Nobody is perfect. And that includes five of the greatest scientists in history—Charles Darwin, William Thomson (Lord Kelvin), Linus Pauling, Fred Hoyle, and Albert Einstein. But the mistakes that these great luminaries made helped advance science. Indeed, as Mario Livio explains, science thrives on error, advancing when erroneous ideas are disproven.As a young scientist, Einstein tried to conceive of a way to describe the evolution of the universe at large, based on General Relativity—his theory of space, time, and gravity. Unfortunately he fell victim to a misguided notion of aesthetic simplicity. Fred Hoyle was an eminent astrophysicist who ridiculed an emerging theory about the origin of the universe that he dismissively called “The Big Bang.” The name stuck, but Hoyle was dead wrong in his opposition.They, along with Darwin (a blunder in his theory of Natural Selection), Kelvin (a blunder in his calculation of the age of the earth), and Pauling (a blunder in his model for the structure of the DNA molecule), were brilliant men and fascinating human beings. Their blunders were a necessary part of the scientific process. Collectively they helped to dramatically further our knowledge of the evolution of life, the Earth, and the universe.

    What is going on? Anatomy of an Epidemic challenges readers to think through that question themselves. First, Whitaker investigates what is known today about the biological causes of mental disorders. Do psychiatric medications fix “chemical imbalances” in the brain, or do they, in fact, create them? Researchers spent decades studying that question, and by the late 1980s, they had their answer. Readers will be startled—and dismayed—to discover what was reported in the scientific journals. Then comes the scientific query at the heart of this book: During the past fifty years, when investigators looked at how psychiatric drugs affected long-term outcomes, what did they find? Did they discover that the drugs help people stay well? Function better? Enjoy good physical health? Or did they find that these medications, for some paradoxical reason, increase the likelihood that people will become chronically ill, less able to function well, more prone to physical illness?  This is the first book to look at the merits of psychiatric medications through the prism of long-term results. Are long-term recovery rates higher for medicated or unmedicated schizophrenia patients? Does taking an antidepressant decrease or increase the risk that a depressed person will become disabled by the disorder? Do bipolar patients fare better today than they did forty years ago, or much worse? When the National Institute of Mental Health (NIMH) studied the long-term outcomes of children with ADHD, did they determine that stimulants provide any benefit?  By the end of this review of the outcomes literature, readers are certain to have a haunting question of their own: Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public?  In this compelling history, Whitaker also tells the personal stories of children and adults swept up in this epidemic. Finally, he reports on innovative programs of psychiatric care in Europe and the United States that are producing good long-term outcomes. Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up.

    Why does music evoke such powerful moods? The answers are at last be- coming clear, thanks to revolutionary neuroscience and the emerging field of evolutionary psychology. Both a cutting-edge study and a tribute to the beauty of music itself, This Is Your Brain on Music unravels a host of mysteries that affect everything from pop culture to our understanding of human nature, including: • Are our musical preferences shaped in utero? • Is there a cutoff point for acquiring new tastes in music? • What do PET scans and MRIs reveal about the brain’s response to music? • Is musical pleasure different from other kinds of pleasure?This Is Your Brain on Music explores cultures in which singing is considered an essential human function, patients who have a rare disorder that prevents them from making sense of music, and scientists studying why two people may not have the same definition of pitch. At every turn, this provocative work unlocks deep secrets about how nature and nurture forge a uniquely human obsession.

    It is a waste product and a commodity pricier than oil. It can save lives and transmit deadly infections. Each one of us has roughly nine pints of it, yet many don’t even know their own blood type. And for all its ubiquity, the few tablespoons of blood discharged by 800 million women are still regarded as taboo; menstruation is perhaps the single most demonized biological event.Rose George, author of The Big Necessity, is renowned for her intrepid work on topics that are invisible but vitally important. In Nine Pints, she takes us from ancient practices of bloodletting to modern “hemovigilance” teams that track blood-borne diseases. She introduces Janet Vaughan, who set up the world’s first system of mass blood donation during the Blitz, and Arunachalam Muruganantham, known as “Menstrual Man” for his work on sanitary pads for developing countries. She probes the lucrative business of plasma transfusions, in which the U.S. is known as the “OPEC of plasma.” And she looks to the future, as researchers seek to bring synthetic blood to a hospital near you.Spanning science and politics, stories and global epidemics, Nine Pints reveals our life's blood in an entirely new light.

    Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

    Building a house would entail no more work than planting a seed in the ground. These scenarios may seem far-fetched, but pioneering geneticist George Church and science writer Ed Regis show that synthetic biology is bringing us ever closer to making such visions a reality. In Regenesis, Church and Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. Until now, nature has been the exclusive arbiter of life, death, and evolution; with synthetic biology, we now have the potential to write our own biological future. Indeed, as Church and Regis show, it even enables us to revisit crucial points in the evolution of life and, through synthetic biological techniques, choose different paths from those nature originally took. Such exploits will involve far more than just microbial tinkering. Full-blown genomic engineering will make possible incredible feats, from resurrecting woolly mammoths and other extinct organisms to creating mirror life forms with a molecular structure the opposite of our own. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

    Psychiatrist and psychoanalyst, Norman Doidge, M.D., traveled the country to meet both the brilliant scientists championing neuroplasticity and the people whose lives they’ve transformed - people whose mental limitations or brain damage were seen as unalterable. We see a woman born with half a brain that rewired itself to work as a whole, blind people who learn to see, learning disorders cured, IQs raised, aging brains rejuvenated, stroke patients learning to speak, children with cerebral palsy learning to move with more grace, depression and anxiety disorders successfully treated, and lifelong character traits changed. Using these marvelous stories to probe mysteries of the body, emotion, love, sex, culture, and education, Dr. Doidge has written an immensely moving, inspiring book that will permanently alter the way we look at our brains, human nature, and human potential.

    Dennett, whom Chet Raymo of The Boston Globe calls "one of the most provocative thinkers on the planet," focuses his unerringly logical mind on the theory of natural selection, showing how Darwin's great idea transforms and illuminates our traditional view of humanity's place in the universe. Dennett vividly describes the theory itself and then extends Darwin's vision with impeccable arguments to their often surprising conclusions, challenging the views of some of the most famous scientists of our day.

    News of both the Ice Man's discovery and his age, which was put at over five thousand years, fascinated scientists and newspapers throughout the world. But what made Sykes's story particularly revelatory was his successful identification of a genetic descendant of the Ice Man, a woman living in Great Britain today. How was Sykes able to locate a living relative of a man who died thousands of years ago?In The Seven Daughters of Eve, he gives us a firsthand account of his research into a remarkable gene, which passes undiluted from generation to generation through the maternal line. After plotting thousands of DNA sequences from all over the world, Sykes found that they clustered around a handful of distinct groups. Among Europeans and North American Caucasians, there are, in fact, only seven. This conclusion was staggering: almost everyone of native European descent, wherever they may live throughout the world, can trace their ancestry back to one of seven women, the Seven Daughters of Eve.Naming them Ursula, Xenia, Helena, Velda, Tara, Katrine, and Jasmine, Sykes has created portraits of their disparate worlds by mapping the migratory patterns followed by millions of their ancestors. In reading the stories of these seven women, we learn exactly how our origins can be traced, how and where our ancient genetic ancestors lived, and how we are each living proof of the almost indestructible strands of DNA, which have survived over so many thousands of years. Indeed, The Seven Daughters of Eve is filled with dramatic stories: from Sykes's identification, using DNA samples from two living relatives, of the remains of Tsar Nicholas and Tsaress Alexandra, to the Caribbean woman whose family had been sold into slavery centuries before and whose ancestry Sykes was able to trace back to the Eastern coast of central Africa. Ultimately, Sykes's investigation reveals that, as a race, what humans have in common is more deeply embedded than what separates us.

