Fascinating...Klass writes with wit, intelligence, and a great deal of insight."—The New York Times Book Review.

    Elizabeth A. Fenn is the first historian to reveal how deeply variola affected the outcome of the war in every colony and the lives of everyone in North America.By 1776, when military action and political ferment increased the movement of people and microbes, the epidemic worsened. Fenn's remarkable research shows us how smallpox devastated the American troops at Québec and kept them at bay during the British occupation of Boston. Soon the disease affected the war in Virginia, where it ravaged slaves who had escaped to join the British forces. During the terrible winter at Valley Forge, General Washington had to decide if and when to attempt the risky inoculation of his troops. In 1779, while Creeks and Cherokees were dying in Georgia, smallpox broke out in Mexico City, whence it followed travelers going north, striking Santa Fe and outlying pueblos in January 1781. Simultaneously it moved up the Pacific coast and east across the plains as far as Hudson's Bay.The destructive, desolating power of smallpox made for a cascade of public-health crises and heartbreaking human drama. Fenn's innovative work shows how this mega-tragedy was met and what its consequences were for America.

    But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    In only a few decades, the medical system has been overrun by organizations seeking to exploit for profit the trust that vulnerable and sick Americans place in their healthcare. Our politicians have proven themselves either unwilling or incapable of reining in the increasingly outrageous costs faced by patients, and market-based solutions only seem to funnel larger and larger sums of our money into the hands of corporations. Impossibly high insurance premiums and inexplicably large bills have become facts of life; fatalism has set in. Very quickly Americans have been made to accept paying more for less. How did things get so bad so fast?Breaking down this monolithic business into the individual industries--the hospitals, doctors, insurance companies, and drug manufacturers--that together constitute our healthcare system, Rosenthal exposes the recent evolution of American medicine as never before. How did healthcare, the caring endeavor, become healthcare, the highly profitable industry? Hospital systems, which are managed by business executives, behave like predatory lenders, hounding patients and seizing their homes. Research charities are in bed with big pharmaceutical companies, which surreptitiously profit from the donations made by working people. Patients receive bills in code, from entrepreneurial doctors they never even saw.The system is in tatters, but we can fight back. Dr. Elisabeth Rosenthal doesn't just explain the symptoms, she diagnoses and treats the disease itself. In clear and practical terms, she spells out exactly how to decode medical doublespeak, avoid the pitfalls of the pharmaceuticals racket, and get the care you and your family deserve. She takes you inside the doctor-patient relationship and to hospital C-suites, explaining step-by-step the workings of a system badly lacking transparency. This is about what we can do, as individual patients, both to navigate the maze that is American healthcare and also to demand far-reaching reform. An American Sickness is the frontline defense against a healthcare system that no longer has our well-being at heart.

    The Seventh Edition updates and revises material to reflect current advances in respiratory science but does not stray from the proven formula students and faculty have enjoyed since 1974.New updates include physiology of pulmonary capillaries, hypoxic pulmonary vasoconstriction, pulmonary edema, surface tension, elastic properties of the lung and chest wall, metabolic functions of the lung, and perinatal respiration. Ample illustrations and pedagogical features help clarify important equations and concepts. USMLE-style review questions at the end of each chapter help students review for class or boards.

