In this selection from The Body, Bill Bryson introduces us to the mysterious, and often devastating, world of disease.

    We have no hereditary aristocracy or landed gentry, and even the poorest among us feel that they can become rich through education, hard work, or sheer gumption. And yet social class remains a powerful force in American life.In Class Matters, a team of New York Times reporters explores the ways in which class--defined as a combination of income, education, wealth, and occupation--influences destiny in a society that likes to think of itself as a land of opportunity. We meet individuals in Kentucky and Chicago who have used education to lift themselves out of poverty and others in Virginia and Washington whose lack of education holds them back. We meet an upper-middle-class family in Georgia who moves to a different town every few years, and the newly rich in Nantucket whose mega-mansions have driven out the longstanding residents. And we see how class disparities manifest themselves at the doctor's office and at the marriage altar.For anyone concerned about the future of the American dream, Class Matters is truly essential reading.Class Matters is a beautifully reported, deeply disturbing, portrait of a society bent out of shape by harsh inequalities. Read it and see how you fit into the problem or--better yet--the solution!--Barbara Ehrenreich, author of Nickel and Dimed and Bait and Switch

    This book connects Lean tools to the Lean journey, shows how to identify and eliminate waste, and aids the reader in seeing Lean for what it truly is: to create a learning and problem solving culture. Written to educate the entire organization on the fundamentals of Lean thinking, this is the perfect source to engage all team members at all levels of an organization.

    Fascinating... may presage a paradigm shift in medicine." --Kirkus Reviews (starred review)Teeming with information and big ideas... Outstanding."--Booklist (starred review) The origin of asthma, autism, Alzheimer's, allergies, cancer, heart disease, obesity, and even some kinds of depression is now clear. Award-winning researcher on the microbiome, professor Rodney Dietert presents a new paradigm in human biology that has emerged in the midst of the ongoing global epidemic of noncommunicable diseases.The Human Superorganism makes a sweeping, paradigm-shifting argument. It demolishes two fundamental beliefs that have blinkered all medical thinking until very recently: 1) Humans are better off as pure organisms free of foreign microbes; and 2) the human genome is the key to future medical advances. The microorganisms that we have sought to eliminate have been there for centuries supporting our ancestors. They comprise as much as 90 percent of the cells in and on our bodies--a staggering percentage! More than a thousand species of them live inside us, on our skin, and on our very eyelashes. Yet we have now significantly reduced their power and in doing so have sparked an epidemic of noncommunicable diseases--which now account for 63 percent of all human deaths.Ultimately, this book is not just about microbes; it is about a different way to view humans. The story that Dietert tells of where the new biology comes from, how it works, and the ways in which it affects your life is fascinating, authoritative, and revolutionary. Dietert identifies foods that best serve you, the superorganism; not new fad foods but ancient foods that have made sense for millennia. He explains protective measures against unsafe chemicals and drugs. He offers an empowering self-care guide and the blueprint for a revolution in public health. We are not what we have been taught. Each of us is a superorganism. The best path to a healthy life is through recognizing that profound truth.

    Why do we mistrust people more in the UK than in Japan? Why do Americans have higher rates of teenage pregnancy than the French? What makes the Swedish thinner than the Greeks? The answer: inequality. This groundbreaking book, based on years of research, provides hard evidence to show how almost everything—-from life expectancy to depression levels, violence to illiteracy-—is affected not by how wealthy a society is, but how equal it is. Urgent, provocative and genuinely uplifting, The Spirit Level has been heralded as providing a new way of thinking about ourselves and our communities, and could change the way you see the world.

    But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    A spiritual history ranging from the first English settlements to the present day, the book is also a lively, deeply learned meditation on hope.Andrew Delbanco tells of the stringent God of Protestant Christianity, who exerted immense force over the language, institutions, and customs of the culture for nearly 200 years. He describes the falling away of this God and the rise of the idea of a sacred nation-state. And, finally, he speaks of our own moment, when symbols of nationalism are in decline, leaving us with nothing to satisfy the longing for transcendence once sustained by God and nation.From the Christian story that expressed the earliest Puritan yearnings to New Age spirituality, apocalyptic environmentalism, and the multicultural search for ancestral roots that divert our own, The Real American Dream evokes the tidal rhythm of American history. It shows how Americans have organized their days and ordered their lives--and ultimately created a culture--to make sense of the pain, desire, pleasure, and fear that are the stuff of human experience. In a time of cultural crisis, when the old stories seem to be faltering, this book offers a lesson in the painstaking remaking of the American dream.

    But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

    It shouldn't take a worldwide pandemic and nationwide protests to bring economic and racial inequality to the forefront of problems we desperately need to solve. But now that the opportunity is here, what should we do? How can we create more equality, opportunity, and growth for everyone? Not someday, but what can government and the private sector do right now to disrupt a status quo that almost everyone wants to change?In Common Sense, the New York Times best-selling author Joel Greenblatt offers an investor's perspective on building an economy that truly works for everyone. With dry wit and engaging storytelling, he makes a lively and provocative case for disruptive new approaches--some drawn from personal experience, some from the outside looking in. How can leading corporations immediately disrupt our education establishment while creating high-paying job opportunities for those currently left behind? If we want a living wage for everyone, how can we afford it while using an existing program to get it done now? If we subsidize banks, what simple changes can we make to the way we capitalize and regulate them to help grow the economy, increase access, and create more jobs (while keeping the risks and benefits where they belong)? Greenblatt also explains how dramatically increasing immigration would be like giving every American a giant bonus and the reason Australia might be the best place to learn about saving for retirement.Not everyone will agree with what Greenblatt has to say--but all of us can benefit from the conversations he aims to start.