    Lanza has teamed with Bob Berman, the most widely read astronomer in the world, to produce Biocentrism, a revolutionary new view of the universe.Every now and then a simple yet radical idea shakes the very foundations of knowledge. The startling discovery that the world was not flat challenged and ultimately changed the way people perceived themselves and their relationship with the world. For most humans of the 15th century, the notion of Earth as ball of rock was nonsense. The whole of Western, natural philosophy is undergoing a sea change again, increasingly being forced upon us by the experimental findings of quantum theory, and at the same time, towards doubt and uncertainty in the physical explanations of the universe’s genesis and structure. Biocentrism completes this shift in worldview, turning the planet upside down again with the revolutionary view that life creates the universe instead of the other way around.In this paradigm, life is not an accidental byproduct of the laws of physics. Biocentrism takes the reader on a seemingly improbable but ultimately inescapable journey through a foreign universe—our own—from the viewpoints of an acclaimed biologist and a leading astronomer. Switching perspective from physics to biology unlocks the cages in which Western science has unwittingly managed to confine itself. Biocentrism will shatter the reader’s ideas of life—time and space, and even death. At the same time it will release us from the dull worldview of life being merely the activity of an admixture of carbon and a few other elements; it suggests the exhilarating possibility that life is fundamentally immortal.The 21st century is predicted to be the Century of Biology, a shift from the previous century dominated by physics. It seems fitting, then, to begin the century by turning the universe outside-in and unifying the foundations of science with a simple idea discovered by one of the leading life-scientists of our age. Biocentrism awakens in readers a new sense of possibility, and is full of so many shocking new perspectives that the reader will never see reality the same way again.

    But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This book takes us to the frontlines of research many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.

    Scientists around the world are currently monitoring the sixth extinction, predicted to be the most devastating extinction event since the asteroid impact that wiped out the dinosaurs. This time around, the cataclysm is us. In prose that is at once frank, entertaining, and deeply informed, The New Yorker writer Elizabeth Kolbert tells us why and how human beings have altered life on the planet in a way no species has before. Interweaving research in half a dozen disciplines, descriptions of the fascinating species that have already been lost, and the history of extinction as a concept, Kolbert provides a moving and comprehensive account of the disappearances occurring before our very eyes. She shows that the sixth extinction is likely to be mankind's most lasting legacy, compelling us to rethink the fundamental question of what it means to be human.

    Armed with a healthy dose of wit and curiosity, medical journalist Randi Hutter Epstein reveals the “invigorating history” (Nature) of hormones and the age-old quest to control them through the back rooms, basements, and labs where endocrinology began.

    She finds that you cannot immunize your child, or yourself, from the world.In this bold, fascinating book, Biss investigates the metaphors and myths surrounding our conception of immunity and its implications for the individual and the social body. As she hears more and more fears about vaccines, Biss researches what they mean for her own child, her immediate community, America, and the world, both historically and in the present moment. She extends a conversation with other mothers to meditations on Voltaire's Candide, Bram Stoker's Dracula, Rachel Carson's Silent Spring, Susan Sontag's AIDS and Its Metaphors, and beyond.On Immunity is a moving account of how we are all interconnected-our bodies and our fates.

    The media seized hold of the story and, in the process, helped to launch one of the most devastating health scares ever. In the years to come Wakefield would be revealed as a profiteer in league with class-action lawyers, and he would eventually lose his medical license. Meanwhile, one study after another failed to find any link between childhood vaccines and autism. Yet the myth that vaccines somehow cause developmental disorders lives on. Despite the lack of corroborating evidence, it has been popularized by media personalities such as Oprah Winfrey and Jenny McCarthy and legitimized by journalists who claim that they are just being fair to “both sides” of an issue about which there is little debate. Meanwhile, millions of dollars have been diverted from potential breakthroughs in autism research; families have spent their savings on ineffective “miracle cures"; and declining vaccination rates have led to outbreaks of deadly illnesses like Hib, measles, and whooping cough. Most tragic of all is the increasing number of children dying from vaccine-preventable diseases. In The Panic Virus Seth Mnookin draws on interviews with parents, public-health advocates, scientists, and anti-vaccine activists to tackle a fundamental question: How do we decide what the truth is? The fascinating answer helps explain everything from the persistence of conspiracy theories about 9/11 to the appeal of talk-show hosts who demand that President Obama “prove” he was born in America. The Panic Virus is the ultimate cautionary tale for our time.