David Agus tackles these fundamental questions and dismantles misperceptions about what “health” really means. Presenting an eye-opening picture of the human body and all the ways it works—and fails—Dr. Agus shows us how a new perspective on our individual health will allow us to achieve a long, vigorous life. Offering insights and access to powerful new technologies that promise to transform medicine, Dr. Agus emphasizes his belief that there is no “right” answer, no master guide that is “one size fits all.” Each one of us must get to know our bodies in uniquely personal ways, and he shows us exactly how to do that. A bold call for all of us to become our own personal health advocates, The End of Illness is a moving departure from orthodox thinking.

    Fields Cookies... What backward messages on records are really trying to tell you... Frank Sinatra's real age... Why you can't counterfeit a lottery ticket... Barbra Streisand's blue movie... The other Boy Scout rituals... Ingmar Bergman's soap commercials... The formula for Play-Doh... and more.

    The Perfection Point is ideal for sports fans interested in the scientific basis of athletic excellence and a fascinating read for science fans interested in the physics of sports.

    Should you act like ‘top dog’ to maintain control? No, you’re better off displaying your friendliness – and not just to your dog. Which breed is the cleverest? That’s the wrong question to ask.These are just some of the extraordinary insights to be found in 'The Genius of Dogs' – the seminal book on how dogs evolved their unique intelligence by award-winning scientist Dr Brian Hare. He shares more than two decades of startling discoveries about the mysteries of the dog mind and how you can use his groundbreaking work to build a better relationship with your own dog.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    And no delay causes more parental anxiety than late talking, which is associated in many parents' minds with such serious conditions as autism and severe intellectual disability. In fact, as children's speech expert Stephen Camarata points out in this enlightening book, children are late in beginning to talk for a wide variety of reasons. For some children, late talking may be a symptom of other, more serious, problems; for many others, however, it may simply be a stage with no long-term complications.Camarata describes in accessible language what science knows about the characteristics and causes of late talking. He explains that late talking is only one of a constellation of autism symptoms. Although all autistic children are late talkers, not all late-talking children are autistic.Camarata draws on more than twenty-five years of professional experience diagnosing and treating late talkers--and on his personal experience of being a late talker himself and having a late-talking son. He provides information that will help parents navigate the maze of doctors, speech therapists, early childhood services, and special education; and he describes the effect that late talking may have on children's post-talking learning styles.

    

    As part of the healing process, she decided to use DNA research to learn more about herself, her family, and the interconnectedness of society. She went deep in search of her genealogy, having her DNA sequenced and tested, and effectively becoming an experimental subject. Remarkably, she was able to trace the path of her ancestors through recorded history and into prehistory. Through the course of her research, she met dozens of scientists working in genetic research. The narrative travels the length and breadth of Europe, from the Neanderthals of central Germany to the Cro-Magnon in France. Bojs visited the ancient caves, realizing that her direct ancestors must have been living in the area when the cave art was painted. A second DNA analysis later revealed she has Sami (i.e. Lapp) genetic material in her genome, and there were further revelations about her hunter-gatherer, Bronze-Age, and Iron-Age relatives, including the Vikings. This fresh, first-person exploration of genes and genetics goes well beyond personal genealogy and reveals much about the shared history of European peoples.

    But how has the earth itself determined our destiny? Our planet wobbles, driving changes in climate that forced the transition from nomadism to farming. Mountainous terrain led to the development of democracy in Greece. Atmospheric circulation patterns later on shaped the progression of global exploration, colonization, and trade. Even today, voting behavior in the south-east United States ultimately follows the underlying pattern of 75 million-year-old sediments from an ancient sea. Everywhere is the deep imprint of the planetary on the human.From the cultivation of the first crops to the founding of modern states, Origins reveals the breathtaking impact of the earth beneath our feet on the shape of our human civilizations.

    You’ll be there as Dr. Kristine Guleserian, noted pediatric cardiothoracic surgeon, fixes the tiny hearts of the tiniest children. Follow the young boy who gets a new heart and then, three weeks later, joins Dr. Guleserian on the mound at Fenway Park to throw out the first pitch at a World Series game. Discover the years of training Dr. G went through to become the highly respected surgeon she is today. See how her warmth, humor, intelligence and dedication provide a shining example of what is good about the American health care system. To get a closer look than this, you’d have to scrub in.

    Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease. Those in cows and termites digest the plants they eat. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squids with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. I Contain Multitudes is the story of these extraordinary partnerships, between the creatures we are familiar with and those we are not. It reveals how we humans are disrupting these partnerships and how we might manipulate them for our own good. It will change both our view of nature and our sense of where we belong in it.

    Jason Fung returns with an eye-opening biography of cancer in which he offers a radical new paradigm for understanding cancer—and issues a call to action for reducing risk moving forward. Our understanding of cancer is slowly undergoing a revolution, allowing for the development of more effective treatments. For the first time ever, the death rate from cancer is showing a steady decline . . . but the “War on Cancer” has hardly been won.In The Cancer Code, Dr. Jason Fung offers a revolutionary new understanding of this invasive, often fatal disease—what it is, how it manifests, and why it is so challenging to treat. In this rousing narrative, Dr. Fung identifies the medical community’s many missteps in cancer research—in particular, its focus on genetics, or what he terms the “seed” of cancer, at the expense of examining the “soil,” or the conditions under which cancer flourishes. Dr. Fung—whose groundbreaking work in the treatment of obesity and diabetes has won him international acclaim—suggests that the primary disease pathway of cancer is caused by the dysregulation of insulin. In fact, obesity and type 2 diabetes significantly increase an individual’s risk of cancer.In this accessible read, Dr. Fung provides a new paradigm for dealing with cancer, with recommendations for what we can do to create a hostile soil for this dangerous seed. One such strategy is intermittent fasting, which reduces blood glucose, lowering insulin levels. Another, eliminating intake of insulin-stimulating foods, such as sugar and refined carbohydrates.For hundreds of years, cancer has been portrayed as a foreign invader we’ve been powerless to stop. By reshaping our view of cancer as an internal uprising of our own healthy cells, we can begin to take back control. The seed of cancer may exist in all of us, but the power to change the soil is in our hands.

    Gravity is a compilation of Q&A posts from Mark Rippetoe s StrengthMill forum. Edited for brevity, efficiency, clarity, accuracy, and taste (in a loose sense, sorry), Mean Ol' Mr. Gravity adds to the information available in Starting Strength: Basic Barbell Training and Practical Programming for Strength Training by tailoring it to the individual through his responses to questions posed by actual humans regarding their own training. It preserves the coarseness, humor, and candor that have become Rip s trademark style. A Question. Goombahboy: Hey Rip, why would you make a book out of a bunch of posts that are already available on the web? What could you possibly have been thinking? Mark Rippetoe: An excellent question. I have no idea, other than the fact that a book like this makes an excellent bathroom companion. The reading-kind of companion. Information and humor in small, easily managed chunks. Conveniently digestible pieces, as it were. Well, you know what I mean. Bozo1988: Yeah, what were you thinking? I mean, I know there s a lot of information here, I know that all of the really stupid stuff that would waste my time while reading it online has been removed, and that the videos posted on the board don t load very fast in a book format anyway, but why a book? Mark Rippetoe: Look, just read the damn thing, okay? You ll be fine.

    Time-saving study tools help readers arrive at a complete understanding of human anatomy. KEY TOPICS: An Introduction to Anatomy, The Cell, Tissues and Early Embryology, The Integumentary System, The Skeletal System: Osseous Tissue and Skeletal Structure, The Skeletal System: Axial Division, The Skeletal System: Appendicular Division, The Skeletal System: Articulations, The Muscular System: Skeletal Muscle Tissue and Muscle Organization, The Muscular System: Axial Musculature, The Muscular System: Appendicular Musculature, Surface Anatomy and Cross-Sectional Anatomy, The Nervous System: Neural Tissue, The Nervous System: The Spinal Cord and Spinal Nerves, The Nervous System: The Brain and Cranial Nerves, The Nervous System: Pathways And Higher-Order Functions, The Nervous System:  Autonomic Division, The Nervous System: General and Special Senses, The Endocrine System, The Cardiovascular System: Blood, The Cardiovascular System: The Heart, The Cardiovascular System: Vessels and Circulation, The Lymphoid System, The Respiratory System, The Digestive System, The Urinary System, The Reproductive System, The Reproductive System: Embryology and HumanDevelopment. MARKET: For all readers interested in human anatomy.

    What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.