The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future.

    But for thousands of years, people have done things like this—and things that make radioactive underpants seem downright sensible! In their hit podcast, Sawbones, Sydnee and Justin McElroy breakdown the weird and wonderful way we got to modern healthcare. And some of the terrifying detours along the way.Every week, Dr. Sydnee McElroy and her husband Justin amaze, amuse, and gross out (depending on the week) hundreds of thousands of avid listeners to their podcast, Sawbones. Consistently rated a top podcast on iTunes, with over 15 million total downloads, this rollicking journey through thousands of years of medical mishaps and miracles is not only hilarious but downright educational. While you may never even consider applying  boiled weasel to your forehead (once the height of sophistication when it came to headache cures), you will almost certainly face some questionable medical advice in your everyday life (we’re looking at you, raw water!) and be better able to figure out if this is a miracle cure (it’s not) or a scam. Table of Contents:Part One: The Unnerving The Resurrection Men Fun w Galvanism Weird Weight Loss Miracle Cure: Opium Black Plague Heroes of Misguided Medicine: Pliny the Elder Erectile Dysfunction The Doctor Is In: Listener Questions Answered Don’t Drill a Hole in Your HeadPart Two: The Gross Mummy Medicine The Guthole Bromance The Unkillable Phineas Gage Max Drank Poopy Water Heroes of Misguided Medicine: Robert Liston Golden Showers of Health Miracle Cure-All: Radium Dr. John Romulus Brinkley The Doctor Is In Q&A Just (Four) Humour Me The Camel Dung MiraclePart Three: The Weird The Dancing Plague Bad Medicine: Tobacco for Health The Seasick-Proof Saloon Miracle Cure-All: Vinegar The Doctor Is In Q&A Heroes of Misguided MedicinePart Four: The Awesome The Poison Squad Bad Medicine: Self Experimentation Eat Your Chocolate! Heroes of Misguided Medicine Parrot Fever Miracle Cure-All: Honey The Miraculous Polio Vaccine The Doctor Is In

    From distressed small communities in Central Appalachia to wealthy suburbs; from disparate cities to once-idyllic farm towns; it's a heartbreaking trajectory that illustrates how this national crisis has persisted for so long and become so firmly entrenched. Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy endeavors to answer a grieving mother's question-why her only son died-and comes away with a harrowing story of greed and need. From the introduction of OxyContin in 1996, Macy parses how America embraced a medical culture where overtreatment with painkillers became the norm. In some of the same distressed communities featured in her bestselling book Factory Man, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.Through unsparing, yet deeply human portraits of the families and first responders struggling to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows, astonishingly, that the only thing that unites Americans across geographic and class lines is opioid drug abuse. But in a country unable to provide basic healthcare for all, Macy still finds reason to hope-and signs of the spirit and tenacity necessary in those facing addiction to build a better future for themselves and their families.

    We wouldn’t have unraveled DNA or discovered Neptune or figured out how to put 5,000 songs in your pocket. Though many of us were scared away from this essential, engrossing subject in high school and college, Steven Strogatz’s brilliantly creative, down‑to‑earth history shows that calculus is not about complexity; it’s about simplicity. It harnesses an unreal number—infinity—to tackle real‑world problems, breaking them down into easier ones and then reassembling the answers into solutions that feel miraculous. Infinite Powers recounts how calculus tantalized and thrilled its inventors, starting with its first glimmers in ancient Greece and bringing us right up to the discovery of gravitational waves (a phenomenon predicted by calculus). Strogatz reveals how this form of math rose to the challenges of each age: how to determine the area of a circle with only sand and a stick; how to explain why Mars goes “backwards” sometimes; how to make electricity with magnets; how to ensure your rocket doesn’t miss the moon; how to turn the tide in the fight against AIDS. As Strogatz proves, calculus is truly the language of the universe. By unveiling the principles of that language, Infinite Powers makes us marvel at the world anew.

