That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research—the Philadelphia chromosome. This book charts not only that landmark discovery, but also—for the first time, all in one place—the full sequence of scientific and medical discoveries that brought about the first-ever successful treatment of a lethal cancer at the genetic level.The significance of this mutant chromosome would take more than three decades to unravel; in 1990, it was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. This dramatic discovery launched a race involving doctors and researchers around the world, who recognized that in principle it might be possible to target CML at its genetic source.Science journalist Jessica Wapner brings extensive original reporting to this book, including interviews with more than thirty-five people with a direct role in this story. Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 70,000 people worldwide who are diagnosed with CML each year. Chief among them is researcher and oncologist Dr. Brian Druker, whose dedication to his patients fueled his quest to do everything within his power to save them.The Philadelphia Chromosome helps us to fully understand and appreciate just how pathbreaking, hard-won, and consequential are the achievements it recounts—and to understand the principles behind much of today’s most important cancer research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

    With numerous illustrations. In this volume is told the story of the first crusaders. It begins with their setting out, and it ends with the death of the last survivor. Eight hundred and thirty-five years have passed since then, and the lines of these men are known to us only by the chronicles of their days. Several of these chronicles were written by men who marched with the crusaders, by two chaplains and an unknown soldier. Two other narratives were finished in Beyond the Sea after the march, and we have accounts of others who saw the crusaders pass, a princess of Byzantium, an Armenian patriarch. There is also the testimony of Arab travelers and historians of the period, and the notes of Genoese sea traders, and the saga of a Norse king. Upon these original chronicles the story in this book is based. It does not deal with the legends that grew up after the crusades. It is not history rewritten. It is the story of a dozen men, most of them leaders, who started out on that long journey-what they saw on the road, and what they did, and what befell them at the Sepulcher of Christ.

    And yet for many years it was equally baffling for scientists themselves. Manjit Kumar gives a dramatic and superbly-written history of this fundamental scientific revolution, and the divisive debate at its heart.For 60 years most physicists believed that quantum theory denied the very existence of reality itself. Yet Kumar shows how the golden age of physics ignited the greatest intellectual debate of the twentieth century.Quantum sets the science in the context of the great upheavals of the modern age. In 1925 the quantum pioneers nearly all hailed from upper-middle-class academic families; most were German; and their average age was 24. But it was their irrational, romantic spirit, formed in reaction to the mechanised slaughter of the First World War that inspired their will to test science to its limits.The essential read for anyone fascinated by this complex and thrilling story and by the band of young men at its heart.

    Here is a narrative account of decisive engagements that succeeded by brilliant strategy more than by direct force. The reader accompanies those who fought, from Roman legionaries and Mongol horsemen to Napoleonic soldiery, American Civil War Rebels and Yankees, World War I Tommies, Lawrence of Arabia's bedouins, Chinese revolutionaries, British Desert Rats, Rommel's Afrika Korps, and Douglas MacArthur's Inchon invaders. However varied their weapons, the soldiers of all these eras followed a commander who faced the same obstacles and demonstrated the strategic and tactical genius essential for victory. "All warfare is based on deception," wrote Sun Tzu in The Art of War in 400 BCE. Bevin Alexander shows how great generals have interpreted this advice, and why it still holds true today.

    The Age of Reason and the Enlightenment led theorists to apply scientific reasoning to the non-scientific disciplines of politics, economics, and moral philosophy. Instead of relying on the woodcuts of dissected bodies in old medical texts, physicians opened bodies themselves to see what was there; instead of divining truth through the authority of an ancient holy book or philosophical treatise, people began to explore the book of nature for themselves through travel and exploration; instead of the supernatural belief in the divine right of kings, people employed a natural belief in the right of democracy.In this provocative and compelling book, Shermer will explain how abstract reasoning, rationality, empiricism, skepticism—scientific ways of thinking—have profoundly changed the way we perceive morality and, indeed, move us ever closer to a more just world.

