Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease.Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human.In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome.These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.

    Now Wright attempts something even more ambitious: explaining the direction of evolution and human history–and discerning where history will lead us next.In Nonzero: The Logic of Human Destiny, Wright asserts that, ever since the primordial ooze, life has followed a basic pattern. Organisms and human societies alike have grown more complex by mastering the challenges of internal cooperation. Wright's narrative ranges from fossilized bacteria to vampire bats, from stone-age villages to the World Trade Organization, uncovering such surprises as the benefits of barbarian hordes and the useful stability of feudalism. Here is history endowed with moral significance–a way of looking at our biological and cultural evolution that suggests, refreshingly, that human morality has improved over time, and that our instinct to discover meaning may itself serve a higher purpose. Insightful, witty, profound, Nonzero offers breathtaking implications for what we believe and how we adapt to technology's ongoing transformation of the world.From the Trade Paperback edition.

    We will directly and indirectly determine what lives, what dies, where, and when. We are in a different phase of evolution; the future of life is now in our hands.”Why are rates of conditions like autism, asthma, obesity, and allergies exploding at an unprecedented pace? Why are humans living longer, getting smarter, and having far fewer kids? How might your lifestyle affect your unborn children and grandchildren? How will gene-editing technologies like CRISPR steer the course of human evolution? If Darwin were alive today, how would he explain this new world? Could our progeny eventually become a different species—or several?In Evolving Ourselves, futurist Juan Enriquez and scientist Steve Gullans conduct a sweeping tour of how humans are changing the course of evolution—sometimes intentionally, sometimes not. For example:   •  Globally, rates of obesity in humans nearly doubled between 1980 and 2014. What’s more, there’s evidence that other species, from pasture-fed horses to lab animals to house cats, are also getting fatter.    •  As reported by U.S. government agencies, the rate of autism rose by 131 percent from 2001 to 2010, an increase that cannot be attributed simply to increases in diagnosis rates.    •  Three hundred years ago, almost no one with a serious nut allergy lived long enough to reproduce. Today, despite an environment in which food allergies have increased by 50 percent in just over a decade, 17 million Americans who suffer from food allergies survive, thrive, and pass their genes and behaviors on to the next generation.    •  In the pre-Twinkie era, early humans had quite healthy mouths. As we began cooking, bathing, and using antibiotics, the bacteria in our bodies changed dramatically and became far less diverse. Today the consequences are evident not only in our teeth but throughout our bodies and minds. Though these harbingers of change are deeply unsettling, the authors argue that we are also in an epoch of tremendous opportunity. New advances in biotechnology help us mitigate the cruel forces of natural selection, from saving prematurely born babies to gene therapies for sickle cell anemia and other conditions. As technology like CRISPR enables us to take control of our genes, we will be able to alter our own species and many others—a good thing, given that our eventual survival will require space travel and colonization, enabled by a fundamental redesign of our bodies.Future humans could become great caretakers of the planet, as well as a more diverse, more resilient, gentler, and more intelligent species—but only if we make the right choices now.Intelligent, provocative, and optimistic, Evolving Ourselves is the ultimate guide to the next phase of life on Earth.

    In this thrill-ride across millennia and continents, the complete history of the planet comes to life: from the Earth's fiery birth to its near-obliteration in the Triassic period, and from the first signs of human life to the tentative future of a world with a burgeoning population and a global warming crisis. Covering a wide range of topics including astrophysics, zoology, and sociology, and complete with maps and illustrations, What on Earth Happened? In Brief is the endlessly entertaining story of the planet, life, and people.

    In 50 Human Brain Ideas You Really Need to Know, Mo Costandi condenses all we know about the brain and how it works into series of introductions to the most important concepts.Outlining both long-standing theories - such as the function of neurons and synaptic transmission - and cutting-edge ideas - including neuroethics and brain-computer interfacing - with straightforward narrative and clear two-colour illustrations, this book is a perfect beginner's guide to the most powerful and mysterious organ in the body.The ideas explored include: The nervous impulse; Differences between the male and female brain; The root of addiction; Neurobiological basis for personality; The relationship between sleep and memory.