    Brilliantly reported and astoundingly fresh, Fire and Fury shows us how and why Donald Trump has become the king of discord and disunion.

    prison system, tracking down a chameleon con artist in Europe, or riding in a cyclone-tossed skiff with a scientist hunting the elusive giant squid, David Grann revels in telling stories that explore the nature of obsession and that piece together true and unforgettable mysteries.Each of the dozen stories in this collection reveals a hidden and often dangerous world and, like Into Thin Air and The Orchid Thief, pivots around the gravitational pull of obsession and the captivating personalities of those caught in its grip. There is the world's foremost expert on Sherlock Holmes who is found dead in mysterious circumstances; an arson sleuth trying to prove that a man about to be executed is innocent, and sandhogs racing to complete the brutally dangerous job of building New York City's water tunnels before the old system collapses. Throughout, Grann's hypnotic accounts display the power-and often the willful perversity-of the human spirit.Compulsively readable, The Devil and Sherlock Holmes is a brilliant mosaic of ambition, madness, passion, and folly.

    They're spoken of in stories and superstitions, relics of an unenlightened age, old wives' tales, passed down through generations. And yet, no matter how wary and jaded we have become, as individuals or as a society, a part of us remains vulnerable to them. Werewolves and wendigos, poltergeists and vampires, angry elves and vengeful spirits.In this beautifully illustrated volume, the host of the hit podcast Lore serves as a guide on a fascinating journey through the history of these terrifying creatures, and explores not only the legends but what they tell us about ourselves. Aaron Mahnke invites us to the desolate Pine Barrens of New Jersey, where the notorious winged, red-eyed Jersey Devil dwells. Mahnke delves into harrowing accounts of cannibalism-some officially documented, others the stuff of speculation . . . perhaps. He visits the dimly lit rooms where séances take place, the European villages where gremlins make mischief, and Key West, Florida, home of a haunted doll named Robert.The monsters of folklore have become not only a part of our language but a part of our collective psyche. Whether these beasts and bogeymen are real or just a reflection of our primal fears, we know, on some level, that not every mystery has been explained, and that the unknown still holds the power to strike fear deep in our hearts and souls. As Aaron Mahnke reminds us, sometimes the truth is even scarier than the lore...

    The book documents the adverse environmental effects caused by the indiscriminate use of pesticides. Carson accused the chemical industry of spreading disinformation, and public officials of accepting the industry's marketing claims unquestioningly.The book appeared in September 1962 and the outcry that followed its publication forced the banning of DDT and spurred revolutionary changes in the laws affecting our air, land, and water. Carson’s book was instrumental in launching the environmental movement.

    As Professor of Anatomy and Forensic Anthropology, she focuses on mortal remains in her lab, at burial sites, at scenes of violence, murder and criminal dismemberment, and when investigating mass fatalities due to war, accident or natural disaster. In All that Remains she reveals the many faces of death she has come to know, using key cases to explore how forensic science has developed, and what her work has taught her. Do we expect a book about death to be sad? Macabre? Sue’s book is neither. There is tragedy, but there is also humour in stories as gripping as the best crime novel. Our own death will remain a great unknown. But as an expert witness from the final frontier, Sue Black is the wisest, most reassuring, most compelling of guides.

    Topics range from ruminations on why Charles Dickens was among the best of writers and the worst of men to the haunting science fiction of J.G. Ballard; from the enduring legacies of Thomas Jefferson and George Orwell to the persistent agonies of anti-Semitism and jihad. Hitchens even looks at the recent financial crisis and argues for the enduring relevance of Karl Marx. The book forms a bridge between the two parallel enterprises of culture and politics. It reveals how politics justifies itself by culture, and how the latter prompts the former. In this fashion, Arguably burnishes Christopher Hitchens' credentials as (to quote Christopher Buckley) our "greatest living essayist in the English language."

