But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    In The Compatibility Gene, one of our foremost immunologists tells the remarkable history of these genes' discovery and the unlocking of their secrets. Davis shows how the compatibility gene is radically transforming our knowledge of the way our bodies work - and is having profound consequences for medical research and ethics. Looking to the future, he considers the startling possibilities of what these wondrous discoveries might mean for you and me.

    Drawing partly on his own career—from young scientist in awe of his elders to crotchety elder statesman—Tattersall offers an idiosyncratic look at the competitive world of paleoanthropology, beginning with Charles Darwin 150 years ago, and continuing through the Leakey dynasty in Africa, and concluding with the latest astonishing findings in the Caucasus.The book's title refers to the 1856 discovery of a clearly very old skull cap in Germany's Neander Valley. The possessor had a brain as large as a modern human, but a heavy low braincase with a prominent brow ridge. Scientists tried hard to explain away the inconvenient possibility that this was not actually our direct relative. One extreme interpretation suggested that the preserved leg bones were curved by both rickets, and by a life on horseback. The pain of the unfortunate individual's affliction had caused him to chronically furrow his brow in agony, leading to the excessive development of bone above the eye sockets.The subsequent history of human evolutionary studies is full of similarly fanciful interpretations. With tact and humor, Tattersall concludes that we are not the perfected products of natural processes, but instead the result of substantial doses of random happenstance.

    The Repository for Germinal Choice–nicknamed the Nobel Prize sperm bank–opened to notorious fanfare in 1980, and for two decades, women flocked to it from all over the country to choose a sperm donor from its roster of Nobel-laureate scientists, mathematical prodigies, successful businessmen, and star athletes. But the bank quietly closed its doors in 1999–its founder dead, its confidential records sealed, and the fate of its children and donors unknown. In early 2001, award-winning columnist David Plotz set out to solve the mystery of the Nobel Prize sperm bank.Plotz wrote an article for Slate inviting readers to contact him–confidentially–if they knew anything about the bank. The next morning, he received an email response, then another, and another–each person desperate to talk about something they had kept hidden for years. Now, in The Genius Factory, Plotz unfolds the full and astonishing story of the Nobel Prize sperm bank and its founder’s radical scheme to change our world.Believing America was facing genetic catastrophe, Robert Graham, an eccentric millionaire, decided he could reverse the decline by artificially inseminating women with the sperm of geniuses. In February 1980, Graham opened the Repository for Germinal Choice and stocked it with the seed of gifted scientists, inventors, and thinkers. Over the next nineteen years, Graham’s “genius factory” produced more than two hundred children.What happened to them? Were they the brilliant offspring that Graham expected? Did any of the “superman” fathers care about the unknown sons and daughters who bore their genes? What were the mothers like? Crisscrossing the country and logging countless hours online, Plotz succeeded in tracking down previously unknown family members–teenage half-brothers who ended up following vastly different paths, mothers who had wondered for years about the identities of the donors they had selected on the basis of code names and brief character profiles, fathers who were proud or ashamed or simply curious about the children who had been created from their sperm samples. The children of the “genius factory” are messengers from the future–a future that is bearing down on us fast. What will families be like when parents routinely “shop” for their kids’ genes? What will children be like when they’re programmed for greatness? In this stunning, eye-opening book, one of our finest young journalists previews America’s coming age of genetic expectations.From the Hardcover edition.

    Although America is the most medically advanced place in the world, many people disregard modern medicine in favor of using their faith to fight life threatening illnesses. Christian Scientists pray for healing instead of going to the doctor, Jehovah's Witnesses refuse blood transfusions, and ultra-Orthodox Jewish mohels spread herpes by using a primitive ritual to clean the wound. Tragically, children suffer and die every year from treatable diseases, and in most states it is legal for parents to deny their children care for religious reasons. In twenty-first century America, how could this be happening? In Bad Faith, acclaimed physician and author Dr. Paul Offit gives readers a never-before-seen look into the minds of those who choose to medically martyr themselves, or their children, in the name of religion. Offit chronicles the stories of these faithful and their children, whose devastating experiences highlight the tangled relationship between religion and medicine in America. Religious or not, this issue reaches everyone -- whether you are seeking treatment at a Catholic hospital or trying to keep your kids safe from diseases spread by their unvaccinated peers. Replete with vivid storytelling and complex, compelling characters, Bad Faith makes a strenuous case that denying medicine to children in the name of religion isn't't just unwise and immoral, but a rejection of the very best aspects of what belief itself has to offer.

    Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

    In helping Memorial Medical Center build a culture of ownership, Carol Jean Hawtrey with the help of Florence Nightingale create a roadmap that every hospital can follow to create a more positive and productive workplace and a build a sustainable source of competitive advantage. In the form of a business parable, the story shows readers why the invisible architecture of core values, corporate culture, and emotional climate is more important than bricks and mortar for creating patient, physician and employee loyalty, and describes eight essential characteristics of a culture of ownership. Dozens of practical strategies for fostering a more positive and productive organization are woven into the story.

