Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading, at that point the largest gain in stock market history. Coming at a time of economic recession and declining technological competitiveness in the United States, the event provoked banner headlines and ignited a period of speculative frenzy over biotechnology as a revolutionary means for creating new and better kinds of pharmaceuticals, untold profit, and a possible solution to national economic malaise. Drawing from an unparalleled collection of interviews with early biotech players, Sally Smith Hughes offers the first book-length history of this pioneering company, depicting Genentech’s improbable creation, precarious youth, and ascent to immense prosperity. Hughes provides intimate portraits of the people significant to Genentech’s science and business, including cofounders Herbert Boyer and Robert Swanson, and in doing so sheds new light on how personality affects the growth of science. By placing Genentech’s founders, followers, opponents, victims, and beneficiaries in context, Hughes also demonstrates how science interacts with commercial and legal interests and university research, and with government regulation, venture capital, and commercial profits. Integrating the scientific, the corporate, the contextual, and the personal, Genentech tells the story of biotechnology as it is not often told, as a risky and improbable entrepreneurial venture that had to overcome a number of powerful forces working against it.

    This book provides the first complete identification guides to the birds of this teeming tropical paradise. It gives descriptions of 820 regional species, illustrated in 88 specially commissioned color plates accompanied by notes detailing distinctive features and habitats. Entries cover nomenclature, plumage, markings, voice, global range, distribution and regional status, habits, and diet. The main text gives practical information on where to find many exotic species, citing major birdwatching locations. Introductory chapters discuss habitats, climate, land-use, and conservation concerns. Professional ornithologists and amateur bird watchers alike will find this the indispensable bird guide for eastern Malaysia and western Indonesia for many years to come. It is also an unrivalled source of information for casual travellers and ecotourists.

    To what extent would you remain committed to your current projects and plans? Would scientists still search for a cure forcancer? Would couples still want children?In Death and the Afterlife, philosopher Samuel Scheffler poses this thought experiment in order to show that the continued life of the human race after our deaths--the afterlife of the title--matters to us to an astonishing and previously neglected degree. Indeed, Scheffler shows that, in certainimportant respects, the future existence of people who are as yet unborn matters more to us than our own continued existence and the continued existence of those we love. Without the expectation that humanity has a future, many of the things that now matter to us would cease to do so. By contrast, the prospect of our own deaths does little to undermine our confidence in the value of our activities. Despite the terror we may feel when contemplating our deaths, the prospect of humanity's imminent extinction would pose a far greater threat to our ability to lead lives of wholehearted engagement.Scheffler further demonstrates that, although we are not unreasonable to fear death, personal immortality, like the imminent extinction of humanity, would also undermine our confidence in the values we hold dear. His arresting conclusion is that, in order for us to lead value-laden lives, what isnecessary is that we ourselves should die and that others should live.Death and the Afterlife concludes with commentary by four distinguished philosophers--Harry Frankfurt, Niko Kolodny, Seana Shiffrin, and Susan Wolf--who discuss Scheffler's ideas with insight and imagination. Scheffler adds a final reply.

    Why, if the human instinct to survive and reproduce is “selfish,” do people engage in self-sacrifice, and even develop ideas like virtue and shame to justify that altruism? Many theories have been put forth, some emphasizing the role of nepotism, others emphasizing the advantages of reciprocation or group selection effects. But evolutionary anthropologist Christopher Boehm finds existing explanations lacking, and in Moral Origins, he offers an elegant new theory.Tracing the development of altruism and group social control over 6 million years, Boehm argues that our moral sense is a sophisticated defense mechanism that enables individuals to survive and thrive in groups. One of the biggest risks of group living is the possibility of being punished for our misdeeds by those around us. Bullies, thieves, free-riders, and especially psychopaths—those who make it difficult for others to go about their lives—are the most likely to suffer this fate. Getting by requires getting along, and this social type of selection, Boehm shows, singles out altruists for survival. This selection pressure has been unique in shaping human nature, and it bred the first stirrings of conscience in the human species. Ultimately, it led to the fully developed sense of virtue and shame that we know today.A groundbreaking exploration of the evolution of human generosity and cooperation, Moral Origins offers profound insight into humanity’s moral past—and how it might shape our moral future.

