Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

    This edition, which was prepared by Kip S. Thorne (Feynman Professor of Theoretical Physics at California Institute of Technology), fully incorporates all the errata and corrections gathered (but never used in a published edition) by Feynman.

    But is it for the better? Amid a chorus of doomsayers, Clive Thompson delivers a resounding "yes." The Internet age has produced a radical new style of human intelligence, worthy of both celebration and analysis. We learn more and retain it longer, write and think with global audiences, and even gain an ESP-like awareness of the world around us. Modern technology is making us smarter, better connected, and often deeper—both as individuals and as a society. In Smarter Than You Think Thompson shows that every technological innovation—from the written word to the printing press to the telegraph—has provoked the very same anxieties that plague us today. We panic that life will never be the same, that our attentions are eroding, that culture is being trivialized. But as in the past, we adapt—learning to use the new and retaining what’s good of the old. Thompson introduces us to a cast of extraordinary characters who augment their minds in inventive ways. There's the seventy-six-year old millionaire who digitally records his every waking moment—giving him instant recall of the events and ideas of his life, even going back decades. There's a group of courageous Chinese students who mounted an online movement that shut down a $1.6 billion toxic copper plant. There are experts and there are amateurs, including a global set of gamers who took a puzzle that had baffled HIV scientists for a decade—and solved it collaboratively in only one month. Smarter Than You Think isn't just about pioneers. It's about everyday users of technology and how our digital tools—from Google to Twitter to Facebook and smartphones—are giving us new ways to learn, talk, and share our ideas. Thompson harnesses the latest discoveries in social science to explore how digital technology taps into our long-standing habits of mind—pushing them in powerful new directions. Our thinking will continue to evolve as newer tools enter our lives. Smarter Than You Think embraces and extols this transformation, presenting an exciting vision of the present and the future.

    In Turing’s Cathedral, George Dyson focuses on a small group of men and women, led by John von Neumann at the Institute for Advanced Study in Princeton, New Jersey, who built one of the first computers to realize Alan Turing’s vision of a Universal Machine. Their work would break the distinction between numbers that mean things and numbers that do things—and our universe would never be the same. Using five kilobytes of memory (the amount allocated to displaying the cursor on a computer desktop of today), they achieved unprecedented success in both weather prediction and nuclear weapons design, while tackling, in their spare time, problems ranging from the evolution of viruses to the evolution of stars. Dyson’s account, both historic and prophetic, sheds important new light on how the digital universe exploded in the aftermath of World War II. The proliferation of both codes and machines was paralleled by two historic developments: the decoding of self-replicating sequences in biology and the invention of the hydrogen bomb. It’s no coincidence that the most destructive and the most constructive of human inventions appeared at exactly the same time.  How did code take over the world? In retracing how Alan Turing’s one-dimensional model became John von Neumann’s two-dimensional implementation, Turing’s Cathedral offers a series of provocative suggestions as to where the digital universe, now fully three-dimensional, may be heading next.

    Instead, follow the data: In seventy-five jaw-dropping graphs, Pinker shows that life, health, prosperity, safety, peace, knowledge, and happiness are on the rise, not just in the West, but worldwide. This progress is not the result of some cosmic force. It is a gift of the Enlightenment: the conviction that reason and science can enhance human flourishing.Far from being a naïve hope, the Enlightenment, we now know, has worked. But more than ever, it needs a vigorous defense. The Enlightenment project swims against currents of human nature–tribalism, authoritarianism, demonization, magical thinking–which demagogues are all too willing to exploit. Many commentators, committed to political, religious, or romantic ideologies, fight a rearguard action against it. The result is a corrosive fatalism and a willingness to wreck the precious institutions of liberal democracy and global cooperation.With intellectual depth and literary flair, Enlightenment Now makes the case for reason, science, and humanism: the ideals we need to confront our problems and continue our progress.