    In addition to fine-tuning and streamlining the prose and the overall presentation, the authors have comprehensively updated the text and the applications to reflect recent economic developments and topics of current interest. Students in particular will find the Study Guide, with its practice questions, exercises, and problems, to be an excellent source of study support and extra review material. It is available in both a one- and a two-volume edition.

    At his death last spring, Roueche left behind seven new narratives that have never been published in book form. This book collects these works along with one earlier classic--all relating true tales of strange illnesses, rare diseases, and the brilliant minds who race to understand and conquer them.

    David Schneider’s The Invention of Surgery is an in-depth biography of the practice that has leapt forward over the centuries from the dangerous guesswork of ancient Greek physicians through the world-changing “implant revolution” of the twentieth century.The Invention of Surgery explains this dramatic progress and highlights the personalities of the discipline's most dynamic historical figures. It links together the lives of the pioneering scientists who first understood what causes disease, how organs become infected or cancerous, and how surgery could powerfully intercede in people’s lives, and then shows how the rise of surgery intersected with many of the greatest medical breakthroughs of the last century, including the evolution of medical education, the transformation of the hospital from a place of dying to a habitation of healing, the development of antibiotics, and the rise of transistors and polymer science.And as Schneider argues, surgery has not finished transforming; new technologies are constantly reinventing both the practice of surgery and the nature of the objects we are permanently implanting in our bodies. Schneider considers these latest developments, asking “What’s next?” and analyzing how our conception of surgery has changed alongside our evolving ideas of medicine, technology, and our bodies.

    Losing Ground argues that the ambitious social programs of the1960s and 1970s actually made matters worse for its supposed beneficiaries, the poor and minorities. Charles Murray startled readers by recommending that we abolish welfare reform, but his position launched a debate culminating in President Clinton’s proposal “to end welfare as we know it.”

    From the start, the drug's manufacturer aggressively marketed its patented time-release formula as a breakthrough in the effort to reduce prescription drug abuse. It wasn't long, however, before thrill-seeking teenagers shattered that illusion of safety; by simply crushing an "Oxy," they were able to tap into a high so seductive it would come to dominate their lives. Some patients, seeking relief from pain, also found themselves drawn to the drug's dark side. Pain Killer takes readers on a journey of discovery that begins with the true story of Lindsay, a high-school cheerleader in Virginia who gets hooked on Oxys, and expands outward to explore the critical issues of legitimate pain management, prescription drug abuse, and how the misuse of science by the drug industry threatens the public good. With the fast-rising abuse of prescription drugs by young people ringing alarm bells within government, the how and why behind the OxyContin disaster is a gripping read not only for parents, but also for medical professionals, community leaders, business executives, and all those concerned with this crisis. The dangers described in Pain Killer also reverberate far beyond the threat from a single drug at a particular moment in time. The focus of our government's war on drugs has clearly misled many of us into thinking that only illegal drugs smuggled from beyond our borders can be abused. As Meier tells the dramatic story, some of the most deadly substances are produced and sold legally right here at home.THE EXTRAORDINARY AND TRUE STORY OF OXYCONTIN EQUAL PARTS crime thriller, medical detective story, and business exposé, Pain Killer takes a hard-hitting look at how a powerful drug touted as the salvation for millions triggered a national tragedy. At its inception, the legal narcotic OxyContin was seen as a pharmaceutical dream, a "wonder" drug that would herald a sea change in medical care while reaping vast profits for its maker. It did do that; but it also unleashed a public health crisis that cut a swath of despair and crime through unsuspecting small towns, suburbs, and cities across the country. As reports of OxyContin overdoses made front-page and network news, doctors, narcotics agents, regulators, industry executives, and lawmakers raced in, scrambling to slow the damage. Behind it all stood one of America's wealthiest families, and a drug company whose relentless promotion helped fuel the problem Written by award-winning journalist Barry Meier, whose special report in the New York Times triggered national interest in OxyContin, Pain Killer chronicles the rise of the multibillion dollar pain management industry and lays bare its excesses and abuses.

    Spar spent most of her life avoiding feminism. Raised after the tumult of the 1960s, she presumed that the gender war was over. “We thought we could glide into the new era with babies, board seats, and husbands in tow,” she writes. “We were wrong.”Spar should know. One of the first women professors at Harvard Business School, she went on to have three children and became the chair of her department. Now, she’s the president of Barnard College, arguably the most important women’s college in the country, and an institution firmly committed to feminism. Wonder Women is Spar’s story, but it is also the culture’s. Armed with reams of new research, she examines how women’s lives have, and have not, changed over the past fifty years—and how it is that the struggle for power has become a quest for perfection. Wise, often funny, and always human, Wonder Women asks: How far have women really come? And what will it take to get true equality for good?