This volume also features increased coverage of computational modelling, discussions of prominent methodological advances and an enhanced art programme.

    What is going on? Anatomy of an Epidemic challenges readers to think through that question themselves. First, Whitaker investigates what is known today about the biological causes of mental disorders. Do psychiatric medications fix “chemical imbalances” in the brain, or do they, in fact, create them? Researchers spent decades studying that question, and by the late 1980s, they had their answer. Readers will be startled—and dismayed—to discover what was reported in the scientific journals. Then comes the scientific query at the heart of this book: During the past fifty years, when investigators looked at how psychiatric drugs affected long-term outcomes, what did they find? Did they discover that the drugs help people stay well? Function better? Enjoy good physical health? Or did they find that these medications, for some paradoxical reason, increase the likelihood that people will become chronically ill, less able to function well, more prone to physical illness?  This is the first book to look at the merits of psychiatric medications through the prism of long-term results. Are long-term recovery rates higher for medicated or unmedicated schizophrenia patients? Does taking an antidepressant decrease or increase the risk that a depressed person will become disabled by the disorder? Do bipolar patients fare better today than they did forty years ago, or much worse? When the National Institute of Mental Health (NIMH) studied the long-term outcomes of children with ADHD, did they determine that stimulants provide any benefit?  By the end of this review of the outcomes literature, readers are certain to have a haunting question of their own: Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public?  In this compelling history, Whitaker also tells the personal stories of children and adults swept up in this epidemic. Finally, he reports on innovative programs of psychiatric care in Europe and the United States that are producing good long-term outcomes. Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up.

    A gifted writer, Vertosick shows us that intelligence - the ability to react to the outside world, to change behaviour, to survive - can be found wherever life exists. He demonstrates the keen intelligence of our immune system, how lowly bacteria mutate and outwit antibiotics, and how canny cancer cells elude our natural defences.

    In the midst of all this death, a bizarre disease appeared in Europe. Eventually known as encephalitis lethargica, or sleeping sickness, it would spread across the world, leaving millions dead or locked in institutions. Then, in 1927, it would disappear as suddenly as it had arrived-or so the doctors at first thought. Asleep, set in 1920s and '30s New York, follows a group of neurologists through hospitals and insane asylums as they try to solve this worldwide epidemic. The symptoms could include not only unending sleep but dangerous insomnia, facial tics, catatonia, Parkinson's, and even violent insanity. Molly Caldwell Crosby, acclaimed author of The American Plague, explores the frightening history of this forgotten disease- and details the frantic effort to conquer it before it strikes again.

    In 1992, in a remote mountain range, a team of scientists discovered the remains of an unusual animal with exquisite long horns. It turned out to be a living species new to Western science -- a saola, the first large land mammal discovered in fifty years. Rare then and rarer now, a live saola had never been glimpsed by a Westerner in the wild when Pulitzer Prize finalist and nature writer William deBuys and conservation biologist William Robichaud set off to search for it in central Laos. Their team endured a punishing trek up and down white-water rivers and through mountainous terrain ribboned with the snare lines of armed poachers who roamed the forest, stripping it of wildlife. In the tradition of Bruce Chatwin, Colin Thubron, and Peter Matthiessen, The Last Unicorn chronicles deBuys's journey deep into one of the world's most remote places. It's a story rich with the joys and sorrows of an expedition into undiscovered country, pursuing a species as rare and elusive as the fabled unicorn. As is true with the quest for the unicorn, in the end the expedition becomes a search for something more: the essence of wildness in nature, evidence that the soul of a place can endure, and the transformative power of natural beauty.

    The renowned biologist Daniel Chamovitz builds on the original edition to present an intriguing look at how plants themselves experience the world—from the colors they see to the schedules they keep, and now, what they do in fact hear and how they are able to taste. A rare inside look at what life is really like for the grass we walk on, the flowers we sniff, and the trees we climb, What a Plant Knows offers a greater understanding of their place in nature.

    The new edition provides invitations - not requirements - to use technology, as well as new conceptual problems, and new projects that focus on writing and working in teams.

    While these are essential, many young ecologists need to figure out how to actually do research themselves. How to Do Ecology provides nuts-and-bolts advice on how to develop a successful thesis and research program. This book presents different approaches to posing testable ecological questions. In particular, it covers the uses, strengths, and limitations of manipulative experiments in ecology. It will help young ecologists consider meaningful treatments, controls, replication, independence, and randomization in experiments, as well as where to do experiments and how to organize a season of work. This book also presents strategies for analyzing natural patterns, the value of alternative hypotheses, and what to do with negative results.Science is only part of being a successful ecologist. This engagingly written book offers students advice on working with other people and navigating their way through the land mines of research. Findings that don't get communicated are of little value. How to Do Ecology suggests effective ways to communicate information in the form of journal articles, oral presentations, and posters. Finally, it outlines strategies for developing successful grant and research proposals. Numerous checklists, figures, and boxes throughout the book summarize and reinforce the main points. In short, this book makes explicit many of the unspoken assumptions behind doing good research in ecology, and provides an invaluable resource for meaningful conversations among ecologists.

