Lehninger Principles of Biochemistry, Fourth Edition brings clarity and coherence to an often unwieldy discipline, while incorporating the field's most important recent developments and applications.

    It can be microscopic, yet also accounts for the largest organisms ever recorded, living for millennia and weighing tens of thousands of tonnes. Its ability to digest rock enabled the first life on land, it can survive unprotected in space, and thrives amidst nuclear radiation.In this captivating adventure, Merlin Sheldrake explores the spectacular and neglected world of fungi: endlessly surprising organisms that sustain nearly all living systems. They can solve problems without a brain, stretching traditional definitions of ‘intelligence’, and can manipulate animal behaviour with devastating precision. In giving us bread, alcohol and life-saving medicines, fungi have shaped human history, and their psychedelic properties, which have influenced societies since antiquity, have recently been shown to alleviate a number of mental illnesses. The ability of fungi to digest plastic, explosives, pesticides and crude oil is being harnessed in break-through technologies, and the discovery that they connect plants in underground networks, the ‘Wood Wide Web’, is transforming the way we understand ecosystems. Yet they live their lives largely out of sight, and over ninety percent of their species remain undocumented.Entangled Life is a mind-altering journey into this hidden kingdom of life, and shows that fungi are key to understanding the planet on which we live, and the ways we think, feel and behave. The more we learn about fungi, the less makes sense without them.

    Nature hailed it as a book of grand and daunting sweep.... A splendid and rewarding tour de force. And New Scientist wrote that it captured the essence of modern biology, calling it an extremely significant book which, as a bonus, is very readable. Now, in The Origins of Life, Maynard Smith and Szathmary have completely rewritten Transitions to bring their ideas to a wider audience of general readers. Here is a brilliant, state-of-the-art account of how life evolved on earth, focusing primarily on six major transitions--dramatic breakthroughs in the way that information was passed between generations. The authors offer illuminating explorations of the origin of life itself, the arrival of the first cells with nuclei, the first reproduction by sexual means, the appearance of multicellular plants and animals, the emergence of cooperation and of animal societies, and the birth of language. The Origins of Life represents the thinking of two leading scientists on questions that engage us all--how life began and how it gradually evolved from tiny invisible cells into whales and trees and human beings.

    She knows how scientists go about their work, and she describes their ways, their visions, and their arguments. Perhaps most poignantly, she understands the complexities and the sad necessity of death. "The beauty of the natural world lies in the details, and most of those details are not the stuff of calendar art," she points out. Few writers have ever covered so many facets of biology so evocatively in one book. The Beauty of the Beastly tells us how the genius of the biological universe resides in its details and proves why, according to Timothy Ferris, author of the acclaimed Coming of Age in the Milky Way, Angier is "one of the strongest and wittiest science writers in the world today."

    He had a talent for drawing and an interest in birds, and he would spend the next thirty-five years traveling to the remotest regions of his new country–often alone and on foot–to render his avian subjects on paper. The works of art he created gave the world its idea of America. They gave America its idea of itself. Here Richard Rhodes vividly depicts Audubon’s life and career: his epic wanderings; his quest to portray birds in a lifelike way; his long, anguished separations from his adored wife; his ambivalent witness to the vanishing of the wilderness. John James Audubon: The Making of an American is a magnificent achievement.

    Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease. Those in cows and termites digest the plants they eat. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squids with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. I Contain Multitudes is the story of these extraordinary partnerships, between the creatures we are familiar with and those we are not. It reveals how we humans are disrupting these partnerships and how we might manipulate them for our own good. It will change both our view of nature and our sense of where we belong in it.

    Paul Colinvaux takes a penetrating look at the science of ecology, bringing to his subject both profound knowledge and an enthusiasm that will encourage a greater understanding of the environment and of the efforts of those who seek to preserve it.

    In One Renegade Cell, Weinberg presents a state-of-the-art account of how cancer begins and how, one day, it will be cured.

    This title shows us how to examine, study, and appreciate microbes in the manner of a birdwatcher, by making sightings of microbial activities and thereby identifying particular microbes as well as understanding what they do and how they do it.

    Converging findings from a variety of disciplines are leading to the emergence of a fundamentally new view of the human mind, and with it a new framework for the behavioral and social sciences. First, with the advent of the cognitive revolution, human nature can finally be defined precisely as the set of universal, species-typical information-processing programs that operate beneath the surface of expressed cultural variability. Second, this collection of cognitive programs evolved in the Pleistocene to solve the adaptive problems regularly faced by our hunter-gatherer ancestors--problems such as mate selection, language acquisition, cooperation, and sexual infidelity. Consequently, the traditional view of the mind as a general-purpose computer, tabula rasa, or passive recipient of culture is being replaced by the view that the mind resembles an intricate network of functionally specialized computers, each of which imposes contentful structure on human mental organization and culture. The Adapted Mind explores this new approach--evolutionary psychology--and its implications for a new view of culture.