    The second half of the nineteenth century -- the so-called Gilded Age -- was a time when Americans were exploring the West and building a nation that would stretch from coast to coast.It was also a time of scientific ferment. Charles Darwin had shaken the very foundations of Victorian society with his theory of evolution by natural selection, and scientists across the civilized world were locked in a great battle over Darwin's idea. While the debate raged in Europe, the hunt for hard evidence increasingly focused on the American West, with its grand mesas, buttes, and badlands. "We must turn to the New World if we wish to see in perfection the oldest monuments of earth's history," advised Sir Charles Lyell, the father of modern geology, after a visit to America. "Certainly in no other country are these ancient strata developed on a grander scale or more plentifully charged with fossils."Could the answer to the history of life and the proof of evolution be found in those fossils? That was the question that two young American paleontologists--Edward Drinker Cope and Othniel Charles Marsh--set out to answer. But what began as a friendly contest quickly turned into bitter rivalry that would spill over into American science and politics and rage relentlessly for nearly three decades.        Cope and Marsh would battle on the prairies, in the halls of Congress, in science journals, and in the popular press. Both wealthy men, they launched lavish, western expeditions and raced across the plains and mountains searching for the remains of the magnificent beasts that once inhabited the continent. Along the way they would encounter George Custer, Sitting Bull, Buffalo Bill, and Red Cloud.         Among the most remarkable fossil discoveries of Cope and Marsh are a bevy of dinosaurs, including some of the best known beasts -- the Triceratops, the Stegosaurus, the Camarasaurus, and the Brontosaurus. Even today, Marsh holds the record for dinosaur discoveries.        Just as valuable, however, were some of Marsh's discoveries of ancient mammals and birds that provided the first real proof of Dar- win's theory--"The best support for the theory in twenty years," the great Darwin himself proclaimed.        The tale of Cope and Marsh is also the story of the rise of American science. When their story begins just after the Civil War, America was an intellectual backwater, with eminent scientists snookered by the great, fake stone statue The Cardiff Giant--a hoax unmasked by Marsh.        But even as Cope and Marsh waged war, they both fought to build up American science and its scientific institutions. Yet despite their discoveries and their Gilded Age celebrity, the names of Cope and Marsh have faded into the recesses of the library and archive. In The Gilded Dinosaur Mark Jaffe exhumes from those archives the notes, journals, and letters of Cope and Marsh to reanimate and retell one of the keenest rivalries in the history of science.

    An x-ray microscope would do the trick, or since we're dreaming, perhaps an Asimov-style nanosubmarine (unfortunately, neither is currently feasible). Think of the wonders we could witness firsthand: antibodies atta- ing a virus, electrical signals racing down nerve fibers, proteins building new strands of DNA. Many of the questions puzzling the current cadre of sci- tists would be answered at a glance. But the nanoscale world of molecules is separated from our everyday world of experience by a daunting million-fold difference in size, so the world of molecules is completely invisible. I created the illustrations in this book to help bridge this gulf and allow us to see the molecular structure of cells, if not directly, then in an artistic rendition. I have included two types of illustrations with this goal in mind: watercolor paintings which magnify a small portion of a living cell by one million times, showing the arrangement of molecules inside, and comput- generated pictures, which show the atomic details of individual molecules. In this second edition of The Machinery of Life, these illustrations are presented in full color, and they incorporate many of the exciting scientific advances of the 15 years since the first edition.

    It discusses neuroanatomy, cell and molecular mechanisms and signaling through a cognitive approach to behaviour. It features an expanded treatment of the nervous system, neurological and psychiatric diseases and perception.

    . . Marmot's message is not just timely, it's urgent." -The Washington Post Book WorldYou probably didn't realize that when you graduate from college you increase your lifespan, or that your co-worker who has a slightly better job is more likely to live a healthier life. In this groundbreaking book, epidemiologist Michael Marmot marshals evidence from nearly thirty years of research to demonstrate that status is not a footnote to the causes of ill health-it is the cause. He calls this effect the status syndrome.The status syndrome is pervasive. It determines the chances that you will succumb to heart disease, stroke, cancers, infectious diseases, even suicide and homicide. And the issue, as Marmot shows, is not simply one of income or lifestyle. It is the psychological experience of inequality-how much control you have over your life and the opportunities you have for full social participation-that has a profound effect on your health.The Status Syndrome will utterly change the way we think about health, society, and how we live our lives.

    An unremarkable student, he nearly flunked out of high school. After being drafted into the army, he enlisted in the navy and went to Vietnam, where the life and death struggles he encountered as a medic piqued his interest in science and medicine. After pursuing his advanced degrees, Venter quickly established himself as a brilliant and outspoken scientist. In 1984 he joined the National Institutes of Health, where he introduced novel techniques for rapid gene discovery, and left in 1991 to form his own nonprofit genomics research center, where he sequenced the first genome in history in 1995. In 1998 he announced that he would successfully sequence the human genome years earlier, and for far less money, than the government-sponsored Human Genome Project would— a prediction he kept in 2001. A Life Decoded is the triumphant story of one of the most fascinating and controversial figures in science today. In his riveting and inspiring account Venter tells of the unparalleled drama of the quest for the human genome, a tale that involves as much politics (personal and political) as science. He also reveals how he went on to be the first to read and interpret his own genome and what it will mean for all of us to do the same. He describes his recent sailing expedition to sequence microbial life in the ocean, as well as his groundbreaking attempt to create synthetic life. Here is one of the key scientific chronicles of our lifetime, as told by the man who beat the odds to make it happen.

