Composed of exquisite, self-contained chapters that, cumulatively, take us through three generations of this adventurous, artistic, and often haunted family, The Edge of Every Day is an inquiry into our assumptions about how the mind can and should work—and a referendum on the treatment of the mentally ill in our society. As she explores the contours of cognition, Sardy also pushes the boundaries of her prose: one chapter is composed of quotes from family members talking about her mother. Another leads us through "loops" of past memory and current experience as she and her husband begin to merge their lives together.

    Even as a reporter, Sheila Hamilton missed the signs as her husband David's mental illness unfolded before her. By the time she had pieced together the puzzle, it was too late. Her once brilliant and passionate partner was dead within six weeks of a diagnosis of bipolar disorder, leaving his wife and nine-year-old daughter without so much as a note to explain his actions, a plan to help them recover from their profound grief, or a solution for the hundreds of thousands of dollars in debt that they would inherit from him.All the Things We Never Knew takes readers on a breathtaking journey, from David and Sheila's early romance through the last three months of their life together and into the year after his death. It details their unsettling spiral from ordinary life into the world of mental illness, examines the fragile line between reality and madness, and reveals the true power of love and forgiveness.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    Days earlier, she had been on the threshold of a new, adult life: at the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?In a swift and breathtaking narrative, Cahalan tells the astonishing true story of her descent into madness, her family’s inspiring faith in her, and the lifesaving diagnosis that nearly didn’t happen.

    When a small vial arrives in her mailbox from "Lewis Carroll," Ayelet Waldman is at a low point. Her mood storms have become intolerably severe; she has tried nearly every medication possible; her husband and children are suffering with her. So she opens the vial, places two drops on her tongue, and joins the ranks of an underground but increasingly vocal group of scientists and civilians successfully using therapeutic microdoses of LSD. As Waldman charts her experience over the course of a month--bursts of productivity, sleepless nights, a newfound sense of equanimity--she also explores the history and mythology of LSD, the cutting-edge research into the drug, and the byzantine policies that control it. Drawing on her experience as a federal public defender, and as the mother of teenagers, and her research into the therapeutic value of psychedelics, Waldman has produced a book that is eye-opening, often hilarious, and utterly enthralling.

    In other words, by all of us."--Dr. Bernie Siegel, author of Love, Medicine and MiraclesRule One for the neurologist in residence: "You ain't never the same when the air hits your brain." In this fascinating book, Dr. Frank Vertosick brings that fact to life through intimate portraits of patients and unsparing yet gripping descriptions of brain surgery.With insight, humor, and poignancy, Dr. Vertosick chronicles his remarkable evolution from naive young intern to world-class neurosurgeon, where he faced, among other challenges, a six week-old infant with a tumor in her brain, a young man struck down in his prime by paraplegia, and a minister with a .22 caliber bullet lodged in his skull. In candid detail, WHEN THE AIR HITS YOUR BRAIN illuminates both the mysteries of the mind and the realities of the operating room."Riveting."--Publishers Weekly

    Illuminating, completely engaging—it's essential reading for all since we all know someone whose life, family or friends are touched by the disease that directly afflicts a fifth of Canadians. In her early twenties, while outwardly thriving in her dream job and enjoying warm familial support and a strong social network, award-winning journalist Anna Mehler Paperny found herself trapped by feelings of failure and despair. Her first suicide attempt—ingesting a deadly mix of sleeping pills and antifreeze—landed her in the ICU, followed by weeks of enforced detention that ran the gamut of horrifying, boring, hilarious, and absurd. This was Anna's entry into the labyrinthine psychiatric care system responsible for providing care to millions of Canadians.As she struggled to survive the psych ward and as an outpatient—enduring the "survivor's" shame of facing concerned family, friends, and co-workers; finding (or not) the right therapist, the right meds; staying healthy, insured, and employed—Anna could not help but turn her demanding journalist's eye on her condition and on the system in which she found herself. She set off on a quest to "know her enemy," interviewing leading practitioners in the field across Canada and the US—from psychiatrists to neurological experts, brain-mapping pioneers to heroic family practitioners, and others dabbling in novel hypotheses. She reveals in courageously frank detail her own experiences with the pharmacological pitfalls and side effects of long-term treatment, and offers moving case studies of conversations with others, opening wide a window into how we treat (and fail to treat) the disease that accounts for more years swallowed up by disability than any other in the world.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Complications lays bare a science not in its idealized form but as it actually is--uncertain, perplexing, and profoundly human.Complications is a 2002 National Book Award Finalist for Nonfiction.

    Leslie Jamison deftly excavates the stories we tell about addiction--both her own and others'--and examines what we want these stories to do, and what happens when they fail us.All the while, she offers a fascinating look at the larger history of the recovery movement, and at the literary and artistic geniuses whose lives and works were shaped by alcoholism and substance dependence, including John Berryman, Jean Rhys, Raymond Carver, Billie Holiday, David Foster Wallace, and Denis Johnson, as well as brilliant figures lost to obscurity but newly illuminated here.For the power of her striking language and the sharpness of her piercing observations, Jamison has been compared to such iconic writers as Joan Didion and Susan Sontag. Yet her utterly singular voice also offers something new. With enormous empathy and wisdom, Jamison has given us nothing less than the story of addiction and recovery in America writ large, a definitive and revelatory account that will resonate for years to come.