    Jen Gunter now delivers the definitive book on vaginal health, answering the questions you've always had but were afraid to ask--or couldn't find the right answers to. She has been called Twitter's resident gynecologist, the Internet's OB/GYN, and one of the fiercest advocates for women's health...and she's here to give you the straight talk on the topics she knows best.Does eating sugar cause yeast infections? Does pubic hair have a function? Should you have a vulvovaginal care regimen?Will your vagina shrivel up if you go without sex?What's the truth about the HPV vaccine?So many important questions, so much convincing, confusing, contradictory misinformation! In this age of click bait, pseudoscience, and celebrity-endorsed products, it's easy to be overwhelmed--whether it's websites, advice from well-meaning friends, uneducated partners, and even healthcare providers. So how do you separate facts from fiction? OB-GYN Jen Gunter, an expert on women's health--and the internet's most popular go-to doc--comes to the rescue with a book that debunks the myths and educates and empowers women. From reproductive health to the impact of antibiotics and probiotics, and the latest trends, including vaginal steaming, vaginal marijuana products, and jade eggs, Gunter takes us on a factual, fun-filled journey. Discover the truth about:- The vaginal microbiome - Genital hygiene, lubricants, and hormone myths and fallacies - How diet impacts vaginal health - Stem cells and the vagina - Cosmetic vaginal surgery - What changes to expect during pregnancy, after childbirth, and through menopause - How medicine fails women by dismissing symptomsPlus: - Thongs vs. lace: the best underwear for vaginal health - How to select a tampon - The full glory of the clitoris and the myth of the G Spot... And so much more. Whether you're a twenty-six-year-old worried that her labia are "uncool" or a sixty-six-year-old dealing with painful sex, this comprehensive guide is sure to become a lifelong trusted resource.

    From butterfly gardens to zoo exhibitions, they are one of the few insects we’ve encouraged to infiltrate our lives. Yet, what has drawn us to these creatures in the first place? And what are their lives really like? In this groundbreaking book, New York Times bestselling author and science journalist Wendy Williams reveals the inner lives of these “flying flowers”—creatures far more intelligent and tougher than we give them credit for. Monarch butterflies migrate thousands of miles each year from Canada to Mexico. Other species have learned how to fool ants into taking care of them. Butterflies’ scales are inspiring researchers to create new life-saving medical technology. Williams takes readers to butterfly habitats across the globe and introduces us to not only various species, but to the scientists who have dedicated their lives to studying them. Coupled with years of research and knowledge gained from experts in the field, this accessible “butterfly biography” explores the ancient partnership between these special creatures and humans, and why they continue to fascinate us today. Touching, eye-opening, and incredibly profound, The Language of Butterflies reveals the critical role they play in our world.

    To reach this unique audience, Whitlock and Schluter motivate learning with interesting biological and medical examples; they emphasize intuitive understanding; and they focus on real data. The book covers basic topics in introductory statistics, including graphs, confidence intervals, hypothesis testing, comparison of means, regression, and designing experiments. It also introduces the principles behind such modern topics as likelihood, linear models, meta-analysis and computer-intensive methods. Instructors and students consistently praise the book's clear and engaging writing, strong visualization techniques, and its variety of fascinating and relevant biological examples.

    There is every reason to believe that, within a few weeks of its onset, the infection was universally present in the nose and throat of the people, disseminated by mouth spray given off on talking by innumerable carriers and, in addition, by the coughing and sneezing of the sick. Susceptibility was very general, though it varied greatly in degree. Among those who escaped well marked sickness there are few who could not recall having had an occluded or running nose, or a raw feeling in the throat, or a cough, or aches and pains, at some time during the period of the prevalence of the disease, these probably representing the price such persons paid for their immunization." - Dr. Bernard Fantus In many ways, it is hard for modern people living in First World countries to conceive of a pandemic sweeping around the world and killing millions of people, and it is even harder to believe that something as common as influenza could cause such widespread illness and death. Although the flu still takes hundreds of lives each year, most of those lost are very young or old or ill with something else that had already weakened them. In fact, most people contract influenza at least once, and many suffer from the flu several times in their lives and survive it with a minimum amount of medical attention. In 1918, the world was still in the throes of the Great War, the deadliest conflict in human history at that point, but while World War I would be a catastrophic war surpassed only by World War II, an unprecedented influenza outbreak that same year inflicted casualties that would make both wars pale in comparison. An illness, or more likely a collection of illnesses, Spanish influenza quickly spread across the world and may have killed upwards of 100 million people, decimating populations across developed nations and possibly wiping out as much as 5% of the world’s population. If anything, the ongoing war and the censorship maintained by the countries fighting it may have resulted in the actual toll of the outbreak being underestimated based on the way soldiers’ deaths were categorized. World War I may have distracted people about the unprecedented nature of the outbreak, but the most alarming aspect of the outbreak in 1918 was the indiscriminate nature in which the scourge attacked young and old, healthy and unhealthy, and rich and poor alike. In fact, the popular name for the outbreak was a reference to the fact that Spain’s own king was stricken with the disease. While he and President Woodrow Wilson ended up surviving it, former First Lady Rose Cleveland did not. The staggering number of fatalities, and the way in which seemingly anybody could suffer during the outbreak, taught people in the early 20th century that regardless of the tremendous strides made by technology, and no matter how stalemated the war was, nobody was safe from nature itself. Of course, it also demonstrated how much more work could be done to prevent similar occurrences. The 1918 pandemic was neither the first nor the last outbreak of the flu, but it was by far the worst, and it forever changed the face of medicine and public health care in both North America and Europe. The 1918 Spanish Flu Pandemic: The History and Legacy of the World’s Deadliest Outbreak chronicles the devastating disease and the damage it wrought across the globe.

