For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions - 98% of the human genome - were dismissed as 'junk'. But in recent years researchers have discovered that variations in this 'junk' DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself - and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.

    During that year of physical recovery, Runyon began to question what he’d done, undertaking the complicated journey from near-death back to high school, and from suicide back to the emotional mainstream of life.In the tradition of Running with Scissors and Girl, Interrupted, The Burn Journals is a truly remarkable book about teenage despair and recovery.

    Like its predecessors, this updated Sixth Edition is organized around the periodic table of elements and provides a systematic treatment of the chemistry of all chemical elements and their compounds. It incorporates important recent developments with an emphasis on advances in the interpretation of structure, bonding, and reactivity.From the reviews of the Fifth Edition: "The first place to go when seeking general information about the chemistry of a particular element, especially when up-to-date, authoritative information is desired."--Journal of the American Chemical Society"Every student with a serious interest in inorganic chemistry should have [this book]."-- Journal of Chemical Education "A mine of information . . . an invaluable guide."-- Nature "The standard by which all other inorganic chemistry books are judged."-- Nouveau Journal de Chimie "A masterly overview of the chemistry of the elements."-- The Times of London Higher Education Supplement "A bonanza of information on important results and developments which could otherwise easily be overlooked in the general deluge of publications."-- Angewandte Chemie

    Yet The Origin of Species (1859) is also a humane and inspirational vision of ecological interrelatedness, revealing the complex mutual interdependencies between animal and plant life, climate and physical environment, and—by implication—within the human world. Written for the general reader, in a style which combines the rigour of science with the subtlety of literature, The Origin of Species remains one of the founding documents of the modern age.

    Lies My Teacher Told Me won the American Book Award and the Oliver Cromwell Cox Award for Distinguished Anti-Racist Scholarship.James W. Loewen, a sociology professor and distinguished critic of history education, puts 12 popular textbooks under the microscope-and what he discovers will surprise you. In his opinion, every one of these texts fails to make its subject interesting or memorable. Worse still is the proliferation of blind patriotism, mindless optimism and misinformation filling the pages.From the truth about Christopher Columbus to the harsh reality of the Vietnam War, Loewen picks apart the lies we've been told. This audiobook, narrated by Brian Keeler (The Hurricane, "All My Children") will forever change your view of the past.

    This thorough introduction to second language research provides a comprehensive review of the research into learner language, internal and external factors in language acquisition, individual differences, and classroom second language learning.

    one of the most important and readable works on the human past published in recent years."Winner of the Pulitzer Prize and a national bestseller: the global account of the rise of civilization that is also a stunning refutation of ideas of human development based on race.In this "artful, informative, and delightful" (William H. McNeill, New York Review of Books) book, Jared Diamond convincingly argues that geographical and environmental factors shaped the modern world. Societies that had a head start in food production advanced beyond the hunter-gatherer stage, and then developed writing, technology, government, and organized religion—as well as nasty germs and potent weapons of war—and adventured on sea and land to conquer and decimate preliterate cultures. A major advance in our understanding of human societies, Guns, Germs, and Steel chronicles the way that the modern world came to be and stunningly dismantles racially based theories of human history.Winner of the Pulitzer Prize, the Phi Beta Kappa Award in Science, the Rhone-Poulenc Prize, and the Commonwealth Club of California's Gold Medal

    It's ever-present. Without it, you would die in minutes. And it has an epic story to tell.In Caesar's Last Breath, New York Times bestselling author Sam Kean takes us on a journey through the periodic table, around the globe, and across time to tell the story of the air we breathe, which, it turns out, is also the story of earth and our existence on it.With every breath, you literally inhale the history of the world. On the ides of March, 44 BC, Julius Caesar died of stab wounds on the Senate floor, but the story of his last breath is still unfolding; in fact, you're probably inhaling some of it now. Of the sextillions of molecules entering or leaving your lungs at this moment, some might well bear traces of Cleopatra's perfumes, German mustard gas, particles exhaled by dinosaurs or emitted by atomic bombs, even remnants of stardust from the universe's creation.Tracing the origins and ingredients of our atmosphere, Kean reveals how the alchemy of air reshaped our continents, steered human progress, powered revolutions, and continues to influence everything we do. Along the way, we'll swim with radioactive pigs, witness the most important chemical reactions humans have discovered, and join the crowd at the Moulin Rouge for some of the crudest performance art of all time. Lively, witty, and filled with the astounding science of ordinary life, Caesar's Last Breath illuminates the science stories swirling around us every second.

     What is it like to be the senior surgeon when a young woman is brought to casualty with a life-threatening bleed? What does the fear of cancer do to a person? Is it ever best not to tell the patient everything? Tender is the Scalpel’s Edge draws on Gautam Das’s real-life experiences working in Britain’s busy NHS hospitals, from the plunging depths of a patient dying on the operating table to the euphoria of a life saved by teamwork and skill. Described in exquisite detail and with extreme sensitivity, Gautam shares his journey from a medical student fighting his own inner demons to a senior NHS consultant surgeon. Shards of his earlier life in India add to the richness of the narrative in tales that observe life with all its contradictions, like the little village boy with bone cancer. While other anecdotes take in the lighter side of life, Tender is the Scalpel’s Edge is written to inform and engross the general reader, as well as those with a curiosity of life behind the surgeon’s mask. Written in a manner similar to other medical biographies including Henry Marsh’s Do No Harm, Atul Gawande’s Being Mortal and When Breath Becomes Air by Paul Kalanithi, Tender is the Scalpel’s Edge is a moving collection of true stories from a professional at the frontline of medical care.

