New emphasis has been given to complexity, networks, and patterns of organisation, leading to a novel kind of 'systemic' thinking. This volume integrates the ideas, models, and theories underlying the systems view of life into a single coherent framework. Taking a broad sweep through history and across scientific disciplines, the authors examine the appearance of key concepts such as autopoiesis, dissipative structures, social networks, and a systemic understanding of evolution. The implications of the systems view of life for health care, management, and our global ecological and economic crises are also discussed. Written primarily for undergraduates, it is also essential reading for graduate students and researchers interested in understanding the new systemic conception of life and its implications for a broad range of professions - from economics and politics to medicine, psychology and law.

    Wallace, a contemporary of Charles Darwin, spent nearly a decade cataloging the plant and animal species which inhabited the unique geographical area of the Malay Archipelago, and remains to this day one of the most extensive works of natural history ever written.

    We get cancer because we can't avoid it—it's a bug in the system of life itself.Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us.Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy.We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move.Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.

    Building a house would entail no more work than planting a seed in the ground. These scenarios may seem far-fetched, but pioneering geneticist George Church and science writer Ed Regis show that synthetic biology is bringing us ever closer to making such visions a reality. In Regenesis, Church and Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. Until now, nature has been the exclusive arbiter of life, death, and evolution; with synthetic biology, we now have the potential to write our own biological future. Indeed, as Church and Regis show, it even enables us to revisit crucial points in the evolution of life and, through synthetic biological techniques, choose different paths from those nature originally took. Such exploits will involve far more than just microbial tinkering. Full-blown genomic engineering will make possible incredible feats, from resurrecting woolly mammoths and other extinct organisms to creating mirror life forms with a molecular structure the opposite of our own. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

    The word conjures up images of horrific diseases sweeping the globe and killing everyone in their path. But such highly lethal illnesses almost never create pandemics. The reality is deadly serious but far more subtle.In Pandemics: What Everyone Needs to Know�, Peter Doherty, who won the Nobel Prize for his work on how the immune system recognizes virus-infected cells, offers an essential guide to one of the truly life-or-death issues of our age. In concise, question-and-answer format, he explains the causes of pandemics, how they can be counteracted with vaccines and drugs, and how we can better prepare for them in the future. Doherty notes that the term "pandemic" refers not to a disease's severity but to its ability to spread rapidly over a wide geographical area. Extremely lethal pathogens are usually quickly identified and confined. Nevertheless, the rise of high-speed transportation networks and the globalization of trade and travel have radically accelerated the spread of diseases. A traveler from Africa arrived in New York in 1999 carrying the West Nile virus; one mosquito bite later, it was loose in the ecosystem. Doherty explains how the main threat of a pandemic comes from respiratory viruses, such as influenza and SARS, which disseminate with incredible speed through air travel. The climate disruptions of global warming, rising population density, and growing antibiotic resistance all complicate efforts to control pandemics. But Doherty stresses that pandemics can be fought effectively. Often simple health practices, especially in hospitals, can help enormously. And research into the animal reservoirs of pathogens, from SARS in bats to HIV in chimpanzees, show promise for our prevention efforts.Calm, clear, and authoritative, Peter Doherty's Pandemics is one of the most critically important additions to the What Everyone Needs to Know� series.What Everyone Needs to Know� is a registered trademark of Oxford University Press.

    Around 95% of all living species died out--a global catastrophe far greater than the dinosaurs' demise 65 million years ago. How this happened remains a mystery. But there are many competing theories. Some blame huge volcanic eruptions that covered an area as large as the continental United States; others argue for sudden changes in ocean levels and chemistry, including burps of methane gas; and still others cite the impact of an extraterrestrial object, similar to what caused the dinosaurs' extinction. Extinction is a paleontological mystery story. Here, the world's foremost authority on the subject provides a fascinating overview of the evidence for and against a whole host of hypotheses concerning this cataclysmic event that unfolded at the end of the Permian.After setting the scene, Erwin introduces the suite of possible perpetrators and the types of evidence paleontologists seek. He then unveils the actual evidence--moving from China, where much of the best evidence is found; to a look at extinction in the oceans; to the extraordinary fossil animals of the Karoo Desert of South Africa. Erwin reviews the evidence for each of the hypotheses before presenting his own view of what happened.Although full recovery took tens of millions of years, this most massive of mass extinctions was a powerful creative force, setting the stage for the development of the world as we know it today.