    Korsgaard presents a compelling new view of humans' moral relationships to the other animals. She defends the claim that we are obligated to treat all sentient beings as what Kant called ends-in-themselves. Drawing on a theory of the good derived from Aristotle, she offers anexplanation of why animals are the sorts of beings for whom things can be good or bad. She then turns to Kant's argument for the value of humanity to show that rationality commits us to claiming the standing of ends-in-ourselves, in two senses. Kant argued that as autonomous beings, we claim to beends-in-ourselves when we claim the standing to make laws for ourselves and each other. Korsgaard argues that as beings who have a good, we also claim to be ends-in-ourselves when we take the things that are good for us to be good absolutely and so worthy of pursuit. The first claim commits us tojoining with other autonomous beings in relations of moral reciprocity. The second claim commits us to treating the good of every sentient creature as something of absolute importance.Korsgaard argues that human beings are not more important than the other animals, that our moral nature does not make us superior to the other animals, and that our unique capacities do not make us better off than the other animals. She criticizes the marginal cases argument and advances a newview of moral standing as attaching to the atemporal subjects of lives. She criticizes Kant's own view that our duties to animals are indirect, and offers a non-utilitarian account of the relation between pleasure and the good. She also addresses a number of directly practical questions: whether wehave the right to eat animals, experiment on them, make them work for us and fight in our wars, and keep them as pets; and how to understand the wrong that we do when we cause a species to go extinct.

    Integrating recent insights from evolutionary biology, genetics, psychology, economics, and other fields, Boyer offers precise models of why humans engage in social behaviors such as forming families, tribes, and nations, or creating gender roles. In fascinating, thought-provoking passages, he explores questions such as, Why is there conflict between groups? Why do people believe low-value information such as rumors? Why are there religions? What is social justice? What explains morality? Boyer provides a new picture of cultural transmission that draws on the pragmatics of human communication, the constructive nature of memory in human brains, and human motivation for group formation and cooperation.

    The book brings together the latest in neuroscience research to present a new and proven approach to brain health and aging." “The most important book you’ll read this year.” The Neurogenesis Diet and Lifestyle brings together the latest in neuroscience research to present a new and proven view of brain health and aging. Only recently has it been discovered that the brain produces new brain cells throughout our entire lives, a process called neurogenesis. The rate at which we form new brain cells has a profound influence upon every aspect of our life. When the rate of neurogenesis is low, we see cognitive deficits and memory problems, anxiety and stress, depression, and lowered immunity. Life is difficult. With high rates of neurogenesis we see the opposite: enhanced cognitive abilities, rapid learning, emotional resilience, protection from anxiety, stress and depression, heightened immunity and robust health. We flourish. Life is wonderful. Given the neurotoxic norms of society, it’s almost universally true that your brain is working far below its capacity. It is deteriorating much faster than it needs to. What good is living longer if your brain can’t go the distance? Recent discoveries in the emerging field of neurogenesis reveal the secrets to radically improve your brain’s health. You can operate at a higher level than you ever dreamed possible – at any age! ”A revolutionary paradigm shift in brain health and brain aging." This scientifically validated, 4-point program of diet and lifestyle will: • Improve your memory and brain power • Inoculate you against stress and depression • Prevent or delay cognitive decline, dementia and Alzheimer’s • Enrich your relationships and sex life • Help you connect with your loving center of peace This book presents the latest neuroscience discoveries to increase brain power, enhance memory, increase brain fitness by seeing what kinds of brain exercises actually work, and build a better brain. It contains dietary recommendations for brain food, brain vitamins, brain supplements, memory vitamins and memory supplements. “This is the best book to give anyone over 50!” This book also spells out the symptoms of dementia, the stages of dementia, signs of cognitive decline and stages of Alzheimer’s. The plan presented in The Neurogenesis Diet and Lifestyle will help to ward off cognitive decline and avoid dementia stages. This lifestyle is the only lifestyle for which there is scientific evidence supporting it, based on a late 2014 research study by the Buck Foundation. The Neurogenesis Diet and Lifestyle is aimed at improving how your brain functions. Your rate of neurogenesis may be the most important factor in your brain health. And increasing your rate of neurogenesis by three to five times can result in powerfully improved memory, learning, cognitive enhancement, as well as improved immunity and protection against stress and depression. You can live and perform well beyond where you are now. For more information, please visit: NeurogenesisDiet.

    

    Bethell writes in a compulsively readable style, and although he provides legitimate insight into the potential benefits of nuclear power and hormesis, some readers will be turned off when he attempts to disprove global warming and especially evolution. Throughout the book, Bethell makes questionable claims about subjects as varied as AIDS ("careful U.S. studies had already shown that at least a thousand sexual contacts are needed to achieve heterosexual transmission of the virus") and extinction ("It is not possible definitely to attribute any given extinction to human activity"), and backs up his arguments with references to the music magazine SPIN and thriller-writer Michael Crichton. Ironically, Bethell ends up proving his own premise by producing a highly politicized account of how liberal intellectuals and unchecked government agencies have created a "white-coated priesthood" whose lust for grant money has driven them to produce fearsome (but in Bethell's view, false) tales of ozone destruction and AIDS pandemics. In the end, this book is unlikely to sway readers who aren't already in Bethell's ideological camp, as any points worthy of discussion get lost in the glut of unsourced claims that populate this latest installment of "The Politically Incorrect Guide" series.

    Excellent Board review.