Their initial optimism is short-lived, however, as the ice field slowly thickens, encasing the ship Endurance in a death-grip, crushing their craft, and marooning 28 men on a polar ice floe.In an epic struggle of man versus the elements, Shackleton leads his team on a harrowing quest for survival over some of the most unforgiving terrain in the world. Icy, tempestuous seas full of gargantuan waves, mountainous glaciers and icebergs, unending brutal cold, and ever-looming starvation are their mortal foes as Shackleton and his men struggle to stay alive.What happened to those brave men forever stands as a testament to their strength of will and the power of human endurance.This is their story, as told by the man who led them.

    

    What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world.Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure.

    A week later, Lincoln Hall, a seasoned Australian climber, was left for dead near the same spot. Hall's death was reported around the world, but the next day he was found alive after spending the night on the upper mountain with no food and no shelter.If David Sharp's death was shocking, it was hardly singular: despite unusually good weather, ten others died attempting to reach the summit that year. In this meticulous inquiry into what went wrong, Nick Heil tells the full story of the deadliest year on Everest since the infamous season of 1996. He introduces Russell Brice, the commercial operator who has done more than anyone to provide access to the summit via the mountain's north side—and who some believe was partly accountable for Sharp's death. As more climbers attempt the summit each year, Heil shows how increasingly risky expeditions and unscrupulous outfitters threaten to turn Everest into a deadly circus.Written by an experienced climber and outdoor writer, Dark Summit is both a riveting account of a notorious climbing season and a troubling investigation into whether the pursuit of the ultimate mountaineering prize has spiraled out of control.

    Enduring half a dozen surgeries, the drugs he received were both miraculous and essential to his recovery. But his most profound suffering came several months later when he went into acute opioid withdrawal while following his physician’s orders. Over the course of four excruciating weeks, Rieder learned what it means to be “dope sick”—the physical and mental agony caused by opioid dependence. Clueless how to manage his opioid taper, Travis’s doctors suggested he go back on the drugs and try again later. Yet returning to pills out of fear of withdrawal is one route to full-blown addiction. Instead, Rieder continued the painful process of weaning himself.Rieder’s experience exposes a dark secret of American pain management: a healthcare system so conflicted about opioids, and so inept at managing them, that the crisis currently facing us is both unsurprising and inevitable. As he recounts his story, Rieder provides a fascinating look at the history of these drugs first invented in the 1800s, changing attitudes about pain management over the following decades, and the implementation of the pain scale at the beginning of the twenty-first century. He explores both the science of addiction and the systemic and cultural barriers we must overcome if we are to address the problem effectively in the contemporary American healthcare system.In Pain in America is not only a gripping personal account of dependence, but a groundbreaking exploration of the intractable causes of America’s opioid problem and their implications for resolving the crisis. Rieder makes clear that the opioid crisis exists against a backdrop of real, debilitating pain—and that anyone can fall victim to this epidemic.

    It was to last five years and transform him from an amiable and somewhat aimless young man into a scientific celebrity. Even more vitally, it was to set in motion the intellectual currents that culminated in the arrival of The Origin of Species in Victorian drawing-rooms in 1859. His journal, reprinted here in a shortened version, is vivid and immediate, showing us a naturalist making patient observations, above all in geology. As well as a profusion of natural history detail, it records many other things that caught Darwin’s eye, from civil war in Argentina to the new colonial settlements of Australia. The editors have provided an excellent introduction and notes for this Penguin Classics edition, which also contains maps and appendices, including an essay on scientific geology and the Bible by Robert FitzRoy, Darwin’s friend and captain of the Beagle.

    An exhilarating account of Sapolsky’s twenty-one-year study of a troop of rambunctious baboons in Kenya, A Primate’s Memoir interweaves serious scientific observations with wry commentary about the challenges and pleasures of living in the wilds of the Serengeti — for man and beast alike. Over two decades, Sapolsky survives culinary atrocities, gunpoint encounters, and a surreal kidnapping, while witnessing the encroachment of the tourist mentality on the farthest vestiges of unspoiled Africa. As he conducts unprecedented physiological research on wild primates, he becomes evermore enamored of his subjects — unique and compelling characters in their own right — and he returns to them summer after summer, until tragedy finally prevents him.By turns hilarious and poignant, A Primate’s Memoir is a magnum opus from one of our foremost science writers.

    Sir Douglas Mawson is remembered as the young Australian who would not go to the South Pole with Robert Scott in 1911, choosing instead to lead his own expedition on the less glamorous mission of charting nearly 1,500 miles of Antarctic coastline and claiming its resources for the British Crown. His party of three set out through the mountains across glaciers in 60-mile-per-hour winds. Six weeks and 320 miles out, one man fell into a crevasse, along with the tent, most of the equipment, all of the dogs' food, and all except a week's supply of the men's provisions.Mawson's Will is the unforgettable story of one man's ingenious practicality and unbreakable spirit and how he continued his meticulous scientific observations even in the face of death. When the expedition was over, Mawson had added more territory to the Antarctic map than anyone else of his time. Thanks to Bickel's moving account, Mawson can be remembered for the vision and dedication that make him one of the world's great explorers.

