That all changed in less than a generation with the discovery and development of a new category of medicine known as antibiotics. By 1955, the age-old evolutionary relationship between humans and microbes had been transformed, trivializing once-deadly infections. William Rosen captures this revolution with all its false starts, lucky surprises, and eccentric characters. He explains why, given the complex nature of bacteria—and their ability to rapidly evolve into new forms—the only way to locate and test potential antibiotic strains is by large-scale, systematic, trial-and-error experimentation. Organizing that research needs large, well-funded organizations and businesses, and so our entire scientific-industrial complex, built around the pharmaceutical company, was born. Timely, engrossing, and eye-opening, Miracle Cure is a must-read science narrative—a drama of enormous range, combining science, technology, politics, and economics to illuminate the reasons behind one of the most dramatic changes in humanity’s relationship with nature since the invention of agriculture ten thousand years ago.

    To reach this unique audience, Whitlock and Schluter motivate learning with interesting biological and medical examples; they emphasize intuitive understanding; and they focus on real data. The book covers basic topics in introductory statistics, including graphs, confidence intervals, hypothesis testing, comparison of means, regression, and designing experiments. It also introduces the principles behind such modern topics as likelihood, linear models, meta-analysis and computer-intensive methods. Instructors and students consistently praise the book's clear and engaging writing, strong visualization techniques, and its variety of fascinating and relevant biological examples.

    Though the process obeyed all the rules of chemistry and physics, the details of that original event pose as deep a mystery as any facing science. How did non-living chemicals become alive? While the question is (deceivingly) simple, the answers are unquestionably complex. Science inevitably plays a key role in any discussion of life's origins, dealing less with the question of why life appeared on Earth than with where, when, and how it emerged on the blasted, barren face of our primitive planet. Astrobiologist Robert Hazen has spent many years dealing with the fundamental questions of life's genesis. As an active research scientist, he is down deep in all the messy details that science has to offer on the subject, tracing the inexorable sequence of events that led to the complicated interactions of carbonbased molecules. As he takes us through the astounding process of emergence, we are witness to the first tentative steps toward life?from the unfathomable abundance of carbon biomolecules synthesized in the black vacuum of space to the surface of the Earth to deep within our planet's restless crust. We are privy to the breathtaking drama that rapidly unfolds as life prevails. The theory of emergence is poised to answer a multitude of questions?even as it raises the possibility that natural processes exist beyond what we now know, perhaps beyond what we even comprehend. Genesis tells the tale of transforming scientific advances in our quest for life's origins. Written with grace, beauty, and authority, it goes directly to the heart of who we are and why we are here.

    H. Hardy was one of this century's finest mathematical thinkers, renowned among his contemporaries as a 'real mathematician ... the purest of the pure'. He was also, as C. P. Snow recounts in his Foreword, 'unorthodox, eccentric, radical, ready to talk about anything'. This 'apology', written in 1940 as his mathematical powers were declining, offers a brilliant and engaging account of mathematics as very much more than a science; when it was first published, Graham Greene hailed it alongside Henry James's notebooks as 'the best account of what it was like to be a creative artist'. C. P. Snow's Foreword gives sympathetic and witty insights into Hardy's life, with its rich store of anecdotes concerning his collaboration with the brilliant Indian mathematician Ramanujan, his aphorisms and idiosyncrasies, and his passion for cricket. This is a unique account of the fascination of mathematics and of one of its most compelling exponents in modern times.

    He draws on interviews with some of the world’s highest performing researchers, the literature and his own experience to identify a small number of important insights that can transform how researchers work. The book is based on an unparalleled breadth of interdisciplinary evidence that speaks directly to researchers of all disciplines and career stages. The lessons in this book will make you more productive, more satisfied with what you produce, and enable you to be happy working less, and being more. The hardback edition has the title and design imprinted on a fabric cover, hand crafted by a book maker in Yorkshire. It contains spectacular colour photography throughout. Chapters are accompanied by close-up images of trees that build up to the forest metaphor that concludes the book. These are bookended by wide perspective canopy images that accompany the front matter (from which the cover design is derived) and concluding chapter. The overall effect is a touch and feel that makes this a book to savour. Mark Reed is Professor of Socio-Technical Innovation at Newcastle University and Visiting Professor at Birmingham City University and the University of Leeds. He has over 140 publications that have been cited more than 10,000 times. He is author of The Research Impact Handbook, which he has used to train over 4000 researchers from more than 200 institutions in 55 countries.

