Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine.In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. Theimmune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immuneresponses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading toserious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immunesystem v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable.

    Politicians of all stripes stress its importance, as do church leaders, captains of industry and every kind of campaigning group--from those supporting global causes, such as tackling world poverty, to others with a largely local focus, such as combating neighborhood crime. In this brilliant, compact introduction, Richard Bellamy offers an eye-opening look at an idea that is as important as it is rare--the prospect of influencing government policy according to reasonably fair rules and on a more or less equal basis with others. Bringing together the most recent scholarship, the book sheds light on how ideas of citizenship have changed through time from ancient Greece to the present, looks at concepts such as membership and belonging, and highlights the relation between citizenship, rights, and democracy. Bellamy also examines the challenges confronting the very possibility of citizenship today, the impact of globalization, the desirability of "global citizenship," the teaching of citizenship in schools, citizenship tests for immigrants, and the many different definitions and types of citizenship in modern society.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    In What If the Earth Had Two Moons, Neil Comins leads us on a fascinating ten-world journey as we explore what our planet would be like under alternative astronomical conditions. In each case, the Earth would be different, often in surprising ways. The title chapter, for example, gives us a second moon orbiting closer to Earth than the one we have now. The night sky is a lot brighter, but that won't last forever. Eventually the moons collide, with one extra-massive moon emerging after a period during which Earth sports a Saturn-like ring. This and nine and other speculative essays provide us with insights into the Earth as it exists today, while shedding new light on the burgeoning search for life on planets orbiting other stars. Appealing to adult and young adult readers alike, this book follows on the author's previous bestseller, What If the Moon Didn't Exist?, with completely new scenarios backed by the latest astronomical research.

    But Shep Doeleman and a global coalition of scientists are on the cusp of doing just that.With exclusive access to the team, journalist Seth Fletcher spent five years following Shep and an extraordinary cast of characters as they assembled the Event Horizon Telescope, a virtual radio observatory the size of the Earth. He witnessed their struggles, setbacks, and breakthroughs, and along the way, he explored the latest thinking on the most profound questions about black holes. Do they represent a limit to our ability to understand reality? Or will they reveal the clues that lead to the long-sought Theory of Everything?Fletcher transforms astrophysics into something exciting, accessible, and immediate, taking us on an incredible adventure to better understand the complexity of our galaxy, the boundaries of human perception and knowledge, and how the messy human endeavor of science really works.Weaving a compelling narrative account of human ingenuity with excursions into cutting-edge science, Einstein’s Shadow is a tale of great minds on a mission to change the way we understand our universe—and our place in it.

    John Brockman brings together the world’s best-known physicists and science writers—including Brian Greene, Walter Isaacson, Nobel Prize-winners Murray Gell-Mann and Frank Wilczek, and Brian Cox—to explain the universe in all wondrous splendor.In Universe, today’s most influential science writers explain the science behind our evolving understanding of the universe and everything in it, including the cutting edge research and discoveries that are shaping our knowledge.Lee Smolin reveals how math and cosmology are helping us create a theory of the whole universe Brian Cox offers new dimensions on the Large Hadron and the existence of a Higgs-Boson particle Neil Turok analyzes the fundamental laws of nature, what came before the big bang, and the possibility of a unified theory.Seth Lloyd investigates the impact of computational revolutions and the informational revolution Lawrence Krauss provides fresh insight into gravity, dark matter, and the energy of empty space Brian Greene and Walter Isaacson illuminate the genius who revolutionized modern science: Albert Einstein and much more.Explore the Universe with some of today’s greatest minds: what it is, how it came into being, and what may happen next.

