Jerry Avorn has some sobering news. Drawing on more than twenty-five years of patient care, teaching, and research at Harvard Medical School, he shares his firsthand experience of the wide gap in our knowledge of the effectiveness of one medication as compared to another. In Powerful Medicines, he reminds us that every pill we take represents a delicate compromise between the promise of healing, the risk of side effects, and an increasingly daunting price. The stakes on each front grow higher every year as new drugs with impressive power, worrisome side effects, and troubling costs are introduced.This is a comprehensive behind-the-scenes look at issues that affect everyone: our shortage of data comparing the worth of similar drugs for the same condition; alarming lapses in the detection of lethal side effects; the underuse of life-saving medications; lavish marketing campaigns that influence what doctors prescribe; and the resulting upward spiral of costs that places vital drugs beyond the reach of many Americans.In this engagingly written book, Dr. Avorn asks questions that will interest every consumer: How can a product judged safe by the Food and Drug Administration turn out to have unexpectedly lethal side effects? Why has the nation’s drug bill been growing at nearly 20 percent per year? How can physicians and patients pick the best medication in its class? How do doctors actually make their prescribing decisions, and why do those decisions sometimes go wrong? Why do so many Americans suffer preventable illnesses and deaths that proper drug use could have averted? How can the nation gain control over its escalating drug budget without resorting to rationing or draconian governmental controls?Using clinical case histories taken from his own work as a practitioner, researcher, and advocate, Dr. Avorn demonstrates the impressive power of the well-conceived prescription as well as the debacles that can result when medications are misused. He describes an innovative program that employs the pharmaceutical industry’s own marketing techniques to reduce use of some of the most overprescribed and overpriced products. Powerful Medicines offers timely and practical advice on how the nation can improve its drug-approval process, and how patients can work with doctors to make sure their prescriptions are safe, effective, and as affordable as possible. This is a passionate and provocative call for action as well as a compelling work of clear-headed science.From the Hardcover edition.

    Come home when you can.” He returns to discover a place both wholly familiar and barely recognizable and is cast into the center of an interracial land dispute with the exigencies of war.   Widely acclaimed when first published in the eighties, the timeless novel Red Earth, White Earth showcases Will Weaver’s rough ease with language and storytelling, frankly depicting life’s uneven terrain and crooked paths.

    Among the new and expanded material is coverage of psychometric and statistical concepts; new and revised tests, inventories, and scales; relevant ethical and legal issues; contemporary measurement theories; and important multicultural issues. In addition, the 17 chapters of this clear and user-friendly book provide guidance on how and when to use tests in different settings with different populations and information on basic procedures like test selection, administration, and reporting. Additional case studies have also been added throughout the text to help readers understand how to work with assessments and assessment results in real world situations.

    Starting with easy, factual questions that test how well you remember a novel and its characters, the quiz progresses to a level of greater difficulty, demanding close reading and interpretative deduction. What really motivates the characters, and what is going on beneath the surface of the story? Designed to amuse and divert, the questions and answers take the reader on an imaginative journey into the world of Jane Austen, where hypothesis and speculation produce fascinating and unexpected insights. The questions are ingenious and fun, and the answers (located in the back of the book), in Sutherland's inimitable style, are fascinating. Completing the book guarantees a hugely improved knowledge and appreciation of Austen. Whether you are an expert or enthusiast, So You Think You Know Jane Austen? guarantees you will know her much better after reading it.

    Now, with The Handy History Answer Book you can step back in time and uncover the real truth behind the events that shaped the world leading up to the end of the 20th century.Open the pages of this historical guide and get ready for an exciting journey. From the excavation of the Neanderthal Man to the creation of MTV, this easy-to-read question and answer book will change your attitude about history for ever.Learn about such notable figures as Julius Caesar, Genghis Khan, Mary, Queen of Scots, Marie Antoinette, Thomas Edison, Franklin D. Roosevelt and Rosa Parks, to name just a few. Enjoy more than 50 photos and illustrations of famous historical moments and individuals.

    The result is lively, funny and moving, especially for anyone who cares about art and the business of writing well.”—Evan Thomas, Newsweek In Writing Places, William Zinsser—the author of On Writing Well, the bestseller that has inspired two generations of writers, journalists, and students—recalls the many colorful and instructive places where he has worked and taught. Gay Talese, author of A Writer’s Life, calls Writing Places, “Wonderful,” while the Pittsburgh Post-Gazette praises this unique memoir for possessing “all the qualities that Zinsser believes matter most in good writing—clarity, brevity, simplicity and humanity.”

    Highly respected and widely read author Isaac Asimov offers a fresh, easy-to-read approach to understanding the greatest writer of all time.Designed to provide the modern reader with a working knowledge of topics pertinent to Shakespeare's audience, this book explores, scene-by-scene, thirty-eight plays and two narrative poems, including their mythological, historical and geographical roots.