    The story begins in Africa, six to seven million years ago, and encompasses twenty known human species, of which Homo sapiens is the sole survivor. Illustrated with spectacular, three-dimensional scientific reconstructions portrayed in their natural habitat developed by a team of physical anthropologists at the American Museum of Natural History and in concert with experts from around the world, the book is both a guide to extinct human species and an astonishing hominid family photo album.The Last Human presents a comprehensive account of each species with information on its emergence, chronology, geographic range, classification, physiology, lifestyle, habitat, environment, cultural achievements, co-existing species, and possible reasons for extinction. Also included are summaries of fossil discoveries, controversies, and publications. What emerges from the fossil story is a new understanding of Homo sapiens. No longer credible is the notion that our species is the end product of a single lineage, improved over generations by natural selection. Rather, the fossil record shows, we are a species with widely varied precursors, and our family tree is characterized by many branchings and repeated extinctions.Exhibition information:Photographs of most of the reconstructions that appear in this book will be featured in exhibits appearing in the new Hall of Human Origins at the American Museum of Natural History in New York City.  The opening of the Hall is planned for November 2006.

    In How to Clone a Mammoth, Beth Shapiro, evolutionary biologist and pioneer in "ancient DNA" research, walks readers through the astonishing and controversial process of de-extinction. From deciding which species should be restored, to sequencing their genomes, to anticipating how revived populations might be overseen in the wild, Shapiro vividly explores the extraordinary cutting-edge science that is being used--today--to resurrect the past. Journeying to far-flung Siberian locales in search of ice age bones and delving into her own research--as well as those of fellow experts such as Svante Paabo, George Church, and Craig Venter--Shapiro considers de-extinction's practical benefits and ethical challenges. Would de-extinction change the way we live? Is this really cloning? What are the costs and risks? And what is the ultimate goal?Using DNA collected from remains as a genetic blueprint, scientists aim to engineer extinct traits--traits that evolved by natural selection over thousands of years--into living organisms. But rather than viewing de-extinction as a way to restore one particular species, Shapiro argues that the overarching goal should be the revitalization and stabilization of contemporary ecosystems. For example, elephants with genes modified to express mammoth traits could expand into the Arctic, re-establishing lost productivity to the tundra ecosystem.Looking at the very real and compelling science behind an idea once seen as science fiction, How to Clone a Mammoth demonstrates how de-extinction will redefine conservation's future.

    The consequences of losing beavers were profound: streams eroded, wetlands dried up, and species from salmon to swans lost vital habitat. Today, a growing coalition of “Beaver Believers”―including scientists, ranchers, and passionate citizens―recognizes that ecosystems with beavers are far healthier, for humans and non-humans alike, than those without them. From the Nevada deserts to the Scottish highlands, Believers are now hard at work restoring these industrious rodents to their former haunts. Eager is a powerful story about one of the world’s most influential species, how North America was colonized, how our landscapes have changed over the centuries, and how beavers can help us fight drought, flooding, wildfire, extinction, and the ravages of climate change. Ultimately, it’s about how we can learn to coexist, harmoniously and even beneficially, with our fellow travelers on this planet.

    In the same period it also produced treatments to control the progress of Parkinson's, rheumatoid arthritis, and schizophrenia. It made realities of open-heart surgery, organ transplants, test-tube babies. Unquestionably, the medical accomplishments of the postwar years stand at the forefront of human endeavor, yet progress in recent decades has slowed nearly to a halt. In this winner of the Los Angeles Times Book Prize, medical doctor and columnist James Le Fanu both surveys the glories of medicine in the postwar years and analyzes the factors that for the past twenty-five years have increasingly widened the gulf between achievement and advancement: the social theories of medicine, ethical issues, and political debates over health care that have hobbled the development of vaccines and discovery of new "miracle" cures. While fully demonstrating the extraordinary progress effected by medical research in the latter half of the twentieth century, Le Fanu also identifies the perils that confront medicine in the twenty-first. 16 pages of black-and-white photographs add to what the Los Angeles Times cited as "a sobering, contrarian challenge" to the "nostrum of medicine as a never-ending font of ‘miracle cures'." "[From] a respected science writer ... important information that ... has been overlooked or ignored by many physicians." —New Republic "Provocative and engrossing and informative." —Houston Chronicle "Marvelously written, meticulously researched ... one of the most thought-provoking and important works to appear in recent years." —Choice

    It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes.This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children.Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.