Wallace’s pieces for Harper’s magazine in the ’90s were, according to Lipsky, “like hearing for the first time the brain voice of everybody I knew: Here was how we all talked, experienced, thought. It was like smelling the damp in the air, seeing the first flash from a storm a mile away. You knew something gigantic was coming.”Then Rolling Stone sent Lipsky to join Wallace on the last leg of his book tour for Infinite Jest, the novel that made him internationally famous. They lose to each other at chess. They get iced-in at an airport. They dash to Chicago to catch a make-up flight. They endure a terrible reader’s escort in Minneapolis. Wallace does a reading, a signing, an NPR appearance. Wallace gives in and imbibes titanic amounts of hotel television (what he calls an “orgy of spectation”). They fly back to Illinois, drive home, walk Wallace’s dogs. Amid these everyday events, Wallace tells Lipsky remarkable things—everything he can about his life, how he feels, what he thinks, what terrifies and fascinates and confounds him—in the writing voice Lipsky had come to love. Lipsky took notes, stopped envying him, and came to feel about him—that grateful, awake feeling—the same way he felt about Infinite Jest. Then Lipsky heads to the airport, and Wallace goes to a dance at a Baptist church.A biography in five days, Although Of Course You End Up Becoming Yourself is David Foster Wallace as few experienced this great American writer. Told in his own words, here is Wallace’s own story, and his astonishing, humane, alert way of looking at the world; here are stories of being a young writer—of being young generally—trying to knit together your ideas of who you should be and who other people expect you to be, and of being young in March of 1996. And of what it was like to be with and—as he tells it—what it was like to become David Foster Wallace.

    But we should--even those of us who take care of our business in pristine, sanitary conditions. For it's not only in developing countries that human waste is a major public health threat: population growth is taxing even the most advanced sewage systems, and the disease spread by waste kills more people worldwide every year than any other single cause of death. Even in America, 1.95 million people have no access to an indoor toilet. Yet the subject remains unmentionable."The Big Necessity "takes aim at the taboo, revealing everything that matters about how people do--and don't--deal with their own waste. Moving from the deep underground sewers of Paris, London, and New York--an infrastructure disaster waiting to happen--to an Indian slum where ten toilets are shared by 60,000 people, Rose George stops along the way to explore the potential saviors: China's five million biogas digesters, which produce energy from waste; the heroes of third world sanitation movements; the inventor of the humble Car Loo; and the U.S. Army's personal lasers used by soldiers to zap their feces in the field.With razor-sharp wit and crusading urgency, mixing levity with gravity, Rose George has turned the subject we like to avoid into a cause with the most serious of consequences.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Determined to clone an endangered flower—the rare ghost orchid Polyrrhiza lindenii—a deeply eccentric and oddly attractive man named John Laroche leads Orlean on an unforgettable tour of America’s strange flower-selling subculture, through Florida’s swamps and beyond, along with the Seminoles who help him and the forces of justice who fight him. In the end, Orlean—and the reader—will have more respect for underdog determination and a powerful new definition of passion.   In this new edition, coming fifteen years after its initial publication and twenty years after she first met the “orchid thief,” Orlean revisits this unforgettable world, and the route by which it was brought to the screen in the film Adaptation, in a new retrospective essay.

    Most thieves, of course, steal for profit. John Charles Gilkey steals purely for the love of books. In an attempt to understand him better, journalist Allison Hoover Bartlett plunged herself into the world of book lust and discovered just how dangerous it can be.John Gilkey is an obsessed, unrepentant book thief who has stolen hundreds of thousands of dollars worth of rare books from book fairs, stores, and libraries around the country. Ken Sanders is the self-appointed "bibliodick" (book dealer with a penchant for detective work) driven to catch him. Bartlett befriended both outlandish characters and found herself caught in the middle of efforts to recover hidden treasure. A cat-and-mouse chase that not only reveals exactly how Gilkey pulled off his dirtiest crimes, where he stashed the loot, and how Sanders ultimately caught him but also explores the romance of books, the lure to collect them, and the temptation to steal them. Bartlett looks at the history of book passion, collection, and theft through the ages, to examine the craving that makes some people willing to stop at nothing to possess the books they love.

    Would you know one if you held it in your hand?In Dark Archives, Megan Rosenbloom seeks out the historic and scientific truths behind anthropodermic bibliopegy--the practice of binding books in this most intimate covering. Dozens of such books live on in the world's most famous libraries and museums. Dark Archives exhumes their origins and brings to life the doctors, murderers, innocents, and indigents whose lives are sewn together in this disquieting collection. Along the way, Rosenbloom tells the story of how her team of scientists, curators, and librarians test rumored anthropodermic books, untangling the myths around their creation and reckoning with the ethics of their custodianship.A librarian and journalist, Rosenbloom is a member of The Order of the Good Death and a cofounder of their Death Salon, a community that encourages conversations, scholarship, and art about mortality and mourning. In Dark Archives--captivating and macabre in all the right ways--she has crafted a narrative that is equal parts detective work, academic intrigue, history, and medical curiosity: a book as rare and thrilling as its subject.