    There are good reasons that language fascinates us so. It not only defines humans as a species, placing us head and shoulders above even the most proficient animal communicators, but it also beguiles us with its endless mysteries. For example: * How did different languages come to be? * Why isn’t there just a single language? * How does a language change, and when it does, is that change indicative of decay or growth? * How does a language become extinct? Dr. John McWhorter, one of America’s leading linguists and a frequent commentator on network television and National Public Radio, addresses these and other questions as he takes you on an in-depth, 36-lecture tour of the development of human language, showing how a single tongue spoken 150,000 years ago has evolved into the estimated 6,000 languages used around the world today.An accomplished scholar, Professor McWhorter is also a skilled popularizer, whose book The Power of Babel was called "startling, provocative, and remarkably entertaining," by the San Diego Union-Tribune.The London Times called him "a born teacher." And Steven Pinker, best known as the author of The Language Instinct, offered this praise for the book: "McWhorter’s arguments are sharply reasoned, refreshingly honest, and thoroughly original."Course Lecture Titles1. What Is Language? 2. When Language Began 3. How Language Changes—Sound Change 4. How Language Changes—Building New Material 5. How Language Changes—Meaning and Order 6. How Language Changes—Many Directions 7. How Language Changes—Modern English 8. Language Families—Indo-European 9. Language Families—Tracing Indo-European 10. Language Families—Diversity of Structures 11. Language Families—Clues to the Past 12. The Case Against the World’s First Language 13. The Case For the World’s First Language 14. Dialects—Subspecies of Species 15. Dialects—Where Do You Draw the Line? 16. Dialects—Two Tongues in One Mouth 17. Dialects—The Standard as Token of the Past 18. Dialects—Spoken Style, Written Style 19. Dialects—The Fallacy of Blackboard Grammar 20. Language Mixture—Words 21. Language Mixture—Grammar 22. Language Mixture—Language Areas 23. Language Develops Beyond the Call of Duty 24. Language Interrupted 25. A New Perspective on the Story of English 26. Does Culture Drive Language Change? 27. Language Starts Over—Pidgins 28. Language Starts Over—Creoles I 29. Language Starts Over—Creoles II 30. Language Starts Over—Signs of the New 31. Language Starts Over—The Creole Continuum 32. What Is Black English? 33. Language Death—The Problem 34. Language Death—Prognosis 35. Artificial Languages 36. Finale—Master Class

    Nobody is perfect. And that includes five of the greatest scientists in history—Charles Darwin, William Thomson (Lord Kelvin), Linus Pauling, Fred Hoyle, and Albert Einstein. But the mistakes that these great luminaries made helped advance science. Indeed, as Mario Livio explains, science thrives on error, advancing when erroneous ideas are disproven.As a young scientist, Einstein tried to conceive of a way to describe the evolution of the universe at large, based on General Relativity—his theory of space, time, and gravity. Unfortunately he fell victim to a misguided notion of aesthetic simplicity. Fred Hoyle was an eminent astrophysicist who ridiculed an emerging theory about the origin of the universe that he dismissively called “The Big Bang.” The name stuck, but Hoyle was dead wrong in his opposition.They, along with Darwin (a blunder in his theory of Natural Selection), Kelvin (a blunder in his calculation of the age of the earth), and Pauling (a blunder in his model for the structure of the DNA molecule), were brilliant men and fascinating human beings. Their blunders were a necessary part of the scientific process. Collectively they helped to dramatically further our knowledge of the evolution of life, the Earth, and the universe.

    Based on selective breeding of human beings, eugenics began in laboratories on Long Island but ended in the concentration camps of Nazi Germany. Cruel and racist laws were enacted in 27 U.S. states, while the supporters of eugenics included progressive thinkers like Woodrow Wilson, Margaret Sanger and Oliver Wendell Holmes. Ultimately, over 60,000 "unfit" Americans were coercively sterilized, a third of them after Nuremberg had declared such practices crimes against humanity. This is a timely and shocking chronicle of bad science at its worst—with many important lessons for the genetic age in which an interest in eugenics has been dangerously revived.

    Indeed, it is probably true to say that only the Bible rivals Homer for sheer depth and scope of cultural and literary influence.Professor Vandiver makes it vividly clear why, after almost 3,000 years, the Iliad remains not only among the greatest adventure stories ever told, but also one of the most compelling meditations on the human condition ever written.12 Lectures:1. Introduction to Homeric Epic2. The Homeric Question3. Glory, Honor, and the Wrath of Achilles4. Within the Walls of Troy5. The Embassy to Achilles6. The Paradox of Glory7. The Role of the Gods8. The Longest Day9. The Death of Patroklos10. Achilles Returns to Battle11. Achilles and Hektor12. Enemies' Tears—Achilles and Priam.

    Lieberman illuminates how these ongoing changes have brought many benefits, but also have created novel conditions to which our bodies are not entirely adapted, resulting in a growing incidence of obesity and new but avoidable diseases, including type-2 diabetes. He proposes that many of these chronic illnesses persist and in some cases are intensifying because of "dysevolution," a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes oblige us to create a more salubrious environment.(With charts and line drawings throughout.)From the Hardcover edition.

