Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.Through a fresh and engaging examination of our evolutionary history, Dr. Moalem reveals how many of the conditions that are diseases today actually gave our ancestors a leg up in the survival sweepstakes. When the option is a long life with a disease or a short one without it, evolution opts for disease almost every time.Everything from the climate our ancestors lived in to the crops they planted and ate to their beverage of choice can be seen in our genetic inheritance. But Survival of the Sickest doesn't stop there. It goes on to demonstrate just how little modern medicine really understands about human health, and offers a new way of thinking that can help all of us live longer, healthier lives..

    These are hilarious true stories that are supported by actual court records, along with legal analysis explaining in plain English how each court reached its particular result. Learn how evidence is hidden from the jury (lawfully), why an armed robber who is caught red handed will be set free if police don't follow procedure, and why doctors are so obsessive about writing things down. * This Kindle version also includes hyperlinks to selected court materials.

    Seasoned researchers and educators Gregory G. Colomb and Joseph M. Williams present an updated third edition of their classic handbook, whose first and second editions were written in collaboration with the late Wayne C. Booth. The Craft of Research explains how to build an argument that motivates readers to accept a claim; how to anticipate the reservations of readers and to respond to them appropriately; and how to create introductions and conclusions that answer that most demanding question, “So what?” The third edition includes an expanded discussion of the essential early stages of a research task: planning and drafting a paper. The authors have revised and fully updated their section on electronic research, emphasizing the need to distinguish between trustworthy sources (such as those found in libraries) and less reliable sources found with a quick Web search. A chapter on warrants has also been thoroughly reviewed to make this difficult subject easier for researchers Throughout, the authors have preserved the amiable tone, the reliable voice, and the sense of directness that have made this book indispensable for anyone undertaking a research project.

    With the brilliant insight he brought to his renowned work inside the FBI's elite serial-crime unit, John Douglas pieces together motives behind violent sociopathic behavior. He not only takes us into the darkest recesses of the minds of arsonists, hijackers, bombers, poisoners, assassins, serial killers, and mass murderers, but also the seemingly ordinary people who suddenly kill their families or go on a rampage in the workplace.Douglas identifies the antisocial personality, showing surprising similarities and differences among various types of deadly offenders. He also tracks the progressive escalation of those criminals' sociopathic behavior. His analysis of such diverse killers as Lee Harvey Oswald, Theodore Kaczynski, and Timothy McVeigh is gripping, but more importantly, helps us learn how to anticipate potential violent behavior before it's too late.

    This set couples a book containing the six easiest chapters from Richard P. Feynman's landmark work, Lectures on Physics—specifically designed for the general, non-scientist reader—with the actual recordings of the late, great physicist delivering the lectures on which the chapters are based. Nobel Laureate Feynman gave these lectures just once, to a group of Caltech undergraduates in 1961 and 1962, and these newly released recordings allow you to experience one of the Twentieth Century's greatest minds—as if you were right there in the classroom.

    They would ask her about her family’s health history, and she would hear the doctor’s familiar sigh after she answered, “I don’t know, I’m adopted.”Being perfectly happy with the loving family she had, Feldman never took an interest in finding her biological parents until diagnosed with a disease that she passed on to her son. Suddenly, Nancy’s lack of family history was affecting someone else.Writing to the Nebraska Children’s Home Society for help, the adoption agency assigned Nancy’s case to Rebecca Crofoot. This began a 17-year journey between the two women who were determined to find information about a family that might not know, or want to know, Nancy existed.Family Medical History: Unknown/Adopted is a heart-warming story of personal, medical, genealogical and emotional discovery.

    The author of such acclaimed books as Hero With a Thousand Faces and The Power of Myth discusses the primitive roots of mythology, examining them in light of the most recent discoveries in archaeology, anthropology, and psychology.

    A light-hearted and informative reminder of all the things that we learnt in school but have since become relegated to the backs of our minds, I Used to Know That features hundreds of important snippets of wisdom, facts, theories, equations, phrases, rules and sayings. A practical guide to turn to when an answer is eluding you, when helping a child with homework or preparing them for the new school year, or maybe just to brush up on trivia for the pub quiz. I Used to Know That covers English Language and Literature, Mathematics, Biology, Chemistry, Physics, History, Geography and General Studies, so never again will you find yourself stumped!

    

    Stringer's new theory, based on archeological and genetic evidence, holds that distinct humans coexisted and competed across the African continent—exchanging genes, tools, and behavioral strategies.Stringer draws on analyses of old and new fossils from around the world, DNA studies of Neanderthals (using the full genome map) and other species, and recent archeological digs to unveil his new theory. He shows how the most sensational recent fossil findings fit with his model, and he questions previous concepts (including his own) of modernity and how it evolved.Lone Survivors will be the definitive account of who and what we were, and will change perceptions about our origins and about what it means to be human.

    Both the book and film were inspired by a series of multimedia presentations on global warming that Gore created and delivers to groups around the world. With this book, Gore, who is one of our environmental heroes—and a leading expert—brings together leading-edge research from top scientists around the world; photographs, charts, and other illustrations; and personal anecdotes and observations to document the fast pace and wide scope of global warming. He presents, with alarming clarity and conclusiveness—and with humor, too—that the fact of global warming is not in question and that its consequences for the world we live in will be disastrous if left unchecked. This riveting new book—written in an accessible, entertaining style—will open the eyes of even the most skeptical.

    Shubin describes how over the last half-century, scientists have been able to explore how genetic recipes build bodies during embryological development--how these inventions and adaptations occur in a nonprogressive manner in different contexts, at different speeds. Paleontology has been transformed over the last 50 years by tools and techniques of molecular biology--and it is that revolution in our understanding of the evolution of life that Shubin traces here. Each of us is a mosaic of precursors that came about at different times and places, with deep rooted connections across species that Darwin, for all he understood, could never even have imagined.

    

    A twenty-eight year old — and not widely famous — Christopher Wren was giving a lecture on astronomy. As his audience listened to him speak, they decided that it would be a good idea to create a Society to promote the accumulation of useful knowledge.With that, the Royal Society was born. Since its birth, the Royal Society has pioneered scientific exploration and discovery. Isaac Newton, Charles Darwin, Albert Einstein, Robert Hooke, Robert Boyle, Joseph Banks, Humphry Davy, Isambard Kingdom Brunel, John Locke, Alexander Fleming — all were fellows.Bill Bryson’s favourite fellow was Reverend Thomas Bayes, a brilliant mathematician who devised Bayes’ theorem. Its complexity meant that it had little practical use in Bayes’ own lifetime, but today his theorem is used for weather forecasting, astrophysics and stock market analysis. A milestone in mathematical history, it only exists because the Royal Society decided to preserve it — just in case. The Royal Society continues to do today what it set out to do all those years ago. Its members have split the atom, discovered the double helix, the electron, the computer and the World Wide Web. Truly international in its outlook, it has created modern science.Seeing Further celebrates its momentous history and achievements, bringing together the very best of science writing. Filled with illustrations of treasures from the Society’s archives, this is a unique, ground-breaking and beautiful volume, and a suitable reflection of the immense achievements of science.