And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most important—yet largely unsung—breakthroughs of the modern era. In Lithium, Walter Brown, a practicing psychiatrist and professor at Brown, reveals two unlikely success stories: that of John Cade, the physician whose discovery would come to save an untold number of lives and launch a pharmacological revolution, and that of a miraculous metal rescued from decades of stigmatization.From insulin comas and lobotomy to incarceration to exile, Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade’s “Lithium Salts in the Treatment of Psychotic Excitement” described, for the first time, lithium’s astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented.With a vivid portrait of the story’s unlikely hero, John Cade, Brown also describes a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources (Cade’s “laboratory” was the unused pantry of an isolated mental hospital). As Brown shows, however, these humble conditions were the secret to his historic success: Cade was free to follow his own restless curiosity, rather than answer to an external funding source. As Lithium makes tragically clear, medical research—at least in America—has transformed in such a way that serendipitous discoveries like Cade’s are unlikely to occur ever again.Recently described by the New York Times as the “Cinderella” of psychiatric drugs, lithium has saved countless of lives and billions of dollars in healthcare costs. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical history—revealing just how close we came to passing over this extraordinary cure.

    This book is for people who want to learn more about niacin and its wonderful healing properties.

    Over the next three months, he was seduced by the drug and descended into psychosis.This confronting and illuminating story charts Luke's recovery from the drug, and his investigation into its usage and prevalence in Australia and the western world. In examining what led to his addiction, Luke also explores the social problems that surround ice, scrutinising whether its abuse is in fact an epidemic, with what we're experiencing now merely the tip of the proverbial iceberg, or yet another moral panic about the underclass. Luke traces the history of methamphetamine from its legal usage in the early 20th century to its contemporary relevance as one of the most foreboding and talked-about illicit drugs in the world. His search for answers sees him exploring meth labs, interviewing addicts and law-enforcement officials, and witnessing firsthand the effects of the drug on individuals, families, and the healthcare system.Combining memoir with reportage, The Ice Age is a vital, compelling first-person account, and an investigation into a drug that is fast becoming the subject of national discussion throughout the western world.

    Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.Winner of the Los Angeles Times Book Prize, Blood was described by judges as "a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented."

    When death is sudden or unexplained, it falls to Shepherd to establish the cause. Each post-mortem is a detective story in its own right - and Shepherd has performed over 23,000 of them. Through his skill, dedication and insight, Dr Shepherd solves the puzzle to answer our most pressing question: how did this person die?From serial killer to natural disaster, 'perfect murder' to freak accident, Shepherd takes nothing for granted in pursuit of truth. And while he's been involved in some of the most high-profile cases of recent times, it's often the less well known encounters that prove the most perplexing, intriguing and even bizarre. In or out of the public eye, his evidence has put killers behind bars, freed the innocent and turned open-and-shut cases on their heads.But a life in death, bearing witness to some of humanity's darkest corners, exacts a price and Shepherd doesn't flinch from counting the cost to him and his family.

    In his first two books, Dr. Dale Bredesen outlined the revolutionary treatments that are changing what had previously seemed like the inevitable outcome of cognitive decline and dementia. And in these moving narratives, you can hear directly from the first survivors of Alzheimer's themselves--their own amazing stories of hope told in their own words. These first person accounts honestly detail the fear, struggle, and ultimate victory of each patient's journey. They vividly describe what it is like to have Alzheimer's. They also drill down on how each of these patients made the program work for them--the challenges, the workarounds, the encouraging results that are so motivating. Dr. Bredesen includes commentary following each story to help point readers to the tips and tricks that might help them as well.Dr. Bredesen's patients have not just survived; they have thrived to rediscover fulfilling lives, rewarding relationships, and meaningful work. This book will give unprecedented hope to patients and their families.

    During the period of 1940 to this day the power brokers, working from their positions of trust, have committed and then covered up the most heinous of crimes known to mankind. Investigative journalist Craig Roberts, author of "Kill Zone--a Sniper Looks at Dealey Plaza", now provides us with the results of his ten -year investigation regarding the secret crimes and coverups of the U.S. Government. You will read his case files on such subjects as the Japanese "Devil Unit 731" who experiments on American POWs in WWII with germ warfare weapons--and what happened when the war ended and the commanding officer was hired by the government instead of hanged for war crimes; Operation Paperclip in WWII when the U.S. brought Nazi scientists to America to work for us on our weapons programs instead of standing trial as war criminals; CIA and military mind control experiments on unsuspecting citizens--including children--without our knowledge; Secret drug and bacteriological weapons experiments on the American population; Atomic guinea pigs, Agent Orange, and the Gulf War Syndrome; what really happened to over 30,000 U.S. POWs after World War II, Korea and Vietnam; International assassinations, drug smuggling and money laundering; What the media did not tell you about the shoot down of TWA 800, the bombing of Pan AM 103, the Oklahoma City bombing, the crash of Arrow Air in Gander, Newfoundland, the derailment of the Sunset Limited in Arizona, the World Trade Center bombing in 1993, and much more….

