It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species births, deaths, disease, war, famine, migration, and a lot of sex. Since scientists first read the human genome in 2001, it has been subject to all sorts of claims, counterclaims, and myths. In fact, as Adam Rutherford explains, our genomes should be read not as instruction manuals, but as epic poems. DNA determines far less than we have been led to believe about us as individuals, but vastly more about us as a species. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about history, and what history tells us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be."

    After college, they married and drove to Amherst, Massachusetts, where Straight met her teacher and mentor, James Baldwin, who encouraged her to write. Once back in Riverside, at weekly driveway barbecues and fish fries with the large, close-knit Sims family, Straight―and eventually her three daughters―learned the stories of Dwayne’s ancestors. Some women escaped violence in post-slavery Tennessee, some escaped murder in Jim Crow Mississippi, and some fled abusive men. Straight’s mother-in-law, Alberta Sims, is the descendant at the heart of this memoir. Susan’s family, too, reflects the hardship and gumption of women pushing onward―from Switzerland, Wisconsin, Canada, and the Colorado Rockies to California.A Pakistani word, biraderi, is one Straight uses to define a complex system of kinship and clan―those who become your family. She and Sims divorced after their third daughter was born, but he lives nearby and the family has remained close. Of her three girls, now grown and working in museums and the entertainment industry, Straight writes, “The daughters of our ancestors carry in their blood at least three continents. We are not about borders. We are about love and survival.” In the Country of Women is a valuable social history and a personal narrative that reads like a love song to America and indomitable women.

    These periods of dislocation can be lonely and unexpected. For May, her husband fell ill, her son stopped attending school, and her own medical issues led her to leave a demanding job. Wintering explores how she not only endured this painful time, but embraced the singular opportunities it offered.A moving personal narrative shot through with lessons from literature, mythology, and the natural world, May’s story offers instruction on the transformative power of rest and retreat. Illumination emerges from many sources: solstice celebrations and dormice hibernation, C.S. Lewis and Sylvia Plath, swimming in icy waters and sailing arctic seas.Ultimately Wintering invites us to change how we relate to our own fallow times. May models an active acceptance of sadness and finds nourishment in deep retreat, joy in the hushed beauty of winter, and encouragement in understanding life as cyclical, not linear. A secular mystic, May forms a guiding philosophy for transforming the hardships that arise before the ushering in of a new season.

    Erin recounts everything from meeting her soulmate at age 14 to her first chemotherapy session at age 19 to what really goes on behind the scenes at a major Internet media company. She authentically captures the agony and the ecstasy of the millennial experience, whether it's her first kiss ("Sean's tongue! In my mouth! Slippery and wet like a slug in the rain.") or her struggles with anxiety ("When people throw caution to the wind, I am stuck imagining the poor soul who has to break his back sweeping caution into a dustpan"). Yet Erin also offers a fresh perspective on universal themes of resilience and love as she writes about surviving cancer, including learning of her mother's own cancer diagnosis within the same year, and her attempts to hide the diagnosis from friends to avoid "un-normaling" everything.

    Despite a successful career as a writer, and an exciting life in New York City, Glynnis was constantly reminded she had neither of the things the world expected of a woman her age: a partner or a baby. She knew she was supposed to feel bad about this. After all, single women and those without children are often seen as objects of pity, relegated to the sidelines, or indulgent spoiled creatures who think only of themselves.Glynnis refused to be cast into either of those roles and yet the question remained: What now? There was no good blueprint for how to be a woman alone in the world. She concluded it was time to create one.Over the course of her fortieth year, which this memoir chronicles, Glynnis embarks on a revealing journey of self-discovery that continually contradicts everything she’d been led to expect. Through the trials of family illness and turmoil, and the thrills of far-flung travel and adventures with men, young and old (and sometimes wearing cowboy hats), she is forced to wrestle with her biggest hopes and fears about love, death, sex, friendship, and loneliness. In doing so, she discovers that holding the power to determine her own fate requires a resilience and courage that no one talks about, and is more rewarding than anyone imagines.Intimate and timely, No One Tells You This is a fearless reckoning with modern womanhood and an exhilarating adventure that will resonate with anyone determined to live by their own rules.

    How many of us understand the way seizures affect the brain, how the heart is connected to wellbeing, or the why the foot carries the key to our humanity? In Adventures in Human Being, award-winning author Gavin Francis leads readers on a journey into the hidden pathways of the human body, offering a guide to its inner workings and a celebration of its marvels.Drawing on his experiences as a surgeon, ER specialist, and family physician, Francis blends stories from the clinic with episodes from medical history, philosophy, and literature to describe the body in sickness and in health, in living and in dying. At its heart, Adventures in Human Being is a meditation on what it means to be human. Poetic, eloquent, and profoundly perceptive, this book will transform the way you view your body.

