A former girlfriend of Hugh Hefner describes how her years inside the Playboy Mansion went from a fairytale of A-list celebrity parties to an oppressive regime of strict rules, scheduled sex, and a total loss of identity, so much so that she even contemplated suicide.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Bobby was a force--irrepressible, glamorous, unapologetically opinionated. Bobby doted on Bess; Bess adored Bobby. Then, at ninety, Bobby died. But in this debut memoir, Bobby is speaking to Bess once more, in a voice as passionate as it ever was in life.Recounting both family lore and family secrets, Bobby brings us four generations of indomitable women and the men who loved them. There's Bobby's mother, who traveled solo from Belarus to America in the 1880s to escape the pogroms, and Bess's mother, a 1970s rebel who always fought against convention. Then there's Bess, who grew up in New York and entered the rough-and-tumble world of L.A. television. Her grandma Bobby was with her all the way--she was the light of Bess's childhood and her fiercest supporter, giving Bess unequivocal love, even if sometimes of the toughest kind.In Nobody Will Tell You This But Me, Bobby reminds Bess of the experiences they shared, and she delivers--in phone calls, texts, and unforgettable heart-to-hearts brought vividly to the page--her signature wisdom:If the earth is cracking behind you, you put one foot in front of the other. Never. Buy. Fake. Anything.I swear on your life every word of this is true.With humor and poignancy, Bess Kalb gives us proof of the special bond that can skip a generation and endure beyond death. This book is a feat of extraordinary ventriloquism and imagination by a remarkably talented writer.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Matt and Liz Logelin were high school sweethearts. After years of long-distance dating, the pair finally settled together in Los Angeles, and they had it all: a perfect marriage, a gorgeous new home, and a baby girl on the way. Liz's pregnancy was rocky, but they welcomed Madeline, beautiful and healthy, into the world. Just twenty-seven hours later, Liz suffered a pulmonary embolism and died instantly, without ever holding the daughter whose arrival she had so eagerly awaited. Though confronted with devastating grief and the responsibilities of a new and single father, Matt did not surrender to devastation; he chose to keep moving forward-to make a life for Maddy. In this memoir, Matt shares bittersweet and often humorous anecdotes of his courtship and marriage to Liz; of relying on his newborn daughter for the support that she unknowingly provided; and of the extraordinary online community of strangers who have become his friends. In honoring Liz's legacy, heartache has become solace.

    "No rock critic-living or dead, American or otherwise-has ever written about pop music with the evocative, hyperpoetic perfectitude of Rob Sheffield." So said Chuck Klosterman about Love is a Mix Tape, Sheffield's paean to a lost love via its soundtrack. Now, in Talking to Girls About Duran Duran, Sheffield shares the soundtrack to his eighties adolescence. When he turned 13 in 1980, Rob Sheffield had a lot to learn about women, love, music and himself, and in Talking to Girls About Duran Duran we get a glimpse into his transformation from pasty, geeky "hermit boy" into a young man with his first girlfriend, his first apartment, and a sense of the world. These were the years of MTV and John Hughes movies; the era of big dreams and bigger shoulder pads; and, like any all-American boy, this one was searching for true love and maybe a cooler haircut. It's all here: Inept flirtations. Dumb crushes. Deplorable fashion choices. Members Only jackets. Girls, every last one of whom seems to be madly in love with the bassist of Duran Duran. Sheffield's coming-of-age story is one that we all know, with a playlist that any child of the eighties or anyone who just loves music will sing along with. These songs-and Sheffield's writing-will remind readers of that first kiss, that first car, and the moments that shaped their lives.

    Until she stumbled on an alternate universe where taste reigned supreme, a world in which people could, after a single sip of wine, identify the grape it was made from, in what year, and where it was produced down to the exact location, within acres. Where she tasted wine, these people detected not only complex flavor profiles, but entire histories and geographies. Astounded by their fanatical dedication and seemingly superhuman sensory powers, Bosker abandoned her screen-centric life and set out to discover what drove their obsession, and whether she, too, could become a cork dork.Thus begins a year and a half long adventure that takes the reader inside elite tasting groups, exclusive New York City restaurants, a California winery that manipulates the flavor of its bottles with ingredients like Mega Purple, and even a neuroscientist's fMRI machine as Bosker attempts to answer the most nagging question of all: what's the big deal about wine? Funny, counter intuitive, and compulsively readable, Cork Dork illuminates not only the complex web of wine production and consumption, but how tasting better can change our brains and help us live better.

    Yet she spent much of her life disassociated from her own body—a disconnection brought on by her father’s sexual abuse and her mother’s remoteness. “Because I did not, could not inhabit my body or the Earth,” she writes, “I could not feel or know their pain.”But Ensler is shocked out of her distance. While working in the Congo, she is shattered to encounter the horrific rape and violence inflicted on the women there. Soon after, she is diagnosed with uterine cancer, and through months of harrowing treatment, she is forced to become first and foremost a body—pricked, punctured, cut, scanned. It is then that all distance is erased. As she connects her own illness to the devastation of the earth, her life force to the resilience of humanity, she is finally, fully—and gratefully—joined to the body of the world.Unflinching, generous, and inspiring, Ensler calls on us all to embody our connection to and responsibility for the world.http://us.macmillan.com/inthebodyofth...

