Pierre (NORML), Tommy Chong, and others - Covers marijuana's physiological and psychological effects, its medicinal uses, the complex politics of cannabis law, pot and parenting, its role in creativity, business, and spirituality, and much more Exploring the role of cannabis in medicine, politics, history, and society, The Pot Book offers a compendium of the most up-to-date information and scientific research on marijuana from leading experts, including Lester Grinspoon, M.D., Rick Doblin, Ph.D., Allen St. Pierre (NORML), and Raphael Mechoulam. Also included are interviews with Michael Pollan, Andrew Weil, M.D., and Tommy Chong as well as a pot dealer and a farmer who grows for the U.S. Government. Encompassing the broad spectrum of marijuana knowledge from stoner customs to scientific research, this book investigates the top ten myths of marijuana; its physiological and psychological effects; its risks; why joints are better than water pipes and other harm-reduction tips for users; how humanity and cannabis have co-evolved for millennia; the brain's cannabis-based neurochemistry; the complex politics of cannabis law; its potential medicinal uses for cancer, AIDS, Alzheimer's, multiple sclerosis, and other illnesses; its role in creativity, business, and spirituality; and the complicated world of pot and parenting. As legalization becomes a reality, this book candidly offers necessary facts and authoritative opinions in a society full of marijuana myths, misconceptions, and stereotypes.

    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    Countless behaviors separate us from the rest of the animal kingdom, but all of them can be traced one way or another to six traits that are unique to the human race—our big toe, our opposable thumb, our oddly shaped pharynx, and our ability to laugh, kiss, and cry. At first glance these may not seem to be connected but they are. Each marks a fork in the evolutionary road where we went one way and the rest of the animal kingdom went another. Each opens small passageways on the peculiar geography of the human heart and mind.Walter weaves together fascinating insights from complexity theory, the latest brain scanning techniques, anthropology, artificial intelligence, cognitive psychology, and robotics to explore how the smallest of changes over the past six million years – all shaped by the forces of evolution -- have enabled a primate once on the brink of extinction to evolve into a creature that would one day create all of the grand and exuberant edifices of human culture.As the story of each trait unfolds, Walter explains why our brains grew so large and complex, why we find one another sexually attractive, how toolmaking laid the mental groundwork for language, why we care about what others think, and how we became the creature that laughs and cries and falls in love. Thumbs, Toes and Tears is original, informative, and delightfully thought-provoking.

    We get cancer because we can't avoid it—it's a bug in the system of life itself.Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us.Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy.We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move.Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.

    Its cricket team evolved in the chaotic aftermath. Initially unrecognised, underfunded and weak, Pakistan's team grew to become a major force in world cricket. Since the early days of the Raj, cricket has been entwined with national identity and Pakistan's successes helped to define its status in the world. Defiant in defence, irresistible in attack, players such as A.H.Kardar, Fazal Mahmood, Wasim Akram and Imran Khan awed their contemporaries and inspired their successors. The story of Pakistan cricket is filled with triumph and tragedy. In recent years, it has been threatened by the same problems affecting Pakistan itself: fallout from the 'war on terror', sectarian violence, corruption, crises in health and education, and a shortage of effective leaders. For twenty years, Pakistan cricket has been stained by the scandalous behaviour of the players involved in match-fixing. Since 2009, the fear of violence has driven Pakistan's international cricket into exile. No one knows when it will return home. But Peter Oborne's narrative is also full of hope. For all its troubles, cricket gives all Pakistanis a chance to excel and express themselves, a sense of identity and a cause for pride in their country. Packed with first-hand recollections, and digging deep into political, social and cultural history, Wounded Tiger is a major study of sport and nationhood.

