Notwithstanding the great strengths of medical science, many people now have concerns about key features of our health-care system-among them, the widespread use of medical drugs and a relative deemphasis on preventive care. But traditional Western medicine is not the only healing system rooted in science. Medical systems from other cultures, including those of India and China, have used natural treatments for centuries, some of which are now directly influencing our own health-care professions. These approaches not only emphasize healing with natural substances, but devote considerable attention to illness prevention and healthful living by considering the whole person rather than just targeting a condition. What is the most effective way to nurture your own optimal health? Are there sound alternatives to the drugs so common in our health-care system, which can carry unwanted consequences and side effects? What about the range of natural methods, such as herbal medications, micronutrients, and the use of food itself as medicine? Are these approaches valid? And, if so, can we integrate the best of Western medicine with the best natural treatments to enjoy prime health and longevity?

    That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research—the Philadelphia chromosome. This book charts not only that landmark discovery, but also—for the first time, all in one place—the full sequence of scientific and medical discoveries that brought about the first-ever successful treatment of a lethal cancer at the genetic level.The significance of this mutant chromosome would take more than three decades to unravel; in 1990, it was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. This dramatic discovery launched a race involving doctors and researchers around the world, who recognized that in principle it might be possible to target CML at its genetic source.Science journalist Jessica Wapner brings extensive original reporting to this book, including interviews with more than thirty-five people with a direct role in this story. Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 70,000 people worldwide who are diagnosed with CML each year. Chief among them is researcher and oncologist Dr. Brian Druker, whose dedication to his patients fueled his quest to do everything within his power to save them.The Philadelphia Chromosome helps us to fully understand and appreciate just how pathbreaking, hard-won, and consequential are the achievements it recounts—and to understand the principles behind much of today’s most important cancer research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

    The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future.

    You learn the points of view your teachers provide, the perspectives that books offer, and the conclusions you draw yourself based on the facts you were given. Hearing different angles on historical events gives you a more insightful, more accurate, and more rewarding understanding of events – especially when a new viewpoint challenges the story you thought you knew.

    And as outbreaks of COVID-19, Ebola, MERS, and Zika have demonstrated, we are woefully underprepared to deal with the fallout. So what can -- and must -- we do in order to protect ourselves from mankind's deadliest enemy?Drawing on the latest medical science, case studies, policy research, and hard-earned epidemiological lessons, Deadliest Enemy explores the resources and programs we need to develop if we are to keep ourselves safe from infectious disease. The authors show how we could wake up to a reality in which many antibiotics no longer cure, bioterror is a certainty, and the threat of a disastrous influenza or coronavirus pandemic looms ever larger. Only by understanding the challenges we face can we prevent the unthinkable from becoming the inevitable.Deadliest Enemy is high scientific drama, a chronicle of medical mystery and discovery, a reality check, and a practical plan of action.

    A lyrical journey from hope to despair and back again, The First Cell explores cancer from every angle: medical, scientific, cultural, and personal. Indeed, Raza describes how she bore the terrible burden of being her own husband's oncologist as he succumbed to leukemia. Like When Breath Becomes Air, The First Cell is no ordinary book of medicine, but a book of wisdom and grace by an author who has devoted her life to making the unbearable easier to bear.

    As recently as 1918, a pandemic of influenza claimed over 50 million lives worldwide. The advent of drugs and vaccines led to an era of hope when we thought our battles with infectious disease were won, but our optimism has been eroded by the recognition that many pathogens have the capacity to transform themselves and escape our efforts to eradicate them. Are we now facing an inevitable repeat of a calamity such as the 1918 influenza pandemic or the Black Death? Can we anticipate and thwart such an event, or are we wilfully creating the conditions that would promote the emergence of new and highly virulent human infectious disease?Sunetra Gupta is Professor of Theoretical Epidemiology at the University of Oxford specialising in infectious diseases. She holds a bachelor's degree from Princeton University and a Ph.D. from the University of London. She has been awarded the Scientific Medal by the Zoological Society of London and the Royal Society Rosalind Franklin Award for her scientific research. She is also a novelist whose books have been awarded the Sahitya Akademi Award, the Southern Arts Literature Prize, shortlisted for the Crossword Award, and longlisted for the DSC and Orange Prizes.