    Yet only now, with the publication of Voyaging, the first of two volumes that will constitute the definitive biography, do we have a truly vivid and comprehensive picture of Darwin as man and as scientist. Drawing upon much new material, supported by an unmatched acquaintance with both the intellectual setting and the voluminous sources, Janet Browne has at last been able to unravel the central enigma of Darwin's career: how did this amiable young gentleman, born into a prosperous provincial English family, grow into a thinker capable of challenging the most basic principles of religion and science? The dramatic story of Voyaging takes us from agonizing personal challenges to the exhilaration of discovery; we see a young, inquisitive Darwin gradually mature, shaping, refining, and finally setting forth the ideas that would at last fall upon the world like a thunderclap in The Origin of Species.

    Humans have feared them for centuries, long considering them the assassins and pariahs of the natural world.Now, in Venomous, the biologist Christie Wilcox investigates and illuminates the animals of our nightmares, arguing that they hold the keys to a deeper understanding of evolution, adaptation, and immunity. She reveals just how venoms function and what they do to the human body. With Wilcox as our guide, we encounter a jellyfish with tentacles covered in stinging cells that can kill humans in minutes; a two-inch caterpillar with toxic bristles that trigger hemorrhaging; and a stunning blue-ringed octopus capable of inducing total paralysis. How do these animals go about their deadly work? How did they develop such intricate, potent toxins? Wilcox takes us around the world and down to the cellular level to find out.Throughout her journey, Wilcox meets the intrepid scientists who risk their lives studying these lethal beasts, as well as “self-immunizers” who deliberately expose themselves to snakebites. Along the way, she puts her own life on the line, narrowly avoiding being envenomated herself. Drawing on her own research, Wilcox explains how venom scientists are untangling the mechanisms of some of our most devastating diseases, and reports on pharmacologists who are already exploiting venoms to produce lifesaving drugs. We discover that venomous creatures are in fact keystone species that play crucial roles in their ecosystems and ours—and for this alone, they ought to be protected and appreciated.Thrilling and surprising at every turn, Venomous will change everything you thought you knew about the planet’s most dangerous animals.

    It presents the important traditional content of mineralogy including crystallography, chemical bonding, controls on mineral structure, mineral stability, and crystal growth to provide a foundation that enables students to understand the nature and occurrence of minerals. Physical, optical, and X-ray powder diffraction techniques of mineral study are described in detail, and common chemical analytical methods are outlined as well. Detailed descriptions of over 100 common minerals are provided, and the geologic context within which these minerals occur is emphasized. Appendices provide tables and diagrams to help students with mineral identification, using both physical and optical properties. Numerous line drawings, photographs, and photomicrographs help make complex concepts understandable. Introduction to Mineralogy not only provides specific knowledge about minerals but also helps students develop the intellectual tools essential for a solid, scientific education. This comprehensive text is useful for undergraduate students in a wide range of mineralogy courses.

    His simple but staggering theory of quantum evolution shows how quantum mechanics gives living organisms the ability to initiate specific actions, including new mutations. As Paul Davies exclaims, "if these ideas are right, they will transform our understanding of the relationship between physics and biology" and may radically revise the notion of random evolution and the debate over consciousness and free will.

