But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    government’s Human Genome Project. Venter hoped that by decoding the genome ahead of schedule, he would speed up the pace of biomedical research and save the lives of thousands of people. He also hoped to become very famous and very rich. Calling his company Celera (from the Latin for “speed”), he assembled a small group of scientists in an empty building in Rockville, Maryland, and set to work.At the same time, the leaders of the government program, under the direction of Francis Collins, head of the National Human Genome Research Institute at the National Institutes of Health, began to mobilize an unexpectedly unified effort to beat Venter to the prize—knowledge that had the potential to revolutionize medicine and society. The stage was set for one of the most thrilling—and important—dramas in the history of science. The Genome War is the definitive account of that drama—the race for the greatest prize biology has had to offer, told by a writer with exclusive access to Venter’s operation from start to finish. It is also the story of how one man’s ambition created a scientific Camelot where, for a moment, it seemed that the competing interests of pure science and commercial profit might be gloriously reconciled—and the national repercussions that resulted when that dream went awry.From the Hardcover edition.

    Written for the non-scientist, Gaia is a journey through time and space in search of evidence with which to support a new and radically different model of our planet. In contrast to conventional belief that living matter is passive in the face of threats to its existence, the book explores the hypothesis that the earth's living matter-air, ocean, and land surfaces-forms a complex system that has the capacity to keep the Earth a fit place for life. Since Gaia was first published, many of Jim Lovelock's predictions have come true, and his theory has become a hotly argued topic in scientific circles. Here, in a new Preface, Lovelock outlines his present state of the debate.

    In all the current highly publicized debates about creationism and its descendant "intelligent design," there is an element of the controversy that is rarely mentioned—the "evidence," the empirical truth of evolution by natural selection. Even Richard Dawkins and Stephen Jay Gould, while extolling the beauty of evolution and examining case studies, have not focused on the evidence itself. Yet the proof is vast, varied, and magnificent, drawn from many different fields of science. Scientists are observing species splitting into two and are finding more and more fossils capturing change in the past—dinosaurs that have sprouted feathers, fish that have grown limbs. Why Evolution Is True weaves together the many threads of modern work in genetics, paleontology, geology, molecular biology, and anatomy that demonstrate the "indelible stamp" of the processes first proposed by Darwin. In crisp, lucid prose accessible to a wide audience, Why Evolution Is True dispels common misunderstandings and fears about evolution and clearly confirms that this amazing process of change has been firmly established as a scientific truth.

    The majority view is that life began with replicating molecules, the precursors of modern genes. The minority belief is that random populations of molecules evolved metabolic activities before exact replication existed and that natural selection drove the evolution of cells toward greater complexity for a long time without the benefit of genes. Dyson analyzes both of these theories with reference to recent important discoveries by geologists and chemists, aiming to stimulate new experiments that could help decide which theory is correct. This second edition covers the impact revolutionary discoveries such as the existence of ribozymes, enzymes made of RNA; the likelihood that many of the most ancient creatures are thermophilic, living in hot environments; and evidence of life in the most ancient of all terrestrial rocks in Greenland have had on our ideas about how life began. It is a clearly written, fascinating book that will appeal to anyone interested in the origins of life.

    The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future.

    It produced a cloud of roiling debris that blackened the sky for months as well as other geologic disasters--and triggered the demise of Tyrannosaurus rex. We know what happened largely because Walter Alvarez--synthesizing the findings of experts from a variety of scientific fields--has written a gripping story of the decades-long search for the cause of the dinosaurs' extinction. Painstakingly assembling clues from the Italian Apennines and the depths of the Pacific and presenting them with the excitement of a great novel, T. rex and the Crater of Doom is a book of undeniable importance and irresistible appeal by a major figure in contemporary science. " Engaging and witty. Read Alvarez for and excellent account of how scientists pose questions and seek to solve them." --Scientific American " First-rate...Alvarez provides the up-close tale of the comet or asteroid that wiped out the dinosaurs." --San Francisco Chronicle

    Suppose, instead of thinking about organisms using genes to reproduce themselves, as we had since Mendel's work was rediscovered, we turn it around and imagine that "our" genes build and maintain us in order to make more genes. That simple reversal seems to answer many puzzlers which had stumped scientists for years, and we haven't thought of evolution in the same way since. Drawing fascinating examples from every field of biology, he paved the way for a serious re-evaluation of evolution. He also introduced the concept of self-reproducing ideas, or memes, which (seemingly) use humans exclusively for their propagation. If we are puppets, he says, at least we can try to understand our strings.