    In thisVery Short Introduction, Alan Taylor presents an engaging overview of the best of this new scholarship. He shows that American colonization derived from a global expansion of European exploration and commerce that began in the fifteenth century. The English had to share the stage with the French, Spanish, Dutch, and Russians, each of whom created alternative Americas. By comparing the diverse colonies of rival empires, Taylor recovers what was truly distinctive about the English enterprise in North America. He focuses especially on slavery as central to the economy, culture, and politicalthought of the colonists and restores the importance of native peoples to the colonial story. To adapt to the new land, the colonists needed the expertise, guidance, alliance, and trade of the Indians who dominated the interior. This historical approach emphasizes the ability of the diverse nativesto adapt to the newcomers and to compel concessions from them.This Very Short Introduction describes an intermingling of cultures and of microbes, plants, and animals--from different continents that was unparalleled in global history.Oxford's Very Short Introductions series offers concise and original introductions to a wide range of subjects--from Islam to Sociology, Politics to Classics, Literary Theory to History, and Archaeology to the Bible. Not simply a textbook of definitions, each volume in this series provides trenchantand provocative--yet always balanced and complete--discussions of the central issues in a given discipline or field. Every Very Short Introduction gives a readable evolution of the subject in question, demonstrating how the subject has developed and how it has influenced society. Eventually, theseries will encompass every major academic discipline, offering all students an accessible and abundant reference library. Whatever the area of study that one deems important or appealing, whatever the topic that fascinates the general reader, the Very Short Introductions series has a handy andaffordable guide that will likely prove indispensable.

    The key difference is often held to be that the Greeks and Romans practiced a "Western Way of War," in which the aim is an open, decisive battle--won by courage instilled, in part, by discipline. Here, Harry Sidebottom looks at how this Western Way of War was constructed and maintained by the Greeks and Romans and why this concept is so prevalent today. All aspects of ancient warfare are thoroughly examined--from philosophy and strategy to the technical skills needed to fight. Sidebottom examines war in the wider context, showing how wars were able to shape classical society, and how an individual's identity was sometimes constructed by war, as in the case of the Christian soldier fighting in God's name. He also explores the ways in which ancient society thought about conflict: Can a war be just? Why was siege warfare particularly bloody? What role did divine intervention play in the outcome of a battle? Taking fascinating examples from the iliad, Tacitus, and the Persian Wars, Sidebottom uses arresting anecdotes and striking visual images to show that any understanding of ancient war is an ongoing process of interpretation.

    C. Cole. Once again, acclaimed science writer K. C. Cole brings the arcane and academic down to the level of armchair scientists in The Hole in the Universe, an entertaining and edifying search for nothing at all. Open the newspaper on any given day and you will read of a newly discovered planet, star, and so on. Yet scientists and mathematicians have spent generations searching the far reaches of the universe for that one elusive state—nothingness. Although this may sound like a simple task, every time the absolute void appears within reach, something new is discovered in its place: a black hole, an undulating string, an additional dimension of space or time—even another universe. A fascinating and literary tour de force, The Hole in the Universe is a virtual romp into the unknown that you never knew wasn't there.

    Beautiful photographs or illustrations accompany each entry. Open the book to any page to discover some new wonder or mystery about the Universe around us.

    Here, Timothy Lim explores the cultural and historical background of the scrolls, and examines their significance for our understanding of the Old Testament and the origins of Christianity and Judaism. Lim tells the fascinating story of the scrolls since their discouvery; their cultural context through the archaeology and history of the Dead Sea region. He explains the science behind their deciphering and dating, and does not omit the cast of characters, scandals, and controversies that have hastened the scrolls' rise to the status of cultrual icon.Beginning with their discovery in the 1940s, through the political, legal, and scholary controversies that still persist today, public interest in the Dead Sea Scrolls has remained exceptionally high. This is an accessible and well-written mini-history that will appeal to anyone interested in the true history of these fascinating documents.

    It tackles many questions, such as: What accounts for the perpetuation of ethnic and religious conflict in Ireland? Why has armedviolence proven so hard to control? Who are the major figures and issues in the conflict? Can we expect more Northern Irelands in the future?

    He was also its most formidable critic, condemning the political, economic, theological, and sexual trappings of civilization along lines that would excite the enthusiasm of romantic individualists and radical revolutionaries alike. In this study of Rousseau's life and works, Robert Wolker shows how his philosophy of history, his theories of music and politics, his fiction, educational, and religious writings, and even his botany, were all inspired by revolutionary ideals of mankind's self-realization in a condition of unfettered freedom. He explains how, in regressing to classical republicanism, ancient mythology, direct communication with God, and solitude, Rousseau anticipated some post-modernist rejections of the Enlightenment as well.

