With the latest findings about the mental and physical benefits of exercise, personal stories from scientists and laypeople alike, as well as researched-based prescriptions for readers, Gretchen Reynolds shows what kind of exercise—and how much—is necessary to stay healthy, get fit, and attain a smaller jeans size. Inspired by Reynolds's wildly popular “Phys Ed” column for The New York Times, this book explains how exercise affects the body in distinct ways and provides the tools readers need to achieve their fitness goals, whether that's a faster 5K or staying trim.

    Full of extraordinary facts and astonishing stories, The Body: A Guide for Occupants is a brilliant, often very funny attempt to understand the miracle of our physical and neurological make up.A wonderful successor to A Short History of Nearly Everything, this book will have you marvelling at the form you occupy, and celebrating the genius of your existence, time and time again.

    Margaret I. Cuomo is inspired to seek out new strategies for waging a smarter war on cancer.This year, about 1.6 million new cases of cancer will be diagnosed and more than 1,500 people will die "per day." We've been asked to accept the disappointing strategy to "manage cancer as a chronic disease." We've allowed pharmaceutical companies to position cancer drugs that extend life by just weeks and may cost $100,000 for a single course of treatment as breakthroughs. Where is the bold leadership that will transform our system from treatment to prevention? Have we forgotten the mission of the National Cancer Act of 1971 to "conquer cancer"?Through an analysis of more than 40 years of medical evidence and interviews with the top cancer researchers, drug company executives, and health policy advisers, Dr. Cuomo reveals intriguing answers to these questions. She shows us how all cancer stakeholders--the pharmaceutical industry, the government, physicians, and concerned Americans--can change the way we view and fight cancer in this country.

    But for thousands of years, people have done things like this—and things that make radioactive underpants seem downright sensible! In their hit podcast, Sawbones, Sydnee and Justin McElroy breakdown the weird and wonderful way we got to modern healthcare. And some of the terrifying detours along the way.Every week, Dr. Sydnee McElroy and her husband Justin amaze, amuse, and gross out (depending on the week) hundreds of thousands of avid listeners to their podcast, Sawbones. Consistently rated a top podcast on iTunes, with over 15 million total downloads, this rollicking journey through thousands of years of medical mishaps and miracles is not only hilarious but downright educational. While you may never even consider applying  boiled weasel to your forehead (once the height of sophistication when it came to headache cures), you will almost certainly face some questionable medical advice in your everyday life (we’re looking at you, raw water!) and be better able to figure out if this is a miracle cure (it’s not) or a scam. Table of Contents:Part One: The Unnerving The Resurrection Men Fun w Galvanism Weird Weight Loss Miracle Cure: Opium Black Plague Heroes of Misguided Medicine: Pliny the Elder Erectile Dysfunction The Doctor Is In: Listener Questions Answered Don’t Drill a Hole in Your HeadPart Two: The Gross Mummy Medicine The Guthole Bromance The Unkillable Phineas Gage Max Drank Poopy Water Heroes of Misguided Medicine: Robert Liston Golden Showers of Health Miracle Cure-All: Radium Dr. John Romulus Brinkley The Doctor Is In Q&A Just (Four) Humour Me The Camel Dung MiraclePart Three: The Weird The Dancing Plague Bad Medicine: Tobacco for Health The Seasick-Proof Saloon Miracle Cure-All: Vinegar The Doctor Is In Q&A Heroes of Misguided MedicinePart Four: The Awesome The Poison Squad Bad Medicine: Self Experimentation Eat Your Chocolate! Heroes of Misguided Medicine Parrot Fever Miracle Cure-All: Honey The Miraculous Polio Vaccine The Doctor Is In

    A series of 24 lectures comprising a course on comparative religion presented by Charles Kimball, director of the Religious Studies Program at the University of Oklahoma.

    But which one? And how?Over the past fifty years, more than three hundred infectious diseases have either newly emerged or reemerged, appearing in territories where they’ve never been seen before. Ninety percent of epidemiologists expect that one of them will cause a deadly pandemic sometime in the next two generations. It could be Ebola, avian flu, a drug-resistant superbug, or something completely new. While we can’t know which pathogen will cause the next pandemic, by unraveling the story of how pathogens have caused pandemics in the past, we can make predictions about the future. In Pandemic: Tracking Contagions, from Cholera to Ebola and Beyond, the prizewinning journalist Sonia Shah—whose book on malaria, The Fever, was called a “tour-de-force history” (The New York Times) and “revelatory” (The New Republic)—interweaves history, original reportage, and personal narrative to explore the origins of contagions, drawing parallels between cholera, one of history’s most deadly and disruptive pandemic-causing pathogens, and the new diseases that stalk humankind today.To reveal how a new pandemic might develop, Sonia Shah tracks each stage of cholera’s dramatic journey, from its emergence in the South Asian hinterlands as a harmless microbe to its rapid dispersal across the nineteenth-century world, all the way to its latest beachhead in Haiti. Along the way she reports on the pathogens now following in cholera’s footsteps, from the MRSA bacterium that besieges her own family to the never-before-seen killers coming out of China’s wet markets, the surgical wards of New Delhi, and the suburban backyards of the East Coast.By delving into the convoluted science, strange politics, and checkered history of one of the world’s deadliest diseases, Pandemic reveals what the next global contagion might look like— and what we can do to prevent it.

