In 1919, Spanish flu killed over 50 million people, more than died in both world wars combined. In 1950, an estimated 50 million people caught smallpox worldwide, of whom 10 million died. In 1980, before measles vaccine was widely used, an estimated 2.6 million children died of measles every year. Today we are hostage to a new pandemic disease -the seemingly unstoppable COVID-19.Less than 100 years ago, losing a child to an infection like diphtheria or polio was a dreaded but almost inevitable sorrow faced by all parents, from the richest to the poorest. Today, these killer diseases are almost never seen in industrialised countries, thanks to the development of vaccines. Immunisation has given modern parents peace of mind their ancestors could not imagine.The history of vaccination is rich with trial, error, sabotage and success. It encompasses the tragedy of lives lost, the drama of competition and discovery, the culpability of botched testing, and the triumph of effective, lifelong immunity. Yet with the eradication in the first world of some of humanity's deadliest foes, complacency in some quarters has set in. COVID-19 has us again racing for a vaccine. The story of past achievements and failures helps us keep the race - and the hope - in perspective.This is a book for everyone who wants to understand our past - and cares about our future.PRAISE'Anyone who has doubts about the life-saving miracle of vaccination should read this' Steven Carroll, Sydney Morning Herald'An entertaining and engaging work that is sure to delight general readers' Australian Book Review'The ideal handbook for pregnant women, parents, travellers, childcare and aged-care workers, GPs and anyone with an interest in public health' The Australian'Isaacs explores the understanding of immunity as it develops from the fifth century BC to the present day and thrills us with the progressive successes of each of the 14 vaccines which a child routinely receives today ... The work is authoritative, beguiling, amusing, instructive and inspirational. It deserves a wide readership, including infectious disease experts, other health professionals and, most assuredly, a diversity of lay people' Sir Gustav Nossal, immunologist and director of The Walter and Eliza Institute of Medical Research, Melbourne, 1965-1996'A rollicking story of human endeavour, error, misinformation, success and failure ... and more than a glimpse of why we need to continue to research, evaluate, educate and fund vaccines to prevent disease' Fiona Stanley, Distinguished Research Professor, University of Western Australia'Effortlessly accessible, Defeating the Ministers of Death brilliantly reveals the people behind the most important public health intervention in history' Professor Andrew J Pollard, Department of Paediatrics, University of Oxford'This book is an unflinching look at the triumphs and inevitable tragedies in the war against infectious diseases. Nonfiction is at its best when it reads like fiction. And David Isaacs has written a page turner' Paul A. Offit, MD, author of Bad Advice: Or Why Celebrities, Politicians, and Activists Aren't Your Best Source of Health Information

    In this psychological portrait of a city in terror, J. H. Powell presents a penetrating study of human nature revealing itself. Bring Out Your Dead is an absorbing account, form the original sources, of an infamous tragedy that left its mark on all it touched.

     Baton Rouge is a little town with big-city problems. Rich with Creole history, colorful locals, and a strong sense of community, it's also the home of Napoleonic codes, stubborn cops, and a sometimes-troubled leadership. Baton Rouge-which literally means "Red Stick"-lives up to its bloody namesake. And after more than ten years as a deputy coroner and then as its chief coroner, Louis Cataldie has seen his fair share of unusual and disturbing cases. They range from the bizarre to the heartbreaking: an LSU professor killed by a barn door; the bones of a young woman found scattered in a churchyard; and as many as three serial killers loose at one time under Cataldie's watch. He has worked the scene of one of the Malvo/ Muhammad Beltway Sniper shootings and had a hand in bringing to justice serial killer Derrick Todd Lee in a controversial investigation that was featured in an ABC Prime Time special with Diane Sawyer and Patricia Cornwell. Coroner's Journal is an unflinching look at a world that television dramas such as CSI can only begin to show us.