    From that day forward his life became a hell of uncontrollable tics, urges, and involuntary utterances. Eventually he is diagnosed with Tourette's Syndrome and Obsessive Compulsive disorder, and Cory embarks on an excruciating journey from specialist to specialist, enduring countless combinations of medications in wildly varying doses. Soon it becomes unclear what tics are symptoms of his disease and what are side effects of the drugs. The only certainty is that it kept getting worse. Despite his lack of control, Cory is aware of every embarrassing movement, and sensitive to every person's reaction to his often aggravating presence. Simply put: Cory Friedman's life is a living hell.Against Medical Advice is the true story of one family's decades-long battle for survival in the face of extraordinary difficulties and a rigid medical establishment.

    There is no better way to study the big questions in philosophy than to compare how the world's greatest minds have analyzed these questions, defined the terms, and then reasoned out potential solutions. Once you've compared the arguments, the final step is always deciding for yourself whether you find an explanation convincing.This course gives you the tools to follow and create logical arguments while exploring famous philosophers' viewpoints on these important questions. Although progress has been made toward answers, brilliant thinkers have continued to wrestle with many big questions that inspire thoughtful people everywhere. These questions include: What is knowledge? Does God exist? Do humans have free will? What is right and wrong? How should society be organized?Given the complexity of these big questions, it should be no surprise that many controversies are far from settled. In fact, by the end of these 36 lectures, you may be even less sure of the right answers to some of the questions than you were at the beginning. But being a philosopher means constantly testing your views - giving a reasoned defense if you believe you are right and modifying your ideas when you realize you are wrong. You'll discover that great thinkers before you have offered convincing answers to hard questions, philosophers after them have made equally persuasive objections, and then still others have refined the debate even further - causing the issues to come into sharper and sharper focus.Join Plato, St. Anselm, Descartes, Locke, Hume, Kant, Mill, Smith, Marx, Rawls, and many others in an exploration of fundamental questions. Get ready to think big!

    There are good reasons that language fascinates us so. It not only defines humans as a species, placing us head and shoulders above even the most proficient animal communicators, but it also beguiles us with its endless mysteries. For example: * How did different languages come to be? * Why isn’t there just a single language? * How does a language change, and when it does, is that change indicative of decay or growth? * How does a language become extinct? Dr. John McWhorter, one of America’s leading linguists and a frequent commentator on network television and National Public Radio, addresses these and other questions as he takes you on an in-depth, 36-lecture tour of the development of human language, showing how a single tongue spoken 150,000 years ago has evolved into the estimated 6,000 languages used around the world today.An accomplished scholar, Professor McWhorter is also a skilled popularizer, whose book The Power of Babel was called "startling, provocative, and remarkably entertaining," by the San Diego Union-Tribune.The London Times called him "a born teacher." And Steven Pinker, best known as the author of The Language Instinct, offered this praise for the book: "McWhorter’s arguments are sharply reasoned, refreshingly honest, and thoroughly original."Course Lecture Titles1. What Is Language? 2. When Language Began 3. How Language Changes—Sound Change 4. How Language Changes—Building New Material 5. How Language Changes—Meaning and Order 6. How Language Changes—Many Directions 7. How Language Changes—Modern English 8. Language Families—Indo-European 9. Language Families—Tracing Indo-European 10. Language Families—Diversity of Structures 11. Language Families—Clues to the Past 12. The Case Against the World’s First Language 13. The Case For the World’s First Language 14. Dialects—Subspecies of Species 15. Dialects—Where Do You Draw the Line? 16. Dialects—Two Tongues in One Mouth 17. Dialects—The Standard as Token of the Past 18. Dialects—Spoken Style, Written Style 19. Dialects—The Fallacy of Blackboard Grammar 20. Language Mixture—Words 21. Language Mixture—Grammar 22. Language Mixture—Language Areas 23. Language Develops Beyond the Call of Duty 24. Language Interrupted 25. A New Perspective on the Story of English 26. Does Culture Drive Language Change? 27. Language Starts Over—Pidgins 28. Language Starts Over—Creoles I 29. Language Starts Over—Creoles II 30. Language Starts Over—Signs of the New 31. Language Starts Over—The Creole Continuum 32. What Is Black English? 33. Language Death—The Problem 34. Language Death—Prognosis 35. Artificial Languages 36. Finale—Master Class

