They discuss how scientists are working out the clockwork mechanisms and what governs them, and they describe how organisms measure different intervals of time, how they are adapted to various cycles, and how light coordinates the time within to the external world. They review problems that can be caused by malfunctioning biological clocks—including jet lag, seasonal affective disorder, and depression. And they warn that although new drugs are being promoted to allow us to stay awake for longer periods, a 24/7 lifestyle can have a harmful impact on our health, both as individuals and as a society.

    Its effects on our view of life have been wide and deep. One of the most world-shaking books ever published, Charles Darwin's On the Origin of Species, first appeared in print over 130 years ago, and it touched off a debate that rages to this day.Every modern evolutionist turns to Darwin's work again and again. Current controversies in the life sciences very often have as their starting point some vagueness in Darwin's writings or some question Darwin was unable to answer owing to the insufficient biological knowledge available during his time. Despite the intense study of Darwin's life and work, however, many of us cannot explain his theories (he had several separate ones) and the evidence and reasoning behind them, nor do we appreciate the modifications of the Darwinian paradigm that have kept it viable throughout the twentieth century.Who could elucidate the subtleties of Darwin's thought and that of his contemporaries and intellectual heirs--A. R. Wallace, T. H. Huxley, August Weismann, Asa Gray--better than Ernst Mayr, a man considered by many to be the greatest evolutionist of the century? In this gem of historical scholarship, Mayr has achieved a remarkable distillation of Charles Darwin's scientific thought and his enormous legacy to twentieth-century biology. Here we have an accessible account of the revolutionary ideas that Darwin thrust upon the world. Describing his treatise as "one long argument," Darwin definitively refuted the belief in the divine creation of each individual species, establishing in its place the concept that all of life descended from a common ancestor. He proposed the idea that humans were not the special products of creation but evolved according to principles that operate everywhere else in the living world; he upset current notions of a perfectly designed, benign natural world and substituted in their place the concept of a struggle for survival; and he introduced probability, chance, and uniqueness into scientific discourse.This is an important book for students, biologists, and general readers interested in the history of ideas--especially ideas that have radically altered our worldview. Here is a book by a grand master that spells out in simple terms the historical issues and presents the controversies in a manner that makes them understandable from a modern perspective.

    The Bathroom Readers' Hysterical Society agrees, and shows it with this endlessly diverting tribute to tabby. From famous cats to the famous with their cats to cats' famous history, from cats who like to paint to cats who travel the world to find their way home, Uncle John's Hysterical Society scours the globe to find the winning-est, wackiest, most wondrous cat tales for this collection.

    The Golden Retriever's personality is as golden as his outer coat. He was bred to please, and please he does. He started out as a hunting partner who delivered birds to hand and has evolved into modern times delivering whatever suits his owner's fancy. Because Golden Retrievers were originally bred to work in tandem with humans, they are also highly trainable. Golden Retrievers For Dummies is intended for busy 21st century dog owners who don't have time to sit down and read through 300 pages at a crack. This is a reference you can jump in and out of as dog questions rear their furry heads. This handy guide is also for you ifYou own a Golden Retriever or thinking about getting one. You've just brought home a Golden pup. You want to find the best way to raise and train your Golden. You want to help your Golde n to not just survive but to thrive. Find out what it takes to own this active, intelligent, and friendly dog. Explore the Golden's personality traits and living requirements. Discover which diseases are hereditary. This reference guide covers all the aspects of dog ownership, including:Looking at breeders, rescue groups, and animal shelters Adopting and caring for older dogs Selecting a puppy with help from an established testing process Dog-proofing your house and yard Crate training, housetraining, and obedience training Canine communication and growing pains Feeding, exercising, and playing with your Golden Dealing with illness, problem behavior, and treatment Grooming for health and beauty If you're serious about this Golden business and not just caving in to the kids or some other wild impulse, follow the advice of responsible dog owners and breeders. Look deep into your dog-loving soul and carefully consider the big picture. Love alone is not enough.

    

    Each case includes an extended discussion, definition of terms, clinical pearls, and USMLE format review questions. This interactive learning system helps you understand essential concepts instead of memorizing facts.

