December 4, 1978.In an appalling demonstration of the way in which a charismatic leader can bend the minds of his followers with a devilish blend of professed altruism and psychological tyranny, some 900 members of the California-based Peoples Temple died in a self-imposed ritual of mass suicide and murder.The followers of the Rev. Jim Jones, 47, a once respected Indianaborn humanitarian who degenerated into egomania and paranoia, had first ambushed a party of visiting Americans, killing California Congressman Leo Ryan, 53, three newsmen and one defector from their heavily guarded colony at Jones-town. Then, exhorted by their leader, intimidated by armed guards and lulled with sedatives and painkillers, parents and nurses used syringes to squirt a concoction of potassium cyanide and potassium chloride onto the tongues of babies. The adults and older children picked up paper cups and sipped the same deadly poison sweetened by purple Kool-Aid.This story is part of the TIME Classic Coverage Collection from Time Inc. This is a reproduction of a story that appeared in the December 4, 1978 issue of TIME magazine. Time Inc. is one of the world’s most influential media companies – home to 90 iconic brands like People, Sports Illustrated, Time, InStyle, Real Simple, Food & Wine, and Fortune. The Spotlight Stories in this collection aim to provide you with a quick read on a single subject, highlighting our readers’ most popular stories and featuring great reporting from our Time Inc. journalists.

    The producers refused. In Doctor Who, the Twelfth Doctor's costume was inspired by David Bowie. In Game of Thrones, Hodor's real name is Wyllis. Matthew Perry plays Chandler in Friends. He says he can't remember a single thing from the show throughout three seasons. In The Simpsons, Hans Moleman has died at least 15 times. Many mobsters contacted James Gandolfini to tell him his performance was excellent in The Sopranos but warned him not to wear shorts in the show. Millie Bobby Brown was 11 when she was cast as Eleven in Stranger Things. The Tourette Syndrome Association praised the show, South Park, for its accurate portrayal of the Tourette's condition. In Family Guy, Meg's full name is Megatron Griffin.

    Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    What is it that makes comics so special? What can this unique art form do that others can’t?In Why Comics?, comics scholar Hillary Chute reveals the history of comics, underground comics (or comix), and graphic novels, through deep thematic analysis, and fascinating portraits of the fearless men and women behind them. As Scott McCloud revealed the methods behind comics and the way they worked in his classic Understanding Comics, Chute will reveal the themes that Comics handle best, and how the form is uniquely equipped to explore them.The topics Why Comics? include:• Why Disaster: with such major works focusing on disasters, from Art Spiegelman’s work, which covers the Holocaust and 9/11 to Keiji Nakazawa’s work covering Heroshima, comics find themselves uniquely suited to convey the scale and disorientation of disaster.• Why Suburbs: through the work of Chris Ware and Charles Burns, Chute reveals the fascinating ways that Comics illustrate the quiet joys and struggles of suburban existence.• Why Punk: With an emphasis on DIY aesthetics and rebelling against what came before, the Punk movement would prove to be a fertile ground for some of the most significant modern cartoonists, creating a truly democratic art form.Chute has created an indispensable guide to comics for those new to the genre, or those who want to understand more about what lies behind their favorite works.

    No military family has sacrificed more during the ensuing war, which has become the longest ever fought by America’s armed forces.While serving in Afghanistan, US Navy SEAL veteran and CIA contractor Jeremy Wise was killed in an al Qaeda suicide bombing that devastated the US intelligence community. Less than three years later, US Army Green Beret sniper Ben Wise was fatally wounded after volunteering for a dangerous assignment during a firefight with the Taliban. Ben was posthumously awarded the Silver Star, while Jeremy received the Intelligence Star—one of the rarest awards bestowed by the U.S. government—and also a star on the CIA’s Memorial Wall. United States Marine Corps combat veteran Beau Wise is the only known American service member to be pulled from the battlefield after losing two brothers in Afghanistan. Told in Beau’s voice, Three Wise Men is an American family’s historic true story of service and sacrifice.

    --Wall Street Journal"Informative and well paced."--The Guardian"An intense ride through the pandemic with chilling details of what really happened. It is also sprinkled with notes of true wisdom that may help all of us better prepare for the future."--Sanjay Gupta, MD, chief medical correspondent, CNNPhysician and former FDA commissioner Scott Gottlieb asks: Has America's COVID-19 catastrophe taught us anything?In Uncontrolled Spread, he shows how the coronavirus and its variants were able to trounce America's pandemic preparations, and he outlines the steps that must be taken to protect against the next outbreak. As the pandemic unfolded, Gottlieb was in regular contact with all the key players in Congress, the Trump administration, and the drug and diagnostic industries. He provides an inside account of how level after level of American government crumbled as the COVID-19 crisis advanced.A system-wide failure across government institutions left the nation blind to the threat, and unable to mount an effective response. We'd prepared for the wrong virus. We failed to identify the contagion early enough and became overly reliant on costly and sometimes divisive tactics that couldn't fully slow the spread. We never considered asymptomatic transmission and we assumed people would follow public health guidance. Key bureaucracies like the CDC were hidebound and outmatched. Weak political leadership aggravated these woes. We didn't view a public health disaster as a threat to our national security.Many of the woes sprung from the CDC, which has very little real-time reporting capability to inform us of Covid's twists and turns or assess our defenses. The agency lacked an operational capacity and mindset to mobilize the kind of national response that was needed. To guard against future pandemic risks, we must remake the CDC and properly equip it to better confront crises. We must also get our intelligence services more engaged in the global public health mission, to gather information and uncover emerging risks before they hit our shores so we can head them off. For this role, our clandestine agencies have tools and capabilities that the CDC lacks.Uncontrolled Spread argues we must fix our systems and prepare for a deadlier coronavirus variant, a flu pandemic, or whatever else nature -- or those wishing us harm -- may threaten us with. Gottlieb outlines policies and investments that are essential to prepare the United States and the world for future threats.