An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

     The daughter of acclaimed British actor Sir John Mills was still a preteen when she began her acting career and was quickly thrust into the spotlight. Under the wing of Walt Disney himself, Hayley Mills was transformed into one of the biggest child starlets of the 1960s through her iconic roles in Pollyanna, The Parent Trap, and many more. She became one of only twelve actors in history to be bestowed with the Academy Juvenile Award, presented at the Oscars by its first recipient, Shirley Temple, and went on to win a number of awards including a Golden Globe, multiple BAFTAs, and a Disney Legacy Award.Now, in her charming and forthright memoir, she provides a unique window into when Hollywood was still 'Tinseltown' and the great Walt Disney was at his zenith, ruling over what was (at least in his own head) still a family business. This behind-the-scenes look at the drama of having a sky-rocketing career as a young teen in an esteemed acting family will offer both her childhood impressions of the wild and glamorous world she was swept into, and the wisdom and broader knowledge that time has given her. Hayley will delve intimately into her relationship with Walt Disney, as well as the emotional challenges of being bound to a wholesome, youthful public image as she grew into her later teen years, and how that impacted her and her choices--including marrying a producer over 30 years her senior when she was 20! With her regrets, her joys, her difficulties, and her triumphs, this is a compelling read for any fan of classic Disney films and an inside look at a piece of real Hollywood history.

    She could barely find the strength to get off the sofa, let alone piece her life back together. Until one day she did something she had never done of her own free will – she pulled on a pair of trainers and went for a run.That first attempt didn’t last very long. But to her surprise, she was back out there the next day. And the day after that. She began to set herself achievable goals – to run 5k in under 30 minutes, to walk to work every day for a week, to attempt 10 push-ups in a row. Before she knew it, her mood was lifting for the first time in years.In Jog On, Bella explains with hilarious and unfiltered honesty how she used running to battle crippling anxiety and depression, without having to sacrifice her main loves: booze, cigarettes and ice cream. With the help of a supporting cast of doctors, psychologists, sportspeople and friends, she shares a wealth of inspirational stories, research and tips that show how exercise often can be the best medicine. This funny, moving and motivational book will encourage you to say ‘jog on’ to your problems and get your life back on track – no matter how small those first steps may be.

    But for thousands of years, people have done things like this—and things that make radioactive underpants seem downright sensible! In their hit podcast, Sawbones, Sydnee and Justin McElroy breakdown the weird and wonderful way we got to modern healthcare. And some of the terrifying detours along the way.Every week, Dr. Sydnee McElroy and her husband Justin amaze, amuse, and gross out (depending on the week) hundreds of thousands of avid listeners to their podcast, Sawbones. Consistently rated a top podcast on iTunes, with over 15 million total downloads, this rollicking journey through thousands of years of medical mishaps and miracles is not only hilarious but downright educational. While you may never even consider applying  boiled weasel to your forehead (once the height of sophistication when it came to headache cures), you will almost certainly face some questionable medical advice in your everyday life (we’re looking at you, raw water!) and be better able to figure out if this is a miracle cure (it’s not) or a scam. Table of Contents:Part One: The Unnerving The Resurrection Men Fun w Galvanism Weird Weight Loss Miracle Cure: Opium Black Plague Heroes of Misguided Medicine: Pliny the Elder Erectile Dysfunction The Doctor Is In: Listener Questions Answered Don’t Drill a Hole in Your HeadPart Two: The Gross Mummy Medicine The Guthole Bromance The Unkillable Phineas Gage Max Drank Poopy Water Heroes of Misguided Medicine: Robert Liston Golden Showers of Health Miracle Cure-All: Radium Dr. John Romulus Brinkley The Doctor Is In Q&A Just (Four) Humour Me The Camel Dung MiraclePart Three: The Weird The Dancing Plague Bad Medicine: Tobacco for Health The Seasick-Proof Saloon Miracle Cure-All: Vinegar The Doctor Is In Q&A Heroes of Misguided MedicinePart Four: The Awesome The Poison Squad Bad Medicine: Self Experimentation Eat Your Chocolate! Heroes of Misguided Medicine Parrot Fever Miracle Cure-All: Honey The Miraculous Polio Vaccine The Doctor Is In

