She’s been moved around the system since she left home at sixteen. She’s also been called a stain on society. And she’s caught in a poverty trap.Skint Estate is the hard-hitting debut memoir about impoverishment, loneliness and violence – set against a grim landscape of sink estates, police cells, refuges and peepshows.

    With swashbuckling wit and fierce honesty, she dishes on herself and her colleagues as they try to prod reluctant governments to fund HIV prevention for the people who need it most—drug injectors, gay men, sex workers, and johns.Pisani chats with flamboyant Indonesian transsexuals about their boob jobs and watches Chinese streetwalkers turn away clients because their SUVs aren't nice enough. With verve and clarity, she shows the general reader how her profession really works; how easy it is to draw wrong conclusions from "objective" data; and, shockingly, how much money is spent so very badly. "Exhibit A": the 45 billion taxpayer dollars the Bush administration is committing to international AIDS programs.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    State Department in 2009, she was confident she could juggle the demands of her position in Washington, D.C., with the responsibilities of her family life in suburban New Jersey. Her husband and two young sons encouraged her to pursue the job; she had a tremendously supportive boss, Secretary of State Hillary Clinton; and she had been moving up on a high-profile career track since law school. But then life intervened. Parenting needs caused her to make a decision to leave the State Department and return to an academic career that gave her more time for her family.The reactions to her choice to leave Washington because of her kids led her to question the feminist narrative she grew up with. Her subsequent article for The Atlantic, Why Women Still Can’t Have It All, created a firestorm, sparked intense national debate, and became one of the most-read pieces in the magazine’s history.Since that time, Anne-Marie Slaughter has pushed forward even further and broken free of her long-standing assumptions about work, life, and family. In the twenty-first century, the feminist movement has stalled, and though many solutions have been proposed for how women can continue to break the glass ceiling or rise above the “motherhood penalty,” so far no solution has been able to unite all women.Now, in her refreshing and forthright voice, Anne-Marie Slaughter returns with her vision of what true equality between men and women really means and how we can get there. Slaughter takes a hard look at our reflexive beliefs—the “half-truths” we tell ourselves that are holding women back. Then she reveals the missing piece of the puzzle, a new focus that can reunite the women’s movement and provide a common banner under which both men and women can advance and thrive.With moving personal stories, individual action plans, and a broad outline for change, Anne-Marie Slaughter presents a future in which all of us can finally finish the business of equality for women and men, work and family.

    In that short time, many doctors decide on the likely diagnosis and best treatment. Often, decisions made this way are correct, but at crucial moments they can also be wrong -- with catastrophic consequences. In this myth-shattering book, Jerome Groopman pinpoints the forces and thought processes behind the decisions doctors make. Groopman explores why doctors err and shows when and how they can -- with our help -- avoid snap judgments, embrace uncertainty, communicate effectively, and deploy other skills that can profoundly impact our health. This book is the first to describe in detail the warning signs of erroneous medical thinking and reveal how new technologies may actually hinder accurate diagnoses. How Doctors Think offers direct, intelligent questions patients can ask their doctors to help them get back on track.Groopman draws on a wealth of research, extensive interviews with some of the country’s best doctors, and his own experiences as a doctor and as a patient. He has learned many of the lessons in this book the hard way, from his own mistakes and from errors his doctors made in treating his own debilitating medical problems.How Doctors Think reveals a profound new view of twenty-first-century medical practice, giving doctors and patients the vital information they need to make better judgments together.

    For many, filing the suit was a radicalizing act that empowered them to "find themselves" and stake a claim. Others lost their way in a landscape of opportunities, pressures, discouragements, and hostilities they weren't prepared to navigate.With warmth, humor, and perspective, the book also explores why changes in the law did not change everything for today's young women.

    Today he is the director of the Center for Compassion and Altruism Research and Education (CCARE) at Stanford University, of which the Dalai Lama is a founding benefactor. But back then his life was at a dead end until at twelve he wandered into a magic shop looking for a plastic thumb. Instead he met Ruth, a woman who taught him a series of exercises to ease his own suffering and manifest his greatest desires. Her final mandate was that he keep his heart open and teach these techniques to others. She gave him his first glimpse of the unique relationship between the brain and the heart.Doty would go on to put Ruth’s practices to work with extraordinary results—power and wealth that he could only imagine as a twelve-year-old, riding his orange Sting-Ray bike. But he neglects Ruth’s most important lesson, to keep his heart open, with disastrous results—until he has the opportunity to make a spectacular charitable contribution that will virtually ruin him. Part memoir, part science, part inspiration, and part practical instruction, Into the Magic Shop shows us how we can fundamentally change our lives by first changing our brains and our hearts.

