In The Botany of Desire, Michael Pollan ingeniously demonstrates how people and domesticated plants have formed a similarly reciprocal relationship. He masterfully links four fundamental human desires—sweetness, beauty, intoxication, and control—with the plants that satisfy them: the apple, the tulip, marijuana, and the potato. In telling the stories of four familiar species, Pollan illustrates how the plants have evolved to satisfy humankind’s most basic yearnings. And just as we’ve benefited from these plants, we have also done well by them. So who is really domesticating whom?

    Psychiatrist and psychoanalyst, Norman Doidge, M.D., traveled the country to meet both the brilliant scientists championing neuroplasticity and the people whose lives they’ve transformed - people whose mental limitations or brain damage were seen as unalterable. We see a woman born with half a brain that rewired itself to work as a whole, blind people who learn to see, learning disorders cured, IQs raised, aging brains rejuvenated, stroke patients learning to speak, children with cerebral palsy learning to move with more grace, depression and anxiety disorders successfully treated, and lifelong character traits changed. Using these marvelous stories to probe mysteries of the body, emotion, love, sex, culture, and education, Dr. Doidge has written an immensely moving, inspiring book that will permanently alter the way we look at our brains, human nature, and human potential.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    Brinkley–America’s most brazen young con man–arrived in the tiny town of Milford, Kansas. He set up a medical practice and introduced an outlandish surgical method using goat glands to restore the fading virility of local farmers.It was all nonsense, of course, but thousands of paying customers quickly turned “Dr.” Brinkley into America’s richest and most famous surgeon. His notoriety captured the attention of the great quackbuster Morris Fishbein, who vowed to put the country’s “most daring and dangerous” charlatan out of business.Their cat-and-mouse game lasted throughout the 1920s and ’30s, but despite Fishbein’s efforts Brinkley prospered wildly. When he ran for governor of Kansas, he invented campaigning techniques still used in modern politics. Thumbing his nose at American regulators, he built the world’s most powerful radio transmitter just across the Rio Grande to offer sundry cures, and killed or maimed patients by the score, yet his warped genius produced innovations in broadcasting that endure to this day. By introducing country music and blues to the nation, Brinkley also became a seminal force in rock ’n’ roll. In short, he is the most creative criminal this country has ever produced.Culminating in a decisive courtroom confrontation that pit Brinkley against his nemesis Fishbein, Charlatan is a marvelous portrait of a boundlessly audacious rogue on the loose in an America that was ripe for the bamboozling.

    But, despite appearances, these are not dogs—they are foxes. They are the result of the most astonishing experiment in breeding ever undertaken—imagine speeding up thousands of years of evolution into a few decades. In 1959, biologists Dmitri Belyaev and Lyudmila Trut set out to do just that, by starting with a few dozen silver foxes from fox farms in the USSR and attempting to recreate the evolution of wolves into dogs in real time in order to witness the process of domestication. This is the extraordinary, untold story of this remarkable undertaking. Most accounts of the natural evolution of wolves place it over a span of about 15,000 years, but within a decade, Belyaev and Trut’s fox breeding experiments had resulted in puppy-like foxes with floppy ears, piebald spots, and curly tails. Along with these physical changes came genetic and behavioral changes, as well. The foxes were bred using selection criteria for tameness, and with each generation, they became increasingly interested in human companionship. Trut has been there the whole time, and has been the lead scientist on this work since Belyaev’s death in 1985, and with Lee Dugatkin, biologist and science writer, she tells the story of the adventure, science, politics, and love behind it all.  In How to Tame a Fox, Dugatkin and Trut take us inside this path-breaking experiment in the midst of the brutal winters of Siberia to reveal how scientific history is made and continues to be made today. To date, fifty-six generations of foxes have been domesticated, and we continue to learn significant lessons from them about the genetic and behavioral evolution of domesticated animals. How to Tame a Fox offers an incredible tale of scientists at work, while also celebrating the deep attachments that have brought humans and animals together throughout time.