    In just 40 days, YOU THE HEALER can teach readers how to use the power of their brains to place them firmly on the path to good health.

    Slip this lovely little book into your purse or bag and take it with you wherever you go. Turn the pages as you are drawn -- you can be inspired every day or once an hour, or you can meditate on your favorite thought all month. Use it as an oracle, or to stimulate deeper insight, joy, and appreciation of your life and the lives of others. This powerful volume is for those who are growing in consciousness and for those who want to. It is the perfect gift for someone you love or for yourself.

    Adopting one-year-old twin girls seemed like an answer to desperate prayers. But when one girl is caught trying to kill her sister with a knife on Christmas Eve four years later, the Bradleys have no choice but to return the disturbed child to the care of an orphanage. Sixteen years pass before their actions come back to haunt them, and by then Paul and Gina's marriage is in trouble; the only light in their lives is Rachel, the child they raised. Then Rachel is kidnapped, and the sacrifice Paul and Gina must make to ensure her safe return results in their own utter humiliation. Will they have the strength to get her back?

    Most people equate it with wealth, power, and happiness. However, true success is not a thing you acquire or achieve. Rather, it is a journey you take your whole life long. In a refreshingly straightforward style, John Maxwell shares unique insights into what it means to be successful. And he reveals a definition that puts genuine success within your reach yet motivates you to keep striving for your dreams. I want to help you discover your personal road map for success, teach you what it means to be on the success journey, answer many of your questions, and equip you with what you'll need to change yourself and keep growing. - John C. Maxwell

    Instead, he founded our nation's leading nonprofit organization for protecting factory farmed animals. In Mercy For Animals, Nathan brings us into the trenches of his organization's work; from MFA's early days in grassroots activism, to dangerous and dramatic experiences doing undercover investigations, to the organization's current large-scale efforts at making sweeping legislative change to protect factory farmed animals and encourage compassionate food choices.But this isn't just Nathan's story. Mercy For Animals examines how our country moved from a network of small, local farms with more than 50 percent of Americans involved in agriculture to a massive coast-to-coast industrial complex controlled by a mere 1 percent of our population--and the consequences of this drastic change on animals as well as our global and local environments. We also learn how MFA strives to protect farmed animals in behind-the-scenes negotiations with companies like Nestle and other brand names--conglomerates whose policy changes can save countless lives and strengthen our planet. Alongside this unflinching snapshot of our current food system, readers are also offered hope and solutions--big and small--for ending mistreatment of factory farmed animals. From simple diet modifications to a clear explanation of how to contact corporations and legislators efficiently, Mercy For Animals proves that you don't have to be a hardcore vegan or an animal-rights activist to make a powerful difference in the lives of animals.

    They force us to confront a fundamental biological problem: how can something as large and complex as a human body organize itself from the simplicity of a fertilized egg? A convergence of ideas from embryology, genetics, physics, networks, and control theory has begun to provide real answers. Based on the central principle of 'adaptive self-organization, ' it explains how the interactions of many cells, and of the tiny molecular machines that run them, can organize tissue structures vastly larger than themselves, correcting errors as they go along and creating new layers of complexity where there were none before.Life Unfolding tells the story of human development from egg to adult, from this perspective, showing how our whole understanding of how we come to be has been transformed in recent years. Highlighting how embryological knowledge is being used to understand why bodies age and fail, Jamie A. Daviesexplores the profound and fascinating impacts of our newfound knowledge.

    But nowhere is this drive to do better more important than in medicine, where lives are on the line with every decision. In his new book, Atul Gawande explores how doctors strive to close the gap between best intentions and best performance in the face of obstacles that sometimes seem insurmountable. Gawande's gripping stories of diligence, ingenuity, and what it means to do right by people take us to battlefield surgical tents in Iraq, to labor and delivery rooms in Boston, to a polio outbreak in India, and to malpractice courtrooms around the country. He discusses the ethical dilemmas of doctors participation in lethal injections, examines the influence of money on modern medicine, and recounts the astoundingly contentious history of hand washing. And as in all his writing, Gawande gives us an inside look at his own life as a practicing surgeon, offering a searingly honest firsthand account of work in a field where mistakes are both unavoidable and unthinkable. At once unflinching and compassionate, Better is an exhilarating journey narrated by arguably the best nonfiction doctor-writer around (Salon). Gawande's investigation into medical professionals and how they progress from merely good to great provides rare insight into the elements of success, illuminating every area of human endeavor.

    Michael Baden's first-person, no-holds-barred account of his distinguished career in forensic pathology. In determining the causes of tens of thousands of deaths, from those of presidents and rock stars to victims of serial killings, exotic sex rituals, mass disasters, child abuse and drug abuse, Baden has come to the unavoidable conclusion that the search for scientific truth is often sullied by the pressures of expediency. He produces dramatic evidence to demonstrate that political intrigue, influence peddling, and professional incompetence have created a national crisis in forensic medicine.