    In the space of a year, it's gone from something that most Americans had never heard of to a cause claiming the mantle of civil rights.But can a boy truly be "trapped" in a girl's body? Can modern medicine really "reassign" sex? Is sex something "assigned" in the first place? What's the loving response to a friend or child experiencing a gender-identity conflict? What should our law say on these issues?When Harry Became Sally: Responding to the Transgender Moment provides thoughtful answers to all of these questions. Drawing on the best insights from biology, psychology, and philosophy, Ryan T. Anderson offers a balanced approach to the policy issues, a nuanced vision of human embodiment, and a sober and honest survey of the human costs of getting human nature wrong.He reveals a grim contrast between the media's sunny depiction and the often sad realities of gender-identity struggles. He introduces readers to people who tried to "transition" but found themselves no better off. Especially troubling is the suffering felt by adults who were encouraged to transition as children but later came to regret it.And there is a reason that many do regret it. As Anderson shows, the most helpful therapies focus not on achieving the impossible--changing bodies to conform to thoughts and feelings--but on helping people accept and even embrace the truth about their bodies and reality. This discussion will be of particular interest to parents who fear how an ideological school counselor might try to steer their child. The best evidence shows that the vast majority of children naturally grow out of any gender-conflicted phase. But no one knows how new school policies might affect children indoctrinated to believe that they really are trapped in the "wrong" body.Throughout the book, Anderson highlights the various contradictions at the heart of this moment: How it embraces the gnostic idea that the real self is something other than the body, while also embracing the idea that nothing but the physical exists. How it relies on rigid sex stereotypes--in which dolls are for girls and trucks are for boys--while also insisting that gender is purely a social construct, and that there are no meaningful differences between women and men. How it assumes that feelings of identity deserve absolute respect, while the facts of our embodiment do not. How it preaches that people should be free to do as they please and define their own truth--while enforcing a ruthless campaign to coerce anyone who dares to dissent.Everyone has something at stake in today's debates about gender identity. Analyzing education and employment policies, Obama-era bathroom and locker-room mandates, politically correct speech codes and religious-freedom violations, Anderson shows how the law is being used to coerce and penalize those who believe the truth about human nature. And he shows how Americans can begin to push back with principle and prudence, compassion and grace.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    I used to say my favorite color was black to be cool, but it is pink—all shades of pink. If I have an accessory, it is probably pink. I read Vogue, and I’m not doing it ironically, though it might seem that way. I once live-tweeted the September issue.In these funny and insightful essays, Roxane Gay takes us through the journey of her evolution as a woman of color while also taking readers on a ride through culture of the last few years and commenting on the state of feminism today. The portrait that emerges is not only one of an incredibly insightful woman continually growing to understand herself and our society, but also one of our culture.Bad Feminist is a sharp, funny, and spot-on look at the ways in which the culture we consume becomes who we are, and an inspiring call-to-arms of all the ways we still need to do better.Feel me, see me, hear me, reach me --Peculiar benefits --Typical first year professor --To scratch, claw or grope clumsily or frantically --How to be friends with another woman --Girls, girls, girls --I once was Miss America --Garish, glorious spectacles --Not here to make friends --How we all lose --Reaching for catharsis : getting fat right (or wrong) and Diana Spechler's Skinny --The smooth surfaces of idyll --The careless language of sexual violence --What we hunger for --The illusion of safety/the safety of illusion --The spectacle of broken men --A tale of three coming out stories --Beyond the measure of men --Some jokes are funnier than others --Dear young ladies who love Chris Brown --So much they would let him beat them --Blurred lines, indeed --The trouble with Prince Charming, or, He who trespassed against us --The solace of preparing fried foods and other quaint remembrances from 1960s Mississippi : thoughts on The help --Surviving Django --Beyond the struggle narrative --The morality of Tyler Perry --The last day of a young black man --When less is more --The politics of respectability --When Twitter does what journalism cannot --The alienable rights of women --Holding out for a hero --A tale of two profiles --The racism we all carry --Tragedy, call, compassion, response --Bad feminist : take one --Bad feminist : take two

    The case exemplifies how the death penalty in America is a direct descendant of lynching — a system that treats the rich and guilty better than the poor and innocent.