    Difficulty breathing. Overwhelming dread. Andrea Petersen was first diagnosed with an anxiety disorder at the age of twenty, but she later realized that she had been experiencing panic attacks since childhood. With time her symptoms multiplied. She agonized over every odd physical sensation. She developed fears of driving on highways, going to movie theaters, even licking envelopes. Although having a name for her condition was an enormous relief, it was only the beginning of a journey to understand and master it—one that took her from psychiatrists’ offices to yoga retreats to the Appalachian Trail. Woven into Petersen’s personal story is a fascinating look at the biology of anxiety and the groundbreaking research that might point the way to new treatments. She compares psychoactive drugs to non-drug treatments, including biofeedback and exposure therapy. And she explores the role that genetics and the environment play in mental illness, visiting top neuroscientists and tracing her family history—from her grandmother, who, plagued by paranoia, once tried to burn down her own house, to her young daughter, in whom Petersen sees shades of herself. Brave and empowering, this is essential reading for anyone who knows what it means to live on edge.

    In FOLKS, THIS AIN'T NORMAL, he discusses how far removed we are from the simple, sustainable joy that comes from living close to the land and the people we love. Salatin has many thoughts on what normal is and shares practical and philosophical ideas for changing our lives in small ways that have big impact.Salatin, hailed by the New York Times as "Virginia's most multifaceted agrarian since Thomas Jefferson [and] the high priest of the pasture" and profiled in the Academy Award nominated documentary Food, Inc. and the bestselling book The Omnivore's Dilemma, understands what food should be: Wholesome, seasonal, raised naturally, procured locally, prepared lovingly, and eaten with a profound reverence for the circle of life. And his message doesn't stop there. From child-rearing, to creating quality family time, to respecting the environment, Salatin writes with a wicked sense of humor and true storyteller's knack for the revealing anecdote. Salatin's crucial message and distinctive voice--practical, provocative, scientific, and down-home philosophical in equal measure--make FOLKS, THIS AIN'T NORMAL a must-read book.

    Paul's School recently came under state investigation after extensive reports of sexual abuse on campus, Lacy Crawford thought she'd put behind her the assault she'd suffered at St. Paul's decades before, when she was fifteen. Still, when detectives asked for victims to come forward, she sent a note.Her criminal case file reopened, she saw for the first time evidence that corroborated her memories. Here were depictions of the naïve, hard-working girl she'd been, a chorister and debater, the daughter of a priest; of the two senior athletes who assaulted her and were allowed to graduate with awards; and of the faculty, doctors, and priests who had known about Crawford's assault and gone to great lengths to bury it.Now a wife, mother, and writer living on the other side of the country, Crawford learned that police had uncovered astonishing proof of an institutional silencing years before, and that unnamed powers were still trying to block her case. The slander, innuendo, and lack of adult concern that Crawford had experienced as a student hadn't been imagined as the effects of trauma, after all: these were the actions of a school that prized its reputation above anything, even a child.This revelation launched Crawford on an extraordinary inquiry into the ways gender, privilege, and power shaped her experience as a girl at the gates of America's elite. Her investigation looks beyond the sprawling playing fields and soaring chapel towers of crucibles of power like St. Paul's, whose reckoning is still to come. And it runs deep into the channels of shame and guilt, witness and silencing, that dictate who can speak and who is heard in American society.An insightful, mature, beautifully written memoir, Notes on a Silencing is an arresting coming-of-age story that wrestles with an essential question for our time: what telling of a survivor's story will finally force a remedy?