    Yet, as the 1700s began, the mysteries of the universe were pondered by "natural philosophers"—the term "scientist" didn't even exist until the mid 19th century—whose explanations couldn't help but be influenced by the religious thought and political and social contexts that shaped their world.The radical ideas of the Enlightenment were especially important and influential. In this course you see how the work of these natural philosophers prepared the way for the more familiar world of science we recognize today.

    Stress is an inherent aspect of life that can have tremendous negative effects on your mental and physical health. This makes coping with stress a critical part of how well we live. Once you understand the inner workings of your stress response system, you'll possess powerful knowledge that will help you understand and better deal with this common aspect of your busy life. Now, from one of the world's foremost researchers on stress and neurobiology, comes a fascinating series of 24 lectures that guide you through the psychological and psychosocial stress that is a central part of everyday life in Western society. You'll learn how the stress-response system is actually a natural survival system-giving, for example, a zebra the best chance to escape from a pursuing lion - that can change from a safety mechanism into a real problem for our physical and mental well-being. You'll see it coming into play against situations it wasn't designed to combat, such as traffic, troublesome thoughts and memories, and concerns over the economy, environment, and international events. And you'll gain valuable insights into how and why stress can affect every part of your body-including your cardiovascular, digestive, and immune systems - and learn about its relationship to important disorders and behaviors, like depression, anxiety, and even addiction.

    We take for granted that we can remember, feel emotion, navigate, empathize, and understand the world around us, but how would our lives change if these abilities were dramatically enhanced--or disappeared overnight?Helen Thomson has spent years traveling the world, tracking down incredibly rare brain disorders. In Unthinkable she tells the stories of nine extraordinary people she encountered along the way. From the man who thinks he's a tiger to the doctor who feels the pain of others just by looking at them to a woman who hears music that’s not there, their experiences illustrate how the brain can shape our lives in unexpected and, in some cases, brilliant and alarming ways.Story by remarkable story, Unthinkable takes us on an unforgettable journey through the human brain. Discover how to forge memories that never disappear, how to grow an alien limb, and how to make better decisions. Learn how to hallucinate and how to make yourself happier in a split second. Find out how to avoid getting lost, how to see more of your reality, even how exactly you can confirm you are alive. Think the unthinkable.

    It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species births, deaths, disease, war, famine, migration, and a lot of sex. Since scientists first read the human genome in 2001, it has been subject to all sorts of claims, counterclaims, and myths. In fact, as Adam Rutherford explains, our genomes should be read not as instruction manuals, but as epic poems. DNA determines far less than we have been led to believe about us as individuals, but vastly more about us as a species. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about history, and what history tells us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be."

    In his first two books, Dr. Dale Bredesen outlined the revolutionary treatments that are changing what had previously seemed like the inevitable outcome of cognitive decline and dementia. And in these moving narratives, you can hear directly from the first survivors of Alzheimer's themselves--their own amazing stories of hope told in their own words. These first person accounts honestly detail the fear, struggle, and ultimate victory of each patient's journey. They vividly describe what it is like to have Alzheimer's. They also drill down on how each of these patients made the program work for them--the challenges, the workarounds, the encouraging results that are so motivating. Dr. Bredesen includes commentary following each story to help point readers to the tips and tricks that might help them as well.Dr. Bredesen's patients have not just survived; they have thrived to rediscover fulfilling lives, rewarding relationships, and meaningful work. This book will give unprecedented hope to patients and their families.