    Provocative. Shocking. Call them what you will...but don't call them open and shut. Did Lizzie Borden murder her own father and stepmother? Was Jack the Ripper actually the Duke of Clarence? Who killed JonBenet Ramsey?America's foremost expert on criminal profiling and twenty-five-year FBI veteran John Douglas, along with author and filmmaker Mark Olshaker, explores those tantalizing questions and more in this mesmerizing work of detection. With uniquely gripping analysis, the authors reexamine and reinterpret the accepted facts, evidence, and victimology of the most notorious murder cases in the history of crime, including the Lindbergh baby kidnapping, the Zodiac Killer, and the Whitechapel murders.Utilizing techniques developed by Douglas himself, they give detailed profiles and reveal chief suspects in pursuit of what really happened in each case.The Cases That Haunt Us not only offers convincing and controversial conclusions, it deconstructs the evidence and widely held beliefs surrounding each case and rebuilds them -- with fascinating, surprising, and haunting results.

    Thomas Homer-Dixon brings to bear his formidable understanding of the urgent problems that confront our world to clarify their scope and deep causes. The Upside of Down provides a vivid picture of the immense stresses that are simultaneously converging on our societies and threatening a breakdown that would profoundly shake civilization. It shows, too, how we can choose a better route into the future. With the immediacy that characterized his award-winning international bestseller, The Ingenuity Gap, Homer-Dixon takes us on a remarkable journey – from the fall of the Roman empire to the devastation of the 9/11 attacks in New York, from Toronto in the 2003 blackout to the ancient temples of Lebanon and the wildfires of California. Incorporating the newest findings from an astonishing array of disciplines, he argues that the great stresses our world is experiencing – global warming, energy scarcity, population imbalances, and widening gaps between rich and poor – can’t be looked at independently. As these stresses combine and converge, the risk of breakdown rises. The first signs are appearing in the wastelands of the Arctic, the mud-clogged streets of Gonaïves, Haiti, and the volatile regions of the Middle East and Asia. But while the consequences of denial in our more perilous world are dire, Homer-Dixon makes clear that we can use our emerging understanding of the complex systems in which we live to avoid catastrophic collapse in a way the Roman empire could not. This vitally important new book shows how, in the face of breakdown, we can still provide for the renewal of our global civilization. We are creating the conditions for catastrophe, but by understanding the underlying principles that make human and natural systems resilient – and by working together to put those principles into effect – we can still limit the severity of collapse and foster regeneration, innovation, and renewal.

    Molecules of Murder describes ten highly toxic molecules which are of particular interest due to their use in notorious murder cases. Each chapter explores the discovery of the molecules, their chemistry and effects in humans, followed by a re-examination of their deliberate misuse in high profile murder cases! Molecules of Murder is written by the highly acclaimed, award winning popular science writer John Emsley and makes enthralling reading for both scientists and non-scientists alike.

    The ability to duplicate that process in a lab, once thought impossible, may now be closer than we think. Today, teams of scientists around the world are being assembled by the boldest entrepreneurs, big business, and governments to solve what is the most difficult technological challenge humanity has ever faced: building the equivalent of a star on earth. If their plans to capture star power are successful, they will unlock thousands, potentially millions, of years of clean, carbon-free energy. Not only would controlled nuclear fusion help solve the climate crisis, it could also make other highly desired technological ambitions possible—like journeying to the stars. Given the rising alarm over deterioration of the environment, and the strides being made in laser and magnetic field technology, powerful momentum is gathering behind fusion and the possibilities it offers. In The Star Builders, award-winning young plasma physicist Arthur Turrell “offers an optimistic outlook for the future of fusion power and is adamant about the need to invest in it” (The New York Times). Turrell describes fascinating star machines with ten times as many parts as the NASA Space Shuttle, and structures that extend over 400 acres in an accessible and entertaining account, spotlighting the individuals, firms, and institutions racing for the finish line: science-minded entrepreneurs like Jeff Bezos and Peter Thiel, companies like Goldman Sachs and Google, universities like Oxford and MIT, and virtually every rich nation. It’s an exciting and game-changing international quest that will make all of us winners.