    Evolutionary Dynamics is concerned with these equations of life. In this book, Martin A. Nowak draws on the languages of biology and mathematics to outline the mathematical principles according to which life evolves. His work introduces readers to the powerful yet simple laws that govern the evolution of living systems, no matter how complicated they might seem. Evolution has become a mathematical theory, Nowak suggests, and any idea of an evolutionary process or mechanism should be studied in the context of the mathematical equations of evolutionary dynamics. His book presents a range of analytical tools that can be used to this end: fitness landscapes, mutation matrices, genomic sequence space, random drift, quasispecies, replicators, the Prisoner's Dilemma, games in finite and infinite populations, evolutionary graph theory, games on grids, evolutionary kaleidoscopes, fractals, and spatial chaos. Nowak then shows how evolutionary dynamics applies to critical real-world problems, including the progression of viral diseases such as AIDS, the virulence of infectious agents, the unpredictable mutations that lead to cancer, the evolution of altruism, and even the evolution of human language. His book makes a clear and compelling case for understanding every living system--and everything that arises as a consequence of living systems--in terms of evolutionary dynamics.

    Cells are built out of molecular circuits that perform logical operations, as electronic devices do, but with unique properties. Bray argues that the computational juice of cells provides the basis of all the distinctive properties of living systems: it allows organisms to embody in their internal structure an image of the world, and this accounts for their adaptability, responsiveness, and intelligence.In Wetware, Bray offers imaginative, wide-ranging and perceptive critiques of robotics and complexity theory, as well as many entertaining and telling anecdotes. For the general reader, the practicing scientist, and all others with an interest in the nature of life, the book is an exciting portal to some of biology’s latest discoveries and ideas.

    Readable and stimulating, yet well-balanced and in-depth, this text tells the story of evolution, from the history of the study to the most revent developments in evolutionary theory. The third edition of this successful textbook features updates and extensive new coverage. The sections on adaptation and diversity have been reorganized for improved clarity and flow, and a completely updated section on the evolution of sex and the inclusion of more plant examples have all helped to shape this new edition. Evolution also features strong, balanced coverage of population genetics, and scores of new applied plant and animal examples make this edition even more accessible and engaging. Dedicated website - provides an interactive experience of the book, with illustrations downloadable to PowerPoint, and a full supplemental package complementing the book - www.blackwellpublishing.com/ridley. Margin icons - indicate where there is relevant information included in the dedicated website. Two new chapters - one on evolutionary genomics and one on evolution and development bring state-of-the-art information to the coverage of evolutionary study. Two kinds of boxes - one featuring practical applications and the other related information, supply added depth without interrupting the flow of the text. Margin comments - paraphrase and highlight key concepts. Study and review questions - help students review their understanding at the end of each chapter, while new challenge questions prompt students to synthesize the chapter concepts to reinforce the learning at a deeper level.

    According to revolutionary new research, some birds rival primates and even humans in their remarkable forms of intelligence. In The Genius of Birds, acclaimed author Jennifer Ackerman explores their newly discovered brilliance and how it came about. As she travels around the world to the most cutting-edge frontiers of research, Ackerman not only tells the story of the recently uncovered genius of birds but also delves deeply into the latest findings about the bird brain itself that are shifting our view of what it means to be intelligent. At once personal yet scientific, richly informative and beautifully written, The Genius of Birds celebrates the triumphs of these surprising and fiercely intelligent creatures.

    Their first intimation of our existence might well be a Super Bowl broadcast or a stray transmission from the Playboy channel. But, of course, they might seem equally strange to us. How strange? Their senses could be entirely different from ours—they might see in the infrared or “hear” radio waves.What would aliens look like? An intelligent octopus-like creature is certainly plausible. What about odd numbers of limbs—a three-legged alien with three arms and three eyes? What about an entire planet of immobile, silicon-based “trees” that communicate with each other via electrical signals?The Science of Aliens gets weirder still. Could a giant interstellar cloud be “alive” and intelligent? Could creatures live at extremely high pressures and temperatures? And which of these many possibilities would be similar enough to us that they could communicate with them, or they with us? Would they have any interest in abducting us? Would they want to have sex with us?In classic Pickover style, here is speculation at the far edge of knowledge—and beyond.