    It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    Frances E. Jensen, a mother, teacher, researcher, and internationally known expert in neurology, introduces us to the mystery and magic of the teen brain. One of the first books to focus exclusively on the neurological development of adolescents, The Teenage Brain presents new findings, dispels widespread myths, and provides practical suggestions for negotiating this difficult and dynamic life stage for both adults and adolescents.Interweaving easy-to-follow scientific data with anecdotes drawn from her experiences as a parent, clinician, and public speaker, Dr. Jensen explores adolescent brain functioning and development, including learning and memory, and investigates the impact of influences such as drugs, multitasking, sleep, and stress. The Teenage Brain reveals how: Adolescents may not be as resilient to the effects of drugs as we previously thought. Occasional use of marijuana has been shown to cause lingering memory problems, and long-term use can affect later adulthood I.Q. Multi-tasking causes divided attention and can reduce learning ability. Emotionally stressful situations in adolescence can have permanent effects on mental health, and may lead to higher risk for certain neuropsychiatric disorders such as depression.Rigorous yet accessible, warm yet direct, The Teenage Brain sheds new light on young adults, and provides practical suggestions for how parents, schools, and even the legal system can better help them during this crucial period.

    The word conjures up images of horrific diseases sweeping the globe and killing everyone in their path. But such highly lethal illnesses almost never create pandemics. The reality is deadly serious but far more subtle.In Pandemics: What Everyone Needs to Know�, Peter Doherty, who won the Nobel Prize for his work on how the immune system recognizes virus-infected cells, offers an essential guide to one of the truly life-or-death issues of our age. In concise, question-and-answer format, he explains the causes of pandemics, how they can be counteracted with vaccines and drugs, and how we can better prepare for them in the future. Doherty notes that the term "pandemic" refers not to a disease's severity but to its ability to spread rapidly over a wide geographical area. Extremely lethal pathogens are usually quickly identified and confined. Nevertheless, the rise of high-speed transportation networks and the globalization of trade and travel have radically accelerated the spread of diseases. A traveler from Africa arrived in New York in 1999 carrying the West Nile virus; one mosquito bite later, it was loose in the ecosystem. Doherty explains how the main threat of a pandemic comes from respiratory viruses, such as influenza and SARS, which disseminate with incredible speed through air travel. The climate disruptions of global warming, rising population density, and growing antibiotic resistance all complicate efforts to control pandemics. But Doherty stresses that pandemics can be fought effectively. Often simple health practices, especially in hospitals, can help enormously. And research into the animal reservoirs of pathogens, from SARS in bats to HIV in chimpanzees, show promise for our prevention efforts.Calm, clear, and authoritative, Peter Doherty's Pandemics is one of the most critically important additions to the What Everyone Needs to Know� series.What Everyone Needs to Know� is a registered trademark of Oxford University Press.

    Breaking down the symbols themselves, they pose a series of questions: What is energy? What is mass? What has the speed of light got to do with energy and mass? In answering these questions, they take us to the site of one of the largest scientific experiments ever conducted. Lying beneath the city of Geneva, straddling the Franco-Swiss boarder, is a 27 km particle accelerator, known as the Large Hadron Collider. Using this gigantic machine—which can recreate conditions in the early Universe fractions of a second after the Big Bang—Cox and Forshaw will describe the current theory behind the origin of mass.Alongside questions of energy and mass, they will consider the third, and perhaps, most intriguing element of the equation: 'c' - or the speed of light. Why is it that the speed of light is the exchange rate? Answering this question is at the heart of the investigation as the authors demonstrate how, in order to truly understand why E=mc2, we first must understand why we must move forward in time and not backwards and how objects in our 3-dimensional world actually move in 4-dimensional space-time. In other words, how the very fabric of our world is constructed. A collaboration between two of the youngest professors in the UK, Why Does E=mc2? promises to be one of the most exciting and accessible explanations of the theory of relativity in recent years.

    Mainstream science--as well as religious and cultural institutions--has maintained that men and women evolved in families in which a man's possessions and protection were exchanged for a woman's fertility and fidelity. But this narrative is collapsing. Fewer and fewer couples are getting married, and divorce rates keep climbing as adultery and flagging libido drag down even seemingly solid marriages.How can reality be reconciled with the accepted narrative? It can't be, according to renegade thinkers Christopher Ryan and Cacilda Jethá. While debunking almost everything we "know" about sex, they offer a bold alternative explanation in this provocative and brilliant book.Ryan and Jethá's central contention is that human beings evolved in egalitarian groups that shared food, child care, and, often, sexual partners. Weaving together convergent, frequently overlooked evidence from anthropology, archaeology, primatology, anatomy, and psychosexuality, the authors show how far from human nature monogamy really is. Human beings everywhere and in every era have confronted the same familiar, intimate situations in surprisingly different ways. The authors expose the ancient roots of human sexuality while pointing toward a more optimistic future illuminated by our innate capacities for love, cooperation, and generosity.With intelligence, humor, and wonder, Ryan and Jethá show how our promiscuous past haunts our struggles over monogamy, sexual orientation, and family dynamics. They explore why long-term fidelity can be so difficult for so many; why sexual passion tends to fade even as love deepens; why many middle-aged men risk everything for transient affairs with younger women; why homosexuality persists in the face of standard evolutionary logic; and what the human body reveals about the prehistoric origins of modern sexuality.In the tradition of the best historical and scientific writing, Sex at Dawn unapologetically upends unwarranted assumptions and unfounded conclusions while offering a revolutionary understanding of why we live and love as we do.

