As recently as 1918, a pandemic of influenza claimed over 50 million lives worldwide. The advent of drugs and vaccines led to an era of hope when we thought our battles with infectious disease were won, but our optimism has been eroded by the recognition that many pathogens have the capacity to transform themselves and escape our efforts to eradicate them. Are we now facing an inevitable repeat of a calamity such as the 1918 influenza pandemic or the Black Death? Can we anticipate and thwart such an event, or are we wilfully creating the conditions that would promote the emergence of new and highly virulent human infectious disease?Sunetra Gupta is Professor of Theoretical Epidemiology at the University of Oxford specialising in infectious diseases. She holds a bachelor's degree from Princeton University and a Ph.D. from the University of London. She has been awarded the Scientific Medal by the Zoological Society of London and the Royal Society Rosalind Franklin Award for her scientific research. She is also a novelist whose books have been awarded the Sahitya Akademi Award, the Southern Arts Literature Prize, shortlisted for the Crossword Award, and longlisted for the DSC and Orange Prizes.

    But this book takes the reader on a journey that starts before her marriage, before she came to be seen as the static icon of the age that bears her name. From her isolated childhood at Kensington Palace, where her daily life was controlled by a man who plotted to one day seize power through her, Victoria emerged shortly after her 18th birthday as a fully-fledged Queen, a young woman who gloried in her newfound power and freedom. Over the next twenty years, she fell in love—twice, if the rumors are to be believed—bore nine children, and kept a daily diary which recorded her private, inward struggles: how to reconcile her role as monarch with her duties as a wife and mother, how to protect her country and her throne in an age of revolution. Ultimately, readers of this book will discover how Queen Victoria redefined the monarchy for her own age—and afterwards.

    But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    Sip coconuts on a Caribbean beach; lay eyes on the awe-inspiring Panama Canal; or hike through sublime cloud forests; all with your trusted travel companion. Get to the heart of Panama and begin your journey now! Inside Lonely Planet Panama: Color maps and images throughout Highlights and itineraries help you tailor your trip to your personal needs and interests Insider tips to save time and money and get around like a local, avoiding crowds and trouble spots Essential info at your fingertips - hours of operation, phone numbers, websites, transit tips, prices Honest reviews for all budgets - eating, sleeping, sight-seeing, going out, shopping, hidden gems that most guidebooks miss Cultural insights give you a richer, more rewarding travel experience - land & wildlife, music, cuisine, arts, politics, history Over 46 maps Covers Panama City, Panama Province, Cocle Province, Peninsula deAzuero, Veraguas Province, Chiriqui Province, Bocas del Toro Province, Colon Province, Comarca de Kuna Yala, Darien Province and more eBook Features: (Best viewed on tablet devices and smartphones) Downloadable PDF and offline maps prevent roaming and data charges Effortlessly navigate and jump between maps and reviews Add notes to personalise your guidebook experience Seamlessly flip between pages Bookmarks and speedy search capabilities get you to key pages in a flash Embedded links to recommendations' websites Zoom-in maps and images Inbuilt dictionary for quick referencing The Perfect Choice: Lonely Planet Panama, our most comprehensive guide to Panama, is perfect for both exploring top sights and taking roads less traveled. Looking for more extensive coverage? Check out Lonely Planet Central America on a Shoestring. Authors: Written and researched by Lonely Planet. About Lonely Planet: Since 1973, Lonely Planet has become the world's leading travel media company with guidebooks to every destination, an award-winning website, mobile and digital travel products, and a dedicated traveler community. Lonely Planet covers must-see spots but also enables curious travelers to get off beaten paths to understand more of the culture of the places in which they find themselves. *Best-selling guide to Panama. Source: Nielsen BookScan. Australia, UK and USA Important Notice: The digital edition of this book may not contain all of the images found in the physical edition.

    Global sea levels, as the result of rapidly melting polar ice rose by more than 300 feet in a very short period of time, causing the planet to become unstable.In Egypt, Peru, Bolivia, Lebanon and other locations we see the existence of ancient damaged but very sophisticated megalithic stone structures which we would be hard pressed to re-create today. They hint that once upon a time one or "Atlantean" civilizations indeed did exist

    Hamilton was reshaping the image of the vampire with her own take on the vampire mythos in her Anita Blake, Vampire Hunter fantasy novel series. While Hamilton's work draws on traditional vampire and fairy lore, her interpretation of these subjects brought new dimensions to the genres, influencing the direction of urban fantasy over the past two decades.Reading Laurell K. Hamilton focuses upon Hamilton's two bestselling series, the Anita Blake, Vampire Hunter series and the Merry Gentry series. The volume is intended as a resource for leaders of book clubs or discussion groups, containing chapters that examine Hamilton's role in the current vampire literature craze, the themes and characters in her work, and responses to Hamilton on the Internet. The book also provides a brief overview of Hamilton's life.