    Thousands have had such dreams, but Richard Proenneke lived them. He found a place, built a cabin, and stayed to become part of the country. One Man's Wilderness is a simple account of the day-to-day explorations and activities he carried out alone, and the constant chain of nature's events that kept him company. From Proenneke's journals, and with first-hand knowledge of his subject and the setting, Sam Keith has woven a tribute to a man who carved his masterpiece out of the beyond.

    We are most familiar with the viruses that give us colds or the flu, but viruses also cause a vast range of other diseases, including one disorder that makes people sprout branch-like growths as if they were trees. Viruses have been a part of our lives for so long, in fact, that we are actually part virus: the human genome contains more DNA from viruses than our own genes. Meanwhile, scientists are discovering viruses everywhere they look: in the soil, in the ocean, even in caves miles underground.This fascinating book explores the hidden world of viruses—a world that we all inhabit. Here Carl Zimmer, popular science writer and author of Discover magazine’s award-winning blog The Loom, presents the latest research on how viruses hold sway over our lives and our biosphere, how viruses helped give rise to the first life-forms, how viruses are producing new diseases, how we can harness viruses for our own ends, and how viruses will continue to control our fate for years to come. In this eye-opening tour of the frontiers of biology, where scientists are expanding our understanding of life as we know it, we learn that some treatments for the common cold do more harm than good; that the world’s oceans are home to an astonishing number of viruses; and that the evolution of HIV is now in overdrive, spawning more mutated strains than we care to imagine.The New York Times Book Review calls Carl Zimmer “as fine a science essayist as we have.” A Planet of Viruses is sure to please his many fans and further enhance his reputation as one of America’s most respected and admired science journalists.

    

    In other words, by all of us."--Dr. Bernie Siegel, author of Love, Medicine and MiraclesRule One for the neurologist in residence: "You ain't never the same when the air hits your brain." In this fascinating book, Dr. Frank Vertosick brings that fact to life through intimate portraits of patients and unsparing yet gripping descriptions of brain surgery.With insight, humor, and poignancy, Dr. Vertosick chronicles his remarkable evolution from naive young intern to world-class neurosurgeon, where he faced, among other challenges, a six week-old infant with a tumor in her brain, a young man struck down in his prime by paraplegia, and a minister with a .22 caliber bullet lodged in his skull. In candid detail, WHEN THE AIR HITS YOUR BRAIN illuminates both the mysteries of the mind and the realities of the operating room."Riveting."--Publishers Weekly

    Jerri Nielsen, the only physician on a staff of forty-one people, discovered a lump in her breast. Consulting via satellite e-mail with doctors in the United States, she was forced to perform a biopsy and treat herself with chemotherapy in order to ensure that she could survive until conditions permitted her rescue. She was eventually rescued by the Air National Guard. Dr. Jerri Nielsens story of her transforming experiences is a thrilling adventure and moving drama. She has written a new chapter for this edition. Since the publication of Ice Bound in hardcover in January 2000, Dr. Nielsen has inspired people throughout the country, met hundreds of fans, received numerous awards including Irish American of the Year, which was presented to her by Hillary Clinton, as well as tremendous praise from the media.

    Reader and protagonist alike are challenged into new ways of understanding culture clash, slavery and the place of Islam in the social fabric of desert-dwelling peoples.In a calm May morning in 1815, Captain James Riley and the crew of the Commerce left port in Connecticut for an ordinary trading voyage. They could never have imagined what awaited them. Their nightmare began with a dreadful shipwreck off the coast of Africa, a hair-raising confrontation with hostile native tribesmen within hours of being washed ashore, and a hellish confinement in a rickety longboat as they tried, without success, to escape the fearsome coast. Eventually captured by desert nomads and sold into slavery, Riley and his men were dragged along on an insane journey through the bone-dry heart of the Sahara—a region unknown to Westerners. Along the way the Americans would encounter everything that could possibly test them: barbarism, murder, starvation, plagues of locusts, death, sandstorms that lasted for days, dehydration, and hostile tribes that roamed the desert on armies of camels. They would discover ancient cities and secret oases. They would also discover a surprising bond between a Muslim trader and an American sea captain, men who began as strangers, were forced to become allies in order to survive, and, in the tempering heat of the desert, became friends—even as the captain hatched a daring betrayal in order to save his men. From the cold waters of the Atlantic to the searing Saharan sands, Skeletons on the Zahara is a spectacular odyssey through the extremes. Destined to become a classic among adventure narratives, Dean King's masterpiece is an unforgettable tale of survival, courage, and brotherhood.

    It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.