In 2017, it claimed nearly fifty thousand lives -- more than gunshots and car crashes combined, and almost as many Americans as were killed in the entire Vietnam War. But even as the overdose crisis ravages our nation -- straining our prison system, dividing families, and defying virtually every legislative solution to treat it-- few understand how it came to be.Opium tells the extraordinary and at times harrowing tale of how we arrived at today's crisis, "mak[ing] timely and startling connections among painkillers, politics, finance, and society" (Laurence Bergreen). The story begins with the discovery of poppy artifacts in ancient Mesopotamia, and goes on to explore how Greek physicians and obscure chemists discovered opium's effects and refined its power, how colonial empires marketed it around the world, and eventually how international drug companies developed a range of powerful synthetic opioids that led to an epidemic of addiction. Throughout, Dr. John Halpern and David Blistein reveal the fascinating role that opium has played in building our modern world, from trade networks to medical protocols to drug enforcement policies. Most importantly, they disentangle how crucial misjudgments, patterns of greed, and racial stereotypes served to transform one of nature's most effective painkillers into a source of unspeakable pain-and how, using the insights of history, state-of-the-art science, and a compassionate approach to the illness of addiction, we can overcome today's overdose epidemic.This urgent and masterfully woven narrative tells an epic story of how one beautiful flower became the fascination of leaders, tycoons, and nations through the centuries and in their hands exposed the fragility of our civilization.

     Where do clouds come from? Why do they look the way they do? And why have they captured the imagination of timeless artists, Romantic poets, and every kid who's ever held a crayon? Journalist and lifelong sky watcher Gavin Pretor-Pinney reveals everything there is to know about clouds, from history and science to art and pop culture. Cumulus, nimbostratus, and the dramatic and seemingly surfable Morning Glory cloud are just a few of the varieties explored in this smart, witty, and eclectic tour through the skies. Generously illustrated with striking photographs and line drawings featuring everything from classical paintings to lava lamps, children's drawings, and Roman coins, The Cloudspotter's Guide will have science and history buffs, weather watchers, and the just plain curious floating on cloud nine.

    It wiped out one-third of Europe's population, taking some 20 million lives. And yet, most of what we know about it is wrong. The details of the Plague etched in the minds of terrified schoolchildren—the hideous black welts, the high fever, and the awful end by respiratory failure—are more or less accurate. But what the Plague really was and how it made history remain shrouded in a haze of myths.Now, Norman Cantor, the premier historian of the Middle Ages, draws together the most recent scientific discoveries and groundbreaking historical research to pierce the mist and tell the story of the Black Death as a gripping, intimate narrative.

    Its author's engaging voice is one reason, and the compelling subjects he addresses is another; the nature of space and time, the role of God in creation, the history and future of the universe. But it is also true that in the years since its publication, readers have repeatedly told Professor Hawking of their great difficulty in understanding some of the book's most important concepts. This is the origin of and the reason for A Briefer History of Time: its author's wish to make its content more accessible to readers - as well as to bring it up-to-date with the latest scientific observations and findings.Although this book is literally somewhat "briefer", it actually expands on the great subjects of the original. Purely technical concepts, such as the mathematics of chaotic boundary conditions, are gone. Conversely, subjects of wide interest that were difficult to follow because they were interspersed throughout the book have now been given entire chapters of their own, including relativity, curved space, and quantum theory.This reorganization has allowed the authors to expand areas of special interest and recent progress, from the latest developments in string theory to exciting developments in the search for a complete unified theory of all the forces of physics. Like prior editions of the book - but even more so - A Briefer History of Time will guide nonscientists everywhere in the ongoing search for the tantalizing secrets at the heart of time and space. Thirty-seven full-color illustrations enhance the text and make A Briefer History of Time an exhilarating addition in its own right to the literature of science.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    By focusing on the experiences of ordinary villagers as they lived-and died-during the Black Death (1345-50), Hatcher vividly places the reader directly inside those tumultuous times and describes in fascinating detail the day-to-day existence of people struggling with the tragic effects of the plague. Dramatic scenes portray how contemporaries must have felt and thought about these momentous events: what they knew and didn't know about the horrors of the disease, what they believed about death and God's vengeance, and how they tried to make sense of it all despite frantic rumors, frightening tales, and fearful sermons.

    Evans connects the dots between coffee and its Islamic origins, the drug ephedra and Mormons, music and Stonehenge, and much more. Chapters also include step-by-step guides for re-creating prehistoric debauchery in your modern life based on Evans's firsthand fieldwork. Readers won't just learn about the beer that destroyed South America's first empire; they'll learn how to make it.

    Murderous Contagion tells the compelling and at times unbearably moving story of the devastating impact of diseases on humankind - from the Black Death of the 14th century to the Spanish flu of 1918-19 and the AIDS epidemic of the modern era. In this book Mary Dobson also relates the endeavours of physicians and scientists to understand and identify the causes of diseases and find ways of preventing them. This is a timely and revelatory work of popular history by a writer whose knowledge of, and enthusiasm for, her subject shines through her every word.