    David Agus tackles these fundamental questions and dismantles misperceptions about what “health” really means. Presenting an eye-opening picture of the human body and all the ways it works—and fails—Dr. Agus shows us how a new perspective on our individual health will allow us to achieve a long, vigorous life. Offering insights and access to powerful new technologies that promise to transform medicine, Dr. Agus emphasizes his belief that there is no “right” answer, no master guide that is “one size fits all.” Each one of us must get to know our bodies in uniquely personal ways, and he shows us exactly how to do that. A bold call for all of us to become our own personal health advocates, The End of Illness is a moving departure from orthodox thinking.

    Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities. . . .But, Zimmer writes, "Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are--our appearance, our height, our penchants--in inconceivably subtle ways." Heredity isn't just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors--using a word that once referred to kingdoms and estates--but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer's lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world's best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.

    Kasser launches an ambitious and exciting inquiry into what makes science science, using the tools of philosophy to ask: * Why is science so successful? * Is there such a thing as the scientific method? * How do we distinguish science from pseudoscience? * Is science rational, cumulative, and progressive? Focusing his investigation on the vigorous debate over the nature of science that unfolded during the past 100 years, Professor Kasser covers important philosophers such as Karl Popper, W. V. Quine, Thomas Kuhn, Paul Feyerabend, Imre Lakatos, Carl Hempel, Nelson Goodman, and Bas van Fraassen.All of these thinkers responded in one way or another to logical positivism, the dominant movement influencing the philosophy of science during the first half of the 20 th century. Logical positivism attempted to ground science exclusively in what could be known through direct experience and logic.It sounds reasonable, but logical positivism proved to be riddled with serious problems, and its eventual demise is an object lesson in how truly difficult it is—perhaps impossible—to secure the logical foundations of a subject that seems so unassailably logical: science.

    This is a world tour of prehistory with profound links to who we are and how we live today.2.5 Million Years of HistoryThis 36-lecture narrative covers human prehistory from our beginnings more than 2.5 million years ago up to and beyond the advent of the world's first preindustrial civilizations.Due to the large spans of time and geography covered in this series, these lectures are divided into six sections:Section I: BeginningsThis section surveys the archaic world of the first humans, you travel into the remote past, learning why the late Harvard biologist Stephen Jay Gould was probably right to observe that we all come from the same African twig on the bushy tree of human evolution.You examine prehistory from Australopithecus africanus through Homo habilis (the first tool-making hominid), and Homo erectus (whose remains were first found on Java but whose origins lie in Africa) through the hardy Neanderthals who lived and hunted successfully in Europe despite the bitter grip of the last Ice Age 100,000 and more years ago. You focus on the first human settlement of Africa as early as 800,000 years ago.Section II: Modern HumansThis section tells the story of the great diaspora of anatomically modern humans in the late Ice Age. Whether and how these modern humans spread from the African tropics into southwestern Asia and beyond remains one of the great controversies among scholars of prehistory.You follow Homo sapiens sapiens north into Europe some 45,000 years ago. You meet the Cro-Magnons, among the first known artists as well as hunter-gatherers, who exhibited degrees of spiritual awareness, social interaction, and fluid intelligence.You venture into the frigid open plains of the Ukraine and Eurasia, where big-game hunters flourished in spite of nine-month winters. Moving to the Americas, debate over the origins of the first human settlement continues.Section III: Farmers and HerdersThis section describes perhaps the most important development in all human prehistory: the beginnings of agriculture and animal domestication.This defining chapter began about 12,000 years ago, when hunter-gatherers in the Near East broke from the long human tradition of intensely mobile foraging and turned to more settled ways of life built around cultivating cereal grains or tending animals.Section IV: Eastern Mediterranean CivilizationsProfessor Fagan describes early civilizations in an increasingly complex eastern Mediterranean world, discussing many theories accounting for the appearance of urban civilization and overall attributes of preindustrial civilizations.You examine Sumerian civilization in Mesopotamia and the intricate patchwork of city-states between the Tigris and Euphrates Rivers. You explore ancient Egypt, the Minoan civilization of Crete, the Mycenaeans, and the Hittites.You learn about the Uluburun shipwreck of southern Turkey, a sealed capsule of international trade from 3,000 years ago.Section V: Africans and AsiansYou analyze the beginnings of South Asian civilization and the mysterious Harappan civilization of the Indus, which traded with Mesopotamia. Professor Fagan resumes the story of South Asian civilization after the collapse of the Harappan and shows how Mauryan rulers on the Ganges encouraged trading much farther afield.You see the impact of monsoons which revolutionized maritime trading among Africa, India, and Southeast Asia, and explore Meroe, Aksum, and the coastal civilization of East Africa.Several lectures cover the beginnings of civilization in China and Southeast Asia.Section VI: Ancient AmericansProfessor Fagan takes you into sophisticated chiefdoms and civilizations that developed in the Americas over the past 3,500 years, including Pueblo cultures of the North American Southwest and the Mississippian culture of the South and Southeast. You learn about Mesoamerican civilization, primordial Olmec culture of the lowlands, and the spectacular ancient Maya civilization.Moving to the highlands, you visit the city-states of Monte Albán in the Valley of Oaxaca and Teotihuacán near the Valley of Mexico. Professor Fagan also describes the rise of Aztec civilization, followed by a journey to the Andes. Finally, you explore the southern highlands, with the rise of Tiwanaku near Lake Titicaca, the Chimu civilization of the coast, and the huge Inka empire.The series closes by analyzing the closing centuries of prehistoric times during the European age of discovery and summarizing the main issues and themes of the course: * What was involved in the archaic world * The appearance and spread of modern humans * Food production * The development of states.