    During that time, it has spread among the neighboring peoples - the Mongol, Himalayan, and Siberian peoples, Manchus and Chinese. At its height is has been practiced in regions as far west as the Volga river and to the east in Beijing. Its capacity for creative adaptation is demonstrated by its recent growth in Europe and America. At the same time, it is at the center of political contestation in ethnically Tibetan regions of China, while its best known exponent, the Dalai Lama, has become one of the most admired religious leaders in the world today. But what does this religion teach? Just what is the position of the Dalai Lama, and how will his succession be assured? Is it true that Tibetan Buddhism in entirely suppressed in China? Scholar Matthew Kapstein offers a brief account responding to these questions and more in this Very Short Introduction, in terms that are accessible to students, general readers, journalists, and others who are curious to learn the most essential features of Tibetan Buddhist history, teachings, and practice. About the Series: Oxford's Very Short Introductions series offers concise and original introductions to a wide range of subjects--from Islam to Sociology, Politics to Classics, Literary Theory to History, and Archaeology to the Bible. Not simply a textbook of definitions, each volume in this series provides trenchant and provocative--yet always balanced and complete--discussions of the central issues in a given discipline or field. Every Very Short Introduction gives a readable evolution of the subject in question, demonstrating how the subject has developed and how it has influenced society. Eventually, the series will encompass every major academic discipline, offering all students an accessible and abundant reference library. Whatever the area of study that one deems important or appealing, whatever the topic that fascinates the general reader, the Very Short Introductions series has a handy and affordable guide that will likely prove indispensable.

    Yet recent theories suggest that there is far more to the universe than what our instruments record--in fact, it could be infinite. Colossal flows of galaxies, large empty regions called voids, and other unexplained phenomena offer clues that our own "bubble universe" could be part of a greater realm called the multiverse. How big is the observable universe? What it is made of? What lies beyond it? Was there a time before the Big Bang? Could space have unseen dimensions? In this book, physicist and science writer Paul Halpern explains what we know--and what we hope to soon find out--about our extraordinary cosmos.Explains what we know about the Big Bang, the accelerating universe, dark energy, dark flow, and dark matter to examine some of the theories about the content of the universe and why its edge is getting farther away from us fasterExplores the idea that the observable universe could be a hologram and that everything that happens within it might be written on its edgeWritten by physicist and popular science writer Paul Halpern, whose other books include "Collider: The Search for the World's Smallest Particles," and "What's Science Ever Done For Us: What the Simpsons Can Teach Us About Physics, Robots, Life, and the Universe"

    Many have attempted to explain this singular success as a result of divine intervention. In this engaging book, David N. Myers charts the long journey of the Jews through history. At the same time, it points to two unlikely-and decidedly this-worldly--factors to explain the survival of the Jews: antisemitism and assimilation. Usually regarded as grave dangers, these two factors have continually interacted with one other to enable the persistence of the Jews. At every turn in their history, not just in the modern age, Jews have adapted to new environments, cultures, languages, and social norms. These bountiful encounters with host societies have exercised the cultural muscle of the Jews, preventing the atrophy that would have occurred if they had not interacted so extensively with the non-Jewish world. It is through these encounters--indeed, through a process of assimilation--that Jews came to develop distinct local customs, speak many different languages, and cultivate diverse musical, culinary, and intellectual traditions.Left unchecked, the Jews' well-honed ability to absorb from surrounding cultures might have led to their disappearance. And yet, the route toward full and unbridled assimilation was checked by the nearly constant presence of hatred toward the Jew. Anti-Jewish expression and actions have regularly accompanied Jews throughout history. Part of the ironic success of antisemitism is its malleability, its talent in assuming new forms and portraying the Jew in diverse and often contradictory images--for example, at once the arch-capitalist and revolutionary Communist. Antisemitism not only served to blunt further assimilation, but, in a paradoxical twist, affirmed the Jew's sense of difference from the host society. And thus together assimilation and antisemitism (at least up to a certain limit) contribute to the survival of the Jews as a highly adaptable and yet distinct group.