Left untouched were many of the things known to cause cancer, including tobacco, the workplace, radiation, or the global environment. Proof of how the world in which we live and work affects whether we get cancer was either overlooked or suppressed. This has been no accident. The War on Cancer was run by leaders of industries that made cancer-causing products, and sometimes also profited from drugs and technologies for finding and treating the disease. Filled with compelling personalities and never-before-revealed information, The Secret History of the War on Cancer shows how we began fighting the wrong war, with the wrong weapons, against the wrong enemies-a legacy that persists to this day. This is the gripping story of a major public health effort diverted and distorted for private gain. A portion of the profits from this book will go to support research on cancer prevention.

    Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    Finding out where it came from and how it first jumped into people is an urgent priority, but early expectations that this would prove an easy question to answer have been dashed. Nearly two years into the pandemic, the crucial mystery of the origin of SARS-CoV-2 is not only unresolved but has deepened.In this uniquely insightful book, a scientist and a writer join forces to try to get to the bottom of how a virus whose closest relations live in bats in subtropical southern China somehow managed to begin spreading among people more than 1,500 kilometres away in the city of Wuhan. They grapple with the baffling fact that the virus left none of the expected traces that such outbreaks usually create: no infected market animals or wildlife, no chains of early cases in travellers to the city, no smouldering epidemic in a rural area, no rapid adaptation of the virus to its new host--human beings.To try to solve this pressing mystery, Viral delves deep into the events of 2019 leading up to 2021, the details of what went on in animal markets and virology laboratories, the records and data hidden from sight within archived Chinese theses and websites, and the clues that can be coaxed from the very text of the virus's own genetic code.The result is a gripping detective story that takes the reader deeper and deeper into a metaphorical cave of mystery. One by one the authors explore promising tunnels only to show that they are blind alleys, until, miles beneath the surface, they find themselves tantalisingly close to a shaft that leads to the light.

     Several hours before the Germans launched the deadliest campaign in military history in 1941, Adolf Hitler and Joseph Goebbels, the minister of popular enlightenment and propaganda, were discussing the timing of their imminent invasion of the Soviet Union. According to Goebbels' journals, the two worked on Hitler's speech, and marveled at the ways in which they were planning to defeat communism and change the map of Europe. But that night, Hitler and Goebbels also discussed the recent advances in cancer research made by Nazi doctors in their pursuit of a "sanitary utopia." As science historian Robert N. Proctor exposes in his provocative new book The Nazi War on Cancer, the Nazi medical establishment was years ahead of the rest of the world in public health reform and research. Proctor is far from being a revisionist historian, and recognizes the extreme sensitivity of his subject matter. In fact, he is a cautious and elegant writer who frequently reminds readers of his earlier book, Racial Hygiene: Medicine Under the Nazis, in which he documents the horrors of Nazi medical experiments. In this book, however, he finds that some Nazi scientific research was actually path-breaking and may have developed some of the era's most successful cancer prevention programs. As Proctor is careful to distinguish, The Nazi War on Cancer is not a book that champions Nazi medical practices; rather, it is "abookabout fascism, and a book about science," as the author seeks to understand how "fascism suppressed certain kinds of science&[and] how fascist ideals fostered research directions and lifestyle fashions that look strikingly like those we today might embrace." Until now, historians' focus on Nazi medical research has traditionally concentrated on political and racial ideology, because "little might appear to be gained by pointing to Nazi success in fighting food dyes, tobacco, or occupational dust." But the extraordinary work conducted during the Wilhelmine and Weimar eras was undeniable — German medicine and public health was the envy of the world at that time. In what is perhaps one of Proctor's most astounding revelations, evidence of the link between cigarette smoking and lung cancer was published as early as 1929 by Nazi physician Fritz Lickint, though cigarette incriminating studies didn't appear in England and the United States until 1950. Hitler was a virulent anti-smoker, and his regime launched one of the most aggressive anti-tobacco campaigns of the twentieth century. By 1938, smoking was banned in many offices, hospitals and rest homes, and "no-smoking" cars were established on all German trains by the following year. According to one propaganda poster, Hitler attributed his "performance at work" to his ability to resist both nicotine and alcohol. Diet was also important to the Nazis, and public health officials strongly promoted the consumption whole-grain breads, vegetables, and fruits, and other foods that were low in fat, high in fiber, and free of artificial colorings and preservatives. Germans were also encouraged to consult their physicians regularly for early cancer detection, and women were taught how to perform breast self-examinations as early as 1936. As one poster caption read: "Every automobile gets a regular checkup; that is obvious. Shouldn't the much more complicated machine of the human body also get regular checkups?" Why were Nazis so concerned with cancer prevention? Proctor notes that cancer "expressed larger cultural idioms" and became "a metaphor for all that was seen as wrong with society." Because of this, the German body "belonged" to the Führer, and good health was considered a citizen's duty. Because Nazi public health workers attributed improper diet as a major contributor to cancer, the effort to become the master race could only be achieved through healthy living. As one Hitler Youth manual asserted, "Nutrition is not a private matter!" It is far from Proctor's intention to express the simplistic and irresponsible sentiment that "good can come from evil" by bringing readers' attention to the progress made by Nazi scientists. Instead, this brave and sophisticated account brilliantly evokes the nuances of ethical paradoxes, as Proctor successfully points out our "need to better understand how the routine practice of science can so easily coexist with the routine exercise of cruelty." —Kera Bolonik

