The most current information on the mechanisms, manifestations, and treatments of disease are clearly and concisely presented. Accessible writing, numerous illustrations in full-color, and complete and separate treatment of pediatric pathophysiology are the hallmarks of this popular and respected text. The new third edition features extensively revised and updated content and an enhanced art program.The book is divided into two parts. Part One presents the general principles of pathophysiology, including cell injury and repair; genetics; fluids and electrolytes, acids and bases; immunity, inflammation, and infection; stress; and cancer. Part Two is organized by body system, and for each system it covers normal anatomy and physiology, alterations of function in adults, and alterations of function in children.• Complete but concise coverage provides a thorough discussion of general pathophysiology and specific disease processes. • Outstanding full-color art program illustrates normal anatomy and physiology, disease processes, and clinical manifestations of disease. • Pediatric content is presented in 9 separate chapters to provide thorough coverage of how disease processes specifically affect children. • Health Alert boxes present brief discussions of new research, diagnostic studies, preventative care, treatments, or other developments related to health or specific diseases. • Quick Check questions appear at the end of major sections of text and are designed to promote critical thinking. Suggested answers to the questions are found on the CD companion included with the text. • Risk Factor boxes illustrate how certain risk factors are associated with specific diseases. • Did You Understand? chapter summaries provide students with a comprehensive review of the major concepts presented in each chapter. • Aging content is identified with a special icon within the adult chapters. • Algorithms are used throughout the text to illustrate normal and compensatory physiology and pathophysiology. • Key terms are boldface in text and listed with page numbers at the end of each chapter for easy reference and chapter review.• Approximately 250 new full-color drawings have been added. • An Introduction to Pathophysiology included in the front matter defines pathophysiology — and related terms such as etiology and epidemiology — and explains why it is important. • Extensive updates, based on the most current research, have been made throughout the book. • To reflect the latest developments, the Biology of Cancer chapter has been completely rewritten. • Several chapters, including Fluids and Electrolytes, Acids and Bases and Alterations of the Reproductive Systems have been extensively edited.

    Stunning photographs showcase the area's unusual geology, and chapters on history and wildlife describe the delicately balanced ecosystems. A guide to desert wildflowers is also included, and trail maps are provided for more than 20 of the best hikes in the park.

    

    . . on addiction.”—Ezra Klein, New York Times.“Accessible and enjoyable. The Craving Mind brilliantly combines the latest science with universal real-life experiences—from falling in love to spending too much time with our phones.”—Arianna Huffington We are all vulnerable to addiction. Whether it’s a compulsion to constantly check social media, binge eating, smoking, excessive drinking, or any other behaviors, we may find ourselves uncontrollably repeating. Why are bad habits so hard to overcome? Is there a key to conquering the cravings we know are unhealthy for us?   This book provides groundbreaking answers to the most important questions about addiction. Dr. Judson Brewer, a psychiatrist and neuroscientist who has studied the science of addictions for twenty years, reveals how we can tap into the very processes that encourage addictive behaviors in order to step out of them. He describes the mechanisms of habit and addiction formation, then explains how the practice of mindfulness can interrupt these habits. Weaving together patient stories, his own experience with mindfulness practice, and current scientific findings from his own lab and others, Dr. Brewer offers a path for moving beyond our cravings, reducing stress, and ultimately living a fuller life.

    Some people will adore the grainy texture of a pear, while others will shudder at the idea of this texture in their mouths. Touching a feather boa will be fun and luxurious to some, and others will bristle at the idea of all those feathers brushing on the skin. Noisy, busy environments will energize some people, and will overwhelm others.The author identifies four major sensory types: Seekers; Bystanders; Avoiders and Sensors. Readers can use the questionnaire to find their own patterns and the patterns of those around them, and can benefit from practical sensory ideas for individuals, families and businesses.Armed with the information in Living Sensationally, people will be able to pick just the right kind of clothing, job and home and know why they are making such choices.

     Whether eating, taking drugs, engaging in sex, or doing good deeds, the pursuit of pleasure is a central drive of the human animal. In The Compass of Pleasure Johns Hopkins neuroscientist David J. Linden explains how pleasure affects us at the most fundamental level: in our brain. As he did in his award-winning book, The Accidental Mind, Linden combines cutting-edge science with entertaining anecdotes to illuminate the source of the behaviors that can lead us to ecstasy but that can easily become compulsive. Why are drugs like nicotine and heroin addictive while LSD is not? Why has the search for safe appetite suppressants been such a disappointment? The Compass of Pleasure concludes with a provocative consideration of pleasure in the future, when it may be possible to activate our pleasure circuits at will and in entirely novel patterns.