    This new edition specifically features three new care plans, two expanded care plans, updated content and language reflecting the most current clinical practice and professional standards, enhanced QSEN integration, a new emphasis on interprofessional collaborative practice, an improved page design, and more. It's everything you need to create and customize effective nursing care plans!

    Enjoy an entertaining look at the history of the Featherweight sewing machine. Expanded third edition updated with the latest research. Packed with photos, stories, and handy information. Learn to date and troubleshoot your machine. A fun read for quilters, Featherweight owners, and history buffs.

    The calls to ban it were more or less instant.Re:cyclists is the tale of what happened next, of how we have spent two centuries wheeling our way about town and country on bikes--or on two-wheeled things that vaguely resembled what we now call bikes. Michael Hutchinson picks his way through those 200 years, discovering how cycling became a kinky vaudeville act for Parisians, how it became an American business empire, and how it went on to find a unique home in the British Isles. He considers the penny-farthing riders exploring the abandoned and lonely coaching roads during the railway era, and the Victorian high-society cyclists of the 1890s bicycle craze--a time when no aristocratic house party was without bicycles and when the Prince of Wales used to give himself an illicit thrill on a weekday afternoon by watching the women's riding-school in the Royal Albert Hall.Re:cyclists looks at how cycling became the sport, the pastime and the social life of millions of ordinary people, how it grew and how it suffered through the 1960s and '70s, and how at the dawn of the twenty-first century it rose again, much changed but still ultimately just someone careering along on two wheels.

    The war at sea was a critical contest, as sea-lanes provided the logistical arteries for British and subsequent Allied armies fighting on the three continents of Africa, Asia, and Europe. Land forces ultimately won World War II, but the battles at sea fundamentally altered the balance of military power on the ground.

    After several failed attempts he got out over the wire and journeyed for weeks as a fugitive from northern France to Marseilles, then across the Pyrenees to Spain and Gibraltar and freedom. He was guided along the way by French civilians, resistance fighters and the organizers of the famous Pat escape line. His straightforward, honest and vivid memoir of his work as a surgeon at Dunkirk, life in the prison camps and his escape attempts gives a fascinating insight into his wartime experience. It records the ingenuity and courage of the individuals, the ordinary men and women, who risked their lives to help him on his way. It is also one of the best accounts we have of what it was like to be on the run in occupied Europe.

     Do you know the best martial art for 'real' street self-defense? Or how board breaking really works - and how you can do it? Uncover the one self-defense myth that will keep you alive! The truth behind martial arts superhumans Which is the original martial art? The truth about your inner badass The surprising reality behind everyone's favorite weapon What meditation can really do for you The secret 'trick' to Bruce Lee's One Inch Punch + Free Bonus Book! And more! From Amazon Best Selling Martial Arts Author Phil Pierce, this guide cracks open the secretive techniques and explores why we are fascinated by the unknown and the mysterious. Whether you train in Karate, Taewkondo, Kung Fu, MMA, Origami or none of these you will find this Kindle Short eye opening and entertaining. Discover the truth behind the legends - Click and Grab your copy now!

    The idea that his foray into meth production was not merely a dalliance with darkness, but was actually a full-blown awakening intrigued us. And most of all, the idea that we came to have no respect for the protagonist of our favorite show utterly fascinated us.We couldn’t look away.Breaking Down Breaking Bad attempts to poke into the dark corners of Walter White’s mind, explore the traits that make this show special, and revels in the joy of what is arguably the best drama ever to appear on television. In doing so, it also peels back the layers of what makes characters like Jesse Pinkman tick, explores why we were so drawn to characters like Gus Fring and Mike Ehrmantraut, and relives some of the greatest moments of this already legendary show.Because the show may be gone, but the conversation about it certainly isn’t.Eric San Juan is the coauthor of A Year of Hitchcock (Scarecrow Press 2009) and Hitchcock’s Villains (Scarecrow Press 2013), as well as Geek Wisdom (Quirk Books 2011) and other books. Before Breaking Bad came along, he thought Deadwood was the greatest thing since sliced bread. He still thinks it’s pretty damn good.

    This new model replaces the popular D5000 and creates a nice bridge between the more beginner-level D3100 and the high-end D7000.This book has one goal: to teach D5100 owners how to make great shots using their new Nikon camera. Users learn how to use the D5100 to create the type of photos that inspired them to buy the camera in the first place. Everything in the book is in service of creating a great image.Starting with the top ten things users need to know about the camera, photographer Rob Sylvan carefully guides readers through the operating features. Owners get practical advice from a pro on which settings to use when, great shooting tips, and even end-of-chapter assignments.

    John, Virgin Islands. It tells you exactly where to go, how to get there, and what to do and see when you arrive. It contains everything you need to know about the St. John's beaches and hiking trails, as well as its confusing system, of roads, foot-paths and goat-trails. Recommended by Caribbean Travel and Life and by many St. Johnians since locals are NOT on vacation and can't always take time off from work to be a tour guide for their guests. Best Selling St John Guidebook since 1994. Updated in 2009.