    Enduring half a dozen surgeries, the drugs he received were both miraculous and essential to his recovery. But his most profound suffering came several months later when he went into acute opioid withdrawal while following his physician’s orders. Over the course of four excruciating weeks, Rieder learned what it means to be “dope sick”—the physical and mental agony caused by opioid dependence. Clueless how to manage his opioid taper, Travis’s doctors suggested he go back on the drugs and try again later. Yet returning to pills out of fear of withdrawal is one route to full-blown addiction. Instead, Rieder continued the painful process of weaning himself.Rieder’s experience exposes a dark secret of American pain management: a healthcare system so conflicted about opioids, and so inept at managing them, that the crisis currently facing us is both unsurprising and inevitable. As he recounts his story, Rieder provides a fascinating look at the history of these drugs first invented in the 1800s, changing attitudes about pain management over the following decades, and the implementation of the pain scale at the beginning of the twenty-first century. He explores both the science of addiction and the systemic and cultural barriers we must overcome if we are to address the problem effectively in the contemporary American healthcare system.In Pain in America is not only a gripping personal account of dependence, but a groundbreaking exploration of the intractable causes of America’s opioid problem and their implications for resolving the crisis. Rieder makes clear that the opioid crisis exists against a backdrop of real, debilitating pain—and that anyone can fall victim to this epidemic.

    Struggling to pay her college tuition, Hindman accepts a dream position in an award-winning ensemble that brings ready money. But the ensemble is a sham. When the group performs, the microphones are off while the music―which sounds suspiciously like the soundtrack to the movie "Titanic"―blares from a hidden CD player. Hindman, who toured with the ensemble and its peculiar composer for four years, writes with unflinching candor and humor about her surreal and quietly devastating odyssey. Sounds Like Titanic is at once a singular coming-of-age memoir about the lengths to which one woman goes to make ends meet and an incisive articulation of modern anxieties about gender, class, and ambition.

    In Counting Backwards, pediatric anesthesiologist Dr. Henry Jay Przybylo delivers an unforgettable account of the procedure’s daily dramas and fundamental mysteries. Przybylo has administered anesthesia more than 30,000 times over his thirty-year career: on newborn babies, screaming toddlers, sullen teenagers, even a gorilla. Filled with intense moments of near-disaster, life-saving successes, and simple grace, Counting Backwards is for anyone curious about what happens after we lose consciousness.

    Carol Wall, a white woman living in a lily-white neighborhood in Middle America, was at a crossroads in her life. Her children were grown; she had successfully overcome illness; her beloved parents were getting older. One day she notices a dark-skinned African man tending her neighbor's yard. His name is Giles Owita. He bags groceries at the supermarket. He comes from Kenya. And he's very good at gardening. Before long Giles is transforming not only Carol's yard, but her life. Though they are seemingly quite different, a caring bond grows between them. But they both hold long-buried secrets that, when revealed, will cement their friendship forever.

    Plagued with fear that her friends and family will be taken from her if she's not watching--that her mother will die, or forget she has children and just move away--Stern treats every parting as her last. Shuttled between a barefoot bohemian life with her mother in Greenwich Village, and a sanitized, stricter world of affluence uptown with her father, Stern has little she can depend on. And when Etan Patz disappears down the block from their MacDougal Street home, she can't help but believe that all her worst fears are about to come true. Tenderly delivered and expertly structured, Stern's memoir is a document of the transformation of New York City and a deep, personal, and comedic account of the trials and errors of seeing life through a very unusual lens.

    Most of all, he was a wily tactician whose mission was to carry his sons across the shoals of inner-city adolescence and through the collapsing civilization of Baltimore in the Age of Crack, and into the safe arms of Howard University, where he worked so his children could attend for free. Among his brood of seven, his main challenges were Ta-Nehisi, spacey and sensitive and almost comically miscalibrated for his environment, and Big Bill, charismatic and all-too-ready for the challenges of the streets.The Beautiful Struggle follows their divergent paths through this turbulent period, and their father's steadfast efforts assisted by mothers, teachers, and a body of myths, histories, and rituals conjured from the past to meet the needs of a troubled present to keep them whole in a world that seemed bent on their destruction. With a remarkable ability to reimagine both the lost world of his fathers generation and the terrors and wonders of his own youth, Coates offers readers a small and beautiful epic about boys trying to become men in black America and beyond.

    George and Ben have three weeks to cycle 1000 miles from the bottom of England to the top of Scotland. There is just one small problem… they have no bikes, no clothes, no food and no money. Setting off in just a pair of Union Jack boxer shorts, they attempt to rely on the generosity of the British public for everything from food to accommodation, clothes to shoes, and bikes to beer.During the most hilarious adventure, George and Ben encounter some of Great Britain's most eccentric and extraordinary characters and find themselves in the most ridiculous situations. Free Country is guaranteed to make you laugh (you may even shed a tear). It will restore your faith in humanity and leave you with a big smile on your face and a warm feeling inside.

    He chronicled the trip on Instagram, where his photos and reflections drew hundreds of thousands of followers, all gathered around the question: What makes a life worth living?In this unflinchingly honest memoir, Jed narrates his adventure--the people and places he encountered on his way to the bottom of the world--as well as the internal journey that started it all. As he traverses cities, mountains, and inner boundaries, Jenkins grapples with the question of what it means to be an adult, his struggle to reconcile his sexual identity with his conservative Christian upbringing, and his belief in travel as a way to wake us up to life back home.A soul-stirring read for the wanderer in each of us, To Shake the Sleeping Self is an unforgettable reflection on adventure, identity, and a life lived without regret.Praise for To Shake the Sleeping Self"[Jenkins is] a guy deeply connected to his personal truth and just so refreshingly present."--Rich Roll, author of Finding Ultra"This is much more than a book about a bike ride. This is a deep soul deepening us. Jedidiah Jenkins is a mystic disguised as a millennial."--Tom Shadyac, author of Life's Operating Manual"Thought-provoking and inspirational . . . This uplifting memoir and travelogue will remind readers of the power of movement for the body and the soul." --Publishers Weekly

    But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.