    In On Being Certain, neurologist Robert Burton challenges the notions of how we think about what we know. He shows that the feeling of certainty we have when we know something comes from sources beyond our control and knowledge. In fact, certainty is a mental sensation, rather than evidence of fact. Because this feeling of knowing seems like confirmation of knowledge, we tend to think of it as a product of reason. But an increasing body of evidence suggests that feelings such as certainty stem from primitive areas of the brain, and are independent of active, conscious reflection and reasoning. The feeling of knowing happens to us; we cannot make it happen. Bringing together cutting edge neuroscience, experimental data, and fascinating anecdotes, Robert Burton explores the inconsistent and sometimes paradoxical relationship between our thoughts and what we actually know. Provocative and groundbreaking, On Being Certain, will challenge what you know (or think you know) about the mind, knowledge, and reason.

    Our memory is unreliable; we can't multiply large sums in our heads; advertising manipulates our judgment; we tend to distrust people who are different from us; supernatural beliefs and superstitions are hard to shake; we prefer instant gratification to long-term gain; and what we presume to be rational decisions are often anything but. Drawing on striking examples and fascinating studies, neuroscientist Dean Buonomano illuminates the causes and consequences of these "bugs" in terms of the brain's innermost workings and their evolutionary purposes. He then goes one step further, examining how our brains function-and malfunction-in the digital, predator-free, information-saturated, special effects-addled world that we have built for ourselves. Along the way, Brain Bugs gives us the tools to hone our cognitive strengths while recognizing our inherent weaknesses.

    Adam Brochert, MD-who scored in the 99th percentile on the Step 2 USMLE-and Theodore X. O'Connell, MD-author of several review and clinical reference books-present essential questions and answers covering the important concepts you need to know to score well on the USMLE Step 2 exam: key conditions you will be expected to recognize, all specialty and subspecialty topics, and necessary clinical concepts.Learn the most important questions and answers with the proven format of the highly acclaimed Secrets Series.Master all specialty and subspecialty topics covered on Step 2.Identify key facts and secrets using the Top 100 Secrets chapter.Review material quickly and easily thanks to bulleted lists, algorithms, and illustrations.Apply the pearls, tips, memory aids, and secrets from well-known and highly popular authors, Adam Brochert, MD and Theodore X. O'Connell, MD. Find information quickly with a second color highlighting chapter and section titles, legends, bullets and icons, and key terms.Consult the book wherever you go thanks to the portable size that fits in your lab coat pocket.

    The Seventh Edition has been updated with stronger coverage of evidence-based practice, including content on how to read, interpret, and critique systematic reviews, which are considered by many to be a cornerstone of evidence-based practice. Also included in the Seventh Edition: a more balanced presentation of medical and social science methods and nomenclature; enhanced coverage of qualitative research; and more!

    Gritty, powerful, and ultimately redemptive, Something for the Pain is a revealing glimpse into the fragility of compassion and sanity in the industrial setting of today’s hospitals.

    While studying brain scans of several family members, he discovered that one perfectly matched a pattern he d found in the brains of serial killers. This meant one of two things: Either his family s scans had been mixed up with those of felons or someone in his family was a psychopath.Even more disturbing: The scan in question was his own.This is Fallon s account of coming to grips with this discovery and its implications. How could he, a happy family man who had never been prone to violence, be a psychopath? How much did his biology influence his behavior?Fallon shares his journey to answer these questions and the discoveries that ultimately led to his conclusion: Despite everything science can teach, humans are even more complex than we can imagine."

    Heralded by Publishers Weekly as one of the best science books of the year, it is a provocative and deeply engaging book that elucidates the ties between a woman's experience of her vagina and her sense of self; her impulses, dreams, and courage; and her role in love and in society in completely new and revelatory ways sure to provoke impassioned conversation.A brilliant and nuanced synthesis of physiology, history, and cultural criticism, Vagina: A New Biography explores the physical, political, and spiritual implications of this startling series of new scientific breakthroughs for women and for society as a whole, from a writer whose conviction and keen intelligence have propelled her works to the tops of bestseller lists, and firmly into the realms of modern classics.

    Sapolsky's acclaimed and successful Why Zebras Don't Get Ulcers features new chapters on how stress affects sleep and addiction, as well as new insights into anxiety and personality disorder and the impact of spirituality on managing stress.As Sapolsky explains, most of us do not lie awake at night worrying about whether we have leprosy or malaria. Instead, the diseases we fear--and the ones that plague us now--are illnesses brought on by the slow accumulation of damage, such as heart disease and cancer. When we worry or experience stress, our body turns on the same physiological responses that an animal's does, but we do not resolve conflict in the same way--through fighting or fleeing. Over time, this activation of a stress response makes us sick.

    Translated into eight languages, it is an essential textbook, an accessible reference, and a bestselling text worldwide.This authoritative textbook retains the successful layout and approach of the bestselling fourth edition Four extra chapters have been added on dry eye, scleritis, corneal and refractive surgery, and systemic diseases.Each chapter have been updated and expanded and the number of illustrations greatly increased.Over a third of the illustrations are new for this editionFour extra chapters have been added on dry eye, scleritis, corneal and refractive surgery, and systemic diseases.The contents of each chapter have been updated and expanded and the number of illustrations has significantly increased.