    He asks: How do we "read" other people?What is the neurochemistry behind love and sex?What does it mean that the brain is teeming with powerful chemicals closely related to recreational drugs?Why does music move us to tears?Where do breakthrough ideas come from? Johnson answers these and many more questions arising from the events of our everyday lives. You do not have to be a neuroscientist to wonder, for example, why do you smile? And why do you sometimes smile inappropriately, even if you don't want to? How do others read your inappropriate smile? How does such interplay occur neurochemically, and what, if anything, can you do about it? Fascinating and rewarding, Mind Wide Open speaks to brain buffs, self-obsessed neurotics, barstool psychologists, mystified parents, grumpy spouses, exasperated managers, and anyone who enjoys speculating and gossiping about the motivations and behaviors of other human beings. Steven Johnson shows us the transformative power of understanding brain science and offers new modes of introspection and tools for better parenting, better relationships, and better living.

    Instead, he finds that he has joined a new world where race is front and center. The recipient of a scholarship designed to increase black student enrollment, Tweedy soon meets a professor who bluntly questions whether he belongs in medical school, a moment that crystallizes the challenges he will face throughout his career. Making matters worse, in lecture after lecture the common refrain for numerous diseases resounds, "More common in blacks than in whites."Black Man in a White Coat examines the complex ways in which both black doctors and patients must navigate the difficult and often contradictory terrain of race and medicine. As Tweedy transforms from student to practicing physician, he discovers how often race influences his encounters with patients. Through their stories, he illustrates the complex social, cultural, and economic factors at the root of many health problems in the black community. These issues take on greater meaning when Tweedy is himself diagnosed with a chronic disease far more common among black people. In this powerful, moving, and deeply empathic book, Tweedy explores the challenges confronting black doctors, and the disproportionate health burdens faced by black patients, ultimately seeking a way forward to better treatment and more compassionate care.

    Mary T. Newport has demonstrated through her care for her husband that there is hope, relief, and perhaps a cure.

    This trend coincided with the addition of several new shots to the nation's already crowded vaccination schedule, grouped together and given soon after birth or in the early months of infancy. Most of these shots contained a little-known preservative called thimerosal, which includes a quantity of the toxin mercury.Evidence of Harm explores the heated controversy over what many parents, physicians, public officials, and educators have called an "epidemic" of afflicted children. Following several families, David Kirby traces their struggle to understand how and why their once-healthy kids rapidly descended into silence or disturbed behavior, often accompanied by severe physical illness. Alarmed by the levels of mercury in the vaccine schedule, these families sought answers from their doctors, from science, from pharmaceutical companies that manufacture vaccines, and finally from the Center for Disease Control and the Food and Drug Administration-to no avail. But as they dug deeper, the families also found powerful allies in Congress and in the small community of physicians and researchers who believe that the rise of autism and other disorders is linked to toxic levels of mercury that accumulate in the systems of some children.An important and troubling book, Evidence of Harm reveals both the public and unsung obstacles faced by desperate families who have been opposed by the combined power of the federal government, health agencies, and pharmaceutical giants. From closed meetings of the FDA, CDC, and drug companies, to the mysterious rider inserted into the 2002 Homeland Security Bill that would bar thimerosal litigation, to open hearings held by Congress, this book shows a medical establishment determined to deny "evidence of harm" that might be connected with thimerosal and mercury in vaccines. In the end, as research is beginning to demonstrate, the questions raised by these families have significant implications for all children, and for those entrusted to oversee our national health.