    Now, award-winning nature writer David Gessner follows the ghosts of these two remarkable writer-environmentalists from Stegner's birthplace in Saskatchewan to the site of Abbey's pilgrimages to Arches National Park in Utah, braiding their stories and asking how they speak to the lives of all those who care about the West.These two great westerners had very different ideas about what it meant to love the land and try to care for it, and they did so in distinctly different styles. Boozy, lustful, and irascible, Abbey was best known as the author of the novel The Monkey Wrench Gang (and also of the classic nature memoir Desert Solitaire), famous for spawning the idea of guerrilla actions—known to admirers as "monkeywrenching" and to law enforcement as domestic terrorism—to disrupt commercial exploitation of western lands. By contrast, Stegner, a buttoned-down, disciplined, faithful family man and devoted professor of creative writing, dedicated himself to working through the system to protect western sites such as Dinosaur National Monument in Colorado.In a region beset by droughts and fires, by fracking and drilling, and by an ever-growing population that seems to be in the process of loving the West to death, Gessner asks: how might these two farseeing environmental thinkers have responded to the crisis?Gessner takes us on an inspiring, entertaining journey as he renews his own commitment to cultivating a meaningful relationship with the wild, confronting American overconsumption, and fighting environmental injustice—all while reawakening the thrill of the words of his two great heroes.

    His passing on March 6, 1900, would have been unremarkable if a city health officer hadn’t noticed a swollen black lymph node on his groin—a sign of bubonic plague. Empowered by racist pseudoscience, officials rushed to quarantine Chinatown while doctors examined Wong’s tissue for telltale bacteria. If the devastating disease was not contained, San Francisco would become the American epicenter of an outbreak that had already claimed ten million lives worldwide.To local press, railroad barons, and elected officials, such a possibility was inconceivable—or inconvenient. As they mounted a cover-up to obscure the threat, ending the career of one of the most brilliant scientists in the nation in the process, it fell to federal health officer Rupert Blue to save a city that refused to be rescued. Spearheading a relentless crusade for sanitation, Blue and his men patrolled the squalid streets of fast-growing San Francisco, examined gory black buboes, and dissected diseased rats that put the fate of the entire country at risk.In the tradition of Erik Larson and Steven Johnson, Randall spins a spellbinding account of Blue’s race to understand the disease and contain its spread—the only hope of saving San Francisco, and the nation, from a gruesome fate.

    Sometimes Brilliant is the adventures of a philosopher, mystic, hippie, doctor, groundbreaking tech innovator, and key player in the eradication of one of the worst pandemics in human history. His story, of what happens when love, compassion and determination meet the right circumstances to effect positive change, is the kind that keeps hope and the sense of possibility alive.After sitting at the feet of Martin Luther King at the University of Michigan in 1963, Larry Brilliant was swept up into the civil rights movement, marching and protesting across America and Europe. As a radical young doctor he followed the hippie trail from London over the Khyber Pass with his wife Girija, Wavy Gravy and the Hog Farm commune to India. There, he found himself in a Himalayan ashram wondering whether he had stumbled into a cult. Instead, one of India’s greatest spiritual teachers, Neem Karoli Baba, opened Larry’s heart and told him his destiny was to work for the World Health Organization to help eradicate killer smallpox. He would never have believed he would become a key player in eliminating a 10,000-year-old disease that killed more than half a billion people in the 20th century alone.Brilliant’s unlikely trajectory, chronicled in Sometimes Brilliant, has brought him into close proximity with political leaders, spiritual masters, cultural heroes, and titans of technology around the world—from the Grateful Dead to Mikhail Gorbachev, from Ram Dass, the Dalai Lama, Lama Govinda, and Karmapa to Steve Jobs and the founders of Google, Salesforce, Facebook, Microsoft and eBay and Presidents Carter, Clinton, Bush and Obama. Anchored by the engrossing account of the heroic efforts of the extraordinary people involved in smallpox eradication in India, this is a riveting and fascinating epidemiological adventure, an honest reckoning of an entire generation, and a deeply moving spiritual memoir. It is a testament to faith, love, service, and what it means to engage with life’s most important questions in pursuit of a better, more brilliant existence.