    Many of the contributors bring their own special touch, presenting a refreshingly eclectic variety of personal icons, from pub signs to seaside piers, from cattle grids to canal boats, and from village cricket to nimbies.First published as a lavish colour coffee-table book, this new expanded paperback edition has double the original number of contributions from many celebrities including Bill Bryson, Michael Palin, Eric Clapton, Bryan Ferry, Sebastian Faulks, Kate Adie, Kevin Spacey, Gavin Pretor-Pinney, Richard Mabey, Simon Jenkins, John Sergeant, Benjamin Zephaniah, Joan Bakewell, Antony Beevor, Libby Purves, Jonathan Dimbleby, and many more: and a new preface by HRH Prince Charles.

    The Beatles learn to be brilliant in an hour and a half. An Englishman arrives back from Calcutta but refuses to adjust his watch. Beethoven has his symphonic wishes ignored. A US Senator begins a speech that will last for 25 hours. The horrors of war are frozen at the click of a camera. A woman designs a ten-hour clock and reinvents the calendar. Roger Bannister lives out the same four minutes over a lifetime. And a prince attempts to stop time in its tracks.Timekeepers is a book about our obsession with time and our desire to measure it, control it, sell it, film it, perform it, immortalise it and make it meaningful. It has two simple intentions: to tell some illuminating stories, and to ask whether we have all gone completely nuts.

    But the so-called Dark Ages also gave us the first universities, eyeglasses, and mechanical clocks, proving that the Middle Ages were home to a vibrant scientific culture.In The Light Ages, Cambridge science historian Seb Falk takes us on an immersive tour of medieval science through the story of one fourteenth-century monk, John of Westwyk. From multiplying Roman numerals to navigating by the stars, curing disease, and telling time with an ancient astrolabe, we learn emerging science alongside Westwyk, while following the gripping story of the struggles and successes of an ordinary man in a precarious world. An enlightening history that argues that these times weren’t so dark after all, The Light Ages shows how medieval ideas continue to color how we see the world today.

    Nuland tells the strange story of Ignác Semmelweis with urgency and the insight gained from his own studies and clinical experience. Ignác Semmelweis is remembered for the now-commonplace notion that doctors must wash their hands before examining patients. In mid-nineteenth-century Vienna, however, this was a subversive idea. With deaths from childbed fever exploding, Semmelweis discovered that doctors themselves were spreading the disease. While his simple reforms worked immediately—childbed fever in Vienna all but disappeared—they brought down upon Semmelweis the wrath of the establishment, and led to his tragic end.

     Emerging as a market town from a cluster of hill villages in the eighth and seventh centuries B.C., Rome grew to become the ancient world’s preeminent power. Everitt fashions the story of Rome’s rise to glory into an erudite page-turner filled with lasting lessons for our time. He chronicles the clash between patricians and plebeians that defined the politics of the Republic. He shows how Rome’s shrewd strategy of offering citizenship to her defeated subjects was instrumental in expanding the reach of her burgeoning empire. And he outlines the corrosion of constitutional norms that accompanied Rome’s imperial expansion, as old habits of political compromise gave way, leading to violence and civil war. In the end, unimaginable wealth and power corrupted the traditional virtues of the Republic, and Rome was left triumphant everywhere except within its own borders. Everitt paints indelible portraits of the great Romans—and non-Romans—who left their mark on the world out of which the mighty empire grew: Cincinnatus, Rome’s George Washington, the very model of the patrician warrior/aristocrat; the brilliant general Scipio Africanus, who turned back a challenge from the Carthaginian legend Hannibal; and Alexander the Great, the invincible Macedonian conqueror who became a role model for generations of would-be Roman rulers. Here also are the intellectual and philosophical leaders whose observations on the art of government and “the good life” have inspired every Western power from antiquity to the present: Cato the Elder, the famously incorruptible statesman who spoke out against the decadence of his times, and Cicero, the consummate orator whose championing of republican institutions put him on a collision course with Julius Caesar and whose writings on justice and liberty continue to inform our political discourse today. Rome’s decline and fall have long fascinated historians, but the story of how the empire was won is every bit as compelling. With The Rise of Rome, one of our most revered chroniclers of the ancient world tells that tale in a way that will galvanize, inform, and enlighten modern readers.