    Someday, we know, we will all die. And, we know, so too will the universe itself.Until the End of Time is Brian Greene's breathtaking new exploration of the cosmos and our quest to understand it. Greene takes us on a journey across time, from our most refined understanding of the universe's beginning, to the closest science can take us to the very end. He explores how life and mind emerged from the initial chaos, and how our minds, in coming to understand their own impermanence, seek in different ways to give meaning to experience: in story, myth, religion, creative expression, science, the quest for truth, and our longing for the timeless, or eternal. Through a series of nested stories that explain distinct but interwoven layers of reality-from the quantum mechanics to consciousness to black holes-Greene provides us with a clearer sense of how we came to be, a finer picture of where we are now, and a firmer understanding of where we are headed.Yet all this understanding, which arose with the emergence of life, will dissolve with its conclusion. Which leaves us with one realization: during our brief moment in the sun, we are tasked with the charge of finding our own meaning.Let us embark.

    Americans eat more bananas than apples and oranges combined. In others parts of the world, bananas are what keep millions of people alive. But for all its ubiquity, the banana is surprisingly mysterious; nobody knows how bananas evolved or exactly where they originated. Rich cultural lore surrounds the fruit: In ancient translations of the Bible, the 'apple' consumed by Eve is actually a banana (it makes sense, doesn't it?). Entire Central American nations have been said to rise and fall over the banana. But the biggest mystery about the banana today is whether it will survive. A seedless fruit with a unique reproductive system, every banana is a genetic duplicate of the next, and therefore susceptible to the same blights. Today's yellow banana, the Cavendish, is increasingly threatened by such a blight -- and there's no cure in sight. Banana combines a pop-science journey around the globe, a fascinating tale of an iconic American business enterprise, and a look into the alternately tragic and hilarious banana subculture (one does exist) -- ultimately taking us to the high-tech labs where new bananas are literally being built in test tubes, in a race to save the world's most beloved fruit.

    In How Not to Be Wrong, Jordan Ellenberg shows us how terribly limiting this view is: Math isn’t confined to abstract incidents that never occur in real life, but rather touches everything we do—the whole world is shot through with it.Math allows us to see the hidden structures underneath the messy and chaotic surface of our world. It’s a science of not being wrong, hammered out by centuries of hard work and argument. Armed with the tools of mathematics, we can see through to the true meaning of information we take for granted: How early should you get to the airport? What does “public opinion” really represent? Why do tall parents have shorter children? Who really won Florida in 2000? And how likely are you, really, to develop cancer?How Not to Be Wrong presents the surprising revelations behind all of these questions and many more, using the mathematician’s method of analyzing life and exposing the hard-won insights of the academic community to the layman—minus the jargon. Ellenberg chases mathematical threads through a vast range of time and space, from the everyday to the cosmic, encountering, among other things, baseball, Reaganomics, daring lottery schemes, Voltaire, the replicability crisis in psychology, Italian Renaissance painting, artificial languages, the development of non-Euclidean geometry, the coming obesity apocalypse, Antonin Scalia’s views on crime and punishment, the psychology of slime molds, what Facebook can and can’t figure out about you, and the existence of God.Ellenberg pulls from history as well as from the latest theoretical developments to provide those not trained in math with the knowledge they need. Math, as Ellenberg says, is “an atomic-powered prosthesis that you attach to your common sense, vastly multiplying its reach and strength.” With the tools of mathematics in hand, you can understand the world in a deeper, more meaningful way. How Not to Be Wrong will show you how.