    The book teaches the basic tools for the design of digital circuits in a clear, easily accessible manner. New to This Edition: *Nine sections on Verilog Hardware Description Language (HDL) inserted in discrete sections, allowing the material to be covered or skipped as desired. The Verilog HDL presentation is at a suitable level for beginning students who are learning digital circuits for the first time. *Reorganized material on combinational circuits is now covered in a single chapter. *The emphasis in the sequential circuits chapters is now on design with D flip-flops instead of JK and SR flip-flops. *The material on memory and programmable logic is now consolidated in one chapter. *Chapter 8 consists mostly of new material and now covers digital design in the Register Transfer Level (P) FL), preparing the reader for more advanced design projects and further Verilog HDL studies. *A new section in Chapter 11 supplements the laboratory experiments with HDL experiments. These unable the reader to check the circuits designed in the laboratory by means of hardware components and/or by HDL simulation.* Text accompanied by Verilog simulator software-SynaptiCAD's VeriLogger Pro evaluation version, a Verilog simulation environment that combines all of the features of a traditional Verilog simulator with a powerful graphical test vector generator. Fast model testing in VeriLogger Pro allows the reader to perform bottom-up testing of every model in a design. All of the HDL examples in the book can be found on the CD-ROM. *A Companion Website includes resources for instructors and students such as transparency masters of all figures in the book, all HDL code examples from the book, a Verilog tutorial, tutorials on using the VeriLogger Pro software, and more. It can be found at http://www.prenhall.com/mano

    This introductory, one-semester text is designed for non-majors.

    This chance encounter in the basement of the Natural History Museum of Los Angeles County sparked Troll’s obsession with Helicoprion, a mysterious monster from deep time.In 2010, tattooed undergraduate student and returning Iraq War veteran Jesse Pruitt became seriously smitten with a Helicoprion fossil in a museum basement in Idaho. These two bizarre-shark disciples found each other, and an unconventional band of collaborators grew serendipitously around them, determined to solve the puzzle of the mysterious tooth whorl once and for all.Helicoprion was a Paleozoic chondrichthyan about the size of a modern great white shark, with a circular saw of teeth centered in its lower jaw—a feature unseen in the shark world before or since. For some ten million years, long before the Age of Dinosaurs, Helicoprion patrolled the shallow seas around the supercontinent Pangaea as the apex predator of its time.Just a few tumultuous years after Pruitt and Troll met, imagination, passion, scientific process, and state-of-the-art technology merged into an unstoppable force that reanimated the remarkable creature—and made important new discoveries.In this groundbreaking book, Susan Ewing reveals these revolutionary insights into what Helicoprion looked like and how the tooth whorl functioned—pushing this dazzling and awe-inspiring beast into the spotlight of modern science.

    If animals could talk, we would ask them to recall their own ancestries, in particular the secrets as to how they avoided almost inevitable annihilation in the face of daily assaults by predators, climactic cataclysms, deadly infections and innate diseases.In Tears of the Cheetah, medical geneticist and conservationist Stephen J. O'Brien narrates fast-moving science adventure stories that explore the mysteries of survival among the earth's most endangered and beloved wildlife. Here we uncover the secret histories of exotic species such as Indonesian orangutans, humpback whales, and the imperiled cheetah-the world's fastest animal which nonetheless cannot escape its own genetic weaknesses.Among these genetic detective stories we also discover how the Serengeti lions have lived with FIV (the feline version of HIV), where giant pandas really come from, how bold genetic action pulled the Florida panther from the edge of extinction, how the survivors of the medieval Black Death passed on a genetic gift to their descendents, and how mapping the genome of the domestic cat solved a murder case in Canada.With each riveting account of animal resilience and adaptation, a remarkable parallel in human medicine is drawn, adding yet another rationale for species conservation-mining their genomes for cures to our own fatal diseases. Tears of the Cheetah offers a fascinating glimpse of the insight gained when geneticists venutre into the wild.

    The material is presented in a brief and quick-access format which allows for topic and exam review. It provides enough detailed and specific information to address most all questions and problems that arise in the ICU. Emphasis on fundamental principles in the text should prove useful for patient care outside the ICU as well.New chapters in this edition include hyperthermia and hypothermia syndromes; infection control in the ICU; and severe airflow obstruction. Sections have been reorganized and consolidated when appropriate to reinforce concepts.Purchase The ICU Book, Third Edition and visit TheICUBook.com, which gives you free access to links from references to PubMed, updated regularly; and a directory of Websites handpicked by Dr. Marino.

    Its signature outline format, full-color illustrations, and end-of-chapter summaries and USMLE-style review questions make it one of the most user-friendly books in the field. New features include boxed, high-yield facts throughout each chapter and expanded coverage of molecular biology.A companion Website features fully searchable online text and additional USMLE-style questions for students and an Image Bank for faculty.

    The book starts with a section on general cell structure and replication. Basic tissue types are covered in the following section, and the third section presents the microstructures of each of the major body systems. The highest -quality color light micrographs and electron micrograph images are accompanied by concise text and captions which explain the appearance, function, and clinical significance of each image. The accompanying website lets you view all the images from the atlas with a virtual microscope, allowing you to view the image at a variety of pre-set magnifications.Includes access to website containing book images and additional material, extra illustrations, self tests, and more. Utilizes virtual microscope function on the website, allowing you to see images first in low-powered and then in high powered magnification. Incorporates new information on histology of bone marrow, male reproductive system, respiratory system, pancreas, blood, cartilage, muscle types, staining methods, and more. Uses Color coding at the side of each page to make it easier to access information quickly and efficiently. Includes access to www.studentconsult.com - where you'll find the complete text and illustrations of the book online, fully searchable - Integration Links to bonus content in other STUDENT CONSULT titles - 300 new USMLE-style review questions, with answers and rationales - content clipping for handheld devices - an interactive community center with a wealth of additional resources - and much more!