    The Grand Question of Lifes Origins 2. The Historical Setting of Origins Research 3. What Is Life? 4. Is There Life on Mars? 5. Earths Oldest Fossils 6. Fossil Isotopes 7. Molecular Biosignatures 8. Emergence 9. The Miller-Urey Experiment 10. Life from the Bottom of the Sea 11. The Deep, Hot Biosphere 12. Experiments at High Pressure 13. More Experiments Under Pressure 14. Deep Space Dust, Molten Rock, and Zeolite 15. Macromolecules and the Tree of Life 16. Lipids and Membrane Self-Organization 17. Life on Clay, Clay as Life 18. Lifes Curious Handedness 19. Self-Replicating Molecular Systems 20. Günter Wächtershäusers Grand Hypothesis 21. The RNA World 22. The Pre-RNA World 23. Natural Selection and Competition 24. Three Scenarios for the Origin of Life

    What makes evolution such a profoundly provocative concept, so convincing to most scientists, yet so socially and politically divisive? The Theory of Evolution: A History of Controversy is an examination of the varied elements that so often make this science the object of strong sentiments and heated debate. Professor Edward J. Larson leads you through the "evolution" of evolution, with an eye toward enhancing your understanding of the development of the theory itself and the roots of the controversies that surround it. In these lectures you will: Explore pre-Darwinian theories of the origins of life, from Genesis and the ancient Greeks to such 18th- and 19th-century scientists as Georges Cuvier and Chevalier de Lamarck Follow the life and work of Charles Darwin, and the impact of his 1859 masterpiece, On the Origin of Species. Darwin's theory of evolution by natural selection was immediately recognized as a threat to traditional religion, but was quickly accepted (the first printing of Origin of Species sold out on the first day) Examine the history of evolutionary science after Darwin-a fascinating story that includes the "rediscovery," after 35 years, of Gregor Mendel's work on genetic variation; the unearthing of prehominid, or early human, fossils by Raymond Dart in 1925 and the Leakey family in the 1950s; and the confusion created by the sensational, but later discredited, discovery of Piltdown Man-a fake evolutionary "missing link"-in 1912 Trace the history of religious objections to evolution, from those of Darwin's own time to contemporary efforts to teach creation science in American schools. This includes a detailed discussion of the famous Scopes "monkey trial," which in fact was a staged media event, designed to create publicity for the town of Dayton, Tennessee. Are Our Genes more Important than We Are? This course makes it clear that the history of controversy surrounding evolution is not limited to a dispute between science and religion. Even within the scientific community, the fine details of the theory of evolution have long been a matter of passionate dispute. In fact, in the last third of the 19th century, the principal objections were scientific, not religious. Although the fossil record was a key piece of evidence for evolution, it had gaps that could be used to argue against the theory. And both proponents and critics wondered how altruistic human qualities such as love and generosity could possibly have evolved through the competitive, often harsh, processes that Darwin described. From Professor Larson's presentation, you will learn that new ideas in evolution science have often created new controversies. For example, is it truly possible, as some scientists now maintain, that humans exist merely to ensure the survival of their genes? Such research has created disagreement among scientists about the degree to which evolution drives human behavior, and has further alienated many segments of the public. Evolution's "Dark Side": Social Darwinism In these lectures, you will review perhaps the most sinister controversy associated with the theory of evolution: social Darwinism. From the beginning, the Darwinian theory of evolution has been linked to economic and political views. Thomas Malthus's theories of population growth and competition for limited resources even inspired Darwin's thinking on natural selection. Unfortunately, later supporters of evolution carried this line of thinking too far. Beginning with Herbert Spencer, who coined the term "survival of the fittest," Darwin's ideas were used as evidence for a wide range of social beliefs, from laissez-faire capitalism to racism, colonialism, and, in perhaps the worst application, Nazism. In the United States, social Darwinism has served as a basis for the creation of IQ tests and for eugenics programs that resulted in the forced sterilization of thousands of mentally ill or retarded Americans. Unsettling Implications: The Growing Gulf Between Science and Religion During the late 19th century, largely through the efforts of scientists who sought to integrate evolutionary science with spiritual belief, evolution was widely accepted by the religious community in the United States. Today, this is hardly the case. In his last four lectures, Professor Larson examines the trends that have, since 1920, widened the gulf between science and religion. These include an increase in fundamentalist Protestantism, the weakening of liberal Protestantism as a counteracting force, and the growing power of a firmly conservative South. In the 1960s, federally funded neo-Darwinian textbooks provoked a conservative backlash. Beginning with the publication of Henry M. Morris's The Genesis Flood, efforts to gain equal time for the teaching of creation science, based on biblical teachings, gathered strength. Rebuffed by the courts, creationism continues to thrive through the increasing numbers of private Christian schools and through home schooling. The growing gulf between science and religion has unsettling implications for our society. Large segments of the American population reject the naturalism of current evolutionary thinking. Nine of 10 Americans believe in spiritual causes for life, with only 10 percent accepting the purely naturalistic explanations espoused by evolution. Strikingly, these statistics are almost exactly the opposite among the scientific community. A Pulitzer Prize-Winning Teacher As both a historian of science and a professor of law, Professor Edward J. Larson brings exceptional qualifications to this subject. His book, Summer for the Gods: The Scopes Trial and America's Continuing Debate Over Science and Religion, won the 1998 Pulitzer Prize in History. His analysis provides an invaluable perspective on the volatile history of what is arguably the single most significant idea of modern times.