    . .Katherine Kelly has been dreaming of her wedding since she was old enough to cut pictures out of magazines and glue them into her bridal binder. When Kaden, the handsome cowboy who holds her heart, proposes on a snowy Christmas Eve, she couldn’t envision anything more perfect or romantic. The spring date is set, all the nuptial details have been meticulously arranged, and she only has six weeks to go before the big day. Then, in a blink, her carefully formed plans begin to rapidly unravel. A freak snowstorm, rampaging rodents, and a lost wedding gown are only the beginning of the troubles they face.Cowboy entrepreneur Kaden Ford still can’t quite believe Katherine Kelly agreed to marry him. She’s beautiful, elegant, intelligent, and the woman who fills his heart with joy. He doesn’t care if they get married in a cathedral or a cabin in the woods. All he wants is to spend his life loving Kat. But when faced with one overwhelming challenge after another, will love be enough to hold them together?Find out in this sweet, charming, small-town romance full of laughter, love, and scheming octogenarian matchmakers.

     Arthur, Duke of Wellington, and Emperor Napoleon Bonaparte were adversaries on an epic scale. Across Europe and beyond, the armies of Great Britain and France clashed, from the Iberian Peninsula to India, from Austerlitz to the final confrontation at Waterloo. What drove the two clever, ambitious, determined men who masterminded these military campaigns? How did the underdog from Corsica develop the strategic military skills and the political cunning that gave him power over swathes of Europe? And how did Wellington, born to be a leader, hone his talents and drive an army to victory after victory?From an outstanding historian and novelist come four epic novels, now available in one volume for the first time, which tell the full story of both these men, from their very early days till the momentous battle at Waterloo which decided the future of Europe.INCLUDES MAPS

    

    Wayne Grudem's bestselling Systematic Theology has several distinctive features:A strong emphasis on the scriptural basis for each doctrineClear writing, with technical terms kept to a minimumA contemporary approach, treating subjects of special interest to the church todayA friendly tone, appealing to the emotions and the spirit as well as the intellectFrequent application to lifeResources for worship within each chapter Bibliographies in each chapter that cross-reference subjects to a wide range of other systematic theologies.

    Wonderfully informative, this comprehensive work includes 3,000 entries and 50 illustrations covering:-EVERY PLAY, including scene-by-scene synopses, critical commentary, sources, textual commentary, and theatrical history-EVERY CHARACTER, from Aaron to Young Talbot, including those without speaking parts-THE POEMS, including the sonnets and long works in verse-ACTORS, PRODUCERS, AND DIRECTORS, including William Kempe, Charles Laughton, Sarah Bernhardt, Sir Laurence Olivier, and others who have brought the plays and characters to life over the centuries-PLACES, real and imaginary, important to Shakespeare's life and works-THEATRICAL AND LITERARY TERMS that relate to the plays and poetry-CONTEMPORARIES OF SHAKESPEARE, including family members, friends and colleagues, patrons, and historical figures-AUTHORS, SCHOLARS, AND PUBLISHERS of Shakespeare's works, critical studies, and histories - and much more, all in easily accessible encyclopedic format

    Everything known about the facts of William Shakespeare's life seems incompatible with the extraordinary genius of his writing. How could a man who left school at the age of 13, and apparently never travelled abroad have authored the incomparable Sonnets or so intricately described Renaissance Venice? Shakespeare 'candidates' abound, among them Sir Francis Bacon, The Earl of Oxford, even Queen Elizabeth I herself, but none have stood up to serious scrutiny. Until now....This remarkable, intriguing, and provocative book offers a completely plausible new candidate; Sir Henry Neville.

    Incredible events, amazing love stories, larger-than-life personalities, and deep theological themes are just some of the treasures found in Joshua, Judges, Ruth, 1 & 2 Samuel, 1 & 2 Kings, 1 & 2 Chronicles, Ezra, Nehemiah, Esther.These books tell the story of the nation of Israel and the God who loves her, punishes her, and always brings this recalcitrant people back to Himself. It is really the story of all of us.David M. Howard Jr. provides an in-depth introduction to the Old Testament historical books, focusing first on the overarching themes of historical narrative in general. He then turns his attention to each book, considering topics like:Authorship and datePlace in the canonHistorical and cultural contextTheology of the bookSpecial issues pertaining to the bookFrom the conquest of Canaan to the fall of Jerusalem, from war to peace and back to war, from kings and queens to farmers and housewives—David Howard covers it all in this invaluable introduction to the Old Testament historical books.

    Tolkien's epic fantasies The Lord of the Rings and The Hobbit have enthralled reader for more than half a century. The realm of Middle-earth is one of the most fully realized worlds in literature, yet the remarkable mythology upon which Tolkien founded is still a mystery to most readers.The Magical Worlds of The Lord of the Rings reveals the ancient folklore and legends that inspired Tolkien's masterpiece. From the Finnish saga Kalevala and the events in Beowulf to Arthurian mythology, Shakespeare, and even World War II, this indispensable guide provides insights not only into literature's most beloved fantasy but also the man who brought it to life.