    But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    After all, what really matters on your wedding day is not so much how it looked as how it felt. In this refreshing guide, expert Meg Keene shares her secrets to planning a beautiful celebration that reflects your taste and your relationship. You'll discover:The real purpose of engagement (hint: it's not just about the planning)How to pinpoint what matters most to you and your partnerDIY-ing your wedding: brilliant or crazy?How to communicate decisions to your familyWhy that color-coded spreadsheet is actually worth itWedding Zen can be yours. Meg walks you through everything from choosing a venue to writing vows, complete with stories and advice from women who have been in the trenches: the Team Practical brides. So here's to the joyful wedding, the sensible wedding, the unbelievably fun wedding! A Practical Wedding is your complete guide to getting married with grace.

    Cat lovers will be enthralled with his insights into the feline world, from the secret of catnip to the true meaning of a purr. Exploring the mysteries of animal communication, Caras explains cat vocabulary (nine consonants, five vowels) and the incredible phenomenon of psi-trailing, a cat's ability to find its way home after being transported several miles away. Filled with charming stories about the felines in his own life, the author helps us see wild and domestic cats for the remarkable creatures they are. The New York Times Book Review called this work, "As thorough and sensitive a tour of the cat's world as a human being can contrive".

    The new edition maintains the scope and expertise that made the book so popular while incorporating the latest research and updating the exquisite program of drawings.

    

    After a brief tale of her own introduction to the paranormal, the author shares funny, poignant, and insightful words straight from the spirit people themselves. Together, the living and the dead seek forgiveness, solve family mysteries, find closure, settle scores, and come together for birthdays, anniversaries, and graduations. Quoting directly from her readings and séances, Priscilla reports the spirit perspective on mental illness, suicide, religion, and even the afterlife itself. For those readers interested in developing their own spirit communication skills, the last section of the book offers meditations and exercises used by the author herself, both personally and with her students. "It Will All Make Sense When You’re Dead" is chock-full of simple and entertaining wisdom, showing us how to live for today, with light hearts and kindness.

    Soon Gen Xers will be the only cohort of Americans who remember life as it was lived before the arrival of the Internet. They are, as Hennessey dubs them, “the last adult generation,” the sole remaining link to a time when childhood was still a bit dangerous but produced adults who were naturally resilient. More than a decade into the social media revolution, the American public is waking up to the idea that the tech sector’s intentions might not be as pure as advertised. The mountains of money being made off our browsing habits and purchase histories are used to fund ever-more extravagant and utopian projects that, by their very natures, will corrode the foundations of free society, leaving us all helpless and digitally enslaved to an elite crew of ultra-sophisticated tech geniuses. But it’s not too late to turn the tide. There’s still time for Gen X to write its own future. A spirited defense of free speech, eye contact, and the virtues of patience, Zero Hour for Gen X is a cultural history of the last 35 years, an analysis of the current social and historical moment, and a generational call to arms.

    She knew instantly that her decision to work in general practice was the ‘biggest and worst mistake of her life’. Fortunately, however, this did not deter her from continuing in general practice, and this fascinating memoir (spanning half a century) is testament to her resilience and professionalism, as well as her pragmatic and charismatic personality. She shares real stories about real people in this intriguing book. Some stories are truly heart-breaking and will have you reaching for the tissues (such as the times when she has lost patients, and encountered and supported abused children and rape victims). But it isn’t all serious. There are lots of light-hearted and heart-warming moments too, such as the stories about Jessie-dog – her bodyguard when she made home visits, and the time when she helped a large (and desperately in need) family to get rehoused, and her time as a country GP. She also recalls with honesty and candidness, the prejudice and unimaginable pressure she had to contend with, as a young female GP in the 1960s. As well as a plethora of fascinating stories, experiences and case studies, this book also gives us, as 21st Century readers, a glimpse into the rapid changes in general practice and the NHS in general. Whether you’re in general practice, or you’re a medical professional, or you have a penchant for all kinds of autobiographies/memoirs, you will find this a thought-provoking and captivating book that’s impossible to put down. Take a peek at the ‘Look Inside’ feature now and be prepared to be instantly intrigued.

    The many-pointed star formed from large icicles balances on a rock in a quiet Dumfriesshire valley, a delicate bamboo screen stands on a Japanese beach, a great serpentine ridge of earth extends along a disused railway cutting on Tyneside, four massive snow rings mark the position of the North Pole.