    Although her body healed rapidly, her memories never returned. Yet after just three weeks in the hospital, Su was released and once again charged with the care of two toddlers and a busy household. Adrift in a world about which she understood almost nothing, Su became an adept mimic, gradually creating routines and rituals that sheltered her and her family, however narrowly, from the near-daily threat of disaster, or so she thought. Though Su would eventually relearn to tie her shoes, cook a meal, and read and write, nearly twenty years would pass before a series of personally devastating events shattered the normal life she had worked so hard to build, and she realized that she would have to grow up all over again.In her own indelible voice, Su offers us a view from the inside of a terrible injury, with the hope that her story will help give other brain injury sufferers and their families the resolve and courage to build their lives anew. Piercing, heartbreaking, but finally uplifting, this book is the true story of a woman determined to live life on her own terms.

    From awkward handshakes to having a girlfriend and everything in between, Shane handles his situation with humor and a "you-only-live-once" perspective on life. While he does talk about everyday issues that are relatable to teens, he also offers an eye-opening perspective on what it is like to have a life threatening disease.

    In her book Self-Inflicted Wounds, comedian, actress, and cohost of CBS’s daytime hit show The Talk, Aisha Tyler recounts a series of epic mistakes and hilarious stories of crushing personal humiliation, and the personal insights and authentic wisdom she gathered along the way. The essays in Self-Inflicted Wounds are refreshingly and sometimes brutally honest, surprising, and laugh-out-loud funny, vividly translating the brand of humor Tyler has cultivated through her successful standup career, as well as the strong voice and unique point of view she expresses on her taste-making comedy podcast Girl on Guy. Riotous, revealing, and wonderfully relatable, Aisha Tyler’s Self-Inflicted Wounds: Heartwarming Tales of Epic Humiliation is about the power of calamity to shape life, learning, and success.

    Jacobs tackles his most challenging experiment yet: a yearlong mission to radically improve every element of his body and mind—from his brain to his fingertips to his abs.From the bestselling author of The Year of Living Biblically and The Know-It-All comes the true and truly hilarious story of one person’s quest to become the healthiest man in the world. Hospitalized with a freak case of tropical pneumonia, goaded by his wife telling him, “I don’t want to be a widow at forty-five,” and ashamed of a middle-aged body best described as “a python that swallowed a goat,” A.J. Jacobs felt compelled to change his ways and get healthy. And he didn’t want only to lose weight, or finish a triathlon, or lower his cholesterol. His ambitions were far greater: maximal health from head to toe. The task was epic. He consulted an army of experts— sleep consultants and sex clinicians, nutritionists and dermatologists. He subjected himself to dozens of different workouts—from Strollercize classes to Finger Fitness sessions, from bouldering with cavemen to a treadmill desk. And he took in a cartload of diets: raw foods, veganism, high protein, calorie restriction, extreme chewing, and dozens more. He bought gadgets and helmets, earphones and juicers. He poked and he pinched. He counted and he measured. The story of his transformation is not only brilliantly entertaining, but it just may be the healthiest book ever written. It will make you laugh until your sides split and endorphins flood your bloodstream. It will alter the contours of your brain, imprinting you with better habits of hygiene and diet. It will move you emotionally and get you moving physically in surprising ways. And it will give you occasion to reflect on the body’s many mysteries and the ultimate pursuit of health: a well-lived life.

    Leah Remini has never been the type to hold her tongue. That willingness to speak her mind, stand her ground, and rattle the occasional cage has enabled this tough-talking girl from Brooklyn to forge an enduring and successful career in Hollywood. But being a troublemaker has come at a cost. That was never more evident than in 2013, when Remini loudly and publicly broke with the Church of Scientology. Now, in this frank, funny, poignant memoir, the former King of Queens star opens up about that experience for the first time, revealing the in-depth details of her painful split with the church and its controversial practices. Indoctrinated into the church as a child while living with her mother and sister in New York, Remini eventually moved to Los Angeles, where her dreams of becoming an actress and advancing Scientology's causes grew increasingly intertwined. As an adult, she found the success she'd worked so hard for, and with it a prominent place in the hierarchy of celebrity Scientologists alongside people such as Tom Cruise, Scientology's most high-profile adherent. Remini spent time directly with Cruise and was included among the guests at his 2006 wedding to Katie Holmes. But when she began to raise questions about some of the church's actions, she found herself a target. In the end, she was declared by the church to be a threat to their organization and therefore a "Suppressive Person," and as a result, all of her fellow parishioners—including members of her own family—were told to disconnect from her. Forever. Bold, brash, and bravely confessional, Troublemaker chronicles Leah Remini's remarkable journey toward emotional and spiritual freedom, both for herself and for her family. This is a memoir designed to reveal the hard-won truths of a life lived honestly—from an author unafraid of the consequences.

    She was ambitious and worked hard; she had just bought an apartment; she was falling in love. But then she started to develop worrying symptoms: her face felt like it was burning whenever she was in front of the computer. Soon this progressed to an intolerance of fluorescent light, then of sunlight itself. The reaction soon spread to her entire body. Now, when her symptoms are at their worst, she must spend months on end in a blacked-out room, losing herself in audio books and elaborate word games in an attempt to ward off despair. It was during this period she began to write this book.

    A mother, wife, and working professional, Reiland was diagnosed with borderline personality disorder at the age of 29—a diagnosis that finally explained her explosive anger, manipulative behaviors, and self-destructive episodes including bouts of anorexia, substance abuse, and promiscuity. A truly riveting read with a hopeful message.