    Forced to remain inside until they'd "proven" themselves sane, all eight emerged with alarming diagnoses and even more troubling stories of their treatment. Rosenhan's study broke open the field of psychiatry, closing down institutions and changing mental health diagnosis forever. But, as Cahalan's new research shows, very little in this saga is exactly as it seems. What really happened behind those closed asylum doors, and what does it mean for our understanding of mental illness today?

    There is no better way to study the big questions in philosophy than to compare how the world's greatest minds have analyzed these questions, defined the terms, and then reasoned out potential solutions. Once you've compared the arguments, the final step is always deciding for yourself whether you find an explanation convincing.This course gives you the tools to follow and create logical arguments while exploring famous philosophers' viewpoints on these important questions. Although progress has been made toward answers, brilliant thinkers have continued to wrestle with many big questions that inspire thoughtful people everywhere. These questions include: What is knowledge? Does God exist? Do humans have free will? What is right and wrong? How should society be organized?Given the complexity of these big questions, it should be no surprise that many controversies are far from settled. In fact, by the end of these 36 lectures, you may be even less sure of the right answers to some of the questions than you were at the beginning. But being a philosopher means constantly testing your views - giving a reasoned defense if you believe you are right and modifying your ideas when you realize you are wrong. You'll discover that great thinkers before you have offered convincing answers to hard questions, philosophers after them have made equally persuasive objections, and then still others have refined the debate even further - causing the issues to come into sharper and sharper focus.Join Plato, St. Anselm, Descartes, Locke, Hume, Kant, Mill, Smith, Marx, Rawls, and many others in an exploration of fundamental questions. Get ready to think big!

    Having studied at Yale and Dartmouth, Dr. Emily Transue arrives in Seattle to start her internship in Internal Medicine just after graduating from medical school. This series of loosely interconnected scenes from the author's medical training concludes her residency three years later.During her first week as a student on the medical wards, Dr. Transue watched someone come into the emergency room in cardiac arrest and die. Nothing like this had ever happened to her before-it was a long way from books and labs. So she began to record her experiences as she gained confidence putting her book knowledge to work.The stories focus on the patients Dr. Transue encountered in the hospital, ER and clinic; some are funny and others tragic. They range in scope from brief interactions in the clinic to prolonged relationships during hospitalization. There is a man newly diagnosed with lung cancer who is lyrical about his life on a sunny island far away, and a woman, just released from a breathing machine after nearly dying, who sits up and demands a cup of coffee.Though the book has a great deal of medical content, the focus is more on the stories of the patients' lives and illnesses and the relationships that developed between the patients and the author, and the way both parties grew in the course of these experiences.Along the way, the book describes the life of a resident physician and reflects on the way the medical system treats both its patients and doctors. On Call provides a window into the experience of patients at critical junctures in life and into the author's own experience as a new member of the medical profession.