    Bill Gates, Bono, and Laura Bush are only a few of the personalities who have lent their names--and opened their pocketbooks--in hopes of curing the disease. Still, in a time when every emergent disease inspires waves of panic, why aren't we doing more to eradicate one of our oldest foes? And how does a parasitic disease that we've known how to prevent for more than a century still infect 500 million people every year, killing nearly 1 million of them? In "The Fever," the journalist Sonia Shah sets out to answer these questions, delivering a timely, inquisitive chronicle of the illness and its influence on human lives. Through the centuries, she finds, we've invested our hopes in a panoply of drugs and technologies, and invariably those hopes have been dashed. From the settling of the New World to the construction of the Panama Canal, through wars and the advances of the Industrial Revolution, Shah tracks malaria's jagged ascent and the tragedies in its wake, revealing a parasite every bit as persistent as the insects that carry it. With distinguished prose and original reporting from Panama, Malawi, Cameroon, India, and elsewhere, "The Fever" captures the curiously fascinating, devastating history of this long-standing thorn in the side of humanity.

    It explores the critical concepts while also examining why they are relevant. The core content is presented within the framework of predicting products, proposing mechanisms, and solving synthesis problems. Readers will fine-tune the key skills involved in solving those types of problems with the help of interactive, step-by-step instructions and problems.

    It’s no coincidence that geniuses not only dare to dream of the impossible for their work, but do the same for their lives. They’re audacious enough to think that they’re not just ordinary players. Few stories better illustrate this better than the life of the father of the modern world, a man of legendary imaginative power and wonder: Nikola Tesla.In this book, you’ll be taken on a whirlwind journey through Tesla’s life and work, and not only learn about the successes and mistakes of one of history’s greatest inventors, but also how to look at the world in a different, more imaginative way.Read this book now and learn lessons from Nikola Tesla on why imagination is so vital to awakening your inner genius, and insights into the real “secret” to creativity, as explained by people like Jobs, Picasso, Dali, and Twain.

    It Combines Comprehensive Medical Content With Dynamic New Features And Interactive Technology To Better Support Instructors And To Help Prepare Students For The Field. An Interactive Skills DVD Is Also Packaged Free With Each Copy Of The Text.

    This newest edition expands on the strengths of earlier versions, helping students bridge the gap between concepts and reasoning. Students are shown, rather than told about, how physics works and are given the opportunity to apply concepts to real-world problems. Each chapter and concept has been scrutinized to ensure clarity, currency, and accuracy while checkpoints, problem solving tactics, and sample problems help students make sense of new concepts. As always, Fundamentals of Physics covers every aspect of basic physics, from force and motion to relativity and will prepare today's students to be tomorrow's scientists.

    The authors bring to life Darwin's reckless student days in Cambridge, his epic five-year voyage on the Beagle, and his grueling struggle to develop his theory of evolution.Adrian Desmond and James Moore's gripping narrative reveals the great personal cost to Darwin of pursuing inflammatory truths—telling the whole story of how he came to his epoch-making conclusions.

    From Edward Lorenz’s discovery of the Butterfly Effect, to Mitchell Feigenbaum’s calculation of a universal constant, to Benoit Mandelbrot’s concept of fractals, which created a new geometry of nature, Gleick’s engaging narrative focuses on the key figures whose genius converged to chart an innovative direction for science. In Chaos, Gleick makes the story of chaos theory not only fascinating but also accessible to beginners, and opens our eyes to a surprising new view of the universe.

    Did you know that two of every three people reading this book will die for reasons connected with the genes they carry? That our DNA gradually changes with age, which is why older parents are more likely to give birth to children with genetic defects than younger parents? That each individual is a kind of living fossil, carrying within a genetic record that goes back to the beginnings of humanity? In The Language of Genes, renowned geneticist Steve Jones explores the meanings and explodes the myths of human genetics, offering up an extraordinary picture of what we are, what we were, and what we may become."An essential book for anyone interested in the development and possible future of our species."--Kirkus Reviews"This is one of the most insightful books on genetics to date and certainly the most entertaining."--The Wall Street Journal

    Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery.The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

    Taken literally, it implies that there are many universes “parallel” to the one we see around us. This multiplicity of universes, according to Deutsch, turns out to be the key to achieving a new worldview, one which synthesizes the theories of evolution, computation, and knowledge with quantum physics. Considered jointly, these four strands of explanation reveal a unified fabric of reality that is both objective and comprehensible, the subject of this daring, challenging book. The Fabric of Reality explains and connects many topics at the leading edge of current research and thinking, such as quantum computers (which work by effectively collaborating with their counterparts in other universes), the physics of time travel, the comprehensibility of nature and the physical limits of virtual reality, the significance of human life, and the ultimate fate of the universe. Here, for scientist and layperson alike, for philosopher, science-fiction reader, biologist, and computer expert, is a startlingly complete and rational synthesis of disciplines, and a new, optimistic message about existence.