    By the middle of the twentieth century, it was killing millions and, as with the Black Death centuries before, physicians stood helpless. Visionaries, though, had begun to make strides earlier. On September 7, 1895, Ludwig Rehn successfully sutured the heart of a living man with a knife wound to the chest for the first time. In 1929, Dr. Werner Forssman inserted a cardiac catheter in his own arm and forced the X-ray technician on duty to take a photo as he successfully threaded it down the vein into his own heart . . . and lived. And on June 6, 1944 D-Day another momentous event occurred far from the Normandy beaches: Dr. Dwight Harken sutured the shrapnel-injured heart of a young soldier and saved his life, and thus the term "cardiac surgeon" was born. In "The Heart Healers," James Forrester, MD, tells the story of these rebels and the risks they took with their own lives and the lives of others to heal the most elemental of human organs: the heart. The result is a compelling chronicle of a disease and its cure, a disease that is still with us, but one that is slowly being worn away by the "Heart Healers."

     Two men, known in medical journals as the Berlin Patients, revealed answers to a functional cure for HIV. Their cures came twelve years apart, the first in 1996 and the second in 2008. Each received his own very different treatment in Berlin, Germany, and each result spurred a new field of investigation, fueling innovative lines of research and sparking hope for the thirty-four million people currently infected with HIV. For the first time, Nathalia Holt, who has participated in some of the most fruitful research in the field, tells the story of how we came to arrive at this astounding and controversial turning point. Holt explores the two men’s stories on a personal level, looking at how their experiences have influenced HIV researchers worldwide—including one very special young family doctor who took the time to look closely at his patients—and how they responded to their medications. Based on extensive interviews with the patients and their doctors as well as her own in-depth research, this book is an unprecedented look at how scientists pursue their inquiries, the human impact their research has, and what is and is not working in the relationship between Big Pharma and medical care.

    The book has the hallmark features for which Lippincott's Illustrated Reviews volumes are so popular: an outline format, over 600 full-color illustrations, end-of-chapter summaries, review questions, plus an entire section of clinical case studies with full-color illustrations. This edition's medical/clinical focus has been sharpened to provide a high-yield review. Five additional case studies have been included, bringing the total to nineteen. Review questions have been reformatted to comply with USMLE Step 1 style, with clinical vignettes.

    Smallpox. Incurable and horrifying Ebola-related fevers. For two decades, while a fearful world prepared for nuclear winter, an elite team of Russian bioweaponeers began to till a new killing field: a bleak tract sown with powerful seeds of mass destruction—by doctors who had committed themselves to creating a biological Armageddon. Biohazard is the never-before-told story of Russia’s darkest, deadliest, and most closely guarded Cold War secret.   No one knows more about Russia’s astounding experiments with biowarfare than Ken Alibek. Now the mastermind behind Russia’s germ warfare effort reveals two decades of shocking breakthroughs . . . how Moscow’s leading scientists actually reengineered hazardous microbes to make them even more virulent . . . the secrets behind the discovery of an invisible, untraceable new class of biological agents just right for use in political assassinations . . . the startling story behind Russia’s attempt to turn a sample of the AIDS virus into the ultimate bioweapon. And in a chilling work of real-world intrigue, Biohazard offers us all a rare glimpse into a shadowy scientific underworld where doctors manufacture mass destruction, where witnesses to errors are silenced forever, and where ground zero is closer than we ever dared believe.

    Whether they’re collecting antique weapons, practicing concealed carry, or firing an AR-15 or a Glock at their local range, many Americans love guns—which horrifies and fascinates many other Americans, and much of the rest of the world. This lively, sometimes raucous book explores from the inside the American love affair with firearms. Dan Baum is both a lifelong gun guy and a Jewish Democrat who grew up in suburban New Jersey feeling like a “child of a bitter divorce with allegiance to both parents.” In Gun Guys he grabs his licensed concealed handgun and hits the road to meet some of the 40 percent of Americans who own guns. We meet Rick Ector, a black Detroit autoworker who buys a Smith & Wesson after suffering an armed robbery—then quits his job to preach the gospel of armed self-defense, especially to the resistant black community; Jeremy and Marcey Parker, a young, successful Kentucky couple whose idea of a romantic getaway is the Blue Ridge Mountain 3-Gun Championship in Bowling Green; and Aaron Zelman, head of Jews for the Preservation of Firearms Ownership. Baum also travels to New Orleans, where he enters the world of a man disabled by a bullet, and to Chicago to interview a killer. Along the way, he takes us to gun shows, gun stores, and shooting ranges trying to figure out why so many of us love these things and why they inspire such passions.In the tradition of Confederates in the Attic and Among the Thugs, Baum brings an entire world to life. Written equally for avid shooters and those who would never touch a firearm, Gun Guys is more than a travelogue. It gives a fresh assessment of the heated politics surrounding guns, one that will challenge and inform people on all sides of the issue.  This may be the first book that goes beyond gun politics to illuminate the visceral appeal of guns—an original, perceptive, and surprisingly funny journey through American gun culture.