    This wide-ranging history of the Underground celebrates the vision and determination of the Victorian pioneers who conceived this revolutionary transport system and the men who tunnelled to make the Tube. From the early days of steam to electrification, via the Underground's contribution to twentieth-century industrial design and its role during two world wars, the story comes right up to the present with its sleek, driverless trains and the wrangles over the future of the system. The Subterranean Railway reveals London's hidden wonder and shows how the railway beneath the streets helped create the city we know today.

    For millennia Europeans believed that the world consisted of three parts: Europe, Africa, and Asia. They drew the three continents in countless shapes and sizes on their maps, but occasionally they hinted at the existence of a "fourth part of the world," a mysterious, inaccessible place, separated from the rest by a vast expanse of ocean. It was a land of myth--until 1507, that is, when Martin Waldseemuller and Matthias Ringmann, two obscure scholars working in the mountains of eastern France, made it real. Columbus had died the year before convinced that he had sailed to Asia, but Waldseemuller and Ringmann, after reading about the Atlantic discoveries of Columbus's contemporary Amerigo Vespucci, came to a startling conclusion: Vespucci had reached the fourth part of the world. To celebrate his achievement, Waldseemuller and Ringmann printed a huge map, for the first time showing the New World surrounded by water and distinct from Asia, and in Vespucci's honor they gave this New World a name: America."The Fourth Part of the World "is the story behind that map, a thrilling saga of geographical and intellectual exploration, full of outsize thinkers and voyages. Taking a kaleidoscopic approach, Toby Lester traces the origins of our modern worldview. His narrative sweeps across continents and centuries, zeroing in on different portions of the map to reveal strands of ancient legend, Biblical prophecy, classical learning, medieval exploration, imperial ambitions, and more. In Lester's telling the map comes alive: Marco Polo and the early Christian missionaries trek across Central Asia and China; Europe's early humanists travel to monastic libraries to recover ancient texts; Portuguese merchants round up the first West African slaves; Christopher Columbus and Amerigo Vespucci make their epic voyages of discovery; and finally, vitally, Nicholas Copernicus makes an appearance, deducing from the new geography shown on the Waldseemuller map that the earth could not lie at the center of the cosmos. The map literally altered humanity's worldview.One thousand copies of the map were printed, yet only one remains. Discovered accidentally in 1901 in the library of a German castle it was bought in 2003 for the unprecedented sum of $10 million by the Library of Congress, where it is now on permanent public display. Lavishly illustrated with rare maps and diagrams, "The Fourth Part of the World "is the story of that map: the dazzling story of the geographical and intellectual journeys that have helped us decipher our world.

    Through scrupulous research and vivid first-person reporting, The First Human reveals the perils and the promises of fossil hunting on a grand competitive scale.

    David Horowitz’s classic Why Israel is the Victim, updated by the author, sets the record straight about the basic truths of the Middle East conflict. In addition to restoring the authentic history of the region – a history of obsessive aggression first by Arab countries determined to physically annihilate the Jewish State and later by terror groups determined to destroy its will to survive and right to exist—this booklet brings the story up to date by showing the systematic way in which Hamas and Hezbollah, under Iran’s direction, have subverted peace in the Middle East. As Shillman Fellow Daniel Greenfield notes in his insightful introduction, this pamphlet “tells us why we should reject the “Blame Israel First” narrative that has so thoroughly saturated the mainstream media… It confronts the myth of Palestinian victimhood… and it delivers a rousing restatement of the true history of the hate that led us to all this.” America should be Israel’s protector. Instead, as David Horowitz notes, under the leadership of Barack Obama, it has become its prosecutor.