    Plait created his popular web site: http://www.badastronomy.com/index.html, to debunk bad astronomy in popular culture. This website proved popular, which led to this first book by Plait, that carries on from the website and in a detailed and clear fashion criticises and disproves popular myths and misconceptions relating to astronomy, and promotes science as a means of explaining the skies. The work describes 24 common astronomical fallacies, including the beliefs that the Coriolis effect determines the direction that water drains in a bathtub, and that planetary alignments can cause disaster on Earth. The author sharply and convincingly dismisses astrology, creationism, and UFO sightings, and explains the principles behind basic general concepts (the Big Bang, why the sky is blue, etc.).

    Beginning with the above questions, she began informally researching every affliction that she encountered in humans to learn whether it happened with animals, too. And usually, it did: dinosaurs suffered from brain cancer, koalas can catch chlamydia, reindeer seek narcotic escape in hallucinogenic mushrooms, stallions self-mutilate, and gorillas experience clinical depression. Natterson-Horowitz and science writer Kathryn Bowers have dubbed this pan-species approach to medicine zoobiquity. Here, they present a revelatory understanding of what animals can teach us about the human body and mind, exploring how animal and human commonality can be used to diagnose, treat, and heal patients of all species.

    Much more commonly, they are linked to sensory deprivation, intoxication, illness, or injury. People with migraines may see shimmering arcs of light or tiny, Lilliputian figures of animals and people. People with failing eyesight, paradoxically, may become immersed in a hallucinatory visual world. Hallucinations can be brought on by a simple fever or even the act of waking or falling asleep, when people have visions ranging from luminous blobs of color to beautifully detailed faces or terrifying ogres. Those who are bereaved may receive comforting “visits” from the departed. In some conditions, hallucinations can lead to religious epiphanies or even the feeling of leaving one’s own body. Humans have always sought such life-changing visions, and for thousands of years have used hallucinogenic compounds to achieve them. As a young doctor in California in the 1960s, Oliver Sacks had both a personal and a professional interest in psychedelics. These, along with his early migraine experiences, launched a lifelong investigation into the varieties of hallucinatory experience. Here, with his usual elegance, curiosity, and compassion, Dr. Sacks weaves together stories of his patients and of his own mind-altering experiences to illuminate what hallucinations tell us about the organization and structure of our brains, how they have influenced every culture’s folklore and art, and why the potential for hallucination is present in us all, a vital part of the human condition.

     Is slipping on a banana peel really as hazardous to your health as the cartoons imply? Answer: Yes. Banana peels ooze a gel that turns out to be extremely slippery. Your foot and body weight provide the pressure. The gel provides the humor (and resulting head trauma). Can you die by shaking someone s hand? Answer: Yes. That's because, due to atomic repulsion, you've never actually touched another person s hand. If you could, the results would be as disastrous as a medium-sized hydrogen bomb. If you were Cookie Monster, just how many cookies could you actually eat in one sitting? Answer: Most stomachs can hold up to sixty cookies, or around four liters. If you eat or drink more than that, you re approaching the point at which the cookies would break through the lesser curvature of your stomach, and then you d better call an ambulance to Sesame Street."

    Gawky, socially awkward and totally unqualified, his first reaction to this exciting opportunity was panic. But he'd always been drawn to off-beat characters, so maybe his enthusiasm would carry the day. Or, you know, maybe it wouldn't...In Gotta Get Theroux This, Louis takes the reader on a joyous journey through his life and unexpectedly successful career. Nervously accepting the BBC's offer of his own series, he went on to create an award-winning documentary style that has seen him immersed in worlds as diverse as racist US militias and secretive pro-wrestlers, the violent gangs of Johannesburg and extreme drinkers in London.Arguably his biggest challenge was corralling celebrities in his When Louis Met series, with Jimmy Savile proving most elusive. Blindsided when the revelations about Savile came to light, Louis was to reflect again on the nature of evil he had spent decades uncovering.Filled with wry observation, larger-than-life characters, and self-deprecating humour, this is Louis at his insightful and honest best.