    If something does not change—and change soon—this is almost a mathematical certainty. This book affects you also. It is not a parochial look at a trivial medical spat in the United Kingdom, but dispatches from the battlefront in a major confrontation—a struggle against compromise in medicine, corruption of science, and a real and present threat to children in the interests of policy and profit. It is a story of how ‘the system’ deals with dissent among its doctors and scientists.” In the pursuit of possible links between childhood vaccines, intestinal inflammation, and neurologic injury in children, Wakefield lost his job in London’s Royal Free Hospital, his country of birth, his career, and his medical license. A recent General Medical Council ruling stated that he was “dishonest, irresponsible and showed callous disregard for the distress and pain of children.” Maligned by the medical establishment and mainstream media, Wakefield endeavors to set the record straight in Callous Disregard. While explaining what really happened, he calls out the organizations and individuals that are acting not for the sake of children affected by autism, but in their own self-interests.

    On one side are parents, bombarded with stories about the dangers of vaccines, now wary of immunizing their sons and daughters. On the other side are doctors, scared to send kids out of their offices vulnerable to illnesses like whooping cough and measles--the diseases of their grandparents.How did anyone come to view vaccines with horror? The answer is rooted in one of the most powerful citizen activist movements in our nation's history. In Deadly Choices, infectious disease expert Paul Offit relates the shocking story of anti-vaccine America--its origins, leaders, influences, and impact. Offering strategies to keep us from returning to an era when children routinely died from infections, Deadly Choices is a vigorous and definitive rebuttal of the powerful anti-vaccine movement.

     With rivalries, reversals, and a race against time, the struggle to eradicate polio is one of the great tales of modern history. It begins with the birth of Jonas Salk, shortly before one of the worst polio epidemics in United States history. At the time, the disease was a terrifying enigma: striking from out of nowhere, it afflicted tens of thousands of children in this country each year and left them-literally overnight-paralyzed, and sometimes at death's door. Salk was in medical school just as a president crippled by the disease, Franklin D. Roosevelt, was taking office-and providing the impetus to the drive for studies on polio. By the early 1950s, Salk had already helped create an influenza vaccine, and was hot on the trail of the polio virus. He was nearly thwarted, though, by the politics of medicine and by a rival researcher eager to discredit his proposed solution. Meanwhile, in 1952, polio was spreading in record numbers, with 57,000 cases in the United States that summer alone. In early 1954, Salk was weighing the possibility of trials of a not-yet-perfected vaccine against-as the summer approached-the prospect of thousands more children being struck down by the disease. The results of the history-making trials were announced at a press conference on April 12, 1955: "The vaccine works." The room-and an entire nation-erupted in cheers for this singular medical achievement. Salk became a cultural hero and icon for a whole generation. Now, at the fiftieth anniversary of the first national vaccination program-and as humanity is tantalizingly close to eradicating polio worldwide-comes this unforgettable chronicle. Salk's work was an unparalleled achievement-and it makes for a magnificent read.

    On a spring night in 2010, Noel Holston, a journalist, songwriter, and storyteller, went to bed with reasonably intact hearing. By dawn, it was gone, thus beginning a long process of hearing-restoration that included misdiagnoses, an obstinate health-insurance bureaucracy, failed cochlear-implant surgery, and a second surgery that finally worked. He negotiated the gauntlet with a wry sense of humor and the aid of his supportive wife, Marty. Life After Deaf details his experience with warmth, understanding, and candor. It’s the story not only of his way back to the world of the hearing, but of a great marriage that weathered serious testing. Their determination and resilience serve as a source of inspiration for all.Life After Deaf is not just for the more than forty million people in the United States alone who cope with some form of hearing loss, but is also for their wide circles of friends, family, caregivers, and audiologists. This highly readable book will be an invaluable guide and source of hope for the large number of baby boomers now handling hearing loss.

