Days earlier, she had been on the threshold of a new, adult life: at the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?In a swift and breathtaking narrative, Cahalan tells the astonishing true story of her descent into madness, her family’s inspiring faith in her, and the lifesaving diagnosis that nearly didn’t happen.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    As the mother of forensic science, Frances Glessner Lee is the reason why homicide detectives are a thing. She is responsible for the popularity of forensic science in television shows and pop culture. Long overlooked in the history books, this extremely detailed and thoroughly researched biography will at long last tell the story of the life and contributions of this pioneering woman.

    Illuminating, completely engaging—it's essential reading for all since we all know someone whose life, family or friends are touched by the disease that directly afflicts a fifth of Canadians. In her early twenties, while outwardly thriving in her dream job and enjoying warm familial support and a strong social network, award-winning journalist Anna Mehler Paperny found herself trapped by feelings of failure and despair. Her first suicide attempt—ingesting a deadly mix of sleeping pills and antifreeze—landed her in the ICU, followed by weeks of enforced detention that ran the gamut of horrifying, boring, hilarious, and absurd. This was Anna's entry into the labyrinthine psychiatric care system responsible for providing care to millions of Canadians.As she struggled to survive the psych ward and as an outpatient—enduring the "survivor's" shame of facing concerned family, friends, and co-workers; finding (or not) the right therapist, the right meds; staying healthy, insured, and employed—Anna could not help but turn her demanding journalist's eye on her condition and on the system in which she found herself. She set off on a quest to "know her enemy," interviewing leading practitioners in the field across Canada and the US—from psychiatrists to neurological experts, brain-mapping pioneers to heroic family practitioners, and others dabbling in novel hypotheses. She reveals in courageously frank detail her own experiences with the pharmacological pitfalls and side effects of long-term treatment, and offers moving case studies of conversations with others, opening wide a window into how we treat (and fail to treat) the disease that accounts for more years swallowed up by disability than any other in the world.

    Braided with that history is the moving story of Powers's beloved son Kevin--spirited, endearing, and gifted--who triumphed even while suffering from schizophrenia until finally he did not, and the story of his courageous surviving son Dean, who is also schizophrenic.A blend of history, biography, memoir, and current affairs ending with a consideration of where we might go from here, this is a thought-provoking look at a dreaded illness that has long been misunderstood.

    When Papa Pilgrim appeared in the Alaska frontier outpost of McCarthy with his wife and fifteen children in tow, his new neighbors had little idea of the trouble to come. The Pilgrim Family presented themselves as a shining example of the homespun Christian ideal, with their proud piety and beautiful old-timey music, but their true story ran dark and deep. Within weeks, Papa had bulldozed a road through the mountains to the new family home at an abandoned copper mine, sparking a tense confrontation with the National Park Service and forcing his ghost town neighbors to take sides in an ever-more volatile battle over where a citizen’s rights end and the government’s power begins. In Pilgrim’s Wilderness, veteran Alaska journalist Tom Kizzia unfolds the remarkable, at times harrowing, story of a charismatic spinner of American myths who was not what he seemed, the townspeople caught in his thrall, and the family he brought to the brink of ruin. As Kizzia discovered, Papa Pilgrim was in fact the son of a rich Texas family with ties to Hoover’s FBI and strange, oblique connections to the Kennedy assassination and the movie stars of Easy Rider. And as his fight with the government in Alaska grew more intense, the turmoil in his brood made it increasingly difficult to tell whether his children were messianic followers or hostages in desperate need of rescue. In this powerful piece of Americana, written with uncommon grace and high drama, Kizzia uses his unparalleled access to capture an era-defining clash between environmentalists and pioneers ignited by a mesmerizing sociopath who held a town and a family captive