    Why do we recognize patterns? Is there such a thing as positive stress? Are we genetically programmed to be in conflict with each other? Those are just some of the 150 questions that the world's best scientific minds answer with elegant simplicity.With contributions from Jared Diamond, Richard Dawkins, Nassim Taleb, Brian Eno, Steven Pinker, and more, everything is explained in fun, uncomplicated terms that make the most complex concepts easy to comprehend.

    Explore computer buildings (datacenters), the flat rocks we live on (tectonic plates), the things you use to steer a plane (airliner cockpit controls), and the little bags of water you're made of (cells).

    We will soon be able to meet and exceed the basic needs of every man, woman and child on the planet. Abundance for all is within our grasp. This bold, contrarian view, backed up by exhaustive research, introduces our near-term future, where exponentially growing technologies and three other powerful forces are conspiring to better the lives of billions. An antidote to pessimism by tech entrepreneur turned philanthropist, Peter H. Diamandis and award-winning science writer Steven Kotler. Since the dawn of humanity, a privileged few have lived in stark contrast to the hardscrabble majority. Conventional wisdom says this gap cannot be closed. But it is closing—fast. The authors document how four forces—exponential technologies, the DIY innovator, the Technophilanthropist, and the Rising Billion—are conspiring to solve our biggest problems. Abundance establishes hard targets for change and lays out a strategic roadmap for governments, industry and entrepreneurs, giving us plenty of reason for optimism.Examining human need by category—water, food, energy, healthcare, education, freedom—Diamandis and Kotler introduce dozens of innovators making great strides in each area: Larry Page, Steven Hawking, Dean Kamen, Daniel Kahneman, Elon Musk, Bill Joy, Stewart Brand, Jeff Skoll, Ray Kurzweil, Ratan Tata, Craig Venter, among many, many others.

    But the son of billionaire investor Warren Buffett says that the only real inheritance handed down from his parents was a philosophy: Forge your own path in life. It is a creed that has allowed him to follow his own passions, establish his own identity, and reap his own successes. In Life Is What You Make It, Buffett expounds on the strong set of values given to him by his trusting and broadminded mother, his industrious and talented father, and the many life teachers he has met along the way.Today’s society, Buffett posits, has begun to replace a work ethic, relishing what you do, with a wealth ethic, honoring the payoff instead of the process. We confuse privilege with material accumulation, character with external validation. Yet, by focusing more on substance and less on reward, we can open doors of opportunity and strive toward a greater sense of fulfillment. In clear and concise terms, Buffett reveals a great truth: Life is random, neither fair nor unfair. From there it becomes easy to recognize the equal dignity and value of every human life—our circumstances may vary but our essences do not. We see that our journey in life rarely follows a straight line but is often met with false starts, crises, and blunders. How we push through and persevere in these challenging moments is where we begin to create the life of our dreams—from discovering our vocations to living out our bliss to giving back to others.Personal and revealing, instructive and intuitive, Life Is What You Make It is about transcending your circumstances, taking up the reins of your destiny, and living your life to the fullest.

    health care system is in crisis. At stake are the quality of care for millions of Americans and the financial well-being of individuals and employers squeezed by skyrocketing premiums—not to mention the stability of state and federal government budgets.In Redefining Health Care, internationally renowned strategy expert Michael Porter and innovation expert Elizabeth Teisberg reveal the underlying—and largely overlooked—causes of the problem, and provide a powerful prescription for change.The authors argue that competition currently takes place at the wrong level—among health plans, networks, and hospitals—rather than where it matters most, in the diagnosis, treatment, and prevention of specific health conditions. Participants in the system accumulate bargaining power and shift costs in a zero-sum competition, rather than creating value for patients. Based on an exhaustive study of the U.S. health care system, Redefining Health Care lays out a breakthrough framework for redefining the way competition in health care delivery takes place—and unleashing stunning improvements in quality and efficiency.With specific recommendations for hospitals, doctors, health plans, employers, and policy makers, this book shows how to move health care toward positive-sum competition that delivers lasting benefits for all.