    We are now all too aware of how it is applied, but we know far less about how the idea came to be--and where it may yet go.Until Proven Safe tracks the idea of quarantine around the globe, through time and space, chasing the story from the lazarettos and quarantine islands of Venice--built before communicable diseases were really understood--to the hallways of the CDC, NASA, and the cutting-edge labs and conference rooms where the future technology of quarantine is being developed. The result is a tour of an idea that could not be more urgent or relevant, a book full of stories, people, and insights that is as compelling as it is definitive.

    But in Tomatoland, which is based on his James Beard Award-winning article, "The Price of Tomatoes," investigative food journalist Barry Estabrook reveals the huge human and environmental cost of the $5 billion fresh tomato industry. Fields are sprayed with more than one hundred different herbicides and pesticides. Tomatoes are picked hard and green and artificially gassed until their skins acquire a marketable hue. Modern plant breeding has tripled yields, but has also produced fruits with dramatically reduced amounts of calcium, vitamin A, and vitamin C, and tomatoes that have fourteen times more sodium than the tomatoes our parents enjoyed. The relentless drive for low costs has fostered a thriving modern-day slave trade in the United States. How have we come to this point?   Estabrook traces the supermarket tomato from its birthplace in the deserts of Peru to the impoverished town of Immokalee, Florida, a.k.a. the tomato capital of the United States. He visits the laboratories of seedsmen trying to develop varieties that can withstand the rigors of agribusiness and still taste like a garden tomato, and then moves on to commercial growers who operate on tens of thousands of acres, and eventually to a hillside field in Pennsylvania, where he meets an obsessed farmer who produces delectable tomatoes for the nation's top restaurants.Throughout Tomatoland, Estabrook presents a who's who cast of characters in the tomato industry: the avuncular octogenarian whose conglomerate grows one out of every eight tomatoes eaten in the United States; the ex-Marine who heads the group that dictates the size, color, and shape of every tomato shipped out of Florida; the U.S. attorney who has doggedly prosecuted human traffickers for the past decade; and the Guatemalan peasant who came north to earn money for his parents' medical bills and found himself enslaved for two years.Tomatoland reads like a suspenseful whodunit as well as an expose of today's agribusiness systems and the price we pay as a society when we take taste and thought out of our food purchases.

    But what would it look like to study the whole of history, from the big bang through the present day -- and even into the remote future? How would looking at the full span of time change the way we perceive the universe, the earth, and our very existence?These were the questions David Christian set out to answer when he created the field of "Big History," the most exciting new approach to understanding where we have been, where we are, and where we are going. In Origin Story, Christian takes readers on a wild ride through the entire 13.8 billion years we've come to know as "history." By focusing on defining events (thresholds), major trends, and profound questions about our origins, Christian exposes the hidden threads that tie everything together -- from the creation of the planet to the advent of agriculture, nuclear war, and beyond.With stunning insights into the origin of the universe, the beginning of life, the emergence of humans, and what the future might bring, Origin Story boldly reframes our place in the cosmos.

    

    In his groundbreaking Before the Dawn, Wade reveals humanity's origins as never before--a journey made possible only recently by genetic science, whose incredible findings have answered such questions as: What was the first human language like? How large were the first societies, and how warlike were they? When did our ancestors first leave Africa, and by what route did they leave? By eloquently solving these and numerous other mysteries, Wade offers nothing less than a uniquely complete retelling of a story that began 500 centuries ago.

    From distressed small communities in Central Appalachia to wealthy suburbs; from disparate cities to once-idyllic farm towns; it's a heartbreaking trajectory that illustrates how this national crisis has persisted for so long and become so firmly entrenched. Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy endeavors to answer a grieving mother's question-why her only son died-and comes away with a harrowing story of greed and need. From the introduction of OxyContin in 1996, Macy parses how America embraced a medical culture where overtreatment with painkillers became the norm. In some of the same distressed communities featured in her bestselling book Factory Man, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.Through unsparing, yet deeply human portraits of the families and first responders struggling to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows, astonishingly, that the only thing that unites Americans across geographic and class lines is opioid drug abuse. But in a country unable to provide basic healthcare for all, Macy still finds reason to hope-and signs of the spirit and tenacity necessary in those facing addiction to build a better future for themselves and their families.

    Our intellectual capacity, our introversion or extraversion, our vulnerability to mental illness, even whether we are a morning person - all of these aspects of our personality are profoundly shaped by our inherited DNA differences.In Blueprint, Robert Plomin, a pioneer in the field of behavioural genetics, draws on a lifetime's worth of research to make the case that DNA is the most important factor shaping who we are. Our families, schools and the environment around us are important, but they are not as influential as our genes. This is why, he argues, teachers and parents should accept children for who they are, rather than trying to mould them in certain directions. Even the environments we choose and the signal events that impact our lives, from divorce to addiction, are influenced by our genetic predispositions. Now, thanks to the DNA revolution, it is becoming possible to predict who we will become, at birth, from our DNA alone. As Plomin shows us, these developments have sweeping implications for how we think about parenting, education, and social mobility.A game-changing book by a leader in the field, Blueprint shows how the DNA present in the single cell with which we all begin our lives can impact our behaviour as adults.