    For others, even among those with philosophies as diverse as William James and Ludwig Wittgenstein, philosophy is simply a tool, or a process for ascertaining individual factual truths specific to a given time and place. It is often said that if you ask any ten philosophers to define their subject, you�1/2re likely to get ten different answers. Here, presented for non-specialist readers, is an easy-to-understand survey of ideas put forth by 100 important philosophers, from the pre-Socratics of ancient Greece to the analytic philosophers of the present day. Each thinker is summarized in a single illustrated page, or in many instances, in a two-page spread. Each entry includes the philosopher�1/2s birth and death dates, titles of major works, major influences, a capsule biographical sketch, and a brief summary of his or her most important ideas. In addition to philosophers in our own Western tradition, readers will find Chinese sages, including Confucius and Lao-tzu, the Indian Buddhist philosopher Ngrjuna, and thinkers representing other cultures. Just a few of the 100 important thinkers represented in this book are:PlatoAristotleAugustine of HippoRoger BaconThomas AquinasThomas HobbesJohn LockeRene DescartesBaruch SpinozaImmanuel KantG.W.F. HegelFriedrich NietzscheWilliam JamesLudwig WittgensteinMartin HeideggerJean-Paul SartreAlfred Jules AyerWillard V.O. QuineThomas KuhnDonald Davidsonand many othersThe text is enhanced with more than 250 illustrations and a glossary of philosophical terms.

    Under the stewardship of the eminent editorial team, comprising two editors with experience gained over previous editions and a third editor new to this edition, and in response to reader feedback, the content has been sub-divided into parts to ensure a logical sequence and grouping of related chapters throughout while the text features enthusiastically received in the last edition have been retained. The new edition opens with sections devoted to the underlying principles of surgical practice, investigation and diagnosis, and pre-operative care. These are followed by chapters covering all aspects of surgical trauma. The remainder of the book considers each of the surgical specialties in turn, from elective orthopaedics through skin, head and neck, breast and endocrine, cardiothoracic and vascular, to abdominal and genitourinary.Key features: Authoritative: emphasises the importance of effective clinical examination and soundly based surgical principles, while taking into account the latest developments in surgical practice.Updated: incorporates new chapters on a wide variety of topics including metabolic response to injury, shock and blood transfusion, and surgery in the tropics.Easy to navigate: related chapters brought together into clearly differentiated sections for the first time.Readable: preserves the clear, direct writing style, uncluttered by technical jargon, that has proved so popular in previous editions.User-friendly: numerous photographs and explanatory line diagrams, learning objectives, summary boxes, biographical footnotes, memorable anecdotes and full-colour presentation supplement and enhance the text throughout.Bailey and Love has a wide appeal to all those studying surgery, from undergraduate medical students to those in preparation for their postgraduate surgical examinations. In addition, its high standing and reputation for unambiguous advice also make it the first point of reference for many practising surgeons. The changes that have been introduced to the 25th edition will only serve to strengthen support for the text among all these groups.

    strategic defense. Ninety percent of all U.S. military forces in Japan are located on Okinawa, one of the Ryukyu Islands, and it was through these troops that the martial art of karate was exported to the U.S.In Okinawa: History of an Island People, noted Eastern affairs specialist George Kerr recounts the fascinating history of the island and its environs, from 1314 A.D. to the late twentieth century. The histories of Japan, Okinawa and the entire Pacific region are crucially intertwined so the study of this fascinating chain of islands is crucial to understanding all of East Asia. First published in 1958, this edition features a new introduction and appendix by Okinawa history scholar Mitsugu Sakihara, making this the most comprehensive resource on the small, vital, and intriguing island of Okinawa.

    A class can be skilled and motivated to learn without a teacher always having to lead. Engaging learners in this way unpicks intrinsic motivation, the foundation that underpins a productive learning environment and helps to develop independent learning.Based on five years of intensive research through Osiris Education's award-winning Outstanding Teaching Intervention program this book is packed with proven advice and innovative tools that were developed in these successful outstanding lessons. Written in the same humorous, thought-provoking style with which they both teach and train, the authors aim to challenge all who teach, from newly qualified teachers to seasoned professionals, to reflect on their day-to-day practice and set an agenda for sustainable improvement.

    The Official Hunger Games Reading Group Guide from Scholastic includes a wide variety of questions that are sure to spark conversation in book clubs and among friends!

    Musicians of this genre have developed an often impenetrable sound that teeters on the edge of screaming, incomprehensible noise. Extreme metal circulates on the edge of mainstream culture within the confines of an obscure 'scene', in which members explore dangerous themes such as death, war and the occult, sometimes embracing violence, neo-fascism and Satanism. In the first book-length study of extreme metal, Keith Kahn-Harris draws on first-hand research to explore the global extreme metal scene. He shows how the scene is a space in which members creatively explore destructive themes, but also a space in which members experience the everyday pleasures of community and friendship. Including interviews with band members and fans, from countries ranging from the UK and US to Israel and Sweden, Extreme Metal: Music and Culture on the Edge demonstrates the power and subtlety of an often surprising and misunderstood musical form.