    In this groundbreaking book, based on his popular course, James Baraz helps you discover a path to the happiness that’s right in front of you, offering a step-by-step program that will reorient your mind away from dissatisfaction and distraction and toward the contentment and delight that is abundantly available in our everyday lives.You can decide to be happy. For years, James Baraz’s online Awakening Joy course has offered participants from around the world the benefits of this simple but profoundly radical proposition. Grounded in simple Buddhist principles but accessible to people of all faiths–or no faith at all–this concept provides the jumping-off point for a transformational journey toward a richer, more meaningful, more positive outlook on life. Now readers everywhere can follow the same ten steps Baraz teaches to his program participants. In this practical down-to-earth guide, you will learn how to• make happiness a habit by inclining your mind toward states that lead to well-being• find joy even during difficult times and avoid the pitfalls that prevent you from achieving the contentment you seek• cultivate effective practices for sustaining joyfulness, such as reclaiming your natural sense of wonder and finding joy in the midst of everyday experiencesEach chapter of Awakening Joy consists of one step in Baraz’s ten-step program and includes engaging exercises and practical advice to make happiness your natural default setting. For everyone from the cynic despondent over life’s many sorrows to the harried commuter raging at freeway traffic, this book offers up a simple yet powerful message of hope grounded in the realization that joy already exists inside every one of us. Like a precious child, it only needs to be recognized, embraced, and nurtured in order to grow to its full potential. Praise"I've personally taken the Awakening Joy program and can say this unequivocally: It's fabulous and it works!  This book, filled with moving stories and rich teachings, will give you wonderful tools to experience true happiness and well-being.  It's a gem!"— Marci Shimoff, New York Times bestselling author of Happy for No Reason"Opening to joy takes courage and intention. This book will inspire you to discover genuine happiness, and show you how. Drawing on perennial wisdom and accessible meditative practices, James and Shoshana offer teachings that can awaken your love of life."— Tara Brach, author of Radical Acceptance"Awakening Joy is an important guide to transforming our everyday experience into genuine happiness.  James and Shoshana's insight, kindness, and clear and practical language make this a direct, pragmatic and valuable manual for a better life."—Sharon Salzberg, author of Lovingkindness: The Revolutionary Art of Happiness"In this beautiful and heartwarming book, James Baraz and Shoshana Alexander take us on a journey that truly awakens joy. There are stories that bring tears to our eyes and practices that transform our lives.  This is a loving, wise, and compassionate testament to what is possible for each one of us.  Highly recommended."—Joseph Goldstein, author of A Heart Full of Peace "I'm so happy that James Baraz's Awakening Joy class is now available in book form.  His class has been helpful to thousands of people.  I plan to give it to all my clients who are struggling with creating a life of meaning and happiness.  Joyfulness is our birthright.  This book shows you how to reclaim it."—M.J. Ryan, author of AdaptAbility"This is a life-changing book that not only teaches practical, useful strategies for increasing your awareness, but also illuminates choices about how you can lead your emotional life." —Paul Ekman, Ph.D., Professor Emeritus, University of California, San Francisco, co-author of Emotional Awareness and author of Emotions Revealed "To awaken joy in oneself and others is one of life's great skills, a skill taught by sages across the centuries, and now distilled in this book."—Roger Walsh M.D., Ph.D., University of California Medical School, author of Essential Spirituality: The Seven Central Practices "This book is an inspiring gift that will open your heart to the presence of love and joy in everyday life."—Frances Vaughan, Ph.D., psychologist, author of Shadows of the Sacred  "Every page of this wonderful book has something that inspires faith or confidence: a new story, a memorable quote, an exercise that invites participation....From beginning to end, it is a joy to read."—Sylvia Boorstein, author of Happiness Is An Inside Job: Practicing for a Joyful Life "This book should be read by every person who cares about making this a better world. It can enhance the joys of working to develop a wiser and more compassionate society, and help make us both happier and more effective in challenging times."—Daniel Ellsberg, author of Secrets: A Memoir of Vietnam and the Pentagon Papers   "This is an important book—and a great read! With its unique mix of story, philosophy, and practice we can explore our needs, free ourselves from the bonds of suffering, and innovate new ways of being that will last our lifetimes.  And, because James has woven himself and his characteristic smile throughout the book, we can have a lot of fun in the process."—Rick Foster, co-author of How We Choose to Be Happy  "Faith, hope, and love have long been considered the essential virtues of the religious life. James Baraz has done us all a great service by elevating joy to its rightful place alongside the trinity of sacred emotions. What a gift is it, to be surprised by joy, and to awaken, in the midst of a difficult world, the impulse to rejoice."—Patricia E. de Jong, Senior Minister, First Congregational Church of Berkeley "Awakening Joy is an inspirational and practical resource which helps us identify where we are or are not experiencing joy in our lives. This original book addresses the primary obstacles or beliefs that hinder our access to joy, and includes timeless practices and ways in which we can expand, cultivate, express, and experience more joy in our lives and within our own nature. Well-written, informative, and a significant contribution to everyone's well-being."—Angeles Arrien, Ph.D., cultural anthropologist, and author of award-winning Second Half of Life: Opening to the Eight Gates of Wisdom"In our pursuit of happiness, this moving book should be a dog eared, worn out companion....As you work through this elegant material, you will find yourself laughing a little longer, dancing a little more, and awakening to the beauty of what lies inside you and in those nearby."—Dacher Keltner, Professor of Psychology, UC Berkeley, and author, Born To Be Good: The Science of a Meaningful Life "I have been deeply touched and inspired by James Baraz's accessible, practical wisdom.  His genuine caring for people and enthusiasm for life generously pour forth and permeate everything that he teaches--now in the pages of this book."—Rabbi Margie Jacobs, Institute for Jewish Spirituality  "Awakening Joy is a wise treasure house of valuable information, anecdotes, potent quotes, and creative suggestions to step into one's power and live life to the max. This book is a rich, inspiring resource I'm excited to share with my yoga students."—Gabriel Halpern, founder and director of the Yoga Circle [Chicago]

