This book provides eloquent support for the idea that spontaneous neuron activity, far from being mere noise, is actually the source of our cognitive abilities. It takes a fresh look at the co-evolution of structure and function in the mammalian brain, illustrating how self-emerged oscillatory timing is the brains fundamental organizer of neuronal information. The small world-like connectivity of the cerebral cortex allows for global computation on multiple spatial and temporal scales. The perpetual interactions among the multiple network oscillators keep cortical systems in a highly sensitive metastable state and provide energy-efficient synchronizing mechanisms via weak links.In a sequence of cycles, Gy�rgy Buzs�ki guides the reader from the physics of oscillations through neuronal assembly organization to complex cognitive processing and memory storage. His clear, fluid writing accessible to any reader with some scientific knowledge is supplemented by extensive footnotes and references that make it just as gratifying and instructive a read for the specialist. The coherent view of a single author who has been at the forefront of research in this exciting field, this volume is essential reading for anyone interested in our rapidly evolving understanding of the brain.

    MATLAB has been incorporated throughtout, both in examples and problems.

    Jonathan Reiner, share the story of Cheney’s thirty-five-year battle with heart disease—providing insight into the incredible medical breakthroughs that have changed cardiac care over the last four decades. For as long as he has served at the highest levels of business and government, Vice President Dick Cheney has also been one of the world’s most prominent heart patients. Now, for the first time ever, Cheney, together with his longtime cardiologist, Jonathan Reiner, MD, shares the very personal story of his courageous thirty-five-year battle with heart disease, from his first heart attack in 1978 to the heart transplant he received in 2012.In 1978, when Cheney suffered his first heart attack, he received essentially the same treatment President Eisenhower had had in 1955. Since then, cardiac medicine has been revolutionized, and Cheney has benefitted from nearly every medical breakthrough. At each juncture, when Cheney faced a new health challenge, the technology was one step ahead of his disease. Cheney’s story is in many ways the story of the evolution of modern cardiac care.Heart is the riveting, singular memoir of both doctor and patient. Like no US politician has before him, Cheney opens up about his health struggles, sharing harrowing, never-before-told stories about the challenges he faced during a perilous time in our nation’s history. Dr. Reiner provides his perspective on Cheney’s case and also gives readers a fascinating glimpse into his own education as a doctor and the history of our understanding of the human heart. He masterfully chronicles the important discoveries, radical innovations, and cutting-edge science that have changed the face of medicine and saved countless lives.Powerfully braiding science with story and the personal with the political, Heart is a sweeping, inspiring, and ultimately optimistic book that will give hope to the millions of Americans affected by heart disease.

    Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading, at that point the largest gain in stock market history. Coming at a time of economic recession and declining technological competitiveness in the United States, the event provoked banner headlines and ignited a period of speculative frenzy over biotechnology as a revolutionary means for creating new and better kinds of pharmaceuticals, untold profit, and a possible solution to national economic malaise. Drawing from an unparalleled collection of interviews with early biotech players, Sally Smith Hughes offers the first book-length history of this pioneering company, depicting Genentech’s improbable creation, precarious youth, and ascent to immense prosperity. Hughes provides intimate portraits of the people significant to Genentech’s science and business, including cofounders Herbert Boyer and Robert Swanson, and in doing so sheds new light on how personality affects the growth of science. By placing Genentech’s founders, followers, opponents, victims, and beneficiaries in context, Hughes also demonstrates how science interacts with commercial and legal interests and university research, and with government regulation, venture capital, and commercial profits. Integrating the scientific, the corporate, the contextual, and the personal, Genentech tells the story of biotechnology as it is not often told, as a risky and improbable entrepreneurial venture that had to overcome a number of powerful forces working against it.

    Initially dismissed as dry leaves and an odd Indian drink, these two commodities came to conquer Europe on a scale unsurpassed by any other American resource or product. A fascinating story of contact, exploration, and exchange in the Atlantic world, Sacred Gifts, Profane Pleasures traces the ways in which these two goods of the Americas both changed and were changed by Europe.Focusing on the Spanish Empire, Marcy Norton investigates how tobacco and chocolate became material and symbolic links to the pre-Hispanic past for colonized Indians and colonizing Europeans alike. Botanical ambassadors of the American continent, they also profoundly affected Europe. Tobacco, once condemned as proof of Indian diabolism, became the constant companion of clergymen and the single largest source of state revenue in Spain. Before coffee or tea became popular in Europe, chocolate was the drink that energized the fatigued and uplifted the depressed. However, no one could quite forget the pagan past of tobacco and chocolate, despite their apparent Europeanization: physicians relied on Mesoamerican medical systems for their understanding of tobacco; theologians looked to Aztec precedent to decide whether chocolate drinking violated Lenten fasts.The struggle of scientists, theologians, and aficionados alike to reconcile notions of European superiority with the fact of American influence shaped key modern developments ranging from natural history to secularization. Norton considers the material, social, and cultural interaction between Europe and the Americas with historical depth and insight that goes beyond the portrayal of Columbian exchange simply as a matter of exploitation, infection, and conquest.