    Well, I was diagnosed 24 years ago, and I still learned something new on every page.”—Michael Kinsley, Vanity Fair columnist and author of Old Age: A Beginner’s Guide Here is the book that John Vine and his wife, Joanne, wish they could have consulted when John was first diagnosed with Parkinson’s disease—a nontechnical, personal guide written from the patient’s perspective. Relying on his experiences over the past 12 years, John writes knowledgeably about all aspects of the disease. John also interviewed other Parkinson’s patients and their partners, whose stories and advice he includes throughout the book. “I wish we’d had John Vine’s book when my brother-in-law was diagnosed. The book is highly informative, unflinchingly honest, and reassuringly optimistic. It’s just what the doctor should have ordered.”—Cokie Roberts, best-selling author and political commentator on ABC News and NPR “John Vine details, in a compelling and accessible way, his experience with Parkinson’s disease. His book is an extraordinary guide to living successfully with Parkinson’s, and a must read for all who want to better understand the condition. Although diagnosed with Parkinson’s, my father lived an active and productive life until his death at age 94. As the book makes clear, while each patient’s journey is unique, common approaches are indispensable in treating the symptoms of the disease.”—Eric H. Holder, Jr. served as the 82nd Attorney General of the United States from 2009 to 2015 “John Vine has written the best primer I’ve ever read for newly diagnosed Parkinson’s patients and their families. It helps them cope with the shock of diagnosis, gives them (jargon-free) the scientific basics they need to know, describes the symptoms they may experience (making clear that every case is different) and catalogs the resources available to navigate living with Parkinson’s. John humanizes the book by describing his own experience and that of 22 other patients and their partners. I’d urge every neurologist to have copies of Vine’s primer on hand to help new PD on their journey forward.”—Morton Kondracke, author of Saving Milly: Love, Politics and Parkinson’s Disease and a member of the Founders' Council of the Michael J. Fox Foundation “My husband has PD, and I devoured this book. It’s wise, wonderfully readable, and, above all, helpful. Since John Vine has PD, he speaks with great authority about the challenges, both physical and psychological. If you have Parkinson’s, live with someone who has it, or just know someone battling the disease, A Parkinson’s Primer is for you.”—Lesley Stahl, award-winning television journalist on the CBS News program 60 Minutes “This is a remarkable book describing the personal experiences of many individuals, including the author, living with Parkinson’s disease. It captures the fact that although there are many possible symptoms in this disease, each person experiences different symptoms and copes with them in various ways. The thoughtful and insightful comments and coping strategies should be helpful for persons with PD, and their partners, regardless of the stage of the disease.”—Stephen Grill, MD, PhD, Director of the Parkinson’s & Movement Disorders Center of Maryland John M. Vine is a lawyer at Covington & Burling LLP in Washington, DC, where he is the senior member and former head of the firm’s employee benefits group. He was diagnosed with Parkinson’s in 2004.

    

    He did not crave my company, cling to and cuddle me endlessly. He showed no need to bond with me, his father, and we did not. He exhausted me, he frustrated me and he scared me. I came to dread coming home from work sometimes, or those moments when it was my turn to wrestle him into bed and begin the long struggle to settle him. I said things that will forever haunt me, like “What is wrong with that child?” and “Is he always going to be this annoying?” What I didn't know then was that he was autistic.When that realisation came, so did the beginning of my mission to understand my son, and to understand autism. This book chronicles that search for understanding and answers. It documents one parent’s attempts to come to terms with, and accept, his child. It is raw and real, sometimes confused and frightened but also, I’d like to think, written with warmth and love and an ability to smile through difficult times.This book is for anyone starting out on a pathway with their child that they did not expect. It’s also for people who, like me, are a little further down that road but still learning, still asking questions and still getting it wrong sometimes. You are not alone.

    Rejecting the idea that we should live in fear, suffer silently, or medicate ourselves unnecessarily through this hormonal shift, Mathews set out to get answers and advice from the medical establishment, alternative therapists, and her many friends in the midst of "the change." When she launched the Megs Menopause website, it quickly became the trending online destination for pre- and menopausal women all over the world.Now, in The New Hot, Mathews offers the results of all her research and discussions: the latest information about hormone treatments (hormone replacement therapy and bioidentical hormone therapy), her best tips and techniques for coping with menopausal symptoms (there are officially thirty-four possible symptoms; Mathews has dealt with thirty-two!), and dishy, girlfriend-to-girlfriend advice about what to really expect when you're aging. Entertaining, stylish, and informative, The New Hot will be the resource women everywhere are talking about, learning from, and recommending to one another.