    Nobel Prize winner Kandel intertwines cogntive psychology, neuroscience, and molecular biology with his own quest to understand memory.

    The school developed a personalized learning plan for every student. They engaged the students by engaging them in interdisciplinary, real-world projects, rather than passively learning and memorizing in a classroom environment. They created mentorship groups, where students would talk through their goals and help each other solve problems, as well as meet one on one with their mentor, weekly. By internalizing a sense of purpose, self-direction, self-sufficiency, collaboration, students learn the cognitive and life skills needed to navigate the next phases of their lives. Virtually 100% of Summit's original 400 students went on to attend four year colleges. In the years that followed, Summit opened 10 more charter schools in California and Washington, to similar success, and national recognition.Today, Tavenner, and Summit Public Schools, are partnering with 400 public schools, across 40 states, and over 3500 teachers and 80,000 students, to bring the Summit Learning Program and teaching practices to school systems everywhere. With generous support from Priscilla Chan and Mark Zuckerberg's nonprofit organization, which calls Summit "the future of education," and over one hundred million dollars in contributions from the Gates Foundation, Summit is revolutionizing how our children are educated.

    The human brain has some capabilities that the brains of other animals lack. It is to these distinctive capabilities that our species owes its dominant position. If machine brains surpassed human brains in general intelligence, then this new superintelligence could become extremely powerful--possibly beyond our control. As the fate of the gorillas now depends more on humans than on the species itself, so would the fate of humankind depend on the actions of the machine superintelligence.But we have one advantage: we get to make the first move. Will it be possible to construct a seed Artificial Intelligence, to engineer initial conditions so as to make an intelligence explosion survivable? How could one achieve a controlled detonation?

    The doctor-patient relationship--the heart of medicine--is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality. By freeing physicians from the tasks that interfere with human connection, AI will create space for the real healing that takes place between a doctor who can listen and a patient who needs to be heard.Innovative, provocative, and hopeful, Deep Medicine shows us how the awesome power of AI can make medicine better, for all the humans involved.