    Like moths of great promise, they were drawn to her well-lighted bookstore and warm hearth on the Left Bank. Shakespeare and Company evokes the zeitgeist of an era through its revealing glimpses of James Joyce, Ernest Hemingway, Scott Fitzgerald, Sherwood Anderson, Andre Gide, Ezra Pound, Gertrude Stein, Alice B. Toklas, D. H. Lawrence, and others already famous or soon to be. In his introduction to this new edition, James Laughlin recalls his friendship with Sylvia Beach. Like her bookstore, his publishing house, New Directions, is considered a cultural touchstone.

    In 2013, the New York Times published an obituary for Yvonne Brill. It began: “She made a mean beef stroganoff, followed her husband from job to job, and took eight years off from work to raise three children.” It wasn’t until the second paragraph that readers discovered why the Times had devoted several hundred words to her life: Brill was a brilliant rocket scientist who invented a propulsion system to keep communications satellites in orbit, and had recently been awarded the National Medal of Technology and Innovation. Among the questions the obituary—and consequent outcry—prompted were, Who are the role models for today’s female scientists, and where can we find the stories that cast them in their true light?      Headstrong delivers a powerful, global, and engaging response. Covering Nobel Prize winners and major innovators, as well as lesser-known but hugely significant scientists who influence our every day, Rachel Swaby’s vibrant profiles span centuries of courageous thinkers and illustrate how each one’s ideas developed, from their first moment of scientific engagement through the research and discovery for which they’re best known. This fascinating tour reveals these 52 women at their best—while encouraging and inspiring a new generation of girls to put on their lab coats.

    It can be slipped into a drink, smeared onto the tip of an arrow or the handle of a door, even filtered through the air we breathe. But how exactly do these poisons work to break our bodies down, and what can we learn from the damage they inflict?In a blend of popular science, medical history, and true crime, Dr. Neil Bradbury explores the morbidly captivating method of murder from a cellular level. Alongside real-life accounts of murderers and their crimes—some notorious, some forgotten, some still unsolved—are the stories of the poisons involved: eleven molecules of death that work their way through the human body and, paradoxically, illuminate the way in which our bodies function.Drawn from historical records and current news headlines, A Taste for Poison weaves together the tales of spurned lovers, shady scientists, medical professionals and political assassins to show how the precise systems of the body can be impaired to lethal effect through the use of poison. From the deadly origins of the gin & tonic cocktail to the arsenic-laced wallpaper in Napoleon’s bedroom.

    Our stories are marbled into their marrow.Drawing upon her years of research and a wealth of remarkable experience, the world-renowned forensic anthropologist Professor Dame Sue Black takes us on a journey of revelation. From skull to feet, via the face, spine, chest, arms, hands, pelvis and legs, she shows that each part of us has a tale to tell. What we eat, where we go, everything we do leaves a trace, a message that waits patiently for months, years, sometimes centuries, until a forensic anthropologist is called upon to decipher it.Some of this information is easily understood, some holds its secrets tight and needs scientific cajoling to be released. But by carefully piecing together the evidence, the facts of a life can be rebuilt. Limb by limb, case by case – some criminal, some historical, some unaccountably bizarre – Sue Black reconstructs with intimate sensitivity and compassion the hidden stories in what we leave behind.

    The media seized hold of the story and, in the process, helped to launch one of the most devastating health scares ever. In the years to come Wakefield would be revealed as a profiteer in league with class-action lawyers, and he would eventually lose his medical license. Meanwhile, one study after another failed to find any link between childhood vaccines and autism. Yet the myth that vaccines somehow cause developmental disorders lives on. Despite the lack of corroborating evidence, it has been popularized by media personalities such as Oprah Winfrey and Jenny McCarthy and legitimized by journalists who claim that they are just being fair to “both sides” of an issue about which there is little debate. Meanwhile, millions of dollars have been diverted from potential breakthroughs in autism research; families have spent their savings on ineffective “miracle cures"; and declining vaccination rates have led to outbreaks of deadly illnesses like Hib, measles, and whooping cough. Most tragic of all is the increasing number of children dying from vaccine-preventable diseases. In The Panic Virus Seth Mnookin draws on interviews with parents, public-health advocates, scientists, and anti-vaccine activists to tackle a fundamental question: How do we decide what the truth is? The fascinating answer helps explain everything from the persistence of conspiracy theories about 9/11 to the appeal of talk-show hosts who demand that President Obama “prove” he was born in America. The Panic Virus is the ultimate cautionary tale for our time.

    Days earlier, she had been on the threshold of a new, adult life: at the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?In a swift and breathtaking narrative, Cahalan tells the astonishing true story of her descent into madness, her family’s inspiring faith in her, and the lifesaving diagnosis that nearly didn’t happen.