    In riveting first-person prose, Dr. Brendan Reilly takes us to the front lines of medicine today. Whipsawed by daily crises and frustrations, Reilly must deal with several daunting challenges simultaneously: the extraordinary patients under his care on the teeming wards of a renowned teaching hospital; the life-threatening illnesses of both of his ninety-year-old parents; and the tragic memory of a cold case from long ago that haunts him still. As Reilly’s patients and their families survive close calls, struggle with heartrending decisions, and confront the limits of medicine’s power to cure, One Doctor lays bare a fragmented, depersonalized, business-driven health-care system where real caring is hard to find. Every day, Reilly sees patients who fall through the cracks and suffer harm because they lack one doctor who knows them well and relentlessly advocates for their best interests.Filled with fascinating characters in New York City and rural New England — people with dark secrets, mysterious illnesses, impossible dreams, and many kinds of courage — One Doctor tells their stories with sensitivity and empathy, reminding us of professional values once held dear by all physicians. But medicine has changed enormously during Reilly’s career, for both better and worse, and One Doctor is a cautionary tale about those changes. It is also a hopeful, inspiring account of medicine’s potential to improve people’s lives, Reilly’s quest to understand the "truth" about doctoring, and a moving testament to the difference one doctor can make.

    Scott Jurek is one of the world's best known and most beloved ultrarunners. Renowned for his remarkable endurance and speed, accomplished on a vegan diet, he's finished first in nearly all of ultrarunning's elite events over the course of his career. But after two decades of racing, training, speaking, and touring, Jurek felt an urgent need to discover something new about himself. He embarked on a wholly unique challenge, one that would force him to grow as a person and as an athlete: breaking the speed record for the Appalachian Trail. North is the story of the 2,189-mile journey that nearly shattered him. When he set out in the spring of 2015, Jurek anticipated punishing terrain, forbidding weather, and inevitable injuries. He would have to run nearly 50 miles a day, every day, for almost seven weeks. He knew he would be pushing himself to the limit, that comfort and rest would be in short supply -- but he couldn't have imagined the physical and emotional toll the trip would exact, nor the rewards it would offer. With his wife, Jenny, friends, and the kindness of strangers supporting him, Jurek ran, hiked, and stumbled his way north, one white blaze at a time. A stunning narrative of perseverance and personal transformation, North is a portrait of a man stripped bare on the most demanding and transcendent effort of his life. It will inspire runners and non-runners alike to keep striving for their personal best.

    In 2009, she saw an advertisement for a job at the University of Iceland and applied on a whim, despite having two young children and a comfortable life in an English cathedral city. The resulting adventure was shaped by Iceland's economic collapse, which halved the value of her salary, by the eruption of Eyjafjallajökull and by a collection of new friends, including a poet who saw the only bombs fall on Iceland in 1943, a woman who speaks to elves and a chef who guided Sarah's family around the intricacies of Icelandic cuisine.Sarah was drawn to the strangeness of Icelandic landscape, and explored hillsides of boiling mud, volcanic craters and fissures, and the unsurfaced roads that link remote farms and fishing villages in the far north. She walked the coast path every night after her children were in bed, watching the northern lights and the comings and goings of migratory birds. As the weeks and months went by, the children settled in local schools and Sarah got to know her students and colleagues, she and her family learned new ways to live.

    She volunteered to take the message to China, where the preaching she did was illegal and could result in her expulsion or worse. Here, she had some distance from her community for the first time. Immersion in a foreign language and culture--and a whole new way of thinking--turned her world upside down, and eventually led her to lose all that she had been sure was true.As a proselytizer in Shanghai, using fake names and secret codes to evade the authorities' notice, Scorah discreetly looked for targets in public parks and stores. To support herself, she found work at a Chinese language learning podcast, hiding her real purpose from her coworkers. Now with a creative outlet, getting to know worldly people for the first time, she began to understand that there were other ways of seeing the world and living a fulfilling life. When one of these relationships became an "escape hatch," Scorah's loss of faith culminated in her own personal apocalypse, the only kind of ending possible for a Jehovah's Witness.Shunned by family and friends as an apostate, Scorah was alone in Shanghai and thrown into a world she had only known from the periphery--with no education or support system. A coming of age story of a woman already in her thirties, this unforgettable memoir examines what it's like to start one's life over again with an entirely new identity. It follows Scorah to New York City, where a personal tragedy forces her to look for new ways to find meaning in the absence of religion. With compelling, spare prose, Leaving the Witness traces the bittersweet process of starting over, when everything one's life was built around is gone.

