An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    Every day people drink coffee on European terraces and kava in Pacific villages; chew betel nut in Indonesian markets and coca leaf on Andean mountainsides; swallow ecstasy tablets in the clubs of Amsterdam and opium pills in the deserts of Rajastan; smoke hashish in Himalayan temples and tobacco and marijuana in every nation on earth. Exploring the spectrum of drug use throughout history--from its roots in animal intoxication to its future in designer neurochemicals--High Society paints vivid portraits of the roles drugs play in different cultures as medicines, religious sacraments, status symbols, and coveted trade goods. From the botanicals of the classical world through the mind-bending self-experiments of 18th- and 19th-century scientists to the synthetic molecules that have transformed our understanding of the brain, Mike Jay reveals how drugs such as tobacco, tea, and opium drove the global trade and cultural exchange that created the modern world and examines the forces that led to the prohibition of opium and cocaine a century ago and the “war on drugs” that rages today.

    Lieberman illuminates how these ongoing changes have brought many benefits, but also have created novel conditions to which our bodies are not entirely adapted, resulting in a growing incidence of obesity and new but avoidable diseases, including type-2 diabetes. He proposes that many of these chronic illnesses persist and in some cases are intensifying because of "dysevolution," a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes oblige us to create a more salubrious environment.(With charts and line drawings throughout.)From the Hardcover edition.

    Psychiatrist and psychoanalyst, Norman Doidge, M.D., traveled the country to meet both the brilliant scientists championing neuroplasticity and the people whose lives they’ve transformed - people whose mental limitations or brain damage were seen as unalterable. We see a woman born with half a brain that rewired itself to work as a whole, blind people who learn to see, learning disorders cured, IQs raised, aging brains rejuvenated, stroke patients learning to speak, children with cerebral palsy learning to move with more grace, depression and anxiety disorders successfully treated, and lifelong character traits changed. Using these marvelous stories to probe mysteries of the body, emotion, love, sex, culture, and education, Dr. Doidge has written an immensely moving, inspiring book that will permanently alter the way we look at our brains, human nature, and human potential.

    Includes tables to compare different agents within a given class of drugs. For use as a review for Boards, self-testing, or reference. Previous edition: c1997.

    It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    one of the most important and readable works on the human past published in recent years."Winner of the Pulitzer Prize and a national bestseller: the global account of the rise of civilization that is also a stunning refutation of ideas of human development based on race.In this "artful, informative, and delightful" (William H. McNeill, New York Review of Books) book, Jared Diamond convincingly argues that geographical and environmental factors shaped the modern world. Societies that had a head start in food production advanced beyond the hunter-gatherer stage, and then developed writing, technology, government, and organized religion—as well as nasty germs and potent weapons of war—and adventured on sea and land to conquer and decimate preliterate cultures. A major advance in our understanding of human societies, Guns, Germs, and Steel chronicles the way that the modern world came to be and stunningly dismantles racially based theories of human history.Winner of the Pulitzer Prize, the Phi Beta Kappa Award in Science, the Rhone-Poulenc Prize, and the Commonwealth Club of California's Gold Medal

    It recounts the life histories of those who had been victims of the 1920s encephalitis lethargica epidemic. Sacks chronicles his efforts in the late 1960s to help these patients at the Beth Abraham Hospital in the Bronx, New York.

    It is a waste product and a commodity pricier than oil. It can save lives and transmit deadly infections. Each one of us has roughly nine pints of it, yet many don’t even know their own blood type. And for all its ubiquity, the few tablespoons of blood discharged by 800 million women are still regarded as taboo; menstruation is perhaps the single most demonized biological event.Rose George, author of The Big Necessity, is renowned for her intrepid work on topics that are invisible but vitally important. In Nine Pints, she takes us from ancient practices of bloodletting to modern “hemovigilance” teams that track blood-borne diseases. She introduces Janet Vaughan, who set up the world’s first system of mass blood donation during the Blitz, and Arunachalam Muruganantham, known as “Menstrual Man” for his work on sanitary pads for developing countries. She probes the lucrative business of plasma transfusions, in which the U.S. is known as the “OPEC of plasma.” And she looks to the future, as researchers seek to bring synthetic blood to a hospital near you.Spanning science and politics, stories and global epidemics, Nine Pints reveals our life's blood in an entirely new light.