    When death is sudden or unexplained, it falls to Shepherd to establish the cause. Each post-mortem is a detective story in its own right - and Shepherd has performed over 23,000 of them. Through his skill, dedication and insight, Dr Shepherd solves the puzzle to answer our most pressing question: how did this person die?From serial killer to natural disaster, 'perfect murder' to freak accident, Shepherd takes nothing for granted in pursuit of truth. And while he's been involved in some of the most high-profile cases of recent times, it's often the less well known encounters that prove the most perplexing, intriguing and even bizarre. In or out of the public eye, his evidence has put killers behind bars, freed the innocent and turned open-and-shut cases on their heads.But a life in death, bearing witness to some of humanity's darkest corners, exacts a price and Shepherd doesn't flinch from counting the cost to him and his family.

    The critically acclaimed series became America’s most watched—and most talked about—network show, even building on its fan base in the drama’s second season. As Kate Pearson, Chrissy Metz presents a character that has never been seen on television, yet viewers see themselves in her, no matter what they look like or where they come from. Considered a role model just for being her authentic self, Chrissy found herself on magazine covers and talk shows, walking red carpets, and as the subject of endless conversations on social media “I don’t know what you’ve been through to play her,” she is often told by fans, “but it was something.”In This is Me, Chrissy Metz shares her story with a raw honesty that will leave readers both surprised but also inspired. Infused with the same authenticity she brings to her starring role, Chrissy’s This is Me is so much more than your standard Hollywood memoir or collection of personal essays. She embraces the spirit of Shonda Rhimes’ Year of Yes, and shares how she has applied the lessons she learned from both setbacks and successes. A born entertainer, Chrissy finds light in even her darkest moments, and leaves the reader feeling they are spending time with a friend who gets it.Chrissy Metz grew up in a large family, one that always seemed to be moving, and growing. Her father disappeared one day, leaving her mother to work a series of menial jobs and his children to learn to live with the threat of hunger and the electricity being cut off. When her mother remarried, Chrissy hoped for “normal” but instead experienced a form of mental pain that seemed crafted just for her. The boys who showed her attention did so with strings attached as well, and Chrissy accepted it, because for her, love always came with conditions.When she set out for Los Angeles, it was the first time she had been away from her family and from Florida. And for years, she got barely an audition. So how does a woman with the deck stacked against her radiate such love, beauty and joy? This too is at the heart of This is Me. With chapters that alternate from autobiographical to instructional, Chrissy offers practical applications of her hard-won insights in a series of “Bee Mindful” interstitials. There she invites you to embrace gratitude in “Say Thank You” or to be honest with your partner and yourself in “The Shrouded Supreme.” Blending love and experience, Chrissy encourages us all to claim our rightful place in a world that may be trying to knock us down, find our own unique gifts, and pursue our dreams.

    We lose love, lose jobs, lose our sense of self. For Nora McInerny, it was losing her husband, her father, and her unborn second child in one catastrophic year.But in the wake of loss, we get to assemble something new from whatever is left behind. Some circles call finding happiness after loss “Chapter 2”—the continuation of something else. Today, Nora is remarried and mothers four children aged 16 months to 16 years. While her new circumstances bring her extraordinary joy, they are also tinged with sadness over the loved ones she’s lost.Life has made Nora a reluctant expert in hard conversations. On her wildly popular podcast, she talks about painful experiences we inevitably face, and exposes the absurdity of the question “how are you?” that people often ask when we’re coping with the aftermath of emotional catastrophe. She knows intimately that when your life falls apart, there’s a mad rush to be okay—to find a silver lining, to get to the happy ending. In this, her second memoir, Nora offers a tragicomic exploration of the tension between finding happiness and holding space for the unhappy experiences that have shaped us.No Happy Endings is a book for people living life after life has fallen apart. It’s a book for people who know that they’re moving forward, not moving on. It’s a book for people who know life isn’t always happy, but it isn’t the end: there will be unimaginable joy and incomprehensible tragedy. As Nora reminds us, there will be no happy endings—but there will be new beginnings.

    His contribution to our understanding not only of mental illness but also of the human condition is truly stunning.The Noonday Demon examines depression in personal, cultural, and scientific terms. Drawing on his own struggles with the illness and interviews with fellow sufferers, doctors and scientists, policymakers and politicians, drug designers and philosophers, Solomon reveals the subtle complexities and sheer agony of the disease. He confronts the challenge of defining the illness and describes the vast range of available medications, the efficacy of alternative treatments, and the impact the malady has had on various demographic populations around the world and throughout history. He also explores the thorny patch of moral and ethical questions posed by emerging biological explanations for mental illness.The depth of human experience Solomon chronicles, the range of his intelligence, and his boundless curiosity and compassion will change the reader's view of the world.

    There he meets David Smith, a medical student recovering from drug addiction, and the two men begin a tennis ritual that allows them to shed their inhibitions and find security in the sport they love and with each other. This friendship between doctor and intern grows increasingly rich and complex, more intimate than two men usually allow. Just when it seems nothing can go wrong, the dark beast from David’s past emerges once again—and almost everything Verghese has come to trust and believe in is threatened as David spirals out of control.