An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    Breaking down the symbols themselves, they pose a series of questions: What is energy? What is mass? What has the speed of light got to do with energy and mass? In answering these questions, they take us to the site of one of the largest scientific experiments ever conducted. Lying beneath the city of Geneva, straddling the Franco-Swiss boarder, is a 27 km particle accelerator, known as the Large Hadron Collider. Using this gigantic machine—which can recreate conditions in the early Universe fractions of a second after the Big Bang—Cox and Forshaw will describe the current theory behind the origin of mass.Alongside questions of energy and mass, they will consider the third, and perhaps, most intriguing element of the equation: 'c' - or the speed of light. Why is it that the speed of light is the exchange rate? Answering this question is at the heart of the investigation as the authors demonstrate how, in order to truly understand why E=mc2, we first must understand why we must move forward in time and not backwards and how objects in our 3-dimensional world actually move in 4-dimensional space-time. In other words, how the very fabric of our world is constructed. A collaboration between two of the youngest professors in the UK, Why Does E=mc2? promises to be one of the most exciting and accessible explanations of the theory of relativity in recent years.

    It is also the first of the final three such collections, since Dr. Gould has announced that the series will end with the turn of the millennium. In this collection, Gould consciously and unconventionally formulates a humanistic natural history, a consideration of how humans have learned to study and understand nature, rather than a history of nature itself. With his customary brilliance, Gould examines the puzzles and paradoxes great and small that build nature's and humanity's diversity and order. In affecting short biographies, he depicts how scholars grapple with problems of science and philosophy as he illuminates the interaction of the outer world with the unique human ability to struggle to understand the whys and wherefores of existence. "From the Hardcover edition."

    Exceptional Coverage. This authoritative volume starts with a clear introduction to the animal world, examining the reasons for the apparently infinite variety of animal forms and major evolutionary developments. Animal anatomy, life cycles and the principles of classification are also explored. This is followed by a superbly illustrated survey of world habitats, showing how they have adapted to each environment, and the threats that face both wildlife and plants today. The main part of the book, an up-to-date and comprehensive animal catalog, looks in detail at each major group and provides fascinating profiles of over 2,000 individual species. Visually Breathtaking. Spectacular photographic portraits bring a vast array of animals vividly to life, with special features on well-known and important animals such as the Galapagos tortoise. Each species profile is supported by maps and symbols showing distribution and habitat, as well as key information on size, population, and conservation status, forming an invaluable reference database. Outstanding Reference. Clear, comprehensive, and thought provoking, the Smithsonian Animal is essential reading for wildlife enthusiasts of all ages and levels of experience.

    This special, large-format volume is geared as much to nonbirders as it is to the out-and-out obsessed, covering more than two hundred species and including more than 330 new illustrations by the author. While its focus is on familiar backyard birds--blue jays, nuthatches, chickadees--it also examines certain species that can be fairly easily observed, such as the seashore-dwelling Atlantic puffin. David Sibley's artwork and expertise bring observed behaviors vividly to life. (For most species, the primary illustration is reproduced life-sized.) And while the text is aimed at adults--including fascinating new scientific research on the myriad ways birds have adapted to environmental changes--it is nontechnical, making it the perfect occasion for parents and grandparents to share their love of birds with young children, who will delight in the big, full-color illustrations of birds in action.

    It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes.This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children.Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.

    In the great halls of science, dogma holds that Darwin's theory of natural selection explains every branch on the tree of life: which species thrive, which wither away to extinction, and what features each evolves. But can adaptation by natural selection really account for everything we see in nature? Yale University ornithologist Richard Prum--reviving Darwin's own views--thinks not. Deep in tropical jungles around the world are birds with a dizzying array of appearances and mating displays: Club-winged Manakins who sing with their wings, Great Argus Pheasants who dazzle prospective mates with a four-foot-wide cone of feathers covered in golden 3D spheres, Red-capped Manakins who moonwalk. In thirty years of fieldwork, Prum has seen numerous display traits that seem disconnected from, if not outright contrary to, selection for individual survival. To explain this, he dusts off Darwin's long-neglected theory of sexual selection in which the act of choosing a mate for purely aesthetic reasons--for the mere pleasure of it--is an independent engine of evolutionary change. Mate choice can drive ornamental traits from the constraints of adaptive evolution, allowing them to grow ever more elaborate. It also sets the stakes for sexual conflict, in which the sexual autonomy of the female evolves in response to male sexual control. Most crucially, this framework provides important insights into the evolution of human sexuality, particularly the ways in which female preferences have changed male bodies, and even maleness itself, through evolutionary time. The Evolution of Beauty presents a unique scientific vision for how nature's splendor contributes to a more complete understanding of evolution and of ourselves.