    Until recently scientists dis­missed these stories—waves that high would seem to violate the laws of physics. But in the past few decades, as a startling number of ships vanished and new evidence has emerged, oceanographers realized something scary was brewing in the planet’s waters. They found their proof in February 2000, when a British research vessel was trapped in a vortex of impossibly mammoth waves in the North Sea—including several that approached 100 feet.As scientists scramble to understand this phenomenon, others view the giant waves as the ultimate challenge. These are extreme surfers who fly around the world trying to ride the ocean’s most destructive monsters. The pioneer of extreme surfing is the legendary Laird Hamilton, who, with a group of friends in Hawaii, figured out how to board suicidally large waves of 70 and 80 feet. Casey follows this unique tribe of peo­ple as they seek to conquer the holy grail of their sport, a 100­-foot wave.In this mesmerizing account, the exploits of Hamilton and his fellow surfers are juxtaposed against scientists’ urgent efforts to understand the destructive powers of waves—from the tsunami that wiped out 250,000 people in the Pacific in 2004 to the 1,740-foot-wave that recently leveled part of the Alaskan coast.Like Jon Krakauer’s Into Thin Air, The Wave brilliantly portrays human beings confronting nature at its most ferocious.

    Our Big Bang, our distant future, parallel worlds, the sub-atomic and intergalactic - none of them are what they seem. But there is a way to understand this immense strangeness - mathematics. Seeking an answer to the fundamental puzzle of why our universe seems so mathematical, Tegmark proposes a radical idea: that our physical world not only is described by mathematics, but that it is mathematics. This may offer answers to our deepest questions: How large is reality? What is everything made of? Why is our universe the way it is?Table of ContentsPreface 1 What Is Reality? Not What It Seems • What’s the Ultimate Question? • The Journey Begins Part One: Zooming Out 2 Our Place in Space Cosmic Questions • How Big Is Space? • The Size of Earth • Distance to the Moon • Distance to the Sun and the Planets • Distance to the Stars • Distance to the Galaxies • What Is Space? 3 Our Place in TimeWhere Did Our Solar System Come From? • Where Did theGalaxies Come From? • Where Did the Mysterious MicrowavesCome From? • Where Did the Atoms Come From? 4 Our Universe by NumbersWanted: Precision Cosmology • Precision Microwave-Background Fluctuations • Precision Galaxy Clustering • The Ultimate Map of Our Universe • Where Did Our Big Bang Come From? 5 Our Cosmic Origins What’s Wrong with Our Big Bang? • How Inflation Works • The Gift That Keeps on Giving • Eternal Inflation 6 Welcome to the Multiverse The Level I Multiverse • The Level II Multiverse • Multiverse Halftime Roundup Part Two: Zooming In 7 Cosmic Legos Atomic Legos • Nuclear Legos • Particle-Physics Legos • Mathematical Legos • Photon Legos • Above the Law? • Quanta and Rainbows • Making Waves • Quantum Weirdness • The Collapse of Consensus • The Weirdness Can’t Be Confined • Quantum Confusion 8 The Level III Multiverse The Level III Multiverse • The Illusion of Randomness • Quantum Censorship • The Joys of Getting Scooped • Why Your Brain Isn’t a Quantum Computer • Subject, Object and Environment • Quantum Suicide • Quantum Immortality? • Multiverses Unified • Shifting Views: Many Worlds or Many Words? Part Three: Stepping Back 9 Internal Reality, External Reality and Consensus Reality External Reality and Internal Reality • The Truth, the Whole Truth and Nothing but the Truth • Consensus Reality • Physics: Linking External to Consensus Reality 10 Physical Reality and Mathematical Reality Math, Math Everywhere! • The Mathematical Universe Hypothesis • What Is a Mathematical Structure? 11 Is Time an Illusion? How Can Physical Reality Be Mathematical? • What Are You? • Where Are You? (And What Do You Perceive?) • When Are You? 12 The Level IV Multiverse Why I Believe in the Level IV Multiverse • Exploring the Level IV Multiverse: What’s Out There? • Implications of the Level IV Multiverse • Are We Living in a Simulation? • Relation Between the MUH, the Level IV Multiverse and Other Hypotheses •Testing the Level IV Multiverse 13 Life, Our Universe and Everything How Big Is Our Physical Reality? • The Future of Physics • The Future of Our Universe—How Will It End? • The Future of Life •The Future of You—Are You Insignificant? Acknowledgments Suggestions for Further Reading Index