    Now comes a gripping account of the doctors and scientists fighting to protect us, an urgent wake-up call about the future of emerging viruses—from the #1 bestselling author of The Hot Zone, soon to be a National Geographic original miniseries.This time, Ebola started with a two-year-old child who likely had contact with a wild creature and whose entire family quickly fell ill and died. The ensuing global drama activated health professionals in North America, Europe, and Africa in a desperate race against time to contain the viral wildfire. By the end—as the virus mutated into its deadliest form, and spread farther and faster than ever before—30,000 people would be infected, and the dead would be spread across eight countries on three continents.In this taut and suspenseful medical drama, Richard Preston deeply chronicles the outbreak, in which we saw for the first time the specter of Ebola jumping continents, crossing the Atlantic, and infecting people in America. Rich in characters and conflict—physical, emotional, and ethical—Crisis in the Red Zone is an immersion in one of the great public health calamities of our time.Preston writes of doctors and nurses in the field putting their own lives on the line, of government bureaucrats and NGO administrators moving, often fitfully, to try to contain the outbreak, and of pharmaceutical companies racing to develop drugs to combat the virus. He also explores the charged ethical dilemma over who should and did receive the rare doses of an experimental treatment when they became available at the peak of the disaster. Crisis in the Red Zone makes clear that the outbreak of 2013–2014 is a harbinger of further, more severe outbreaks, and of emerging viruses heretofore unimagined—in any country, on any continent. In our ever more interconnected world, with roads and towns cut deep into the jungles of equatorial Africa, viruses both familiar and undiscovered are being unleashed into more densely populated areas than ever before.The more we discover about the virosphere, the more we realize its deadly potential. Crisis in the Red Zone is an exquisitely timely book, a stark warning of viral outbreaks to come.

    Confusing messages from health authorities and ineffective treatments have left many people desperate for reliable solutions. An enormous alternative industry is filling the void, selling products that are often of questionable safety and totally unknown effectiveness.In Clean, doctor and journalist James Hamblin explores how we got here, examining the science and culture of how we care for our skin today. He talks to dermatologists, microbiologists, allergists, immunologists, aestheticians, bar-soap enthusiasts, venture capitalists, Amish people, theologians, and straight-up scam artists, trying to figure out what it really means to be clean. He even experiments with giving up showers entirely, and discovers that he is not alone.Along the way he realizes that most of our standards of cleanliness are less related to health than most people think. A major part of the picture has been missing: a little-known ecosystem known as the skin microbiome--the trillions of microbes that live on our skin and in our pores. These microbes are not dangerous; they're more like an outer layer of skin that no one knew we had, and they influence everything from acne, eczema, and dry skin to how we smell. The new goal of skin care will be to cultivate a healthy biome--and to embrace the meaning of "clean" in the natural sense. This can mean doing much less, saving time, money, energy, water, and plastic bottles in the process.Lucid, accessible, and deeply researched, Clean explores the ongoing, radical change in the way we think about our skin, introducing readers to the emerging science that will be at the forefront of health and wellness conversations in coming years.

    From the moment a doctor in Raleigh, North Carolina, put "male" on Jacob Tobia's birth certificate, everything went wrong. Alongside "male" came many other, far less neutral words: words that carried expectations about who Jacob was and who Jacob should be, words like "masculine" and "aggressive" and "cargo shorts" and "SPORTS!"Naturally sensitive, playful, creative, and glitter-obsessed, as a child Jacob was given the label "sissy." In the two decades that followed, "sissy" joined forces with "gay," "trans," "nonbinary," and "too-queer-to-function" to become a source of pride and, today, a rallying cry for a much-needed gender revolution. Through revisiting their childhood and calling out the stereotypes that each of us have faced, Jacob invites us to rethink what we know about gender and offers a bold blueprint for a healed world--one free from gender-based trauma and bursting with trans-inclusive feminism.From Jacob's Methodist childhood and the hallowed halls of Duke University to the portrait-laden parlors of the White House, Sissy takes you on a gender odyssey you won't soon forget. Writing with the fierce honesty, wildly irreverent humor, and wrenching vulnerability that have made them a media sensation, Jacob shatters the long-held notion that people are easily sortable into "men" and "women." Sissy guarantees that you'll never think about gender--both other people's people's and your own--the same way again.