    To start building a more straightforward, accurate understanding of current breakthroughs in neuroscience, you have to start by shattering popular brain myths.Each of these 24 lectures takes as its focus a single powerful, prevalent brain myth, and uses it as a launch pad from which to explore myriad topics in neuroscience: decision making, memory, dreams, emotions, neuroplasticity, consciousness, mental illness, and much more.Our memory is an accurate, objective record of the past. Our senses reflect the world as it really exists. Our dreams have hidden meanings. We are only using 10% of our total brain power. Modern technology (including social media) is making us less intelligent. Dr. Viskontas doesn't just settle for obliterating these and other myths. Instead, she replaces them with scientific facts gathered from experiments, research, and case studies. The result is an eye-opening adventure into the latest understanding of why the brain works the way it does.Whatever order you enjoy these lectures in, you'll be left with insights that will help you better determine the hard scientific truths behind the breaking news (and myths) of tomorrow.

    Albert-László Barabási, the nation’s foremost expert in the new science of networks and author of Bursts, takes us on an intellectual adventure to prove that social networks, corporations, and living organisms are more similar than previously thought. Grasping a full understanding of network science will someday allow us to design blue-chip businesses, stop the outbreak of deadly diseases, and influence the exchange of ideas and information. Just as James Gleick and the Erdos–Rényi model brought the discovery of chaos theory to the general public, Linked tells the story of the true science of the future and of experiments in statistical mechanics on the internet, all vital parts of what would eventually be called the Barabási–Albert model.

    Now he offers a framework for envisioning the twenty-first century--an age in which the marriage of human sensitivity and artificial intelligence fundamentally alters and improves the way we live. Kurzweil's prophetic blueprint for the future takes us through the advances that inexorably result in computers exceeding the memory capacity and computational ability of the human brain by the year 2020 (with human-level capabilities not far behind); in relationships with automated personalities who will be our teachers, companions, and lovers; and in information fed straight into our brains along direct neural pathways. Optimistic and challenging, thought-provoking and engaging, The Age of Spiritual Machines is the ultimate guide on our road into the next century.

    Lavishly illustrated with over sixty original artworks, All Yesterdays aims to challenge our notions of how prehistoric animals looked and behaved. As a critical exploration of palaeontological art, All Yesterdays asks questions about what is probable, what is possible, and what is commonly ignored.Written by palaeozoologist Darren Naish, and palaeontological artists John Conway and C.M. Kosemen, All Yesterdays is scientifically rigorous and artistically imaginative in its approach to fossils of the past - and those of the future.

    Like Jared Diamond's Guns, Germs and Steel, Mapping Human History is a groundbreaking synthesis of science and history. Drawing on a wide range of sources, including the latest genetic research, linguistic evidence, and archaeological findings, Olson reveals the surprising unity among modern humans and "demonstrates just how naive some of our ideas about our human ancestry have been" (Discover).Olson offers a genealogy of all humanity, explaining, for instance, why everyone can claim Julius Caesar and Confucius as forebears. Olson also provides startling new perspectives on the invention of agriculture, the peopling of the Americas, the origins of language, the history of the Jews, and more. An engaging and lucid account, Mapping Human History will forever change how we think about ourselves and our relations with others.

    On its first publication in 1972 it sparked an international debate and became a rallying-point for feminism, changing the terminology of anthropologists forever. Starting with her demolition of the Biblical myth that woman was an afterthought to the creation of man, Elaine Morgan rewrites human history and evolution.This lively, informative book sets out to solve the riddle of our origins; its answer is controversial. Elaine Morgan has made The Aquatic Ape Hypothesis a plausible alternative to conventional theories of evolution and The Descent of Woman first set out an understanding of who humans are and where they came from.Elaine Morgan was best known as a writer for television until the publication of The Descent of Woman in 1972, which became an international bestseller. She then spent ten years researching human evolution before publishing The Aquatic Ape (published by Souvenir Press as a revised edition, The Aquatic Ape Hypothesis) in 1982. In the years since, The Aquatic Ape Hypothesis has gone on to win widespread support among scientists.It is a measure of Elaine Morgan's enduring importance, provocative thought and international reputation that in January 2006, the first Chinese translation of The Aquatic Ape Hypothesis became a Number 1 bestseller in Taiwan.