by personal demons. Four hundred years ago, he drank and brawled in the taverns and streets of Rome, moving from one rooming house to another, constantly in and out of jail, all the while painting works of transcendent emotional and visual power. He rose from obscurity to fame and wealth, but success didn't alter his violent temperament. His rage finally led him to commit murder, forcing him to flee Rome a hunted man. He died young, alone, and under strange circumstances.Caravaggio scholars estimate that between sixty and eighty of his works are in existence today. Many others -- no one knows the precise number -- have been lost to time. Somewhere, surely, a masterpiece lies forgotten in a storeroom, or in a small parish church, or hanging above a fireplace, mistaken for a mere copy.Jonathan Harr embarks on a journey to discover the long-lost painting known as The Taking of Christ -- its mysterious fate and the circumstances of its disappearance have captivated Caravaggio devotees for years. After Francesca Cappelletti stumbles across a clue in that dusty archive, she tracks the painting across a continent and hundreds of years of history. But it is not until she meets Sergio Benedetti, an art restorer working in Ireland, that she finally manages to assemble all the pieces of the puzzle.

    One Country. And a lot of whisky.As stars of "Outlander", Sam and Graham eat, sleep and breathe the Highlands on this epic road trip around their homeland. They discover that the real thing is even greater than fiction."Clanlands" is the story of their journey. Armed with their trusty campervan and a sturdy friendship, these two Scotsmen are on the adventure of a lifetime to explore the majesty of Scotland. A wild ride by boat, kayak, bicycle and motorbike, they travel from coast to loch and peak to valley and delve into Scotland's history and culture, from timeless poetry to bloody warfare.With near-death experiences, many weeks in a confined space together, and a cast of unforgettable characters, Graham and Sam's friendship matures like a fine Scotch. They reflect on their acting careers in film and theatre, find a new awestruck respect for their native country and, as with any good road trip, they even find themselves.Hold onto your kilts ... this is Scotland as you've never seen it before.

    This is the perfect guide for parents who want to teach their children science through their favorite adventures as well as for the millions of adult fans of the series intrigued by its marvels and mysteries.- An ALA Booklist Editors' Choice -