    The daughter of immigrants, she was raised in an Oakland, California community that cared deeply about social justice; her parents--an esteemed economist from Jamaica and an admired cancer researcher from India--met as activists in the civil rights movement when they were graduate students at Berkeley. Growing up, Harris herself never hid her passion for justice, and when she became a prosecutor out of law school, a deputy district attorney, she quickly established herself as one of the most innovative change agents in American law enforcement. She progressed rapidly to become the elected District Attorney for San Francisco, and then the chief law enforcement officer of the state of California as a whole. Known for bringing a voice to the voiceless, she took on the big banks during the foreclosure crisis, winning a historic settlement for California's working families. Her hallmarks were applying a holistic, data-driven approach to many of California's thorniest issues, always eschewing stale "tough on crime" rhetoric as presenting a series of false choices. Neither "tough" nor "soft" but smart on crime became her mantra. Being smart means learning the truths that can make us better as a community, and supporting those truths with all our might. That has been the pole star that guided Harris to a transformational career as the top law enforcement official in California, and it is guiding her now as a transformational United States Senator, grappling with an array of complex issues that affect her state, our country, and the world, from health care and the new economy to immigration, national security, the opioid crisis, and accelerating inequality.By reckoning with the big challenges we face together, drawing on the hard-won wisdom and insight from her own career and the work of those who have most inspired her, Kamala Harris offers in The Truths We Hold a master class in problem-solving, in crisis management, and leadership in challenging times. Through the arc of her own life, on into the great work of our day, she communicates a vision of shared struggle, shared purpose, and shared values. In a book rich in many home truths, not least is that a relatively small number of people work very hard to convince a great many of us that we have less in common than we actually do, but it falls to us to look past them and get on with the good work of living our common truth. When we do, our shared effort will continue to sustain us and this great nation, now and in the years to come.

    Home to some of the best music, athletes, soldiers, whiskey, waffles, and weather the country has to offer, the South has also been bathing in backward bathroom bills and other bigoted legislation that Trae Crowder has targeted in his Liberal Redneck videos, which have gone viral with over 50 million views. Perfect for fans of Stuff White People Like and I Am America (And So Can You), The Liberal Redneck Manifesto skewers political and religious hypocrisies in witty stories and hilarious graphics—such as the Ten Commandments of the New South—and much more! While celebrating the South as one of the richest sources of American culture, this entertaining book issues a wake-up call and a reminder that the South’s problems and dreams aren’t that far off from the rest of America’s.

    He reveals the astonishing new culture wars playing out in our workplaces, universities, schools and homes in the names of social justice, identity politics and intersectionality.We are living through a postmodern era in which the grand narratives of religion and political ideology have collapsed. In their place have emerged a crusading desire to right perceived wrongs and a weaponization of identity, both accelerated by the new forms of social and news media. Narrow sets of interests now dominate the agenda as society becomes more and more tribal--and, as Murray shows, the casualties are mounting.

    Among them: a successful, first generation Chinese immigrant musician suffering sexual dysfunction; a young woman whose father abandoned her at age nine with her younger siblings in an isolated cottage in the depth of winter; and a glamorous workaholic whose narcissistic, negligent mother greeted her each morning of her childhood with Good morning, Monster.Each patient presents a mystery, one that will only be unpacked over years. They seek Gildiner's help to overcome an immediate challenge in their lives, but discover that the source of their suffering has been long buried.As in such recent classics as The Glass Castle and Educated, each patient embodies self-reflection, stoicism, perseverance, and forgiveness as they work unflinchingly to face the truth. Gildiner's account of her journeys with them is moving, insightful, and sometimes very funny. Good Morning Monster offers an almost novelistic, behind-the-scenes look into the therapist's office, illustrating how the process can heal even the most unimaginable wounds.