    Electric Circuits is the most widely used introductory circuits textbook of the past decade. The book has remained popular due to its success in implementing three themes throughout the text: (1) It builds an understanding of concepts based on information the student has previously learned; (2) The text helps stress the relationship between conceptual understanding and problem-solving approaches; (3) The authors provide numerous examples and problems that use realistic values and situations to give students a strong foundation of engineering practice.

    Escaping to a new life in Constantinople, the two land upon its shores lonely and penniless. Needing to make money fast, they plot and plan a number of outrageous money-making schemes, until they chance upon their greatest idea yet.Armed with a wicked plan to steal precious silk seeds from the faraway land of Seres, Nicander and Marius must embark upon a terrifyingly treacherous journey across unknown lands, never before completed. But first they must deceive the powerful emperor Justinian and the rest of his formidable Byzantine Empire in order to begin their journey into the unknown...An adventurous tale of mischief, humour and deception, Nicander and Marius face danger of the highest order, where nothing in the land of the Roman Empire is quite what it seems.

    With evolution as a unifying theme, this textbook emphasises on natural selection and the evolutionary process that explains biodiversity.

    It is known for scientific accuracy and currency; a modular presentation that helps students to focus on the main concepts; and art that teaches better than any other book. The fifth edition builds upon this success with new features that help students synthesize and connect important topics such as Connecting the Concepts exercises and Key Concepts quizzes; and a variety of tools to help instructors enliven their lectures like our exclusive video clips from Discovery Channel.

    Building a house would entail no more work than planting a seed in the ground. These scenarios may seem far-fetched, but pioneering geneticist George Church and science writer Ed Regis show that synthetic biology is bringing us ever closer to making such visions a reality. In Regenesis, Church and Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. Until now, nature has been the exclusive arbiter of life, death, and evolution; with synthetic biology, we now have the potential to write our own biological future. Indeed, as Church and Regis show, it even enables us to revisit crucial points in the evolution of life and, through synthetic biological techniques, choose different paths from those nature originally took. Such exploits will involve far more than just microbial tinkering. Full-blown genomic engineering will make possible incredible feats, from resurrecting woolly mammoths and other extinct organisms to creating mirror life forms with a molecular structure the opposite of our own. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

    His face was extremely expressive. Were these the qualities which had made me crazy about him? Oh no! Then what was it? Why was I so crazy about him? There were many handsome men all around me, in my house, in my neighbourhood, in my college. On the contrary, they were as young as me, unmarried too. Then what was it that I was so attracted towards him? The answer was crystal clear. It was his style, his versatile personality, his attitude of asking, `So What?` in an audacious manner. I was enchanted by his straightforwardness, his ham-handedness. All his qualities attracted my basic attitude for sure. डॉक्टरांचे निळे टपोरे डोळे आरपार वेध घ्यायचे. त्यांचे एखाद्या लहान मुलासारखे खळाळून हसणे पाहत राहावेसे वाटे. त्यांचा भावदर्शी चेहरा मोहित करायचा. अंहं. पण ज्याच्यासाठी मी वेडावून जावे, असे त्यांच्याजवळ विशेष असे काय होते? घरीदारी, कॉलेजमध्ये त्यांच्याहूनही देखणी मंडळी मी पाहत होते. शिवाय ते सर्व माझ्या बरोबरीच्या वयाचे होते. अविवाहित होते. मग डॉक्टरांचेच इतके आकर्षण मला का वाटत होते? –आणि मग एकच उत्तर डोळ्यांसमोर येत होते – ‘डॉक्टरांचे कलंदर व्यक्तिमत्त्व’, ‘सो व्हॉट?’ असं बेदरकारपणे विचारणारा त्यांचा बेधडक स्वभाव. त्यांच्या रांगडेपणाने, धसमुसळ्या सî

    I am no "scholar" of any sort. But I am very grateful to scholars for their sound work. I have found hints, suggestions for what I say here in all kinds of scholarly books, from the Yoga and Plato and St. John the Evangel and the early Greek philosophers like Herakleitos down to Fraser and his "Golden Bough," and even Freud and Frobenius. Even then I only remember hints--and I proceed by intuition. This leaves you quite free to dismiss the whole wordy mass of revolting nonsense, without a qualm.

    She then journeyed to Afghanistan and Iraq -- where she mingled with tense Iraqis, watching the gathering storm clouds of an American-led invasion -- as well as Iran, Mongolia, Uzbekistan, China, and Vietnam.Whether she's writing about being served goat's head in a Kyrgyz yurt, checking out bowling alleys in Baghdad, or trying to cook a chicken in a crumbling apartment, Burkett offers an eclectic series of adventures that are alternately comical, poignant, and discomfiting.

    It discusses neuroanatomy, cell and molecular mechanisms and signaling through a cognitive approach to behaviour. It features an expanded treatment of the nervous system, neurological and psychiatric diseases and perception.

    Comprehensive overview of Philippine History including Pre-Spanish life and culture, Spanish rule, the Filipino -American War, American rule, and the campaign for Independence, among other subjects.