    Includes timelines, boxed features on significant medical breakthroughs, fascinating case histories, anecdotes and medical curiosities. Contains 150 color photographs.

    Flow spans its fascinating, occasionally wacky and sometimes downright scary story: from mikvahs (ritual cleansing baths) to menopause, hysteria to hysterectomies—not to mention the Pill, cramps, the history of underwear, and the movie about puberty they showed you in 5th grade. Flow answers such questions as: What’s the point of getting a period? What did women do before pads and tampons? What about new drugs that promise to end periods—a hot idea or not? Sex during your period: gross or a turn-on? And what’s normal, anyway?  With color reproductions of (campy) historical ads and early (excruciating) femcare devices, it also provides a fascinating (and mind-boggling) gallery of this complex, personal and uniquely female process. As irreverent as it is informative, Flow gives an everyday occurrence its true props – and eradicates the stigma placed on it for centuries.

    Its job is to protect us from cancer. This gene--known simply as p53--constantly scans our cells to ensure that when they grow and divide as part of the routine maintenance of our bodies, they do so without mishap. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, sending in the repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control (as happens in cancer), p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or handicapped by some other fault in the system. Not surprisingly, p53 is the most studied single gene in history. p53: The Gene that Cracked the Cancer Code tells the story of the discovery of the gene and of medical science's mission to unravel its mysteries and get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, the book reveals the excitement of the hunt for new cures--the hype, the enthusiasm, the lost opportunities, the blind alleys and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is at the cutting edge. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.

    Some of their responses to those outbreaks are almost too strange to believe in hindsight. Get Well Soon delivers the gruesome, morbid details of some of the worst plagues we’ve suffered as a species, as well as stories of the heroic figures who selflessly fought to ease the suffering of their fellow man. With her signature mix of in-depth research and storytelling, and not a little dark humor, Jennifer Wright explores history’s most gripping and deadly outbreaks, and ultimately looks at the surprising ways they’ve shaped history and humanity for almost as long as anyone can remember.

    Suggesting he would like Merck to be more like the maker of Wrigley's chewing gum, the CEO said it had long been his dream to make drugs for healthy people, to "sell to everyone." That dream now drives the marketing machinery of the most profitable industry on earth. From award-winning Ray Moynihan,—one of the world's top medical journalists—Selling Sickness reveals how widening the boundaries of illness and lowering the threshold for treatments is creating millions of new patients and billions in new profits. This in turn is driving up personal drug bills and threatening to bankrupt national health systems all over the world. As more and more ordinary life is "medicalized," the industry moves ever closer to being able to "sell to everyone."

    Vaccine Epidemic focuses on the searing debate surrounding individual and parental vaccination choice in the United States. Featuring more than twenty experts from the fields of ethics, law, science, medicine, business, and history, Vaccine Epidemic urgently calls for reform. It is the essential handbook for the vaccination choice movement and required reading for all people contemplating vaccination for themselves and their children. Louise Kuo Habakus and Mary Holland edit and introduce a diverse array of interrelated topics concerning the explosive vaccine controversy, including:      • The human right to vaccination choice      • The ethics and constitutionality of vaccination mandates     • Personal narratives of parents, children, and soldiers who have suffered vaccine injury     • Vaccine safety science and evidence-based medicine     • Corrupting conflicts of interest in the national vaccine program     • What should parents do? A review of eight advice books on vaccines that span the gamut.

    From biblical plagues, to the AIDS crisis, to supergerms of the future, this updated and revised edition of the original covers the whole gamut of diseases that have threatened humanity since its origins.It also includes a new chapter on the history of bioterrorism and the deplorable role it has played and is likely to play in the phenomenal diversity of diseases.