    See ISBN 9780465094646History is full of strange animal stories invented by the brightest and most influential, from Aristotle to Disney. But when it comes to understanding animals, we’ve got a long way to go.Whether we’re watching a viral video of romping baby pandas or looking at a picture of penguins ‘holding hands’, we often project our own values – innocence, abstinence, hard work – onto animals. So you’ve probably never considered that moose get drunk and that penguins are notorious cheats.In The Unexpected Truth About Animals Zoologist Lucy unravels many such myths – that eels are born from sand, that swallows hibernate under water, and that bears gave birth to formless lumps that are licked into shape by their mothers – to show that the stories we create reveal as much about us as they do about the animals.Astonishing, illuminating and laugh-out-loud funny.

    At 28 years old, Scott Harrison had it all. A top nightclub promoter in New York City, his life was an endless cycle of drugs, booze, models--repeat. But 10 years in, desperately unhappy and morally bankrupt, he asked himself, "What would the exact opposite of my life look like?" Walking away from everything, Harrison spent the next 16 months on a hospital ship in West Africa and discovered his true calling. In 2006, with no money and less than no experience, Harrison founded charity: water. Today, his organization has raised over $300 million to bring clean drinking water to more than 8.2 million people around the globe.In Thirst, Harrison recounts the twists and turns that built charity: water into one of the most trusted and admired nonprofits in the world. Renowned for its 100% donation model, bold storytelling, imaginative branding, and radical commitment to transparency, charity: water has disrupted how social entrepreneurs work while inspiring millions of people to join its mission of bringing clean water to everyone on the planet within our lifetime.In the tradition of such bestselling books as Shoe Dog and Mountains Beyond Mountains, Thirst is a riveting account of how to build a better charity, a better business, a better life--and a gritty tale that proves it's never too late to make a change.100% of the author's net proceeds from Thirst will go to fund charity: water projects around the world.

    He chronicles the torture of finding a job before the internet when you had to talk on the phone all the time, and fantasizes, as we all do, about who to tell off when he finally wins an Oscar. As Gary himself says, "These are essays from my childhood and young adulthood about things that still annoy me."Original, brazen, and laugh out loud funny, Do You Mind if I Cancel? is something not to be missed.

    But as you will see in Playing God, earning an M.D. is just the first step to becoming a real physician.In this page-turning, thrilling, and moving memoir, Dr. Anthony Youn reveals that the true metamorphosis from student to doctor occurs not in medical school but in the formative years of residency training and early practice. It is only through actually saving and losing patients, taking on the medical establishment, wrestling with financial and emotional survival, and fighting for patients’ lives that a young doctor becomes a mature and competent physician.Dr. Youn takes you from the operating rooms of a university surgery residency program to the gleaming offices of top Beverly Hills plastic surgeons to opening the doors of his empty clinic as a new doctor with no money, no patients, and mountains of debt. Playing God leaves you with an unexpected answer to that profound question: “What does it mean to be a doctor?” In Playing God, you will take a journey through the world of surgery, hospitals, and the practice of medicine unlike any that you have traveled before.

    Then came an irresistible opportunity: she won a fellowship to spend three months, all expenses paid, anywhere in the world to research and write a book. Did she choose a glittering metropolis, a romantic village, an exotic paradise? Um, no. Nell chose Bleaker Island, a snowy, windswept pile of rock off the Falklands. There, in a guesthouse where she would be the only guest, she imagined she could finally rid herself of distractions and write her 2,500 words a day. In three months, surely she'd have a novel, right?It's true that there aren't many distractions on Bleaker, other than sheep, penguins, paranoia and the weather. But as Nell gets to work on her novel--a delightful Dickensian fiction she calls Bleaker House--she discovers that an excruciatingly erratic Internet connection and 1100 calories a day (as much food as she could carry in her suitcase, budgeted to the raisin) are far from ideal conditions for literary production. With deft humour, this memoir traces Nell's island days and slowly reveals details of the life and people she has left behind in pursuit of her art. They pop up in her novel, as well, as memoir and novel start to reflect one another. It seems that there is nowhere Nell can run--neither a remote island nor the pages of her notebook--to escape herself.A whimsical, entertaining, thought-provoking blend of memoir and travelogue, laced with tongue-in-cheek writing advice, Bleaker House brilliantly captures the hopes, fears, self-torture and humour of being young and yearning to make a creative life. With winning honesty and wit, Nell's race to finish her book emerges as a fascinating narrative in its own right.