    The most fatal virus known to science, rabies — a disease that spreads avidly from animals to humans — kills nearly one hundred percent of its victims once the infection takes root in the brain. In this critically acclaimed exploration, journalist Bill Wasik and veterinarian Monica Murphy chart four thousand years of the history, science, and cultural mythology of rabies. From Greek myths to zombie flicks, from the laboratory heroics of Louis Pasteur to the contemporary search for a lifesaving treatment, Rabid is a fresh and often wildly entertaining look at one of humankind’s oldest and most fearsome foes.

    All of those organisms are rooted in a single origin, with a common code that underwrites our existence. This paradox - that our biology is indistinct from all life, yet we consider ourselves to be special - lies at the heart of who we are.In this original and entertaining tour of life on Earth, Adam Rutherford explores how many of the things once considered to be exclusively human are not: we are not the only species that communicates, makes tools, utilises fire, or has sex for reasons other than to make new versions of ourselves. Evolution has, however, allowed us to develop our culture to a level of complexity that outstrips any other observed in nature.THE BOOK OF HUMANS tells the story of how we became the creatures we are today, bestowed with the unique ability to investigate what makes us who we are. Illuminated by the latest scientific discoveries, it is a thrilling compendium of what unequivocally fixes us as animals, and reveals how we are extraordinary among them.

    Yet, David Wootton argues, from the fifth century BC until the 1930s, doctors actually did more harm than good. In this controversial new account of the history of medicine, he asks just how much good it has done us over the years, and how much harm it continues to do today.

    Almost a decade earlier, Dr. Sacks had published his masterpiece Awakenings but the book had hardly been an immediate success, and the rumpled clinician was still largely unknown. Over the ensuing four years, the two men worked closely together until Sacks asked Weschler to abandon the profile, a request to which Weschler acceded. The two remained close friends, however, across the next thirty years and then, just as Sacks was dying, he urged Weschler to take up the project once again. This book is the result of that entreaty.Weschler sets Sacks's brilliant table talk and extravagant personality in vivid relief. We see Sacks rowing and ranting and caring deeply; composing the essays that would form The Man Who Mistook His Wife for a Hat ; recalling his turbulent drug-fueled younger days; helping his patients and exhausting his friends; and waging intellectual war against a medical and scientific establishment that failed to address his greatest concern: the spontaneous specificity of the individual human soul. And all the while he is pouring out a stream of glorious, ribald, hilarious, and often profound conversation that establishes him as one of the great talkers of the age.

    Created in the 1890s by George Washington Vanderbilt, a member of one of America's wealthiest families, the estate combined a 250-room French Renaissance-style chateau with 125,000 acres of gardens, forests, and working farms. Biltmore House served as Vanderbilt's primary residence for almost 20 years. After Mr. Vanderbilt's death in 1914, life at Biltmore continued for his wife Edith and daughter Cornelia. In 1930, Cornelia Vanderbilt Cecil and her husband, Hon. John Francis Amherst Cecil, opened Biltmore House--the largest private home in the United States--to the public, firmly establishing the Asheville area as a major tourist destination.

    Warren Andiman, an HIV/AIDS researcher who has been on the front lines battling infectious diseases for over forty years. In Animal Viruses and Humans: A Narrow Divide, Andiman traces the history of eight zoonotic viruses —deadly microbes that have made the leap directly from animals to human populations: Middle East Respiratory Syndrome (MERS), Swine influenza, Hantavirus, Monkeypox, Severe Acute Respiratory Syndrome (SARS), Rabies, Ebola, and Henipaviruses (Nipah and Hendra). He also illustrates the labor intensive and fascinating detective work that infectious disease specialists must do to uncover the source of an outbreak.Andiman also looks to the future, envisioning the effects on zoonoses (diseases caused by zoonotic viruses) of climate change, microenvironmental damage, population shifts, and globalization. He reveals the steps that we can, and must, take to stem the spread of animal viruses, explaining, “The zoonoses I've chosen to write about . . . are meant to describe only a small sample of what is already out there but, more menacingly, what is inevitably on its way, in forms we can only imagine.” Warren Andiman, MD is professor emeritus of pediatrics and epidemiology at the Yale Schools of Medicine and Public Health.