    His theories on the evolutionary tensions between parent and offspring, sibling and sibling, man and woman, friend and friend, and a person and himself or herself have not only revolutionized genetics and evolutionary biology but have influenced disciplines from medicine and the social sciences to history, economics, and literary studies. But unlike other renowned scientists, Trivers has spent time behind bars, drove a getaway car for Huey P. Newton, and founded an armed group in Jamaica to protect gay men from mob violence. Now, in the entertaining tradition of Surely You're Joking Mr. Feynman, Trivers tell us in his inimitable voice about the inimitable life behind the revolutionary science. He comments with irreverent wit and penetrating insight on everything from American racism to the history of psychiatry to who killed Peter Tosh, musical heir to Bob Marley. Sprinkled with anecdotes about such luminaries as Richard Dawkins and Stephen Jay Gould, and with photographs throughout, this volume is sure to enlighten and entertain anyone with an interest in science, the human condition, or the nature of creative genius. PRAISE FOR WILD LIFE"To call Robert Trivers an acclaimed biologist is an understatement akin to calling the late Richard Feynman a popular professor of physics." -- PSYCHOLOGY TODAY"Who would have guessed that arguably today’s most original thinker in evolutionary theory could possibly have led the extraordinary life Robert Trivers recounts in these pages. We are taken on a wild trip from inspired meditations on the biology of self deception, through a steamy Jamaican underworld, to Black Panthers in California, to frank appraisals of distinguished or over-rated scientists, the whole adding up to a disarmingly frank and utterly unique memoir of a rollercoaster of a life. -- RICHARD DAWKINS, bestselling author of The Selfish Gene and The God Delusion“Robert Trivers is not just a brilliant evolutionary thinker but a world-class raconteur, adventurer, kibitzer, people-watcher, jester, and provocateur. This memoir is filled with sharp and hilarious observations about the living world, not least a certain species of hairless primate, not least a certain member of that species named Robert Trivers.” – STEVEN PINKER,best-selling author of How the Mind Works and The Better Angels of Our Nature: Why Violence Has Declined“It would not be hyperbole to say that Robert Trivers is one of the most important evolutionary theorists since Charles Darwin. But contrary to the image most people have of theoretical scientists as stodgy intellectuals holed up in their offices buried in paper, Trivers' memoir reveals a man whose life has been wild in every sense of the word. A lust for life doesn’t begin to sum up a career devoted to truth, courage, and the audacity to think what no one else has thought, and to act in ways few others would dare (you’ll even learn how to defend yourself in a knife fight). If that were not enough, Trivers is witty, clever, and compassionate. This book is destined to become a classic in scientific autobiography." -- MICHAEL SHERMER, Editor in Chief, The SkepticABOUT THE AUTHORRobert Trivers is a professor of anthropology and biological sciences at Rutgers University.

    It's also a book full of entertainment and wonders. In The Song of the Dodo, we follow Quammen's keen intellect through the ideas, theories, and experiments of prominent naturalists of the last two centuries. We trail after him as he travels the world, tracking the subject of island biogeography, which encompasses nothing less than the study of the origin and extinction of all species. Why is this island idea so important? Because islands are where species most commonly go extinct -- and because, as Quammen points out, we live in an age when all of Earth's landscapes are being chopped into island-like fragments by human activity. Through his eyes, we glimpse the nature of evolution and extinction, and in so doing come to understand the monumental diversity of our planet, and the importance of preserving its wild landscapes, animals, and plants. We also meet some fascinating human characters. By the book's end we are wiser, and more deeply concerned, but Quammen leaves us with a message of excitement and hope.

    Now, in The New Science of the Human Past, Reich describes just how the human genome provides not only all the information that a fertilized human egg needs to develop but also contains within it the history of our species. He delineates how the Genomic Revolution and ancient DNA are transforming our understanding of our own lineage as modern humans; how genomics deconstructs the idea that there are no biologically meaningful differences among human populations (though without adherence to pernicious racist hierarchies); and how DNA studies reveal the deep history of human inequality--among different populations, between the sexes, and among individuals within a population.

    

    If animals could talk, we would ask them to recall their own ancestries, in particular the secrets as to how they avoided almost inevitable annihilation in the face of daily assaults by predators, climactic cataclysms, deadly infections and innate diseases.In Tears of the Cheetah, medical geneticist and conservationist Stephen J. O'Brien narrates fast-moving science adventure stories that explore the mysteries of survival among the earth's most endangered and beloved wildlife. Here we uncover the secret histories of exotic species such as Indonesian orangutans, humpback whales, and the imperiled cheetah-the world's fastest animal which nonetheless cannot escape its own genetic weaknesses.Among these genetic detective stories we also discover how the Serengeti lions have lived with FIV (the feline version of HIV), where giant pandas really come from, how bold genetic action pulled the Florida panther from the edge of extinction, how the survivors of the medieval Black Death passed on a genetic gift to their descendents, and how mapping the genome of the domestic cat solved a murder case in Canada.With each riveting account of animal resilience and adaptation, a remarkable parallel in human medicine is drawn, adding yet another rationale for species conservation-mining their genomes for cures to our own fatal diseases. Tears of the Cheetah offers a fascinating glimpse of the insight gained when geneticists venutre into the wild.

    

    It hold the remains of an ancient sea where dozens of strange creatures lived—a forgotten corner of evolution preserved in awesome detail. In this book Stephen Jay Gould explores what the Burgess Shale tells us about evolution and the nature of history.