    

    By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains unknown. The hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept headings introduce each section. Every chapter contains extensive references. Most important, every chapter has been subjected to a rigorous, collaborative revision process where, in addition to incorporating comments from expert reviewers, each co-author reads and reviews the other authors' prose. The result is a truly integrated work with a single authorial voice. Features : - Places the latest hot topics sensibly in context - including genomics, protein structure, array technology, stem cells and genetics diseases. - Incorporates and emphasises new genomic data. - All of molecular biology is brought together into one section (chapters 4-7) covering classically defined molecular biology and molecular genetics. - Two chapters deal exclusively with methods and contain information on the latest tools and techniques. - New chapters on "Pathogens, Infection, and Innate Immunity". - Cell Biology Interactive CD-ROM is packaged with every copy of the book. - Contains over 1,600 illustrations, electron micrographs and photographs, of which over 1,000 are originally conceived by the authors.

    Now in its fourth edition, Honey for a Child’s Heart discusses everything from the ways reading affects both children’s view of the world and their imagination to how to choose good books. Illustrated with drawings from dozens of favorites, it includes an indexed and updated list of the best new books on the market and the classics that you want your children to enjoy. Author Gladys Hunt’s tastes are broad, her advice is rooted in experience, and her suggestions will enrich the cultural and spiritual life of any home.

    Original, well researched, and well documented by distinguished sources, The Field is a book of hope and inspiration for today's world.

    When they received their prompts, they responded by transforming these seeds into any form of creative work they wanted to share. The result is a stunning collection of words, art, poetry, and stories by some of our most celebrated children book creators. A section of extra story starters by every contributor provides fresh inspiration for readers to create works of their own. Here is an innovative book that offers something for every kind of reader and creator! With contributions by Sherman Alexie, Tom Angleberger, Jessixa Bagley, Tracey Baptiste, Sophie Blackall, Lisa Brown, Peter Brown, Lauren Castillo, Kate DiCamillo, Margarita Engle, Deborah Freedman, Adam Gidwitz, Chris Grabenstein, Jennifer L. Holm, Victoria Jamieson, Travis Jonker, Jess Keating, Laurie Keller, Jarret J. Krosoczka, Kirby Larson, Minh Lê, Grace Lin, Kate Messner, Daniel Nayeri, Naomi Shihab Nye, Debbie Ohi, R.J. Palacio, Linda Sue Park, Dav Pilkey, Andrea Davis Pinkney, Jewell Parker Rhodes, Dan Santat, Gary Schmidt, John Schu, Colby Sharp, Bob Shea, Liesl Shurtliff, Lemony Snicket, Laurel Snyder, Javaka Steptoe, Mariko Tamaki, Linda Urban, Frank Viva, and Kat Yeh.

    The new edition offers a wealth of new information, especially in the areas of taxonomy, genomics, plant hormones, and Arabidopsis research.

    Using the latest aerial surveillance, state-of-the-art cameras, and high definition technology, the creators of Planet Earth have assembled more than 400 stunning photographs of wondrous natural landscapes from around the globe, including incredible footage of the rarely spotted, almost mythical creatures that live in these habitats. Many of the images reveal inaccessible places that few have seen and record animal behavior that has never been filmed or photographed before. With the help of this highly advanced technology and the world's premier wildlife photographers, the book takes us on a spectacular journey from the world's greatest rivers and impressive gorges, to its mightiest mountains, hidden caves and caverns, and vast deserts. Planet Earth captures breathtaking sequences of predators and their prey, lush vistas of forests viewed from the tops of towering trees, the oceans and their mysterious creatures viewed from beneath the surface, and much more—in a magnificent adventure that brings unknown wonders of the natural world into our living rooms.Copub: BBC Worldwide Americas

    This brilliantly clear and gratifyingly concise treatment of the ancient Greek discipline identifies the illogical in everything from street signs to tax forms. Complete with puzzles you can try yourself, Logic Made Easy invites readers to identify and ultimately remedy logical slips in everyday life. Designed with dozens of visual examples, the book guides you through those hair-raising times when logic is at odds with our language and common sense. Logic Made Easy is indeed one of those rare books that will actually make you a more logical human being.