    But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This book takes us to the frontlines of research many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.

    Now, in The New Science of the Human Past, Reich describes just how the human genome provides not only all the information that a fertilized human egg needs to develop but also contains within it the history of our species. He delineates how the Genomic Revolution and ancient DNA are transforming our understanding of our own lineage as modern humans; how genomics deconstructs the idea that there are no biologically meaningful differences among human populations (though without adherence to pernicious racist hierarchies); and how DNA studies reveal the deep history of human inequality--among different populations, between the sexes, and among individuals within a population.

    But Cullen was no mercy killer, nor was he a simple monster. He was a favorite son, husband, beloved father, best friend, and celebrated caregiver. Implicated in the deaths of as many as 300 patients, he was also perhaps the most prolific serial killer in American history.Cullen's murderous career in the world's most trusted profession spanned sixteen years and nine hospitals across New Jersey and Pennsylvania. When, in March of 2006, Charles Cullen was marched from his final sentencing in an Allentown, Pennsylvania, courthouse into a waiting police van, it seemed certain that the chilling secrets of his life, career, and capture would disappear with him. Now, in a riveting piece of investigative journalism nearly ten years in the making, journalist Charles Graeber presents the whole story for the first time. Based on hundreds of pages of previously unseen police records, interviews, wire-tap recordings and videotapes, as well as exclusive jailhouse conversations with Cullen himself and the confidential informant who helped bring him down, THE GOOD NURSE weaves an urgent, terrifying tale of murder, friendship, and betrayal.Graeber's portrait of Cullen depicts a surprisingly intelligent and complicated young man whose promising career was overwhelmed by his compulsion to kill, and whose shy demeanor masked a twisted interior life hidden even to his family and friends. Were it not for the hardboiled, unrelenting work of two former Newark homicide detectives racing to put together the pieces of Cullen's professional past, and a fellow nurse willing to put everything at risk, including her job and the safety of her children, there's no telling how many more lives could have been lost.In the tradition of In Cold Blood, THE GOOD NURSE does more than chronicle Cullen's deadly career and the breathless efforts to stop him; it paints an incredibly vivid portrait of madness and offers a penetrating look inside America's medical system. Harrowing and irresistibly paced, this book will make you look at medicine, hospitals, and the people who work in them, in an entirely different way.

    They speak their own language, they abide by their own rules, and they seem to exist to drive adults crazy. But adolescence is a typical stage of human development that is the essential preparation for success in the adult world. The more you understand about your teen’s brain, the better prepared you will be to handle this turbulent time in your child’s life.Professor Abigail Baird has devoted the majority of her career to studying adolescence, and in this Audible Original, she shares the latest perspectives on this amazing time of cognitive and behavioral growth. The 10 lectures in this series will reveal that adolescent behavior is much easier to understand than most people think. Rather than seeing the teen years as a crucible to be endured by parents and young people alike, this series offers a practical perspective for adults who hope to help teens truly thrive in their personal journeys to adulthood—not merely to survive their adolescence.Whether you are a parent, someone who works with teens, or even a teen yourself, this course will shed new light on a period of human development that is all too often incorrectly described as a time where psychological peril is inevitable.

    Now, a new edition addresses current developments in cancer research and offers more tips on how people living with cancer can fight it and how healthy people can prevent it. The new edition of Anticancer includes: � The latest research on anticancer foods, including new alternatives to sugar and cautions about some that are now on the market � New information about how vitamin D strengthens the immune system � Warnings about common food contaminants that have recently been proven to contribute to cancer progression � A new chapter on mind-body approaches to stress reduction, with recent studies that show how our reactions to stress can interfere with natural defenses and how friendships can support healing in ways never before understood � A groundbreaking study showing that lifestyle modification, as originally proposed in Anticancer, reduces mortality for breast cancer by an astounding 68 percent after completion of treatment � New supporting evidence for the entire Anticancer program