    It shows how a leading American psychiatrist of the early twentieth century came to believe that mental illnesses were the product of chronic infections that poisoned the brain. Convinced that he had uncovered the single source of psychosis, Henry Cotton, superintendent of the Trenton State Hospital, New Jersey, launched a ruthless campaign to “eliminate the perils of pus infection.” Teeth were pulled, tonsils excised, and stomachs, spleens, colons, and uteruses were all sacrificed in the assault on “focal sepsis.”Many patients did not survive Cotton’s surgeries; thousands more were left mangled and maimed. Cotton’s work was controversial, yet none of his colleagues questioned his experimental practices. Subsequent historians and psychiatrists too have ignored the events that cast doubt on their favorite narratives of scientific and humanitarian progress.In a remarkable feat of historical detective work, Andrew Scull exposes the full, frightening story of madness among the mad-doctors. Drawing on a wealth of documents and interviews, he reconstructs in vivid detail a nightmarish, cautionary chapter in modern psychiatry when professionals failed to police themselves.

    As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power.The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village.Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable.Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito's reign through human history and her indelible impact on our modern world order.

    While the fighting still raged, Ryszard Kapuscinski, Poland's leading foreign correspondent, traveled to Ethiopia to seek out and interview Selassie's servants and closest associates on how the Emperor had ruled and why he fell. This "sensitive, powerful. . .history" (The New York Review of Books) is Kapuscinski's rendition of their accounts—humorous, frightening, sad, grotesque—of a man living amidst nearly unimaginable pomp and luxury while his people teetered between hunger and starvation.

    Christine Gleason, one of today's most prominent pediatricians, is also a born storyteller who takes readers into life and death situations encountered in the neonatal intensive care unit.

    First published in 1954, it details his experiences when taking mescaline. The book takes the form of Huxley's recollection of a mescaline trip that took place over the course of an afternoon in May 1953. The book takes its title from a phrase in William Blake's 1793 poem 'The Marriage of Heaven and Hell'. Huxley recalls the insights he experienced, which range from the "purely aesthetic" to "sacramental vision". He also incorporates later reflections on the experience and its meaning for art and religion.

    This riveting narrative offers an account of COVID-19, reminding us of women's leadership and resilience, reflecting back hope and humanity as we all figure out a new normal, together. Throughout history, men have fought, lost, and led us through the world's defining crises. That all changed with COVID-19. In Canada, women's presence in the response to the pandemic has been notable. Women are our nurses, doctors, PSWs. Our cashiers, long-haulers, cooks. In Canada, women are leading the fast-paced search for a vaccine. They are leading our provinces and territories. At home, they are leading families through self-isolation, often bearing the responsibility for their physical and emotional health. They are figuring out what working from home looks like, and many of them are doing it while homeschooling their kids. Women crafted the blueprint for kindness during the pandemic, from sewing masks to kicking off international mutual-aid networks. And, perhaps not surprisingly, women have also suffered some of the biggest losses, bearing the brunt of our economic skydive. Through intimate portraits of Canadian women in diverse situations and fields, Women of the Pandemic is a gripping narrative record of the early months of COVID-19, a clear-eyed look at women's struggles, which highlights their creativity, perseverance, and resilience as they charted a new path forward during impossible times.

    Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.Through a fresh and engaging examination of our evolutionary history, Dr. Moalem reveals how many of the conditions that are diseases today actually gave our ancestors a leg up in the survival sweepstakes. When the option is a long life with a disease or a short one without it, evolution opts for disease almost every time.Everything from the climate our ancestors lived in to the crops they planted and ate to their beverage of choice can be seen in our genetic inheritance. But Survival of the Sickest doesn't stop there. It goes on to demonstrate just how little modern medicine really understands about human health, and offers a new way of thinking that can help all of us live longer, healthier lives..