    Then, in a dramatic change, described by scientists as 'the greatest riddle in human history', all the skills & qualities that we value most highly in ourselves appeared already fully formed, as tho bestowed on us by hidden powers. In Supernatural Hancock sets out to investigate this mysterious before-&-after moment & to discover the truth about the influences that gave birth to the modern mind. His quest takes him on a detective journey from the beautiful painted caves of prehistoric France, Spain & Italy to rock shelters in the mountains of S. Africa, where he finds extraordinary Stone Age art. He uncovers clues that lead him to the Amazon rainforest to drink the hallucinogen Ayahuasca with shamans, whose paintings contain images of 'super-natural beings' identical to the animal-human hybrids depicted in prehistoric caves. Hallucinogens such as mescaline also produce visionary encounters with exactly the same beings. Scientists at the cutting edge of consciousness research have begun to consider the possibility that such hallucinations may be real perceptions of other dimensions. Could the supernaturals 1st depicted in the painted caves be the ancient teachers of humankind? Could it be that human evolution isn't just the meaningless process Darwin identified, but something more purposive & intelligent that we've barely begun to understand?AcknowledgementsPart 1: Visions 1: Plant that enables men to see the dead 2: Greatest riddle of archeology 3: Vine of souls Part 2: Caves 4: Therianthropy5: Riddles of the caves6: Shabby academy 7: Searching for a Rosetta Stone8: Code in the mind 9: Serpents of the Drakensberg10: Wounded healer Part 3: Beings 11: Voyage into the supernatural 12: Shamans in the sky 13: Spirit love 14: Secret commonwealth15: Here is a thing that will carry me away16: Dancers between worlds Part 4: Codes 17: Turning in to channel DMT18: Amongst the machine elves19: Ancient teachers in our DNA?20: Hurricane in the junkyard Part 5: Religions 21: Hidden Shamans22: Flesh of the GodsPart 6: Mysteries 23: Doors leading to another world Appendices Critics & criticisms of David Lewis-Williams' Neuropsychological theory of rock & cave artPsilocybe semilanceata-a hallucinogenic mushroom native to Europe / Roy Watlng Interview with Rick StrassmanReferences Index

    Once introduced by famed psychedelics advocate Timothy Leary as "one of the most important people on the planet," radical philosopher Terence McKenna was an iconic legend in the psychedelic community. He died in 2000, but his ideas live on in the writings of author Dennis McKenna. On their Amazonian journey together, the brothers explored the outer limits of psychedelic experience and were haunted ever since by the curious events that overtook them in that primeval rainforest.

    Humans have "subdued 75 per cent of the land surface, concocted a wizardry of industrial and medical marvels, strung lights all across the darkness." We now collect the DNA of vanishing species in a "frozen ark," equip orangutans with iPads, create wearable technologies and synthetic species that might one day outsmart us. With her distinctive gift for making scientific discovery intelligible to the layperson, Ackerman takes us on an exciting journey to understand this bewildering new reality, introducing us to many of the people and ideas now creating--perhaps saving--the future.The Human Ageis a surprising, optimistic engagement with the dramatic transformations that have shaped, and continue to alter, our world, our relationship with nature and our prospects for the future.

    It promised to shed light on the deep mysteries of consciousness, as well as offer relief to addicts and the mentally ill. But in the 1960s, with the vicious backlash against the counter-culture, all further research was banned. In recent years, however, work has quietly begun again on the amazing potential of LSD, psilocybin and DMT. Could these drugs in fact improve the lives of many people? Diving deep into this extraordinary world and putting himself forward as a guinea-pig, Michael Pollan has written a remarkable history of psychedelics and a compelling portrait of the new generation of scientists fascinated by the implications of these drugs. How to Change Your Mind is a report from what could very well be the future of human consciousness.

    The aim remains to provide a reference to the aspects of medical microbiology particularly important for clinical infections and chemotherapy. Geo. F. Brooks (U. of California, San Francisco), Jane

    DON'T SWALLOW YOUR GUM! takes on these myths and misconceptions, and exposes the truth behind some of those weird and worrisome things we think about our bodies. Entries dispel the following myths and more:- You need to drink 8 glasses of water a day- Chewing gum stays in your stomach for seven years- You can catch poison ivy from someone who has it- If you drop food on the floor and pick it up within five seconds, it's safe to eat- Strangers have poisoned kids' Halloween candyWith the perfect blend of authoritative research and a breezy, accessible tone, DON'T SWALLOW YOUR GUM is full of enlightening, practical, and quirky facts that will debunk some of the most perennial misconceptions we believe about our health and well-being.