    But behind her seemingly flawless façade lay a dangerous secret—for the better part of her life Cheney had been battling debilitating bipolar disorder and concealing a pharmacy's worth of prescriptions meant to stabilize her moods and make her "normal."In bursts of prose that mirror the devastating highs and extreme lows of her illness, Cheney describes her roller-coaster life with shocking honesty—from glamorous parties to a night in jail; from flying fourteen kites off the edge of a cliff in a thunderstorm to crying beneath her office desk; from electroshock therapy to a suicide attempt fueled by tequila and prescription painkillers.With Manic, Cheney gives voice to the unarticulated madness she endured. The clinical terms used to describe her illness were so inadequate that she chose to focus instead on her own experience, in her words, "on what bipolar disorder felt like inside my own body." Here the events unfold episodically, from mood to mood, the way she lived and remembers life. In this way the reader is able to viscerally experience the incredible speeding highs of mania and the crushing blows of depression, just as Cheney did. Manic does not simply explain bipolar disorder—it takes us in its grasp and does not let go.In the tradition of Darkness Visible and An Unquiet Mind, Manic is Girl, Interrupted with the girl all grown up. This harrowing yet hopeful book is more than just a searing insider's account of what it's really like to live with bipolar disorder. It is a testament to the sharp beauty of a life lived in extremes.

    As the current CEO of Children's National in Washington, D.C., the author presents an argument to place children's medical requirements and their need to thrive well into adulthood at the forefront of American medicine, and he admits that 'these kids have been my real teachers

    Pink, author of Drive and A Whole New MindA psychiatrist’s stories of his most bizarre cases, The Naked Lady Who Stood on Her Head by Gary Small, M.D., and Gigi Vorgan—co-authors of The Memory Bible—offers a fascinating and highly entertaining look into the peculiarities of the human mind. In the vein of The Man Who Mistook His Wife for a Hat, Awakenings, and the other bestselling works of Oliver Sacks, The Naked Lady Who Stood on Her Head surprises, enthralls, and illuminates as it focuses on medical mysteries that would stump and amaze the brilliant brains on House, M.D.

    Instead, he finds that he has joined a new world where race is front and center. The recipient of a scholarship designed to increase black student enrollment, Tweedy soon meets a professor who bluntly questions whether he belongs in medical school, a moment that crystallizes the challenges he will face throughout his career. Making matters worse, in lecture after lecture the common refrain for numerous diseases resounds, "More common in blacks than in whites."Black Man in a White Coat examines the complex ways in which both black doctors and patients must navigate the difficult and often contradictory terrain of race and medicine. As Tweedy transforms from student to practicing physician, he discovers how often race influences his encounters with patients. Through their stories, he illustrates the complex social, cultural, and economic factors at the root of many health problems in the black community. These issues take on greater meaning when Tweedy is himself diagnosed with a chronic disease far more common among black people. In this powerful, moving, and deeply empathic book, Tweedy explores the challenges confronting black doctors, and the disproportionate health burdens faced by black patients, ultimately seeking a way forward to better treatment and more compassionate care.

    Kathryn Mannix has studied and practiced palliative care for thirty years. In With the End in Mind , she shares beautifully crafted stories from a lifetime of caring for the dying, and makes a case for the therapeutic power of approaching death not with trepidation, but with openness, clarity, and understanding. Weaving the details of her own experiences as a caregiver through stories of her patients, their families, and their distinctive lives, Dr. Mannix discusses the universal, but deeply personal, process of dying. With meditations on life, death, and the space between them, With the End in Mind describes the possibility of meeting death gently, with forethought and preparation, and shows the unexpected beauty, dignity, and profound humanity of life coming to an end.